Clinical trials: Human Embryo Cryopreservation
Embryo Transfer, Luteal Support
Modified Luteal Support for Frozen-Thawed Embryo Transfer - A Prospective Study
This study evaluates the outcomes of frozen-thawed embryo transfer (FET) success rate with modified luteal support - addition of a single injection of HCG and GnRH-agonist, on day of ET and 4 days later, respectively vs.
- Trial name
- NCT02825290
- Testing
- Choriogonadotropin alfa, Triptorelin acetate
- Where
- Israel
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Primary Infertility, Secondary Infertility
LANDA Embryo Freezing Technique.
The aim of this study is to track the outcome from the patients who had embryo cryopreservation as part of their Advanced Reproductive Technology (ART) treatment at West Coast Fertility Centers.
- Conditions
- Primary Infertility, Secondary Infertility, Genital Diseases, Male, Genital Diseases, Female
- Trial name
- Freezing (NCT01271400)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- West Coast Fertility Centers
In Vitro Fertilization
Follow-up Protocol on the Outcome of Frozen-thawed Embryo Transfer Cycles From Clinical Trial P05690 (P05711)
Clinical trial objective is to collect the outcome of Frozen-Thawed Embryo Transfer (FTET) cycles performed after the embryos are cryopreserved in the base study P05690 in order to estimate the cumulative pregnancy rate for each…
- Trial name
- NCT00702546
- Testing
- corifollitropin alfa, recFSH (follitropin alfa), gonadatropin releasing hormone (GnRH) antagonist ganirelix
- Volunteers
- 102 people
- Sponsor
- Organon and Co
Infertility
Oocyte Cryopreservation: Slow Cooling Versus Vitrification Techniques on Oocyte Survival
Oocyte cryopreservation has been studied for many years without much success in refining a method that has consistent, reliable results in producing viable embryos and clinical pregnancies.
- Trial name
- NCT00602966
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- UConn Health
Infertility
Graduated Embryo Score (GES) in the Fresh Cycle Predicts Outcome From Frozen Embryo Transfer
Evaluation of embryo quality in the fresh cycle as a predictor of outcome from frozen embryo transfer.
- Trial name
- GES/FET (NCT00694434)
- Where
- United States
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Sher Institute for Reproductive Medicine, Las Vegas
Infertility
Comparison of Transfers of Fresh and Thawed Embryos in High Responder Patients
This study tests the hypothesis that controlled ovarian stimulation impairs endometrial receptivity in high responders.
- Trial name
- NCT00963079
- Testing
- Embryo cryopreservation, Fresh blastocyst transfer
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fertility Center of Las Vegas
In Vitro Fertilization
Follow-up Study of Frozen-thawed Embryo Transfer (FTET) Cycles After Cryopreservation of Embryos in Clinical Trial P05787 (P05716)
To collect the outcome of frozen-thawed embryo transfer cycles after the embryos are cryopreserved up to at least 1 year in Trial P05787 (NCT00696800), in order to estimate the cumulative pregnancy rate for each treatment group.
- Trial name
- NCT00702273
- Testing
- 150 µg Corifollitropin Alfa, 200 IU RecFSH/Follitropin beta (Days 1 to 7), 200 IU RecFSH/Follitropin beta (Days 8 to hCG)
- Volunteers
- 344 people
- Sponsor
- Organon and Co
Human Embryo Cryopreservation
Comparison Between Three Freezing Protocols to Preserve Human Embryos
This randomized study compares three different freezing methods to store human in vitro fertilization (IVF) embryos: vitrification with two commercial kits or slow freezing.
- Trial name
- NCT00910390
- Testing
- Slow freezing, VIT-Irvine, Vit-Vitrolife
- Where
- Belgium
- Volunteers
- 584 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Infertility
Comparison of Transfers of Fresh and Thawed Embryos in Normal Responder Patients
This study tests the hypothesis that controlled ovarian stimulation impairs endometrial receptivity in normal responders.
- Trial name
- NCT00963625
- Testing
- Embryo cryopreservation, Fresh blastocyst transfer
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fertility Center of Las Vegas
Clinical Pregnancy, Live Birth
Efficacy Study of Segmentation of PGD Treatment
A single centre observational study into the segmentation of preimplantation genetic diagnosis (PGD) treatment by comparing cumulative pregnancy rates following cryopreservation of all genetically transferable embryos after PGD…
- Trial name
- NCT02133950
- Testing
- elective cryopreservation of available embryos after PGD, PGD and elective fresh embryo transfer plus cryopreservation of supernumerary available embryos after PGD
- Where
- Belgium
- Volunteers
- 252 people
- Sponsor
- Universitair Ziekenhuis Brussel
Cryopreservation, Embryo Implantation
Optimal Length of Progesterone Supplementation Before the Transfer of Cryopreserved(Frozen)-Thawed Embryos in an Artificial Cycle With Exogenous Estrogen and Progesterone.
The aim of the study is to determine whether 5 or 7 days of progesterone supplementation before transfer of a day 5 cryopreserved thawed embryos in an artificial cycle results in a significant higher pregnancy rate.
