Clinical trials: Hyaluronic Acid
Gingival Recession
Effects of the Adjunctive Use of Hyaluronic Acid-based Gel With Coranally Advanced Flap in the Gingival Recession
The study aimed to evaluate the effect of Hyaluronic Acid-based gel use in addition to the coronally advanced flap (CAF) technique in type 1 gingival recession (RT1) on postoperative morbidity, clinical parameters, and patient…
- Trial name
- NCT07437885
- Testing
- Hyaluronic acid, Steril saline solution
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Ordu University
Palatal Donor Site Wound Healing, Palatal Wound
Influence of Hyaluronic Acid in the Healing of Palatal Donor Sites During Free Gingival Graft Procedures
The goal of this study is to evaluate the use of a gel containing cross-linked hyaluronic acid (xHyA) at the palatal donor site following soft tissue harvesting procedures.
- Trial name
- HA Palate (NCT07458685)
- Testing
- Test - xHyA, Negative control
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Milan
Rhinitis Sicca
Clinical Study on the Treatment of Rhinitis Sicca With Sodium Hyaluronate Adjustable Nasal Irrigator
To observe the therapeutic effect of sodium hyaluronate adjustable nasal irrigator on various types of rhinitis sicca and compare it with the therapeutic effect of the commonly used physiological seawater nasal spray in clinical…
- Trial name
- NCT07308015
- Testing
- Physiological seawater adjustable nasal irrigator, Sodium hyaluronate adjustable nasal irrigator
- Where
- China
- Volunteers
- 200 people
- Sponsor
- China-Japan Union Hospital
Dry Eye Syndrome
Sodium Hyaluronate Ophthalmic Solution, 0.18% for Treatment of Dry Eye Syndrome
The purpose of this study was to determine if Sodium Hyaluronate, 0.18% is effective in treating the signs and symptoms of dry eye disease.
- Trial name
- NCT01382225
- Testing
- Sodium Hyaluronate Ophthalmic Solution, 0.18%, Vehicle
- Volunteers
- 1,936 people
- Sponsor
- Alcon Research
Aging
Evaluation of Anti-aging Performance and Tolerance of a Hyaluronic Acid-based Filler NCTF135HA®
The NCTF135HA medical device from Laboratoires FILL-MED by FILORGA Company is an injectable solution for the treatment of wrinkles and biorevitalization of injected mature skin using a multi-injection technique with CE marking.
- Trial name
- HEBE2 (NCT05609617)
- Testing
- injection, Cream application
- Where
- France
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Laboratoires FILLMED
Infertility
Evaluation Study Between Density Gradient and Swimming Down for Semen Processing
This study evaluates the quality of sperm produced after semen processing using Density Gradient (DG) and swimming down (SD).
- Trial name
- NCT02329704
- Testing
- Diff-Quik staining for morphology evaluation, Motility Evaluation for grade A and B, Concentration (mil/ml)
- Where
- 2 sites in Bahrain, Egypt
- Volunteers
- 100 people
- Sponsor
- Ahmad Mustafa Mohamed Metwalley
Dental Implants
Clinical and Radiographic Evaluation of Natural Bovine Bone With Hyaluronic Acid on Osseointegration of Immediate Implant.
the goal of this study is to evaluate the effective of natural bovine bone with hyaluronic acid on osseointegration of immediate implants in single rooted badly decayed maxillary anterior teeth and premolars.
- Trial name
- NCT07199725
- Testing
- immediate dental implant, immediate dental implant, natural bovine bone substitute material
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Suez Canal University
Ocular Dryness
Clinical Investigation on the Use of Ophthalmic Solution Based on Sodium Hyaluronate in Treatment of Eye Discomfort
The purpose of this study is to assess the performance and safety resulting from the treatment of an ophthalmic solution for the ocular discomfort and in particular in presence of ocular dryness.
- Trial name
- NCT05777798
- Testing
- Hyalistil Bio PF
- Where
- 2 sites in Italy
- Volunteers
- 28 people
- Sponsor
- SIFI SpA
Effect of Putty Form Bone Graft in Immediate Implant Placment
Evaluation of Hyaluronic Acid in Addition to Xenograft in Immediate Implant Placement Within Maxillary Esthetic Zone
Study design: The present study will be carried out on twenty patients selected from the department of Oral Medicine, Periodontology, Oral Diagnosis and Radiology, Faculty of Dentistry, Mansoura University for replacement of non…
- Trial name
- NCT06783517
- Testing
- cerabone, cerabone®plus
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Furcation Defects
Comparison of Platelet Rich Fibrin as Graft & Membrane Vs Hyaluronic Acid & Amniotic Membrane in the Treatment of Interradicular Defects
This study is intended to compare the efficacy of platelet-rich fibrin as a graft and a membrane versus hyaluronic acid(Gengigel) and amniotic membrane in the treatment of mandibular grade II furcation defects.
