Clinical trials: Hydrocephalus.
Hydrocephalus in Children
Precision Surgery for Pediatric Hydrocephalus: VPS vs. ETV With ML-Guided Prediction
Study type: Multicenter retrospective cohort study with prospective validation Primary purpose: To determine whether an individualized, imaging-guided treatment algorithm Ventriculoperitoneal shunt (VPS) vs endoscopic third…
- Trial name
- VPS ETV ML (NCT07330206)
- Testing
- MRI-Guided Precision Shunt or ETV Strategy
- Where
- China
- Volunteers
- 800 people
- Sponsor
- West China Hospital
Motor Condition as Measured by Quantified Scale, Cognitive Investigation
Normal Pressure Hydrocephalus Treatment by Acetazolamide
Normal pressure hydrocephalus (NPH) is an uncommon cause of dementia possibly reversible with treatment. First described in 1965 it consists of a triad of gait disturbance, cognitive deterioration, and urinary incontinence…
- Trial name
- NCT02163330
- Testing
- Acetazolamide, sugar pill
- Where
- Israel
- Volunteers
- 2 people
- Sponsor
- Rabin Medical Center
Pediatric Hydrocephalus
HCRN Core Data Project: Characterizing Patient Populations in the Hydrocephalus Clinical Research Network (HCRN)
The Hydrocephalus Clinical Research Network (HCRN) has been established by philanthropic funding to conduct multi-institutional research (clinical trials and observational studies) on pediatric hydrocephalus.
- Trial name
- NCT00670735
- Where
- 14 sites in United States, Canada
- Volunteers
- 1,400 people
- Sponsor
- University of Utah
Hydrocephalus, Shunt Malfunction
Role of Endoscopic Third Ventriculostomy in Management of Malfunctioning Ventriculoperitoneal Shunt
The aim of this study is to analyze our experience in management of malfunctioning ventriculoperitoneal shunt by using endoscopic third ventriculostomy (ETV).
- Trial name
- NCT06341946
- Testing
- Endoscopic third ventriculostomy
- Volunteers
- 30 people
- Sponsor
- Sohag University
Acute Brain Injury, Traumatic Brain Injury
Bedside Cranial Ultrasound for Risk-Stratified Imaging in Pediatric Acute Brain Injury
Acute brain injury (ABI) is a leading cause of death and long-term disability in children. Diagnosis depends on fast neuroimaging, and head computed tomography (CT) is the bedside reference standard despite exposing the…
- Conditions
- Acute Brain Injury, Traumatic Brain Injury, Intracranial Hemorrhage, Hydrocephalus
- Trial name
- CUPID-Peds (NCT07772323)
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Virginia Commonwealth University
Hydrocephalus
UVC in Prevention of Surgical Wound Infection
The LF-PODD study investigates the use of UVC (270nm) light in the prevention of surgical wound infections. Three devices are used in the study, two of which are actively producing UVC light (265 and 275 nm) and one device does…
- Trial name
- UVCJAS (NCT07600463)
- Testing
- UVC Irradiation
- Where
- Finland
- Volunteers
- 75 people
- Sponsor
- Ville Leinonen
Hydrocephalus, Cerebral Ventricle
Impact of Cerebral Ventricular Dilatations and Cerebrospinal Fluid Pulsations on Periventricular White Matter in Hydrocephalic Patients
Hydrocephalus is characterized by excessive accumulation of cerebrospinal fluid (CSF) in the ventricles of the brain. One of the forms of hydrocephalus is called "normal pressure", although one of the main signs is precisely an…
- Conditions
- Hydrocephalus, Cerebral Ventricle, Cerebrospinal Fluid, White Matter Fiber
- Trial name
- HYDRODIFF (NCT05825521)
- Testing
- MRI
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Hemodynamic Instability, Water on the Brain
Multi-parameters'Change Process During Dehydration Therapy on Brain Edema Patients.
This study aims to investigate the inner mechanism during different dehydration therapies such as mannitol injection and hypertonic saline.
- Conditions
- Hemodynamic Instability, Water on the Brain, Intracranial Pressure Increase
- Trial name
- NCT03828032
- Testing
- Mannitol injection, Hypertonic saline injection
- Volunteers
- 80 people
- Sponsor
- Ting Li
Hydrocephalus, Normal Pressure
A Study Comparing Shunt Placement Versus Endoscopic Third Ventriculostomy in the Treatment of Hydrocephalus
The main purpose of this study is to compare two types of treatment of hydrocephalus: placement of a ventriculoperitoneal (VP) shunt versus an endoscopic third ventriculostomy (ETV).
- Trial name
- NCT01115270
- Testing
- Non-invasive measures
- Where
- United States
- Volunteers
- 196 people
- Sponsor
- University of California, Los Angeles
Normal Pressure Hydrocephalus
Computerised Testing of Cognitive Response to Cerebrospinal Fluid Shunting in Idiopathic Normal Pressure Hydrocephalus
A novel computerised neuropsychological test battery for normal pressure hydrocephalus (NPH) has been developed. The aim is to provide the clinician with a free of charge, standardized tool, assessing the cognitive decline or…
- Trial name
- NCT01618500
- Where
- 4 sites in Denmark, Sweden
- Volunteers
- 80 people
- Sponsor
- Umeå University
Idiopathic Normal Pressure Hydrocephalus (INPH), Brain Diseases
Ventriculomegaly and Gait Disturbance in the Senior Population in the Region of Västerbotten
Idiopathic normal pressure hydrocephalus (INPH) is a treatable disease of the elderly, typically causing gait impariment, dementia and urinary incontinence.
