Clinical trials: Human Immunodeficiency Virus Type 1
HIV-1-infection, Weight Gain
Explorations Into the Mechanism for INSTI-associated Weight Gain: a Focus on Energy Balance
Weight gain following antiretroviral therapy (ART) initiation occurs with all modern regimens. Recent real-world reports suggest that integrase strand transfer inhibitor (INSTI)-based ART may be associated with excess weight gain…
- Trial name
- NCT04495348
- Testing
- Doravirine
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- University of Colorado, Denver
HIV
Safety Study of Zinc Finger Nuclease CCR5-modified Hematopoietic Stem/Progenitor Cells in HIV-1 Infected Patients
The purpose of the study is to evaluate the safety and feasibility of administering SB-728mR-HSPC after conditioning with busulfan.
- Trial name
- NCT02500849
- Testing
- SB-728mR-HSPC Infusion 3 days following busulfan conditioning
- Where
- 5 sites in United States
- Volunteers
- 12 people
- Sponsor
- City of Hope Medical Center
Lymphoma, Nonneoplastic Condition
Biomarkers in Blood Samples From Patients With HIV Infection and Stage III or Stage IV Hodgkin Lymphoma Undergoing Chemotherapy
RATIONALE: Studying samples of blood in the laboratory from patients undergoing treatment with HIV infection and Hodgkin lymphoma may help doctors learn more about the effects of therapy on HIV.
- Trial name
- NCT01319526
- Testing
- DNA analysis, RNA analysis, laboratory biomarker analysis
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- AIDS Malignancy Consortium
HIV-1 Infection
Progesterone Supplementation for HIV-positive Pregnant Women on Anti-Retrovirals
In pregnancy, cART is considered optimal for maternal health and for preventing the emergence of resistance that could compromise further care.
- Trial name
- ProSPAR (NCT02400021)
- Testing
- Prometrium
- Where
- 5 sites in Canada
- Volunteers
- 40 people
- Sponsor
- Mount Sinai Hospital, Canada
Infection, Human Immunodeficiency Virus, HIV Infections
Incidence of Human Immunodeficiency Virus-1 (HIV-1) Infection in HIV-1 Uninfected High Risk Men Who Have Sex With Men
Studies to assess the effectiveness of interventions to prevent HIV infection depend upon robust estimates of Baseline HIV incidence rates.
- Trial name
- NCT03310515
- Testing
- Risk reduction counseling, Social harm interview, Computer-Assisted Self Interviewing technique
- Where
- 9 sites in China
- Volunteers
- 578 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
HIV-1 Infection
Study of Options for Second-Line Effective Combination Therapy (SELECT)
The study was conducted on people who were taking their first anti-HIV drug regimen (including an Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI), a type of anti-HIV drug) but the drugs in this regimen were not doing a…
- Trial name
- SELECT (NCT01352715)
- Testing
- Lopinavir/ritonavir, Raltegravir, Emtricitabine/tenofovir disoproxil fumarate
- Where
- 16 sites in Brazil, India and 7 more
- Volunteers
- 515 people
- Sponsor
- Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
HIV
Clinical Trial to Evaluate the Effects of Letermovir Prophylaxis on T-cell Immune Activation in Participants With Treated HIV-1 Infection
People living with HIV (PLWH), even with an undetectable viral load (VL) on antiretroviral treatment (ART), develop health conditions, such as heart disease, diabetes, various cancers, and conditions that can affect the brain…
- Trial name
- PROACTIV (NCT06626555)
- Testing
- Letermovir
- Volunteers
- 36 people
- Sponsor
- University College, London
HIV Infections
Comparison of Three Anti-HIV Regimens to Prevent Nevirapine Resistance in Women Who Take Nevirapine During Pregnancy
HIV infected pregnant women may take single-dose nevirapine (SD NVP) prior to giving birth to prevent mother-to-child transmission (MTCT) of HIV.
- Trial name
- NCT00099632
- Testing
- Emtricitabine/Tenofovir Disoproxil Fumarate, Lamivudine/Zidovudine, Lopinavir/Ritonavir
- Where
- 8 sites in Haiti, India and 4 more
- Volunteers
- 484 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV
Assessment of VAC-3S Therapeutic Properties When Combined With Standard ART in the Course of HIV-1 Infection
The purpose of this study is to evaluate the protective effect of VAC-3S in controlled HIV patients receiving standard of care antiretroviral treatment.
- Trial name
- NCT02041247
- Testing
- VAC-3S
- Where
- 12 sites in France, Germany and 1 more
- Volunteers
- 90 people
- Sponsor
- InnaVirVax
HIV Infections
Safety and Effectiveness of Giving Combinations of Three or Four Anti-HIV Drugs to HIV-Infected Patients
The purpose of this study is to see if it is safe and effective to give combinations of three or four anti-HIV drugs to HIV-infected patients.
- Trial name
- NCT00002211
- Testing
- Nelfinavir mesylate, Delavirdine mesylate, Stavudine
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Pharmacia and Upjohn
HIV-1 Infection
Study for Evaluation of the Safety, Pharmacokinetics, and Antiviral Activity of UB-421 Subcutaneous Formulation Administered in HIV-1 Infected Treatment Naive Patients
This is a phase I, open-label, dose-escalation study to investigate short-term safety, pharmacokinetics, and antiviral activity of UB-421 SC with 4 weekly doses in treatment naive HIV-1 infected patients.
