Clinical trials: Human Gut Microbiota
Coronary Disease
Bile Acids and Gut Microbiota as Potent Coronary Atheroma Risk Factors: a Prospective Study in Human
The purpose of this study is to describe the composition of bile acids and the gut microbiota comparing two populations: patients with coronary atheroma and the healthy subjects.
- Trial name
- MABAC (NCT02375893)
- Testing
- No intervention, Healthy subject
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Healthy, Human Gut Microflora
The Impact of Steviol Glycosides on Human Gut Microflora Profile and Function
Diet and dietary ingredients can have a profound effect on gut microflora, both positive and negative. The reported effects on low and non caloric sweeteners (LNCS) on human gut microflora are contradictory in some of the in…
- Trial name
- NCT05264636
- Testing
- Sucrose, Steviol Glycosides
- Where
- Canada
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Cargill
Human Immunodeficiency Virus
Improving Prognosis in HIV Infection
The primary objective of this study is to assess the safety of probiotics in cART-treated immunologic non-responder (INR) patients with chronic HIV infection.
- Trial name
- NCT02640625
- Testing
- Probiotic compound
- Where
- Norway
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Obesity
Investigation of the Gut Microbiota in Regulating Nutrient Absorption in Humans
We propose to study both stool and urine energy loss in 24 individuals on two experimental diets (50% increased and 50% reduced nutrient load relative to body size) in a random cross-over design.
- Trial name
- NCT02037295
- Testing
- Vancomycin, Overfeeding diet (OF), Underfeeding diet (UF)
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Focus of the Study is on Gut Health
Effects of a Dietary Fiber on Fecal Microbiota and Metabolism
The purpose of the study is to examine how a dietary fiber affects metabolism in healthy overweight and obese adults. The fiber will be added to foods that participants will consume for two, three-week periods.
- Trial name
- NCT01518088
- Testing
- Dietary Fiber
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ingredion Incorporated
Gastrointestinal Microbiome
Human Pilot Study - HA35 (Hyaluronan Molecular Weight 35) Dietary Supplement for Promoting Intestinal Health
The purpose of this study is to evaluate whether oral HA35 supplementation changes the normal intestinal bacteria, increases intestinal protection, decrease intestinal inflammation and permeability, and to assess any health…
- Trial name
- NCT02867605
- Testing
- Hyaluronan
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Very Preterm Infants
Feeding the Preterm Gut Microbiota - Impact of Infant-feeding on Preterm Gut Microbiota Development
Preterm infants are especially vulnerable to gut microbiota disruption and dysbiosis since their early gut microbiota is less abundant and diverse.
- Trial name
- FEEDMI (NCT03663556)
- Testing
- Infant-feeding
- Where
- 2 sites in Portugal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto
Colorectal Neoplasms, Gastrointestinal Microbiome
Predicting Adenomatous Polyps in the Colon Using Images of a Human Tongue
This is a prospective, multicenter, single-arm clinical investigation designed to evaluate the accuracy of the Gixam™ System in identifying subjects with colorectal adenomas compared to optical colonoscopy.
- Trial name
- NCT06305364
- Testing
- Gixam
- Where
- 3 sites in United States
- Volunteers
- 426 people, healthy volunteers welcome
- Sponsor
- Jubaan Ltd.
Inflammatory Bowel Diseases
Study of an Environmental Risk Factor in Crohn's Disease
Inflammatory bowel disease (IBD) are lifelong chronic diseases affecting the gastrointestinal tract. The precise etiology and the different actors participating to the pathophysiological process leading to the disease development…
- Trial name
- EVICTION (NCT04960826)
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Human Gut Microbiota
Effects of Pre-, Pro- & Anti-biotics on Gut Microbiota
The purpose of this study is to compare and contrast the effects of a prebiotic (Trametes Versicolor), a probiotic (Saccharomyces boulardii) and an antibiotic (amoxicillin) on the gut microbiota of healthy volunteers.