- Conditions
- Idiopathic Normal Pressure Hydrocephalus (INPH), Brain Diseases, Central Nervous System Diseases, Dementia
- Trial name
- VESPR (NCT05204745)
- Where
- Sweden
- Volunteers
- 6,500 people
- Sponsor
- Umeå University
NPH (Normal Pressure Hydrocephalus)
Examining the Feasibility of Using Pressure Gradient Regulated Automated Cerebral Spinal Fluid Drainage During External Lumbar Drain Trials
The intellidrop device is an FDA-approved system that automates safe, small volume of cerebral spinal fluid drainage with continuous pressure monitoring, reducing nursing workload and human error while improving patient mobility…
- Trial name
- UPGRADE (NCT07494812)
- Testing
- Intellidrop Automated CSF Drainage System
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Texas Southwestern Medical Center
Post-Hemorrhagic Hydrocephalus
Shunt Outcomes of Post-Hemorrhagic Hydrocephalus
This multicenter, prospective pilot study will compare the effectiveness of two established procedures used in the treatment of post-hemorrhagic hydrocephalus in very low birth weight infants, specifically ventricular reservoirs…
- Trial name
- SOPHH (NCT01480349)
- Where
- 7 sites in United States, Canada
- Volunteers
- 146 people
- Sponsor
- University of Utah
Brain Injuries, Subarachnoid Hemorrhage
An Evaluation of a Non-invasive Brain Monitor
HS-1000 device, a proprietary new non-invasive brain monitor, is expected to safely and accurately monitor physiological signs of the brain with minimal discomfort to patients, providing information about normal or abnormal…
- Conditions
- Brain Injuries, Subarachnoid Hemorrhage, Vasospasm, Intracranial, Hydrocephalus
- Trial name
- NCT02775136
- Testing
- HS-1000 recording
- Where
- 4 sites in Germany
- Volunteers
- 160 people
- Sponsor
- HeadSense Medical
Hydrocephalus
Value of MRI CSF Flowmetry in Assessment of Grey Zone Hydrocephalic Patients
To evaluate accuracy of (MRI) cerebrospinal fluid flowmetry after shunt operation in patients with borderline (grey zone) hydrocephalus.
- Trial name
- NCT04060810
- Testing
- MR CSF flowmetry
- Volunteers
- 10 people
- Sponsor
- Assiut University
Blocked Ventricular Shunts
Multi-Center Study of ShuntCheck
Multi-Center Study of ShuntCheck
- Trial name
- NCT00788385
- Testing
- ShuntCheck test
- Sponsor
- NeuroDx Development
Hydrocephalus
Diagnosing Malfunctioning Hydrocephalic Shunt Valves With a Flow Sensor
The study hypothesis is that a transit-time ultrasonic sensor can help doctors diagnose a malfunctioning shunt valve. The study will simulate an implanted shunt flow monitoring system by placing the flow sensor and a programmable…
- Trial name
- NCT00652249
- Where
- United States
- Sponsor
- Transonic Systems Inc.
Probable Alzheimer Disease, Parkinson Disease
In Vivo Alzheimer Proteomics
In France, an estimated 860 000 patients are affected by Alzheimer Disease (AD) which represents, as in other developed countries, a major public health issue.
- Conditions
- Probable Alzheimer Disease, Parkinson Disease, Neurological Disease Without Cognitive Degradation, Brain Trauma
- Trial name
- PROMARA (NCT02263235)
- Testing
- administration of stable isotope-labelled leucine-, collection of CSF, blood, urine, saliva
- Where
- France
- Volunteers
- 89 people
- Sponsor
- University Hospital, Montpellier
Hydrocephalus
ShuntCheck Versus Radionuclide in Evaluating Shunt Function in Symptomatic NPH Patients
The purpose of this study is to compare the accuracy of ShuntCheck (SC) and ShuntCheck plus Micro-Pumper (SC+MP) to radionuclide shunt patency testing (SPS) in evaluating shunt function in patients with adult hydrocephalus (AH)…
- Trial name
- SCNPH (NCT01323764)
- Testing
- ShuntCheck test
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- NeuroDx Development
Head Injury
Effect of Intrathoracic Pressure Regulation on Traumatic Brain Injury
The purpose of this study is to demonstrate proof of clinical concept that application of the Intrathoracic Pressure Regulator (ITPR) will result in an increase in Cerebral Perfusion Pressure (CPP) and a decrease in Intracranial…
- Trial name
- NCT01824589
- Testing
- -7 cm H2O ITPR, -12cm H2O ITPR
- Volunteers
- 1 people
- Sponsor
- Advanced Circulatory Systems