Clinical trials: Human Immunodeficiency Viruses
HIV Infections, Renal Insufficiency, Chronic
Impact of Screening Patients With HIV for Kidney Disease
The Infectious Disease Society of America has recently recommended that patients with Human Immunodeficiency Virus (HIV) be screened for kidney disease on a regular basis.
- Conditions
- HIV Infections, Renal Insufficiency, Chronic, Proteinuria
- Trial name
- NCT00392132
- Where
- United States
- Sponsor
- University of Mississippi Medical Center
HIV Infections
Influence of Probenecid and Quinine on the Pharmacokinetics of Azidothymidine
Part I studies the effect of quinine on how zidovudine (AZT) is used by the body and eliminated through the kidneys in HIV infected patients. Part II studies the effect of probenecid and quinine on the same aspects.
- Trial name
- NCT00000706
- Testing
- Quinine sulfate, Probenecid, Zidovudine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Therapeutic Schools: Affect Management and HIV Prevention
Adolescents are at risk for HIV because of sexual and drug behavior intiated during this developmental period. Those with psychological distress are less likely than their peers to benefit from frequently used skills-based…
- Trial name
- NCT00500487
- Testing
- Affect Management, HIV Prevention Skills, General Health Promotion
- Where
- United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
HIV Infections, Helminthiasis
Empiric Therapy of Helminth Co-infection to Reduce HIV-1 Disease Progression
Abstract: Over 25 million HIV-1 infected individuals are currently living in Africa and as many as 50-90% may be co-infected with soil transmitted helminths such as roundworms, hookworms or whipworms.
- Trial name
- THE or PHE (NCT00507221)
- Testing
- Albendazole, Praziquantel, Current standard of care in Kenya
- Where
- Kenya
- Volunteers
- 948 people
- Sponsor
- University of Washington
HIV Infections
Safety and Effectiveness of Low-Dose Methotrexate for Reducing Inflammation in HIV-Infected Adults on ARV Medications
People with HIV infection who are taking antiretroviral therapy (ART) could be at risk for cardiovascular disease (CVD), which can be caused by inflammation.
- Trial name
- NCT01949116
- Testing
- LDMTX, Folic acid
- Where
- 22 sites in United States
- Volunteers
- 176 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV-1 Infection
A Proof of Concept Study to Evaluate the Antiviral Activity, Safety, and Pharmacokinetics of the CCR5 Antagonist TBR 652 in HIV 1-Infected, Antiretroviral Treatment-Experienced, CCR5 Antagonist-Naïve Patients
A double-blind, randomized, placebo-controlled, dose-escalating study to assess the antiviral activity, safety, tolerability, and pharmacokinetics (PK) of the CCR5 antagonist TBR 652 monotherapy dosed orally once daily (QD) for…
- Trial name
- NCT01092104
- Testing
- TBR-652, TBR-652 50 mg, TBR-652 75 mg
- Volunteers
- 52 people
- Sponsor
- Tobira Therapeutics, Inc.
HIV, Human Immunodeficiency Virus
An Extension of Protocol PRO 140_CD01 Study
This is an extension of Protocol PRO 140_CD 01 to further evaluate the long-term suppression of HIV-1 replication following substitution of stable combination antiretroviral therapy with a PRO 140 (Monoclonal CCR5 antibody)…
- Trial name
- NCT02355184
- Testing
- PRO 140 350mg weekly subcutaneous (SC) injection.
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- CytoDyn, Inc.
HIV Infections
Treatment of AIDS and AIDS Related Complex. Part-1- Treatment of Patients With ARC (AZT Vs. Placebo)
Primary: To determine the clinical effect of zidovudine (AZT) compared to placebo in terms of time to progression to AIDS (i.e., occurrence of major opportunistic infections, dementia, and malignancies) or death.
- Trial name
- NCT00002063
- Testing
- Zidovudine
- Where
- 8 sites in United States
- Sponsor
- Glaxo Wellcome
Human Immunodeficiency Virus, Human Immunodeficiency Virus I Infection
HIV Therapeutic DNA Vaccine (ICVAX) Phase I Clinical Trial in Hong Kong
The goal of this randomized clinical trial is to evaluate the safety and immunogenicity of the HIV Therapeutic DNA Vaccine (ICVAX) in participants with HIV-1 infection under antiretroviral therapy (ART).
