Clinical trials: Hydrocephalus.
Hydrocephalus
Assessment of CSF Shunt Flow During Activities of Daily Living and Sleep With a Thermal Measurement Device
This study evaluates the performance of a device for non-invasively assessing cerebrospinal fluid (CSF) shunt flow over multiple measurements performed by a study subject during activities of daily living and sleep
- Trial name
- NCT07050628
- Testing
- wireless thermal anisotropy measurement device
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- Rhaeos, Inc.
Cysticercosis, Neurocysticercosis
Natural History of Treated Neurocysticercosis and Long-Term Outcomes
Neurocysticercosis is a brain disease due to the larval stage of the pork tapeworm (Taenia solium). The most common symptoms patient experience from infection inside the substance of the brain (parenchymal disease) are seizures…
- Trial name
- NCT00001205
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Ventricular Peritoneal Shunt, Shunt Complications
Keyhole Surgery for the Positioning of the Distal Catheter in Ventricular Peritoneal Shunt Placement
Ventriculoperitoneal shunting (VPS) was first described at the beginning of the 20th century as a diversionary procedure in patients with a hydrocephalus.
- Conditions
- Ventricular Peritoneal Shunt, Shunt Complications, Shunt Failure, Randomized Controlled Trial
- Trial name
- NCT01739179
- Testing
- VP Shunt Surgery for laparoscopic insertion of the peritoneal catheter, VP Shunt Surgery for open insertion of the peritoneal catheter
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Hydrocephalus in Infants
Clinical Application and Functionality for an Application for Measurement of Head Circumference.
Title of clinical study:Clinical application, validation, and functionality evaluation of the Mobile Head Circumference Application in neonates and children Sponsor: University Hospitals NHS Foundation Trust Purpose of…
- Trial name
- NCT05762848
- Testing
- Mobile Phone Head Circumference App
- Where
- United Kingdom
- Volunteers
- 37 people
- Sponsor
- University of Cambridge
Hydrocephalus, Normal Pressure, Hydrocephalus
Pilot Study of the CereVasc® eShunt® System in Normal Pressure Hydrocephalus
The eShunt System includes proprietary delivery componentry and the eShunt Implant, a permanent implant deployed in a minimally invasive, neurointerventional procedure.
- Trial name
- NCT05250505
- Testing
- eShunt Implant
- Where
- Argentina
- Volunteers
- 30 people
- Sponsor
- CereVasc Inc
Ventriculomegaly
Magnetic Resonance Imaging (MRI) of Ventriculomegaly: Morphology and Outcome
This study compares the accuracy of fast magnetic resonance imaging (MRI) using the half Fourier single shot rapid acceleration with relaxation enhancement technique to ultrasound in the diagnosis of fetal abnormalities.
- Trial name
- NCT00870675
- Where
- United States
- Volunteers
- 434 people
- Sponsor
- National Institute for Biomedical Imaging and Bioengineering (NIBIB)
Intraventricular Hemorrhage Neonatal, Post-hemorrhagic Hydrocephalus
Advanced MRI in IVH
55,000 babies are born prematurely in the UK annually. Bleeding in the fluid spaces of the brain (ventricles) is common after prematurity; in England around 450 babies suffer from severe bleeds every year.
- Trial name
- NCT07412886
- Testing
- Advanced MRI
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Myasthenia Gravis, Guillain-Barre Syndrome
Neurology Inpatient Clinical Education Trial
The objective of this study is to compare the effectiveness of a personalized patient education program to the current hospital education and evaluate its impact using patient satisfaction scores.
- Conditions
- Myasthenia Gravis, Guillain-Barre Syndrome, Multiple Sclerosis, Seizures
- Trial name
- NCT03826056
- Testing
- Current standard discharge educational intervention, Personalized discharge educational intervention
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Idiopathic Normal Pressure Hydrocephalus
Improved Analysis Methods for Infusion Tests
Objective: Patients with Idiopathic Normal Pressure Hydrocephalus are improved with shunt surgery. To increase the accuracy of the diagnosis, supplementary tests that characterize the cerebrospinal fluid (CSF) dynamics are used.
- Trial name
- NCT01319136
- Where
- 2 sites in Sweden
- Volunteers
- 48 people
- Sponsor
- Umeå University
Aneurysmal Subarachnoid Hemorrhage, Hydrocephalus
Quality of Life in Elderly After Aneurysmal Subarachnoid Hemorrhage (SAH)
In all the Western populations, the annual incidence of subarachnoid hemorrhage (SAH) increase with age. In patients older than 70 years, the occurrence of SAH exposes them to high risk of morbidity and a poor quality of life.
- Conditions
- Aneurysmal Subarachnoid Hemorrhage, Hydrocephalus, Cerebral Vasospasm
- Trial name
- FASHE (NCT00692744)
- Where
- 2 sites in France
- Volunteers
- 353 people
- Sponsor
- University Hospital, Rouen
Hydrocephalus, Alzheimer Disease
MR Evaluation of Cerebrospinal Fluid (CSF) Dynamics
The Researchers are trying to test a MR imaging method for detection of Cerebral Spinal Fluid (CSF) flow in the brain to help diagnosis and better understand diseases that affect brain function.
