Clinical trials: Human Immunodeficiency Viruses
HIV, Pregnancy
Maternal Determinants of HIV-exposed and HIV-unexposed Fetal Growth, Birth Outcomes and Early Infant Growth
The purpose of this study is to understand how differences in the nutritional status and concentration of hormones and cytokines associated with cachexia in HIV+ and HIV- pregnant women living in a semi-rural and rural region of…
- Conditions
- HIV, Pregnancy, Malnutrition, Cachexia
- Trial name
- NCT01647841
- Where
- Tanzania
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Cornell University
Oral Pre-exposure Prophylaxis (PrEP), Long-acting Injectable Cabotegravir for PrEP
PathToScale: An Implementation Evaluation
The purpose of this study is to evaluate the implementation and clinical outcomes of expanded pre-exposure prophylaxis delivery modalities and service delivery points offering long-acting injectable cabotegravir and oral…
- Trial name
- NCT06319105
- Testing
- Standard intervention: Offer PrEP choice
- Where
- Malawi
- Volunteers
- 9,900 people, healthy volunteers welcome
- Sponsor
- Georgetown University
HIV Infections
Injectable Cabotegravir Compared to TDF/FTC For PrEP in HIV-Uninfected Men and Transgender Women Who Have Sex With Men
This study will evaluate the safety and efficacy of the injectable drug cabotegravir (CAB LA), for pre-exposure prophylaxis (PrEP) in HIV-uninfected cisgender men and transgender women who have sex with men (MSM and TGW).
- Trial name
- NCT02720094
- Testing
- Cabotegravir Oral Tablet, TDF/FTC tablets, CAB LA
- Where
- 43 sites in United States, Argentina and 5 more
- Volunteers
- 4,570 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV - Human Immunodeficiency Virus, Cognitive Symptoms
COMO: Cognition Study With HIV+ Patients (CTNPT 015)
The purpose of this study is to contribute evidence towards the potential to improve cognition in HIV+ individuals experiencing cognitive decline through personalized change in antiretroviral (ARV) medication.
- Trial name
- COMO (NCT02144688)
- Testing
- Change in antiretrovirals
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- Marie-Josée Brouillette
HIV Infections
Immune System Function Following Vaccination in HIV Infected Children Taking Anti-HIV Drugs
The purpose of this study is to determine immune system function following vaccination in HIV-infected children currently taking anti-HIV drugs.
- Trial name
- NCT00257127
- Testing
- Pneumococcal 7-valent conjugate vaccine, Pneumococcal polysaccharide vaccine, Hepatitis B vaccine
- Where
- 26 sites in United States, Puerto Rico
- Volunteers
- 101 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Human Immunodeficiency Virus (HIV), Acquired Immune Deficiency Syndrome (AIDS)
Pediatric Enhanced Surveillance Study
The Pediatric Enhanced Surveillance Study is a three part study of HIV-infected infants and children in South Africa to examine, clinical, immunologic, virologic, metabolic, psychosocial and behavioral outcomes.
- Trial name
- PESS (NCT02043769)
- Where
- 5 sites in South Africa
- Volunteers
- 396 people
- Sponsor
- Columbia University
HIV
Trial of Vitamin D in HIV Progression, Birth Outcomes, and Child Health
The purpose of this study to assess the effect of maternal vitamin D3 (cholecalciferol) supplementation on maternal HIV progression, small-for-gestational age infants, and infant stunting at 12 months postpartum for HIV-infected…
- Trial name
- ToV5 (NCT02305927)
- Testing
- Vitamin D3 (cholecalciferol)
- Where
- Tanzania
- Volunteers
- 2,300 people
- Sponsor
- Wafaie Fawzi
HIV Infections
Switching HIV-1 Infected Subjects From a Highly Active Anti-Retroviral Treatment (HAART) Regimen Dosed Twice Daily or More Frequently to a Once-Daily Regimen
The purpose of this study is to demonstrate that virologically controlled HIV-infected individuals can successfully switch from a standard-of-care regimen dosed twice-daily or more frequently to a simpler once-daily (QD) regimen…
- Trial name
- NCT00135369
- Testing
- stavudine extended-release, lamivudine, efavirenz
- Where
- 47 sites in United States, Puerto Rico
- Volunteers
- 300 people
- Sponsor
- Bristol-Myers Squibb
Influenza, HIV Infections
Immunogenicity of Novel H1N1 Vaccination Among HIV-Infected Compared to HIV-Uninfected Persons
The purpose of this research is to determine the effectiveness of the novel H1Nl influenza (inactivated/killed formulation) vaccine among both HIV-infected and HIV-uninfected persons.
- Trial name
- NCT00996970
- Where
- 3 sites in United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Food Insecurities, Cardiometabolic Comorbidities
Human Immunodeficiency Virus (HIV) Food Insecurities
The objectives of this study are to better understand how FI (food insecurities) contributes to the development of cardiometabolic comorbidities among PWH (People with HIV) and to test a novel bilingual FI intervention designed…
- Conditions
- Food Insecurities, Cardiometabolic Comorbidities, HIV, PreDiabetes
- Trial name
- NCT04943861
- Testing
- weCare/Secure, Usual Care
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Wake Forest University Health Sciences
Dyslipidemia
A 12-Week Study Comparing Pitavastatin 4 mg vs. Pravastatin 40 mg in HIV-Infected Subjects
A 12-Week, Randomized, Double-Blind, Active-Controlled, Parallel-Group Study.
