Clinical trials: Human Immunodeficiency Viruses
HIV Infections
A Phase I Safety and Immunogenicity Trial of UBI SynVac (HIV-1 MN Octameric V3 Peptide Vaccine)
To determine the safety, immunogenicity, and optimal dose of rgp120/HIV-1MN octameric V3 peptide vaccine (SynVac) in healthy volunteers.
- Trial name
- NCT00000775
- Testing
- rgp120/HIV-1MN Monovalent Octameric V3 Peptide Vaccine
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Evaluating the Safety of and Immune Response to an HIV Vaccine in Healthy, HIV-Uninfected Adults in Uganda
The RV 156A clinical trial is evaluating an experimental HIV vaccine in people who are not infected with HIV. Participants in that study are randomly assigned to receive either the HIV vaccine or placebo.
- Trial name
- NCT01549509
- Testing
- VRC-HIVADV014-00-VP Vaccine
- Where
- Uganda
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV, ART
Delivery Optimization for Antiretroviral Therapy (The DO ART Study)
The investigators propose the Delivery Optimization for Antiretroviral Therapy Study - The DO ART Study - a prospective randomized study of strategies to optimize community-based ART initiation, monitoring and resupply among…
- Trial name
- DO ART (NCT02929992)
- Testing
- ART initiation in the home, Mobile Van Refill and Monitoring, Clinic ART Initiation
- Where
- 2 sites in South Africa, Uganda
- Volunteers
- 1,539 people, healthy volunteers welcome
- Sponsor
- University of Washington
Malaria in Pregnancy
Daily Co-trimoxazole Prophylaxis to Prevent Malaria in Pregnancy
Malaria is a major contributor of disease burden in Sub-Saharan Africa, and pregnant women and children are the most vulnerable population.
- Trial name
- NCT00711906
- Testing
- Cotrimoxazole, Sulfadoxine-pyrimethamine
- Where
- 2 sites in Zambia
- Volunteers
- 352 people
- Sponsor
- Institute of Tropical Medicine, Belgium
HIV Infections
Non-interventional Study on Use of Darunavir With Ritonavir in Clinical Practice
The purpose of this non-interventional study is a description of use of darunavir in daily practice, in retrospective and perspective manner.
- Trial name
- NCT01375881
- Testing
- darunavir/ritonavir plus background regimen
- Volunteers
- 31 people
- Sponsor
- Janssen-Cilag S.p.A.
HIV Infection, Tobacco-Related Carcinoma
Impact of Behavior Modification Interventions and Lung Cancer Screening on Smoking Cessation in People Living With HIV: A Feasibility Study
This clinical trial evaluates the usefulness of using a smartphone-based HIV-specific smoking cessation intervention at the time of lung cancer screening in helping people living with HIV quit smoking.
- Trial name
- NCT04949464
- Testing
- Computed Tomography, Smoking Cessation Intervention
- Where
- 11 sites in United States
- Volunteers
- 100 people
- Sponsor
- AIDS Malignancy Consortium
HIV Disease Progression
Acceptability, Feasibility and Effectiveness of Online Peer Support Group for ART Adherence Among Youth
In Uganda, Youth living with HIV/AIDS (YLHIVA) enrolled in HIV treatment experience suboptimal treatment adherence and have lower viral load suppression (VLS) rates compared to younger children or adults.
- Trial name
- NCT05688709
- Testing
- WhatsApp peer support group
- Where
- 3 sites in Uganda
- Volunteers
- 488 people, healthy volunteers welcome
- Sponsor
- Infectious Diseases Research Collaboration, Uganda
Substance Use
Substance Abuse Treatment to HIV Care (SAT2HIV): The Implementation & Sustainment Facilitation Experiment
A cluster randomized experiment focused on testing the extent to which the organization-focused Implementation \& Sustainment Facilitation (ISF) strategy is an effective adjunct to the staff-focused Addiction Technology Transfer…
- Trial name
- NCT03120598
- Testing
- ATTC strategy, ISF strategy
- Where
- 39 sites in United States
- Volunteers
- 190 people
- Sponsor
- RTI International
HIV Infections
Piloting At-birth Point of Care HIV Testing Strategies in Kenya
Innovative strategies to expedite HIV diagnosis among exposed infants, including at-birth testing and two portable point-of-care (POC) diagnostic systems, will be piloted using an implementation framework.
- Trial name
- NCT03435887
- Testing
- Alere q HIV-1/2 Detect for point of care infant testing, GeneXpert HIV-1 Qual for point of care infant testing, HIV DNA PCR testing (Standard of Care)
- Where
- 5 sites in United States, Kenya
- Volunteers
- 1,999 people
- Sponsor
- University of Kansas Medical Center
HIV Infections, Sexually Transmitted Diseases
Increasing Engagement and Improving HIV Outcomes Via HealthMPowerment
The overall goal of this 3-arm randomized trial is to test whether a network-driven online intervention tailored for intersectional stigma amelioration can elicit online social support, promote intervention engagement, and…
- Conditions
- HIV Infections, Sexually Transmitted Diseases, Stigma, Social
- Trial name
- NCT03678181
- Testing
- Information Resources, Social Support, HIV Testing
- Where
- 3 sites in United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
HIV Infection
Single DermaVir Immunization in HIV-1 Infected Patients on HAART
DermaVir is a plasmid DNA-containing synthetic nanomedicine. It is administered topically with DermaPrep to target Langerhans cells.
