Clinical trials: Human Microbiome
Healthy
Pilot Study on the Effect of a XOS95 on the Human Gut Microbiome
The purpose of this clinical trial is to assess the efficacy of a novel prebiotic, XOS95, at two different dosages, in comparison to a placebo by assessing shifts in microbial populations after 8 weeks of supplementation…
- Trial name
- NCT03074019
- Testing
- Xylooligosaccacharide, Maltodextrin
- Where
- Canada
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Prenexus Health
Colorectal Polyp, Inflammation
Impact of Dietary Intervention on Inflammation and Microbiome Composition Post-Colonoscopy
This study aims to investigate the impact of various healthy diets, specifically a modified plant-based Mediterranean diet, on the gut microbiome and overall well-being post-colonoscopy.
- Conditions
- Colorectal Polyp, Inflammation, Dietary Intervention, Microbiota
- Trial name
- NCT06603519
- Testing
- Modified Plant-Based Mediterranean Diet
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Gastrointestinal Disease
Casein Glycomacropeptide in Healthy Subjects
Casein glycomacropeptide (CGMP) has anti-inflammatory properties in experimental rodent colitis and using human in vitro inflammation models. Its use as a food ingredient has proven safe and with no influence on dietary intake.
- Trial name
- NCT02832700
- Testing
- Casein glycomacropeptide
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Human Microbiome
A Clinical Study to Assess the Effect of Change of Bile Acid on the PD and Safety of Metformin and Microbiome Profiles
This clinical trial is intended to evaluate the effect of change of bile acid pool with cholestyramine on the pharmacodynamics and safety of metformin and intestinal microbiome profiles in healthy volunteers
- Trial name
- NCT04335526
- Testing
- Cholestyramine Resin
- Where
- South Korea
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Mucosal Microbiome, Gastric Intestinal Metaplasia
Mucosal Microbiome in Human Gastric Intestinal Metaplasia and Duodenal Tissue.
To investigate the mucosal microbiome in human gastric intestinal etaplasia and duodenal tissue.
- Conditions
- Mucosal Microbiome, Gastric Intestinal Metaplasia, Duodenum
- Trial name
- NCT02428426
- Testing
- endomicroscopy, targeted biopsy and 16s rRNA gene sequencing
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Shandong University
Microbial Colonization
Rewilding the Human Gut: Reintroduction of the Species Limosilactobacillus Reuteri
The large intestine is home to trillions of microbes, known as the gut microbiome, which perform essential functions, such as digesting food and fighting disease.
- Trial name
- NCT03501082
- Testing
- L Reuteri PB-W1 Strain, L. Reuteri DSM20016T Strain, Non-Industrialized-Type Diet
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Pediatric Obesity
Pediatric Obesity and the Infant Microbiome (BEACH)
The impact of breastfeeding on the infant microbiome in vaginally and Cesarean delivered offspring from obese and normal weight mothers.
- Trial name
- BEACH (NCT02843087)
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University of Florida
Human Microbiome
Microbiome Composition Changes on 4 Week Gluten-free Diet Challenge
Changes in the gut microbiomes of healthy volunteers who followed a gluten-free diet (GFD) for four weeks were studied. Per participant, nine stool samples were collected: one at baseline, four during the GFD period, and four…
- Trial name
- NCT02731976
- Testing
- Dietary intervention
- Where
- Netherlands
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Colorectal Cancer
Diet Modulation of Bacterial Sulfur and Bile Acid Metabolism and Colon Cancer Risk
Determine in the context of a controlled crossover diet-intervention trial the role of taurocholic acid metabolism by gut bacteria in African American subjects at elevated risk for colorectal cancer (CRC).
- Trial name
- NCT03550885
- Testing
- High taurine and saturated fat diet, Low in taurine and saturated fat diet
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
Healthy, Elderly
Safety of Lactobacillus Rhamnosus GG Vs. Placebo in Elderly Subjects Receiving Trivalent Inactivated Influenza Vaccine
This is a phase I, randomized controlled trial to evaluate the safety of Lactobacillus rhamnosus GG (LGG) versus placebo in elderly subjects receiving the trivalent inactivated influenza vaccine.