- Trial name
- NCT01301066
- Testing
- Pitavastatin, Pravastatin
- Where
- 35 sites in United States
- Volunteers
- 252 people
- Sponsor
- Kowa Research Institute, Inc.
Medication Adherence, HIV
Examining HIV Treatment Adherence During Early Disease
Determine the level, patterns, and correlates of objectively measured ART adherence in early and advanced-stage disease, among pregnant and non-pregnant individuals, to determine the need and nature of interventions to support…
- Trial name
- META (NCT02419066)
- Where
- 2 sites in South Africa, Uganda
- Volunteers
- 904 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
HIV-1-infection
Combining TLR9 Agonist With bNAbs for Reservoir Reduction and Immunological Control of HIV
This study is designed to evaluate the safety and efficacy of lefitolimod and 3BNC117/10-1074 in HIV-1-infected individuals on ART and during ATI as intervention to reduce the HIV-1 reservoir
- Trial name
- TITAN (NCT03837756)
- Testing
- Saline, Lefitolimod, 3BNC117 and 10-1074
- Where
- 8 sites in United States, Australia and 2 more
- Volunteers
- 47 people
- Sponsor
- University of Aarhus
HIV, Pregnancy
Implementing a Comprehensive Prevention of Mother-to-Child Transmission of HIV Program for South African Couples
This study will test the effectiveness of a behavioral intervention to increase Prevention of Mother-to-Child Transmission of HIV (PMTCT) protocol uptake among South African HIV positive pregnant women.
- Trial name
- NCT02085356
- Testing
- Protect your family
- Where
- South Africa
- Volunteers
- 1,967 people
- Sponsor
- University of Miami
Nontuberculous Mycobacteria, Mycobacterium Tuberculosis
Mycobacterial and Opportunistic Infections in HIV-Negative Thai and Taiwanese Patients Associated With Autoantibodies to Interferon-gamma
Opportunistic infections are caused by bacteria, mycobacteria, fungi or viruses that do not normally cause infections in people with healthy immune systems.
- Conditions
- Nontuberculous Mycobacteria, Mycobacterium Tuberculosis, Opportunistic Infections
- Trial name
- NCT00814827
- Where
- 5 sites in China, Taiwan and 1 more
- Volunteers
- 224 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Positive, HIV Negative
India HIV-CervCa Project
The investigators propose to prospectively study the difference in treatment (CTRT) completion and toxicities between HIV positive and HIV negative women in India with locally advanced cervical cancer receiving CTRT.
- Conditions
- HIV Positive, HIV Negative, Cervical Cancer
- Trial name
- NCT07167069
- Testing
- Radiation Therapy
- Where
- India
- Volunteers
- 180 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
HIV Infections
A Phase I Multicenter Study of the Safety and Immunogenicity of MN rgp120/HIV-1 Vaccine Given Either Alone or in Combination With IIIB rgp120/HIV-1 Vaccine in Healthy Adult Subjects (NOTE: Original Study Extended ONLY for Patients Previously Enrolled on VEU 009)
AMENDED 10/1/93: To evaluate the influence of prior immunization with an rgp120 vaccine on immune response to a subsequent immunization with a different strain of rgp120 (VEU 009X extension - in patients previously enrolled on…
- Trial name
- NCT00001021
- Testing
- rgp120/HIV-1IIIB, rgp120/HIV-1MN
- Where
- 3 sites in United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Healthy Aging
Preventing Chronic Disease: ActuaYa
The purpose of the study is to help older Hispanic women to increase physical activity, reach a healthy body weight, increase self-esteem and mood and increase knowledge about chronic diseases such as hypertension, diabetes, and…
- Trial name
- NCT04088552
- Testing
- Go4Life-Physical Activity/Exercise Program "Workout to Go" 5, ActuaYa Educational Sessions
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Miami
HIV/AIDS, Cervical Dysplasia
Factors Predicting Persistence of Oncogenic HPV and Cervical Dysplasia in HIV Infected Kenyan Women
This study will utilize a longitudinal study design to better understand the natural history of oncogenic Human Papillomavirus (HPV) infections in Human Immunodeficiency Virus (HIV)-infected and HIV-uninfected Kenyan women…
- Conditions
- HIV/AIDS, Cervical Dysplasia, HIV Infections
- Trial name
- NCT04045652
- Where
- 3 sites in United States, Kenya and 1 more
- Volunteers
- 223 people
- Sponsor
- Indiana University
Sexual Behavior
Development of a Novel HIV Risk Reduction Intervention for Abused Women
The purpose of this study is to develop and evaluate an HIV risk reduction intervention for women with a history of abuse.
- Trial name
- NCT02118948
- Testing
- Abuse-focused intervention, Sexual behavior-focused intervention
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- The Miriam Hospital
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