Clinical trials: Human Papillomavirus Virus
Human Papillomavirus-Related Carcinoma
A Vaccine Promotion Package (TweenVax) to Improve Adolescent HPV Vaccination, TweenVax Trial
This clinical trial compares the effect of a vaccine promotional intervention, TweenVax, to standard of care vaccination promotion practices on rates of human papillomavirus (HPV) vaccination in adolescents.
- Trial name
- NCT07104240
- Testing
- Best Practice, Educational Intervention, Health Promotion and Education
- Where
- United States
- Volunteers
- 1,836 people, healthy volunteers welcome
- Sponsor
- Emory University
Papillomavirus Infections, Coronavirus Disease (COVID-19)
Safety and Immunogenicity of 9-valent Human Papillomavirus (9vHPV) Vaccine Coadministered With Messenger Ribonucleic Acid (mRNA)-1273 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) (COVID-19) Vaccine (V503-076)
The purpose of this study to evaluate the safety and immunogenicity of a 2-dose regimen of 9vHPV vaccine, where the first dose is administered concomitantly with a first dose of a 2-dose regimen of mRNA-1273 vaccine versus…
- Trial name
- NCT05119855
- Testing
- 9vHPV Vaccine, mRNA-1273 Vaccine
- Where
- 38 sites in United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Cervical Intraepithelial Neoplasia Grade 2/3, Carcinoma Cervix
Extended VALidation of HUman Papillomavirus Assays and Collection DEvices for HPV Testing on Self-samples
The "Extended VALHUDES" study is a Clinical Performance / Diagnostic Test Accuracy Study that aims to extend validation, achieved as part of the "Belgian VALHUDES", of HPV testing using BD Onclarity on samples collected using…
- Trial name
- Ext-VALHUDES (NCT04788849)
- Testing
- BD Onclarity™ HPV assay
- Where
- 2 sites in Italy
- Volunteers
- 300 people
- Sponsor
- University of Milano Bicocca
HPV Infection, HPV 16 Infection
Evaluation of the Q-Pad hrHPV Test System for Identifying Precancer
The EQUIP Study is testing whether high-risk human papillomavirus (hrHPV), the virus that causes most cervical cancers, can be accurately detected from menstrual blood collected at home.
- Conditions
- HPV Infection, HPV 16 Infection, High Risk HPV, Cervical Cancer Screening
- Trial name
- EQUIP (NCT07281599)
- Testing
- Q-Pad hrHPV Test System
- Where
- 3 sites in United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Qurasense
Cervical Intraepithelial Neoplasia, Human Papillomavirus
Comparisons of the Effects and Clinical Outcomes of CH2 Vaginal Gel Versus Placebo on CIN1
In Taiwan, Pap smear screen has been offered every year for women over 30 years old since 1995. The incidence of cervical invasive cancer decreased from 25/100,000 person in 1995 to 7.0/100,1000 person in 2016.
- Trial name
- NCT06582004
- Testing
- CH2 vaginal gel
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
HPV
Human Papillomavirus (HPV) Vaccination Acceptance by African-American Parents: Identifying Psychosocial Barriers
This will enroll 300 mothers of teenage girls and boys to identify barriers to HPV vaccination among low-income, African-American teens.
- Trial name
- NCT00680147
- Testing
- brief informational intervention to promote HPV vaccine acceptance
- Where
- United States
- Volunteers
- 614 people, healthy volunteers welcome
- Sponsor
- Syracuse University
Cervical Intraepithelial Neoplasia
Immediate Treatment vs Colposcopic Follow-up for Biopsy-Proven CIN 1
This study looks at immediate treatment of a cervix with CIN 1 versus regular six-month follow-up with colposcopy and treatment if CIN 1 progresses.
- Trial name
- NCT00156026
- Testing
- loop electrosurgical excision procedure (LEEP)
- Where
- 10 sites in Brazil, Canada
- Volunteers
- 415 people
- Sponsor
- Ontario Clinical Oncology Group (OCOG)
Adult Solid Tumor
Study of SQZ-eAPC-HPV in Patients With HPV16+ Recurrent, Locally Advanced or Metastatic Solid Tumors
This is a Phase 1/2, first-in-human, open label, multicenter study to assess safety and tolerability, antitumor activity, and immunogenic and pharmacodynamic effects of SQZ-eAPC-HPV as monotherapy and in combination with…
- Trial name
- NCT05357898
- Testing
- SQZ-eAPC-HPV, Pembrolizumab
- Where
- 9 sites in United States
- Volunteers
- 20 people
- Sponsor
- SQZ Biotechnologies
Infection by Human Papilloma Virus
Lot-to-Lot Consistency Clinical Trial of Recombinant Human Papillomavirus 9-valent (Types 6/11/16/18/31/33/45/52/58) Vaccine (Escherichia Coli)
To support international market access and comply with World Health Organization Prequalification requirements, this lot-to-lot consistency trial is planned for initiation.