- Conditions
- Cryopreservation, Embryo Implantation, Progesteron
- Trial name
- PROFETA-5 (NCT02032797)
- Testing
- Progesterone
- Where
- Belgium
- Volunteers
- 300 people
- Sponsor
- Universitair Ziekenhuis Brussel
Frozen Embryo Transfer (FET), Assisted Reproductive Techniques
Direct Warming Frozen Embryo Transfer Outcomes in Assisted Reproductive Technology
The goal of this clinical trial is to evaluate whether the direct warming method for frozen embryo transfers (FET) can improve live birth and pregnancy outcomes in women aged 18-45 undergoing IVF treatments.
- Conditions
- Frozen Embryo Transfer (FET), Assisted Reproductive Techniques, In Vitro Fertilization (IVF), Cryopreservation of Embryos
- Trial name
- DW-FET-RCT (NCT06741748)
- Testing
- Direct Warming Method, Conventional Multi-step Thawing Method
- Where
- 3 sites in Hong Kong, United Kingdom
- Volunteers
- 578 people
- Sponsor
- Chinese University of Hong Kong
Infertility
The PrISICE Clinical Trial (Pre-Implantation Screening and Investigation on the Cryopreservation of Embryos)
The trial objective is to determine whether the deferred transfer of embryos following cryopreservation at the blastocyst stage following pre-implantation genetic screening (PGS-FET) improves live birthrates compared to both the…
- Trial name
- PrISICE (NCT03371745)
- Testing
- Trophectoderm biopsy, Cryopreservation, Embryo Transfer
- Where
- 3 sites in United States
- Volunteers
- 32 people
- Sponsor
- Yale University
Infertility
Vitrification and Slow Freezing for Cryopreservation of Blastocyst
Improvement in the treatment of infertility by Assisted Reproductive Techniques (ART) allows single embryo transfer to be applied without compromising pregnancy rates after the first in vitro fertilization (IVF) or Intra…
- Trial name
- NCT02068924
- Testing
- Slow freezing versus vitrification
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Infertility
Influence of Post-thaw Embryo Culture Interval on Assisted Reproduction Success Rates
The transfer of frozen / thawed embryos has been routinely performed in the last 30 years as part of Assisted Reproduction treatment (ART).
- Trial name
- NCT03381001
- Testing
- embryo transfer after thaw and culture, embryo transfer with no culture
- Where
- Brazil
- Volunteers
- 268 people
- Sponsor
- Federal University of Minas Gerais
Polycystic Ovary Syndrome, Infertility
Live Birth After Fresh Embryo Transfer Vs Frozen-thawed Embryo Transfer in Women With Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of childbearing age. However, the optimal infertility treatment for PCOS patients is still a matter of controversy.
- Trial name
- FreFro-PCOS (NCT01841528)
- Testing
- fresh embryo transfer, frozen-thawed embryo transfer
- Where
- 14 sites in China
- Volunteers
- 1,180 people
- Sponsor
- Zi-jiang Chen
Infertility
What is the Best Preparation for Embryo Transfer in Cryo Cycles: a Natural Cycle or Light Hormonal Stimulation?
The study investigates if, among women with a regular cycle (between 25 and 45 days), the endometrium is better prepared for the transfer of an embryo that was cryopreserved and if the subsequent embryo implantation rate is…
- Trial name
- NCT00492934
- Testing
- human menopausal gonadotrophins
- Where
- Belgium
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gasthuisberg
Infertility
Oocyte Cryopreservation Comparing Fresh and Vitrified Sibling Oocytes
Vitrification is a method to cryopreserve biological specimens that are sensitive to chilling injury such as oocytes and embryos, and it has been employed with increased survival rate and live births (Hong et al., 1999; Kuleshova…
- Trial name
- NCT00986687
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- UConn Health
Ovarian Hyperstimulation Syndrome, Infertility Drugs
Transfer of Fresh Versus Frozen/Thawed Embryos in IVF Cycles Where GnRH Agonist is Utilized for Oocyte Maturation.
It has been suggested that in IVF cycles where GNRH agonist is utilized for final oocyte maturation in patients at risk of ovarian hyperstimulation, pregnancy rates are reduced.
- Conditions
- Ovarian Hyperstimulation Syndrome, Infertility Drugs, Female
- Trial name
- NCT00365027
- Testing
- Delayed embryo transfer
- Sponsor
- HaEmek Medical Center, Israel
Breast Cancer
Risk of Infertility Related to Adjuvant Chemotherapy for Early Breast Cancer: Oocyte/Embryo Cryopreservation
The aim of the study is to perform a French multicenter prospective interventional study in order to assess the feasibility and safety of ovarian hyperstimulation for oocyte / embryo cryopreservation in young women with breast…
- Trial name
- CHACRY (NCT02871167)
- Testing
- Controlled ovarian hyperstimulation (COH), Oocyte/embryo freezing
- Where
- 28 sites in France
- Volunteers
- 140 people
- Sponsor
- Centre Oscar Lambret