- Trial name
- NCT04099823
- Testing
- MRI screening form, Urine pregnancy test, MR brain
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Hydrocephalus
Assessment of Flow in Cerebrospinal Fluid Shunts With a Wireless Thermal Anisotropy Measurement Device in Asymptomatic Patients
This study evaluates the performance of the study device, FlowSense®, a sensor for non-invasively assessing cerebrospinal fluid (CSF) shunt flow.
- Trial name
- NCT06410885
- Testing
- Thermal Anisotropy Measurement Device
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Rhaeos, Inc.
Hydrocephalus, Normal Pressure, Ventriculomegaly, Cerebral
Volumetrics and Proteomics in Shunted Normal Pressure Hydrocephalus
Idiopathic normal pressure hydrocephalus (=iNPH) is a condition with disturbed circulation of cerebrospinal fluid (=CSF) causing symptoms such as balance and gait disorders, urinary incontinence and cognitive impairment in…
- Conditions
- Hydrocephalus, Normal Pressure, Ventriculomegaly, Cerebral, Shunt; Complications, Hydrocephalus Acquired
- Trial name
- LiNPH (NCT04785560)
- Testing
- Initial shunt setting post-operatively of the Certas Plus shunt valve.
- Where
- Sweden
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University Hospital, Linkoeping
Normal Pressure Hydrocephalus
European Study on Prediction of Outcome in Patients With Idiopathic Normal Pressure Hydrocephalus
The purpose of the study is to determine the predictive values and prognostic accuracies of CSF dynamic measures, the TAP -TEST (high-volume cerebrospinal fluid withdrawal), resistance to CSF outflow and compliance in the…
- Trial name
- NCT00874198
- Testing
- Ventriculo-peritoneal Shunt
- Where
- Germany
- Volunteers
- 156 people
- Sponsor
- International Neuroscience Institute Hannover
Aneurysm, Ruptured, Hyperglycemia
Shunt-dependency After aSAH - Role of Early Hyperglycaemia in CSF and Blood
The goal of this study is to confirm the association of early increased glucose levels in cerebro-spinal fluid (CSF) and ventriculo-peritoneal-shunt (VPS)-dependency also evaluating the influence of blood glucose on VPS…
- Conditions
- Aneurysm, Ruptured, Hyperglycemia, Hydrocephalus
- Trial name
- HCP-Glc (NCT06486909)
- Testing
- Cerebrospinal Fluid (CSF) Sample, Blood Serum Sample
- Where
- 3 sites in Switzerland
- Volunteers
- 160 people
- Sponsor
- Isabel Hostettler
Chronic Hydrocephalus
NIMIP: Non Invasive Measurement of the Intracranial Pressure
The intracranial pressure (ICP), defined by the hydrostatic pressure of the cerebrospinal fluid (CSF), is a key parameter for diagnosing and treating several neurosurgical diseases.
- Trial name
- MINIPIC (NCT01685450)
- Testing
- Echodia® hand-held equipment
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Clermont-Ferrand
Developing the ABEP-H, Determining the Effect of ABEP-H
The Effect of an Avatar-Based Education Program on Shunt Complications and Parents' Knowledge and Care Skills
Hydrocephalus is a common childhood neurosurgical disease. Ventriculoperitoneal (VP) shunt is usually used in the treatment of hydrocephalus. However, VP shunt may have some complications.
- Trial name
- NCT05370131
- Testing
- Avatar-Based Education Program in Hydrocephalus (ABEP-H)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Hydrocephalus, Ventriculoperitoneal Shunt Malfunction
Comparison of Programmable and Non-programmable CSF Shunts Among Adult Hydrocephalus Patients With Different Etiologies
Programmable valve (PV) has been shown as a solution to the high revision rate in pediatric hydrocephalus patients, but it remains controversial among adults.
- Trial name
- NCT05534659
- Testing
- Programmable valve, Non-programmable valve
- Volunteers
- 325 people
- Sponsor
- Chang Gung Memorial Hospital
Idiopathic Normal Pressure Hydrocephalus
Novel Parameters for the Prediction of Ventriculoperitoneal Shunting Efficacy in Patients With iNPH
INPH is a chronic, progressive disease characterised by enlarged ventricles in the absence of elevated intracranial pressure. Patients often present with the Hakim triad comprising gait disturbance, dementia and urinary…
- Trial name
- iNPH (NCT02495610)
- Testing
- Gait analysis and MRI:
- Where
- Switzerland
- Volunteers
- 70 people
- Sponsor
- University of Zurich
Normal Pressure Hydrocephalus
White Matter Distortion and Dementia Biomarkers in Normal Pressure Hydrocephalus (NPH)
Idiopathic Normal Pressure Hydrocephalus (iNPH) is a progressive condition of the elderly that results in severe disability. iNPH can dramatically respond to Cerebral spinal fluid(CSF)-shunting where excess ventricular fluid is…
- Trial name
- OWN-NPH (NCT07103681)
- Testing
- Ventriculoperitoneal Shunt (VP), Brain and Skin Biopsy, MRI Brain
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Imperial College London