- Trial name
- NCT04620304
- Testing
- UB-421 SC(dB4C7C22-6 mAb)
- Where
- Taiwan
- Volunteers
- 15 people
- Sponsor
- United BioPharma
HIV
Phase I Study of HIV 1 Antigen Expanded Specific T Cell Therapy
This is a phase 1, single-site study is to evaluate the safety and immunologic and virologic efficacy of ex vivo expanded HIV-1 multi-antigen specific T-cell (HXTC) therapy in HIV-infected individuals with viral suppression on…
- Trial name
- HXTC (NCT02208167)
- Testing
- HXTC infusion
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of North Carolina, Chapel Hill
HIV-1-infection
DORAvirine Versus DOlutegravir Based Antiretroviral Regimens in Treatment-naïve People Living With HIV-1 Infection
Phase III trial evaluating doravirine as an alternative to dolutegravir in treatment naïve people living with HIV-1 infection.
- Trial name
- ELDORADO (NCT06203132)
- Testing
- Doravirine + tenofovir DF + lamivudine, Dolutegravir + tenofovir DF + lamivudine or emtricitabine
- Where
- 19 sites in Brazil, Cameroon and 4 more
- Volunteers
- 610 people
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV-1-infection
Optimising DNA Vaccinations in Healthy Volunteers
This is a two part study to evaluate the immunogenicity and tolerability of DNA-C CN54ENV plasmid DNA (CN54ENV) administered with electroporation (EP), with and without DNA encoding recombinant interleukin-12 (GENEVAX® IL-12).
- Trial name
- DNAVAC001 (NCT03663998)
- Testing
- CN54ENV DNA, GENEVAX® IL-12 DNA
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Imperial College London
HIV Infection
A Phase I Safety and Immunogenicity Preventive Vaccine Trial Based on the HIV-1 Tat and V2-deleted Env Proteins (ISS P-002)
This Phase I study was directed at evaluating the safety profile and the immunogenicity of the vaccination with recombinant HIV-1 Tat and V2-deleted Env (delta-V2 Env) proteins administered in association in healthy…
- Trial name
- NCT01441193
- Testing
- HIV-1 Tat/delta-V2 Env combined vaccine, HIV-1 delta-V2 Env vaccine, HIV-1 Tat vaccine 7.5 microg
- Where
- 3 sites in Italy
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Barbara Ensoli, MD
HIV 1 Infection
Study on Retention in Care and on Clinical Chracteristics of HIV-infected Women Treated With Bictegravir/Emtricitabine/Tenofovir Alafenamide (BIKWO).
Women are an underrepresented population in clinical studies on HIV and antiretroviral therapy. This study aims to help bridge this gap by providing real-world data on therapeutic management with B/F/TAF (Biktarvy) in an…
- Trial name
- BIKWO (NCT07859904)
- Testing
- Bictegravir (BIC) plus Emtricitabine (FTC) plus Tenofovir Alafenamide (TAF)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Ente Ospedaliero Ospedali Galliera
Acquired Immunodeficiency Syndrome
Open Label Study of NVP+CBV Treatment in Women Who Have Received sdNVP for the pMTCT of HIV
To determine the response to treatment with NVP, ZDV and 3TC in HIV positive women, who previously received NVP for the prevention of mother to child transmission.
- Trial name
- NCT00144157
- Testing
- Nevirapine, Zidovudine, 3TC
- Where
- 3 sites in South Africa
- Volunteers
- 53 people
- Sponsor
- Boehringer Ingelheim
HIV Prevention, HIV Infections
Rectal Microbicide Safety and Acceptability Trial of Topically Applied Tenofovir Compared With Oral Tablet
To date, the majority of microbicide research has focused on the assessment of the safety and effectiveness of vaginal microbicides used for the prevention of HIV transmission via the vaginal compartment.
- Trial name
- RMP02-MTN006 (NCT00984971)
- Testing
- Tenofovir, Open label tenofovir tablet
- Where
- 2 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- CONRAD
HIV Infections
A Phase 4 Cross-Sectional Study of Bone Mineral Density in HIV-1 Infected Subjects
A Phase 4 study is to characterize the profile of low bone mineral density (BMD) in ≥ 50 year old male subjects and post-menopausal female subjects on any tenofovir disoproxil fumarate (TDF)-based regimen
- Trial name
- NCT01850212
- Where
- 73 sites in Austria, Belgium and 11 more
- Volunteers
- 476 people
- Sponsor
- Gilead Sciences
Human Immunodeficiency Virus
Raltegravir (Isentress/MK-0518) and HIV-1 Infected CD4 Cells During Acute/Early HIV-1
This is an investigator-initiated, two-year, randomized, controlled, single-center, open-label, pilot study comparing 3-drug highly active antiretroviral therapy (HAART) to 3-drug HAART plus raltegravir for persons with acute and…
- Trial name
- UW PIC 330 (NCT00781287)
- Testing
- 3-drug anti-HIV therapy, Raltegravir
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Washington
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