- Trial name
- NCT07668271
- Testing
- 9-valent HPV vaccine (Cecolin 9)
- Where
- China
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Xiamen Innovax Biotech Co., Ltd
Cervical Cancer, Cervical Dysplasia
Clinical Validation of Cervical Cancer Screening Methods
This single-institution cross-sectional non-inferiority validation study evaluates alternative techniques and tests for primary cervical cancer screening programs in Russia, particularly: local cytology staining techniques, local…
- Conditions
- Cervical Cancer, Cervical Dysplasia, Human Papilloma Virus
- Trial name
- NCT04783649
- Testing
- Papanicolaou cytological test, Local cytological test (H&E stain), Validated HPV DNA Test
- Where
- Russia
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- N.N. Petrov National Medical Research Center of Oncology
Cervical Intraepithelial Neoplasia, Cervical Cancer
The Durability of Protection and Immuno-persistence Study of a Recombinant HPV 16/18 Bivalent Vaccine in Female
The primary objective of this study is to evaluate the durability of protection and immuno-persistence of Recombinant Human Papillomavirus Bivalent (Types 16,18) Vaccine administered in females aged 18-45 years.
- Conditions
- Cervical Intraepithelial Neoplasia, Cervical Cancer, Vaginal Intraepithelial Neoplasia, Vulvar Intraepithelial Neoplasia
- Trial name
- NCT05045755
- Testing
- Recombinant Human Papillomavirus Bivalent (Types 16, 18) Vaccine (Escherichia coli)
- Where
- China
- Volunteers
- 1,339 people
- Sponsor
- Jun Zhang
Human Papillomavirus Infection
The Human Papilloma Virus Effect on Sexual Life
Human Papilloma Virus (HPV) is one of the most common causes of sexually transmitted diseases and its link with malignancies is well established, especially with anogenital tract cancers (cervical, vaginal, vulvar, anal cancers).
- Trial name
- HPVandFSFI (NCT03837028)
- Testing
- FSFI
- Where
- Turkey (Türkiye)
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Antisepsis Regimen After Surgical Treatment of HPV Infected Lesions
Antisepsis Regimen in the Surgical Treatment of Human Papilloma Virus Generated Cervical Lesions: Polyhexamethylene Biguanide Versus Chlorhexidine
Treatments for the macroscopic or pathologic lesions caused by HPV infection can be classified as topical, surgical, destructive, or immunomodulatory.
- Trial name
- NCT01740245
- Testing
- Chlorhexidine vaginal suppositories, Polyhexamethylene biguanide vaginal suppositories
- Where
- Italy
- Sponsor
- AGUNCO Obstetrics and Gynecology Centre
Human Papillomavirus Infection
Brief Interventions to Increase HPV Vaccine Acceptance in School-based Health Centers
Using health behavior theories and theories related to the effects of persuasive messages (i.e., inoculation theory), we plan to: 1.
- Trial name
- NCT01087164
- Testing
- Compliance, Message sidedness
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Indiana University
Infections, Papillomavirus
Study to Assess Immune Responses and Safety of the GSK-580299 Vaccine in Healthy Women (26 to 45 Years)
This study is designed to evaluate the immunogenicity and safety of GSK Biologicals' human papillomavirus (HPV) vaccine in adult female subjects aged 26-45 years.
- Trial name
- NCT01277042
- Testing
- GSK580299 (CervarixTM), Engerix-BTM
- Where
- China
- Volunteers
- 1,212 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Anal Cancer, HIV Infections
Pilot Study to Determine the Safety and Efficacy of Gardasil Against the Human Papilloma Virus (HPV) in HIV-infected Men
This study will investigate the efficacy and safety of the quadrivalent vaccine (Gardasil) against the human papilloma virus (HPV) in HIV (human immunodeficiency virus) infected males.
- Trial name
- MIRB #862 (NCT00666107)
- Testing
- Gardasil
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Southern California Institute for Research and Education
Papillomavirus Vaccines, HPV Vaccinations
HPV Vaccine Integrated Service Implementation Research in Cameroon
The goal of this implementation research study is to understand whether a package of community-based interventions can increase access to and uptake of the human papillomavirus (HPV) vaccine among very young adolescent girls and…
- Conditions
- Papillomavirus Vaccines, HPV Vaccinations, HPV Vaccines, HPV Vaccine Acceptability
- Trial name
- HPV-PASSREV (NCT06683664)
- Testing
- Integrated health service delivery for very young adolescents
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Population Services International
HPV Infection
HPV Vaccine in Postpartum Women
The purpose of this study is to determine the acceptability of HPV vaccination in postpartum women in Central Pennsylvania. Participants will be recruited while inpatient in the postpartum unit.
- Trial name
- NCT04430907
- Testing
- HPV 9-valent Vaccine, Recombinant
- Volunteers
- healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
HPV-16 +ve Oropharyngeal Carcinoma
Safety Study of Recombinant Listeria Monocytogenes(Lm)Based Vaccine Virus Vaccine to Treat Oropharyngeal Cancer
It is the investigators intention to investigate whether a specially designed vaccine, based on a genetically modified strain of the bacterium Listeria monocytogenes and called ADXS11-001 is safe to use and is able to boost the…
- Trial name
- REALISTIC: (NCT01598792)
- Testing
- ADXS11-001
- Where
- 4 sites in United Kingdom
- Volunteers
- 2 people
- Sponsor
- University of Liverpool
Verruca Plantaris
Nitric Oxide Releasing Solution (NORS) For The Treatment Of Human Papillomavirus(HPV) Verrucae Plantaris (Plantar Warts)
A phase 2a multicenter, randomized, double-blinded, placebo-controlled clinical trial to evaluate the safety and efficacy of topical nitric oxide releasing solution (NORS) for the treatment of human papillomavirus (HPV) caused…
- Trial name
- NCT05877313
- Testing
- Sterile water foot bath, Nitric Oxide
- Where
- 3 sites in Canada
- Volunteers
- 20 people
- Sponsor
- Sanotize Research and Development corp.
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