Clinical trials: Human Spermatozoa Parameters
Healthy, Cancer
Effect of Long-time Human Sperm Storage in Liquid Nitrogen on Semen Parameters
Sperm cryopreservation is an essential tool for men fertility preservation in the context of gonadotoxic treatments or/and pathologies such as cancers, gamete donation and ART.
- Conditions
- Healthy, Cancer, Infertility, Male, Cryopreservation
- Trial name
- CRYOFERT (NCT06448000)
- Where
- France
- Volunteers
- 101 people
- Sponsor
- University Hospital, Clermont-Ferrand
Cryopreservation, Human Spermatozoa Parameters
Hypotaurine Supplementation Benefits in Cryopreservation
Although it is widely used, slow freezing can induce strong functional and nuclear spermatic alterations reducing the chances of pregnancy.
- Conditions
- Cryopreservation, Human Spermatozoa Parameters, Hypotaurine Supplementation, Spermatozoa DNA Alterations
- Trial name
- HYPOTAURINE (NCT04011813)
- Testing
- Hypotaurine : antioxidant and osmoregulator
- Volunteers
- 33 people
- Sponsor
- University Hospital, Clermont-Ferrand
Spermatic Parameters, Embryonic Kinetics
Impact of Nuclear Human Sperm Quality on Embryo Development
To date, none study shows the impact of human spermatozoa nuclear alteration on embryonic development kinetic with morpho-kinetics tools.
- Trial name
- PRIMOSPERMO (NCT03320590)
- Testing
- Time Lapse (material to observe embryonic development)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Clermont-Ferrand
Sperm Preservation, Irradiated Semen
Impact of Ionizing Treatment on the Nuclear Structure of Human Spermatozoa.
Differentiated thyroid cancer is the third cause of cancer in young men of childbearing age. Its treatment by irradiation with Radioactive Iodine 131 therapy (RAT) could alter spermatogenesis and result in azoospermia and…
- Trial name
- NCT04715828
- Testing
- Cryopreserved semen, Acute and low irradiation, Long and low irradiation
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Clermont-Ferrand
Male Infertility
Metabolic Syndrome and Male Infertility
Multidisciplinary, multicentric, cross-sectional study on men in infertile couples who conduct their sperm test through their diagnosis of infertility
- Trial name
- Metasperme (NCT01974947)
- Testing
- Blood sample, sperm sample and clinical examens
- Where
- France
- Volunteers
- 170 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sperm Quality, Oligoasthenospermia
Effect of Treatment With Myo-inositol on Human Semen Parameters in Patients Undergoing In Vitro Fertilization Cycles
Myo-Inositol (MI) is a precursors for the synthesis of phosphatidylinositol polyphosphates (PIPs). In male reproduction, it was shown that MI concentration in the seminiferous tubules is higher than in serum and it was increasing…
- Trial name
- NCT01560065
- Testing
- myo-inositol + folic acid
- Where
- Italy
- Sponsor
- AGUNCO Obstetrics and Gynecology Centre