- Trial name
- NCT01368029
- Testing
- Lactobacillus rhamnosus GG ATCC 53103 (LGG)
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Irritable Bowel Disease
Assessing Uniqueness of Inflammatory Bowel Disease Related Microbiome-derived Biomarkers
To assess the differential expression of IBD-related microbiome-derived biomarkers including bacterial strains and peptides such as antimicrobial peptides (AMP) found in inner-colonic samples (HygiSample™) in comparison to home…
- Trial name
- NCT05640583
- Testing
- Hygieacare System
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- HyGIeaCare, Inc.
Bacterial Communities
Sources of Bacterial Contamination in Human Milk Samples From the MiLC Trial
This observational study is a sub-study of the MiLC Trial (ClinicalTrials.gov Identifier: NCT03123874). Our objective is to characterize the bacterial communities of women's breasts, hands, their pump and milk collection kit, and…
- Trial name
- NCT03371511
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Cornell University
Urticaria
The Association Between Human Microbiome and Vitamin D in Chronic Urticaria
A double-blind study to evaluate the role of human microbiome and vitamin D in the development of urticaria.
- Trial name
- NCT05497596
- Testing
- Vitamin D
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Covid19, Periodontitis
Oral Health, Microbial Burden and COVID-19
An observational study of patients with COVID-19 confirmed cases (with various degrees of severity) and controls. Oral and nasal swabs will be taken from 150 patients (50 with mild form and 50 with severe form of COVID-19 with or…
- Trial name
- ORACLE (NCT04668911)
- Testing
- Swab
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Eastman Dental Insitute and Hospital
Pediatric
The Roles of Human Microbiome and Vitamin D in the Development of Childhood Allergic Diseases
A birth cohort study to evaluate the role of human microbiome and vitamin D in the development of allergic diseases in young child before one year of age.
- Trial name
- NCT05670262
- Where
- Taiwan
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Healthy
Effect of 12-week Probiotic Consumption Immobilized on Oat Flakes on Blood and Urine Biomarkers and Human Microbiome
The purpose of this clinical trial was to evaluate the effects Lactococcus cremoris spp. im-mobilized on oat flakes on human microbiome and blood and urine biomarkers of associated with human health.
- Trial name
- FOODBIOMES CT2 (NCT06293859)
- Testing
- Probiotic oat flakes, Conventional oat flakes
- Where
- Greece
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of the Aegean
Microbial Colonization, Metabolic Syndrome
Effects of Pulse Consumption, Gut Microbiome, and Appetite in Healthy Participants
The purpose of the study is to investigate the effects of pulse consumption versus no pulse consumption on the gut microbiome, meal satiety, and short-chain fatty acid metabolomics.
- Trial name
- PULSE (NCT07043712)
- Testing
- High pulse consumption
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Probiotic, Human Papillomavirus Infection, Pap Smear, Microbiome
The Influence of Oral Probiotic on the Vaginal Flora and Microenvironment Alteration in the Vaginosis Infection Women
A single-blind, randomized, and probiotic-treatment including adult women with vaginitis and/or HPV positive. After oral probiotics, all participants will be followd-up cervical swabs and vaginal microbiome alteration till the…
- Trial name
- NCT06001190
- Testing
- probiotic:Lactobacillus crispatus
- Where
- Taiwan
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Influenza, Influenza Vaccines
Comparative Immunologic Mechanisms and Microbiome Interactions Following Different Influenza Vaccine Formulations in Older Adults
This prospective, randomized, open-label clinical study aims to evaluate the immunogenicity and underlying immune mechanisms of different influenza vaccine formulations in adults aged ≥65 years.
- Conditions
- Influenza, Influenza Vaccines, Microbiome, Immune Response
- Trial name
- NCT07805837
- Testing
- Standard-Dose Influenza Vaccine, MF59-Adjuvanted Influenza Vaccine, High-Dose Influenza Vaccine
- Where
- South Korea
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Korea University Guro Hospital
Healthy Adult Participants
Kimchi and Gut Health
The goal of this study is to learn about the effects of eating kimchi on the gut health of healthy adults in the USA. The investigators will be researching the changes in the gut microbiome, biomarkers of gut health and…
- Trial name
- NCT07435831
- Testing
- 60 grams per day of intervention food
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, Davis