Clinical trials: Human Energy Expenditure
Cardiovascular Diseases, Natriuretic Peptides
GENESIS: Genotype Guided - Natriuretic Peptides - Cardiometabolic Health Study
Natriuretic Peptides (NP) are hormones produced by the heart, and they have a wide range of favorable metabolic benefits. Lower levels of these hormones are associated with an increased likelihood of the development of diabetes…
- Conditions
- Cardiovascular Diseases, Natriuretic Peptides, Cardiometabolic Diseases, Energy Expenditure
- Trial name
- NCT05216042
- Testing
- Study diet, Exercise capacity VO2 max determination, Exercise Challenge
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Mitochondrial Diseases, Mitochondrial Myopathies
Human Mitochondrial Stress-driven Obesity Resistance
The overarching aim of this observational study is to determine alterations in energy balance while exploring the underlying cellular mechanisms in human genetic models of mitochondrial stress.
- Conditions
- Mitochondrial Diseases, Mitochondrial Myopathies, Mitochondrial Disorder
- Trial name
- MITO-OB-RES (NCT06080568)
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Weight
Energy Expenditure Assessment of Premature Infants
The goal of this study is verify if the energy expenditure in preterm infant fed with human milk is different from preterm formula.
- Trial name
- NCT00769509
- Testing
- energy expenditure in preterm fed with preterm formula, assessment of energy expenditure
- Where
- Brazil
- Volunteers
- 25 people
- Sponsor
- Oswaldo Cruz Foundation
Menstrual Dysfunction
Stress and Menstrual Health
The goal of this experimental study is to determine how stressors that do not directly impact energy state or energy demands (hereafter called "non-energetic stressors") affect reproductive health in pre-menopausal women.
- Trial name
- NCT07566260
- Testing
- Heat stress, Sleep stress, Exercise stress
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Duke University
Time Restricted Feeding
Prolonged Overnight Fast, Energy Metabolism and Skeletal Muscle Anabolic Sensitivity
Recent research shows that timing of nutritional intake and daily periods of fasting may have important health effects. In humans, limiting daily food intake to a narrow window (typically ~8 hours) can bring about some beneficial…
- Trial name
- NCT05420181
- Testing
- Short 10hr fast, Long 16h fast
- Where
- United Kingdom
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Healthy, Obesity
Stearoyl-CoA Desaturase and Energy Metabolism in Humans
The aim of this study is to examine if changing stearoyl-coenzyme A desaturase-1 (SCD1) activity through dietary interventions can increase energy metabolism in humans.
- Trial name
- SEM (NCT02647970)
- Testing
- PUFA-Cys/Met diet, SFA+Cys/Met diet
- Where
- Norway
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Fasting
The Meta-SHIFT Study: How Metabolic Shift Shapes Human Immunometabolism - a Fasting Trial
During fasting, the body shifts from using carbohydrates to relying more on fat as its main source of energy. This process is known as the 'metabolic shift'.
- Trial name
- Meta-SHIFT (NCT07527208)
- Testing
- Fasting
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cornell University
Healthy
Importance of the GH/IGF-1 Axis for Human Substrate and Energy Metabolism During Calorie Restriction
This study will investigate whether growth hormone is modulated by the enzyme SIRT1 and by that is stimulating lipolysis on expense of IGF-I production.
- Trial name
- NCT01209429
- Testing
- GH hormone infusion, 42 hour fast, 12 hour fast
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Obesity, Diabetes Mellitus, Type 2
Intestinal Metabolic Reprogramming as a Key Mechanism of Gastric Bypass in Humans
The purpose of this research study is to determine how gastric bypass surgery effects metabolism in obesity and Type 2 Diabetes.
