Clinical trials: Hyaluronic Acid
Acne, Acne Scars
Restylane Silk Acne Scar Efficacy Evaluation Study
Randomized, double-blind, placebo-controlled, research pilot study. 30 subjects aged 22-55 years old of all skin types will be asked to sign an informed consent form prior to any study procedures.
- Conditions
- Acne, Acne Scars, AdverseEvent
- Trial name
- NCT02955381
- Testing
- Restylane Silk, 1.0 ml, Saline, 1.0 ml
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Schweiger Dermatology, PLLC
Periodontal Pocket
Effects of Polynucleotides and Hyaluronic Acid Based Subgingival Periodontal Pockets Re-instrumentation
The purpose of this randomized controlled clinical trial (RCT) was to investigate the clinical and biochemical efficacy of a gel containing PDRN and HA used in association with subgingival re-instrumentation in the treatment of…
- Trial name
- NCT05210686
- Testing
- subgingival re-instrumentation
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Adhesive Capsulitis
Efficacy of Intra-articular Hyaluronate Injection for Adhesive Capsulitis
Objective: To evaluate the efficacy of intra-articular hyaluronic acid (HA) injections for the treatment of adhesive capsulitis (AC) of the shoulder.
- Trial name
- NCT05983081
- Testing
- hyaluronic acid, Physical Therapy
- Where
- Taiwan
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Tri-Service General Hospital (TSGH)
Atrophic Scar
Vollure for the Correction of Atrophic Facial Scarring
Subjects will be randomized to receive up to 1cc of Juvéderm Vollure on one side of their face and up to 1cc of Saline on the other. On Day 30, this treatment with the same left-right assignment can be repeated.
- Trial name
- JVAS (NCT04519515)
- Testing
- Allergan Vollure
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Siperstein Dermatology
Periapical Periodontitis
Hyaluronic Acid in Endodontic Microsurgery
This randomized clinical trial (RCT) will evaluate the effectiveness of cross-linked hyaluronic acid as an adjunct to endodontic microsurgery in adult patients with apical periodontitis affecting maxillary or mandibular first…
- Trial name
- NCT07501585
- Testing
- Hyaluronic Acid, Endodontic microsurgery
- Where
- Russia
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Bern
Cicatrix
Intraoperative Hyaluronic Acid Gel Injection for Improvement of Scar Quality Following Reduction Mammaplasty
The purpose of this study is to determine the efficacy of hyaluronic acid gel injections compared to saline injections in improving scar quality in patients undergoing breast reduction surgery.
- Trial name
- NCT00958425
- Testing
- Hyaluronic acid gel, Saline
- Volunteers
- healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
PRF, Gingival Recession
Clinical Evaluation of Platelet Rich Fibrin Membrane With or Without Hyaluronic Acid Along With Coronally Advanced Flap in the Treatment of Rt1 Gingival Recession
Gingival recession is a common mucogingival deformity that may result in root hypersensitivity, esthetic concern, plaque accumulation, and difficulty in oral hygiene maintenance.
- Conditions
- PRF, Gingival Recession, Hyaluronic Acid
- Trial name
- NCT07662447
- Testing
- root coverage with multilayered PRF, root coverage with multilayered PRF and hyaluronic acid
- Where
- United Arab Emirates
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gulf Medical University
Abortion, Spontaneous
High Molecular Weight Hyaluronic Acid, α-lipoic Acid, Magnesium, Vitamin B6 and Vitamin D, in the Prevention of Spontaneous Abortion
The study aims to verify if the association of high molecular weight hyaluronic acid, α-lipoic acid (ALA), magnesium, vitamin B6 and vitamin D, reduces the risk of miscarriage in patients at risk.
- Trial name
- NCT05449171
- Testing
- high molecular weight hyaluronic acid, α-lipoic acid (ALA), magnesium, vitamin B6 and vitamin D
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Lo.Li.Pharma s.r.l
Temporomandibular Arthritis
Intra-articular Injection for the Relief of Temporomandibular Joint Pain
Which is more effective in the treatment of nonspecific temporomandibular osteoarthritis: platelet-rich plasma (PRP), hyaluronic acid, or triamcinolone acetonide?
- Trial name
- NCT07571265
- Testing
- platelet rich plasma and triamcinolone acetonide and hyaluronic acid and saline intra articular injection
- Where
- Egypt
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Cairo University
Aesthetic
"Profile HIT" (Holistic Individualized Treatment)
The "Holistic Individualized Treatment" (HIT) approach is used to identify treatment priorities, focus areas, and appropriate products for soft tissue filler treatments.
- Trial name
- HIT-PRF (NCT05819502)
- Testing
- Restylane line of injectables
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Erevna Innovations Inc.
Volume Deficiency in the Mid-Face, Aging
Study of STYLAGE® XXL for Volume Deficiency in the Mid-Face
The primary objective of the study is to demonstrate the superiority of STYLAGE® XXL versus no treatment at 24 weeks after baseline for the creation or restoration of volume deficit in the mid-face.