- Trial name
- GIHU004 (NCT00712530)
- Testing
- DermaVir, HAART
- Where
- Hungary
- Volunteers
- 9 people
- Sponsor
- Genetic Immunity
HIV Infection
Patients Infected With HIV Since More Than 10 Years With a Plasma Viral RNA <400 Copies / mL in the Absence of Any Treatment: Study Mechanisms Involved in Controlling the Infection
The investigators have previously described a limited group of HIV-1-infected patients, we called HIV controllers (HIC), who have been infected for more than 10 years, in whom viral replication is spontaneously controlled without…
- Trial name
- ANRS CO18 (NCT01065207)
- Testing
- blood test at day one
- Where
- France
- Volunteers
- 250 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
HIV Infections
Safety and Effectiveness of Giving Adefovir (Preveon) Plus Other Anti-HIV Drugs to HIV-Infected Patients Who Have Not Responded to Other Anti-HIV Drug Combinations
The purpose of this study is to see if it is safe and effective to give adefovir plus other anti-HIV drugs to HIV-infected patients who have failed other anti-HIV drug combinations.
- Trial name
- NCT00002398
- Testing
- Levocarnitine, Adefovir dipivoxil
- Where
- United States
- Sponsor
- Gilead Sciences
PUBLIC HEALTH EVALUATION
Sharing HIV/AIDS Responsibilities and Efforts
PUBLIC HEALTH EVALUATION PROTOCOL on Impact of Task Shifting Type II for ART Delivery on Patient and Process Outcomes in Uganda
- Trial name
- SHARE (NCT02417636)
- Testing
- Task Shifting
- Where
- Uganda
- Volunteers
- 1,760 people
- Sponsor
- Infectious Diseases Institute
Infection, Human Immunodeficiency Virus, HIV Infections
An Efficacy, Safety, and Tolerability Study Comparing Dolutegravir (DTG) Plus Lamivudine (3TC) With Dolutegravir Plus Tenofovir/Emtricitabine in Treatment naïve HIV Infected Participants (Gemini 2)
This study will compare safety, efficacy, and tolerability of a two drug regimen of dolutegravir (DTG) plus (+) lamivudine (3TC) administered once daily with DTG plus two nucleoside reverse transcriptase inhibitors (tenofovir…
- Trial name
- NCT02831764
- Testing
- Dolutegravir (DTG), Lamivudine (3TC), Tenofovir disoproxil fumarate/Emtricitabine (TDF/FTC FDC)
- Where
- 105 sites in United States, Argentina and 16 more
- Volunteers
- 722 people
- Sponsor
- ViiV Healthcare
HIV Infections
Integrating PrEP Into Family Planning Services at Title X Clinics in the Southeastern US
Pre-exposure Prophylaxis (PrEP) is a daily pill to prevent HIV that, when taken as prescribed, reduces the risk of getting HIV from sexual intercourse or drug use.
- Trial name
- NCT04097834
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
HIV-1 Infection
Pilot Study to Assess the Impact of a Mobile Health Application (App) on Clinical Outcomes and Satisfaction of Older HIV-Infected Patients, as an Emerging Tool for Care, Education and Prevention.
In recent years, HIV care has been reframed by the concepts of the HIV care and prevention. The success of these strategies will depend on integrated prevention and care system and sustained behavioral modification.
- Trial name
- NCT04137016
- Testing
- Mobile application
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
HIV Infection
A Multicenter Study to Assess the Tolerability of Once Daily Lopinavir/Ritonavir (LPV/r) Liquid Versus Capsules
Guidelines have continued to list lopinavir/ritonavir as a preferred protease inhibitor-containing regimen for HIV-infected individuals. There has recently been increasing interest in once daily therapy.
- Trial name
- NCT00281606
- Testing
- Different formulations of once-daily lopinavir/ritonavir
- Where
- 5 sites in United States
- Volunteers
- 65 people
- Sponsor
- University of California, San Diego
HIV/AIDS
Innovative Strategy to Offer Online Test and Treat for Thai MSM/TG
This study will ask Thai MSM and transgender women (TG) participants to self-select to participate in one of the 3 different study groups which provide various degrees of integrated online interventions and offline interventions…
- Trial name
- NCT03203265
- Testing
- Group A: Offline HTC, Group B1: Offline HIV testing and post-test counseling, Group B2: Online HIV testing and post-test counseling
- Where
- Thailand
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Thai Red Cross AIDS Research Centre
HIV Infections, Depression
Bupropion For Reducing High-Risk Behaviors in Depressed Men Who Have Sex With Men (MSM)
The primary purpose of this study was to test the whether high-risk, HIV-seronegative persons with mild-to-moderate depression would be more likely to adopt protective behavior change when provided with pharmacotherapy for their…
- Trial name
- NCT00285584
- Testing
- Bupropion
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- NYU Langone Health
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