- Conditions
- Obesity, Diabetes Mellitus, Type 2, Endocrine System Diseases, Glucose Metabolism Disorders
- Trial name
- NCT02710370
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Pittsburgh
Gastritis
The Metabolic Contribution of the Human Microbiota to Resting Energy Expenditure
The purpose of our study is to evaluate the metabolic contribution of the human microbiota to resting energy expenditure
- Trial name
- A-P-REE (NCT00487955)
- Testing
- Resting Energy Expenditure examination
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Brown Adipose Tissue
Effect of Glyceroltrinitrate on Human Energy Expenditure and Brown Adipose Tissue Thermogenesis
The aim of this study is to evaluate the efficacy of glyceroltrinitrate (Nitroderm® TTS) to activate and expand human BAT as compared to mild cold exposure.
- Trial name
- NEXT (NCT05711199)
- Testing
- Glyceroltrinitrat
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Obesity
Effect of ASEA on Energy Expenditure and Fat Oxidation in Humans
To test the effect of ASEA consumption on 24-hour resting energy expenditure. Hypothesis: consumption of 8-oz of ASEA water (4-oz before breakfast and 4-oz before bedtime) will significantly elevate 24-h resting energy…
- Trial name
- NCT01884727
- Testing
- Salt Water, ASEA water
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Energy Expenditure, Exercise
Sources and Mechanisms of Energy Compensation
Excess energy, obesity and obesity-related diseases are important global health issues. Although it is known that obesity is an issue of energy balance, the components of energy expenditure seem to be inter-related in complex…
- Conditions
- Energy Expenditure, Exercise, Energy Intake, Food Preferences
- Trial name
- NCT06432517
- Testing
- Power Bike（Ergoselect 100P）
- Where
- China
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences
Muscular Fatigue
Oleuropein and Muscle Energy Metabolism
Preclinical studies performed at Nestlé Research (NR) identified oleuropein as a novel activator of mitochondrial calcium import.
- Trial name
- NCT05217433
- Testing
- Olive leaf extract
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Aging
CALERIE (Washington University): Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy
This study is one of three CALERIE trials that test the hypothesis that a reduced calorie, nutritionally sound diet increases the length of life and prevents some age-related chronic diseases such as cancer, diabetes, and…
- Trial name
- NCT00099138
- Testing
- Caloric Restriction (CR), Exercise
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Energy Metabolism, Nutrition, Healthy
Technologies and Systems for Assessing Human Energy Metabolism and Nutritional Rehabilitation
The objective of this observational study is to integrate the doubly labeled water (DLW) database from healthy individuals with multimodal data-including, but not limited to, weight, height, age, sex, race, elevation-from cohorts…
- Trial name
- NCT07056504
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences
Healthy
Study of the Effects of Temperature on Metabolism in Human Muscle
This study will examine the role of temperature in changing energy metabolism in human muscle. In order to do this, researchers will use magnetic resonance imaging (MRI) to provide information about how parts of muscle operate…
- Trial name
- NCT00001753
- Testing
- Magnetic resonance imaging
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Obesity, Healthy Volunteers
Brain Dopamine Function in Human Obesity
Background: Dopamine is a natural chemical in the brain that may influence eating behavior and physical activity. Researchers want to measure the brain s dopamine activity and understand how it differs in people with obesity.
- Conditions
- Obesity, Healthy Volunteers, Overweight
- Trial name
- NCT03648892
- Testing
- [c11] raclopride, [18F]fallypride
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Anorexia Nervosa
Hormonal And Metabolic Signatures In Human Hypothalamic Neurons In Anorexia Nervosa
The goal of this observational study is to investigate cellular mechanisms of neuroendocrine and metabolic signaling in adult women with anorexia nervosa (AN) compared to healthy controls.
- Trial name
- HOPE (NCT07580209)
- Where
- Switzerland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Maria Miletta
Obesity
Respiratory Quotient and Food Liking, Food Wanting and Food Consumption
The purpose of this study is to observe the influence of carbohydrate-to-fat balance on liking, wanting and food consumption in humans. 16 normal-weight men (age: 23 ± 3 y)had completed a randomized 4-condition crossover study.
- Trial name
- NCT01122082
- Testing
- food preloads
- Where
- France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Burgundy