- Conditions
- Volume Deficiency in the Mid-Face, Aging, Aesthetics
- Trial name
- MidFaceXXL (NCT05355454)
- Testing
- STYLAGE® XXL
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Laboratoires Vivacy
Fertility Issues
The Combination of Sperm Selection by IMSI and Hyaluronic Acid Binding Assay May Improve ICSI Outcome.
In this prospective randomized sibling-oocytes blinded study, investigators examine the combination of two sperm selection methods that logically seem to complete each other, and potentially may improve ICSI outcomes.
- Trial name
- NCT06156722
- Testing
- Sperm selection by IMSI, Sperm selection by IMSI and spermslow
- Where
- Israel
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Gingival Overgrowth
Comparison Between Laser, Synthetic Gel and Herbal Gel as Topical Agents After Gum Surgery
This study would be conducted to assess the effectiveness of low-level laser therapy, hyaluronic acid gel and herbal gel as adjunctive aids in the healing of gingivectomy wounds.
- Trial name
- CLSHGTAGS (NCT03569683)
- Testing
- External bevel gingivectomy, Diode laser Biostimulation, Hyaluronic acid (Gengigel) topical application.
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
In Recent Years, There Has Been a Rise in the Use of Immediate Loading Protocols, Dental Implant Stability
Effect of Topical Application of Atorvastatin Gel Versus Hyaluronic Acid on Immediate Loading Dental Implant in Posterior Maxilla
Background: In recent years, there has been a rise in the use of immediate loading protocols; however, the complex anatomy of the posterior maxilla presents challenges.
- Trial name
- NCT06976866
- Testing
- implant surgery
- Where
- Egypt
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Amira attia
Aesthetic
Aesthetic Improvement of Facial Rhytids Using Injectables
Revanesse® Renew™+ (Prollenium Medical Technologies Inc.) is a non-crosslinked HA skin booster that combines low- and high-molecular-weight HA at a concentration of 14 mg/mL in a sterile aqueous gel for intradermal injection7.
- Trial name
- NCT07383766
- Testing
- Revanesse® Renew™+
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Erevna Innovations Inc.
Aging, Pain
RHA® 4 With New Anesthetic - Nasolabial Folds
This is a randomized, controlled, double-blinded, within-subject (split-face), multicenter, prospective study to investigate whether RHA® 4 with New Anesthetic Agent is non-inferior to RHA® 4 (with lidocaine) in terms of…
- Trial name
- NCT04087395
- Testing
- RHA®4 with new anesthetic agent, RHA®4-Lidocaine
- Where
- 3 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Teoxane SA
Chronic Periodontitis
Efficacy and Safety of a Commercially Available Injectable Hyaluronic Acid Dental Filler for Periodontal Pockets
This is a controlled, randomized, single-blinded, multicenter, prospective clinical study. In addition to the standard periodontal treatment procedure on all teeth that need to be treated, the 4 teeth with the deepest pockets…
- Trial name
- NCT02391974
- Testing
- PERIOSYAL FILL
- Where
- 3 sites in Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Teoxane SA
Dermal Filler, Hyaluronic Acid
The Evaluation of the Safety and Effectiveness of ANIMERS Chiara LA and JUVÉDERM VOLUMA® for Aging Mid-Face
This study is to evaluate the safety and effectiveness for the correction of aging mid-face of treatment group compared with the active control group.
- Conditions
- Dermal Filler, Hyaluronic Acid, Lidocaine, Aging Mid-Face
- Trial name
- NCT04622085
- Testing
- ANIMERS Chiara LA, JUVÉDERM VOLUMA®
- Where
- Taiwan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- SciVision Biotech Inc.
Intrauterine Abnormalities in Infertility, Asherman Syndrome
Safety and Performance of the Semical Adhesion Barrier Gel for Prevention of Intra-uterine Adhesion
The aim of this study was to obtain short- and long-term performance and safety data of cross-linked hyaluronic acid-based adhesion barrier gel used to prevent intrauterine adhesion formation.
- Conditions
- Intrauterine Abnormalities in Infertility, Asherman Syndrome, Intra-uterine Adhesions, Postoperative Adhesion of Uterus
- Trial name
- SEMFERTIL (NCT07160764)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Semikal Technology
Resorption of Tooth or Root
Clinical and Radiographic Evaluation of Hyaluronic Acid Compared to Propylene Glycol as Vehicle for Double Antibiotic Paste in Lesion Sterilization and Tissue Repair Technique for Non-Vital Primary Molars
Lesion sterilization and tissue repair therapy technique will be used in primary molars with root resorption using Hyaluronic acid as a vehicle for the double antibiotic therapy in comparison to the conventional technique using…
- Trial name
- LSTR (NCT05116306)
- Testing
- Hyaluronic acid, Propylene glycol
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Ain Shams University