- Trial name
- CPRFGMHATID (NCT03578744)
- Testing
- Conventional Flap surgery
- Where
- India
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Osteoarthritis Of Knee
Trial to Assess the Structural Effect and Long-term Symptomatic Relief of Intra-articular Injections of Hyaluronic Acid in Primary Knee OA
The present study is designed to test the hypothesis that Intra-Articular Hyaluronic Acid (IAHA) is superior to placebo in slowing structural progression and on long term symptomatic effect in primary knee Osteoarthritis (OA)…
- Trial name
- ViscOA (NCT02280538)
- Testing
- Intra-Articular Hyaluronic Acid
- Where
- 2 sites in Portugal
- Volunteers
- 300 people
- Sponsor
- Universidade Nova de Lisboa
Periodontal Diseases
Application of Hyaluronic Acid in Diabetes
sub gingival application of hyaluronic acid create great clinical improvement of periodontal pocket treatment.
- Trial name
- NCT05543434
- Testing
- Hyaluronic acid
- Where
- Egypt
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cairo University
Alveolar Bone Resorption, Alveolar Ridge Enlargement
Is Cross-linked Hyaluronic Acid a Biologic Alternative for Alveolar Ridge Preservation?
Even after atraumatic tooth removal and/or immediate implant placement, some reduction of the alveolar ridge dimension is expected.
- Conditions
- Alveolar Bone Resorption, Alveolar Ridge Enlargement, Tooth Extraction, Hyaluronic Acid
- Trial name
- NCT07496437
- Testing
- DBBM + FGG, Hyaluronic acid + collagen sponge + FGG
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Paralysis, Unilateral, Vocal Cord
Early Intracordal Hyaluronic Acid Injection During Spontaneous Reinnervation for Unilateral Recurrent Laryngeal Nerve Paralysis
Backgrounds: Unilateral vocal cord paralysis caused from recurrent laryngeal nerve (RLN) injury is not an unusual disease and may deteriorate patients'voice and swallowing outcomes.
- Trial name
- NCT02163772
- Testing
- Intracordal hyaluronate injection
- Where
- Taiwan
- Volunteers
- 29 people
- Sponsor
- Chang Gung Memorial Hospital
Stress Incontinence, Female
Injecting Plasma-rich Platelets & Hyaluronic Acid for Patients With Stress Urinary Incontinence
Injection of PRP and hyaluronic acid in stress incontinence patients
- Trial name
- NCT06012370
- Testing
- PRP injection
- Volunteers
- 20 people
- Sponsor
- Kasr El Aini Hospital
Dry Eye Disease, Cataract
Hyaluronic Acid-containing Artificial Tears in Post-cataract Surgery Dry Eye Disease
To compare the effects of hydroxypropyl guar (HPG)/hyaluronic acid (HA)- and carboxymethylcellulose (CMC)/HA-based lubricant eye drops on subjective and objective outcomes in dry eye disease (DED) patients after cataract surgery.
- Trial name
- NCT06221345
- Testing
- Systane HYDRATION® Preservative-Free Lubricant Eye Drops, Optive Fusion® Lubricant Eye Drops (Unit Dose)
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- Chang Gung Memorial Hospital
Gastrointestinal Microbiome
Human Pilot Study - HA35 (Hyaluronan Molecular Weight 35) Dietary Supplement for Promoting Intestinal Health
The purpose of this study is to evaluate whether oral HA35 supplementation changes the normal intestinal bacteria, increases intestinal protection, decrease intestinal inflammation and permeability, and to assess any health…
- Trial name
- NCT02867605
- Testing
- Hyaluronan
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Lipodystrophies, Aesthetics Procedure
Safety Study of Filler Agent Composed of Autologous Mesenchymal Stem Cells and Hyaluronic Acid
Lipodystrophies are part of a clinically heterogeneous group of disorders characterized by loss (lipoatrophies) and / or accumulation of fat, which usually results in a change of normal tissue surface.
- Trial name
- LipAge (NCT02034786)
- Testing
- Adipose tissue collection, Transdermal injection
- Where
- Brazil
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Cryopraxis Criobiologia Ltda.
Midface Volume Deficit
Restylane Perlane Lidocaine for Correction of Midface Volume Deficit and/or Midface Contour Deficiency
This is a randomized, multi-center, evaluator-blinded, no-treatment controlled study to evaluate the efficacy and safety of Restylane Perlane Lidocaine for correction of Midface Volume Deficit and/or Midface Contour Deficiency.
- Trial name
- NCT03097783
- Testing
- Restylane Perlane Lidocaine
- Where
- China
- Volunteers
- 169 people
- Sponsor
- Galderma R&D
Osteoarthritis Knees Both
Treatment of Symptomatic Bilateral Knee Osteoarthritis: Intra-articular Injection of Autologous Microfragmented Adipose Tissue and Hyaluronic Acid vs Intra Articular Injection of Autologous Microfragmented Adipose Tissue
The HYALOFAT study is a randomized controlled double-blind trial with parallel treatment arms and 1:1 allocation. By means of a double-blind randomized controlled trial in patients with symptomatic bilateral OA of the knees, the…
- Trial name
- NCT07121556
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Istituto Ortopedico Rizzoli