- Trial name
- NCT07530198
- Testing
- ICVAX (TERESA-EPT I device), ICVAX (PharmaJet Tropis device), ICVAX (TriGrid device)
- Where
- Hong Kong
- Volunteers
- 22 people
- Sponsor
- Immuno Cure Holding (HK) Limited
HIV Infection, Metabolic Syndrome
Safety, Tolerability and Effectiveness of DTG/3TC vs BIC/TAF/FTC in PWH Without Antiretroviral Experience
Background: The primary goal of antiretroviral therapy is to prevent HIV-associated morbidity and mortality. The effectiveness of first-line regimens is supported by a large number of clinical trials; current concerns focus on…
- Conditions
- HIV Infection, Metabolic Syndrome, Antiretroviral Treatment
- Trial name
- TEOTL (NCT07031063)
- Testing
- DTG/3TC, Bictegravir (BIC) plus Emtricitabine (FTC) plus Tenofovir Alafenamide (TAF)
- Where
- Mexico
- Volunteers
- 124 people
- Sponsor
- Instituto Mexicano del Seguro Social
HIV Infections
Evaluation of Simplified Antiretroviral Treatment Strategies in HIV Infected Children Treated by Antiretroviral (ARV) Before One Year of Age
The MONOD trial aim to evaluate the implementation of early antiretroviral treatment strategies in HIV-infected infants and assess the feasibility and efficacy of simplifying the initial proposed regimen after a successful one…
- Trial name
- NCT01127204
- Testing
- AZT-3TC-LPV/r twice a day, ABC-3TC-EFV once a day
- Where
- 4 sites in Burkina Faso, Côte d’Ivoire
- Volunteers
- 161 people
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV, Osteoporosis
Fracture and Bone Mineral Density in HIV+ Patients Recently Started on Antiretroviral Therapy (ART)
In a group of HIV-positive patients under observation since their first exposure to ART or monitored off of ART, BMD changes over one year will be determined.
- Trial name
- NCT01591252
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Alabama at Birmingham
HIV Infections, HIV Wasting Syndrome
The Effect of Anti-HIV Treatment on Body Characteristics of HIV-Infected Children
The purpose of this study is to see how beginning or changing anti-HIV medications affects the body composition (weight, height, growth, body fat, and muscle mass, or fat and muscle distribution) of HIV-infected children.
- Conditions
- HIV Infections, HIV Wasting Syndrome, Lipodystrophy
- Trial name
- NCT00006064
- Where
- 3 sites in United States, Puerto Rico
- Volunteers
- 100 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV
SHARE Project Define
The overall goal of the current study is to define modifiable intervention targets that are developmentally- and culturally-relevant in pathways between cumulative stress and self-management outcomes - alcohol use and HIV - among…
- Trial name
- NCT06125509
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Florida State University
HIV Infections
Effects of Two Anti-HIV Drug Regimens on Quality of Life and Health Care Use Among SMART Study Participants
The purpose of this study is to compare the effects of two different anti-HIV drug regimens on quality of life and health care utilization among SMART study participants.
- Trial name
- NCT00385632
- Testing
- Antiretroviral Regimens
- Where
- 67 sites in United States
- Volunteers
- 1,224 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Acquired Immunodeficiency Syndrome, Mycobacterium Avium-Intracellulare Infection
Subcutaneously Administered Interleukin-12 Therapy in HIV-Infected Patients With Disseminated Mycobacterium Avium Complex Infection
Disseminated infection with Mycobacteria avium complex (MAC) is one of the most common systemic bacterial infections in advanced stages of the acquired immunodeficiency syndrome (AIDS).
- Trial name
- NCT00001763
- Testing
- Interleukin-12
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
A Study of Abacavir Plus Indinavir Sulfate Plus Efavirenz in HIV-Infected Patients
To compare the virologic response between abacavir (ABC, 1592U89) regimens (drug vs. placebo) and between the 2 dosing regimens (BID vs.
- Trial name
- NCT00001086
- Testing
- Indinavir sulfate, Abacavir sulfate, Efavirenz
- Where
- 56 sites in United States, Puerto Rico
- Volunteers
- 300 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infection, Recurrent Non-Small Cell Lung Carcinoma
Erlotinib Hydrochloride in Treating Non-Small Cell Lung Cancer That is Metastatic or Cannot be Removed by Surgery in Patients With HIV Infection
This phase I trial studies the side effects and best dose of erlotinib hydrochloride in treating non-small cell lung cancer that has spread to other parts of the body or cannot be removed by surgery in patients with human…
- Conditions
- HIV Infection, Recurrent Non-Small Cell Lung Carcinoma, Stage IIIA Non-Small Cell Lung Cancer, Stage IIIB Non-Small Cell Lung Cancer
- Trial name
- NCT02134886
- Testing
- Erlotinib Hydrochloride, Laboratory Biomarker Analysis, Pharmacological Study
- Where
- 5 sites in United States
- Volunteers
- 48 people
- Sponsor
- National Cancer Institute (NCI)
HIV
Effect of Gender and HIV Infection on Zidovudine and Lamivudine Pharmacokinetics
This study evaluated the blood and blood cell concentrations of zidovudine and lamivudine in men versus women and in those with versus without HIV infection.
- Trial name
- NCT01386970
- Testing
- zidovudine 300mg and lamivudine 150mg as Combivir
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Osteopenia, Osteoporosis
Bone Mineral Density (BMD) in HIV Infection
Osteopenia and osteoporosis are increasingly reported in HIV-infected patients, and appear to be more frequent than in general population.
- Trial name
- NCT00146094
- Testing
- BMD Measurement, antiretrovirals
- Where
- 3 sites in France
- Volunteers
- 44 people
- Sponsor
- University Hospital, Strasbourg, France
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