- Trial name
- NCT01414010
- Testing
- Trametes versicolor extract, Saccharomyces boulardii, Amoxicillin
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Diet Modification
Effect of Phytin on Human Gut Microbiome (EPoM)
Within many plants, such as seeds, nuts and cereals, there is a compound called phytic acid. Phytic acid has many beneficial properties, including producing molecules which slows down the damage that can be caused to other…
- Trial name
- EPoM (NCT03917693)
- Testing
- Phytin, rice extract
- Where
- 2 sites in United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Quadram Institute Bioscience
Gut -Microbiota, As a Preliminary Study, Healthy Population's Gut Microbiota is Studied to See if Cellobiose Supplementation is Altering the Microbial Community or Not
In Vivo Human Study on Commercial Cellobiose as a Potential Prebiotic Candidate
The goal of this project is to investigate whether cellobiose, a type of sugar, has a beneficial effect on gut health when consumed by humans.
- Trial name
- C-prebiotics (NCT07097389)
- Testing
- Cellobiose, Oligofructose P95
- Where
- United Kingdom
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Manxi Huang
Digestion Rate
Food DNA Digestion
This pilot study investigates the digestion rate of naturally occurring food DNA through the human digestive tract by detecting residual food DNA in stool samples.
- Trial name
- Anna Bauer (NCT06687226)
- Testing
- Reconstitutable food powder
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Duke University
Probiotics
Effect of Probiotic Administration on Gut Flora Composition
Healthy human gut contains a large number of bacteria, which belong to several different species. Some genes in these bacteria encode enzymes that the human body cannot produce.
- Trial name
- NCT03330678
- Testing
- Probiotic (VSL#3)
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Gut Microbiota
Effects of Riboflavin on Faecalibacterium Prausnitzii and the Gut Microbiota
The purpose of this trial is to investigate comprehensively the effect of riboflavin supplementation on the abundance of F. prausnitzii and on other members of the gut microbiota in faeces of healthy volunteers.
- Trial name
- NCT02929459
- Testing
- Riboflavin Dose 1, Riboflavin Dose 2
- Where
- Netherlands
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- dsm-firmenich Switzerland AG
Alcohol Use Disorder, Human Immunodeficiency Virus
Gut Microbiota-Mediated Inflammatory Interactions Between AUD and HIV Infection
Alcohol use disorder (AUD) has been associated with high prevalence of inflammation-associated co-morbidities in people living with HIV even those receiving effective antiretroviral therapy (ART).
- Trial name
- NCT06139224
- Testing
- 4 week prebiotic consumption
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Gut Microbiota
Westlake Gut Microbiome Study
The Westlake Gut Microbiome study is a prospective cohort study. This project aims to characterize the gut microbiome among Chinese populations from different regions of China, and explore the relationships between gut microbiota…
- Trial name
- NCT04435548
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Westlake University
Human Microbiome
A Clinical Study to Assess the Effect of Change of Bile Acid on the PD and Safety of Metformin and Microbiome Profiles
This clinical trial is intended to evaluate the effect of change of bile acid pool with cholestyramine on the pharmacodynamics and safety of metformin and intestinal microbiome profiles in healthy volunteers
- Trial name
- NCT04335526
- Testing
- Cholestyramine Resin
- Where
- South Korea
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Inflammation, Microbiota
The Role of Dietary Titanium Dioxide on the Human Gut Microbiome and Health
This proposal will quantify dietary exposure of a nano- food additive in the U.S. food supply, and determine its impact on the human gut microbiome, gut inflammation, permeability and oxidative stress.
- Conditions
- Inflammation, Microbiota, Gastrointestinal Irritation
- Trial name
- NCT05864352
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Lowell
Obesity
Interactions of Human Gut Microbiota With Intestinal Sweet Taste Receptors
The purpose of this study is to collect data to examine whether short-term consumption of non-caloric artificial sweeteners (NCASs), such as saccharin, can lead to changes in blood sugar levels and in the composition of the…
- Trial name
- ISTAR-micro (NCT03032640)
- Testing
- Oral Glucose Tolerance Test (OGTT), Assessment of dietary compliance, Stool sampling
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute