Clinical trials: Hydroxymethylglutaryl-CoA Reductase Inhibitors
Heart Failure, Atrial Fibrillation
Statins in Reducing Events in the Elderly (STAREE) Heart Sub-study
The STAREE-HEART sub-study will examine the effect of statin treatment over a 3-year period compared with placebo on markers of cardiac ageing (myocardial dysfunction).
- Conditions
- Heart Failure, Atrial Fibrillation, Healthy Ageing, Hypercholesterolemia
- Trial name
- STAREE-HEART (NCT04536870)
- Testing
- Echocardiography, ECG screening
- Where
- 2 sites in Australia
- Volunteers
- 369 people, healthy volunteers welcome
- Sponsor
- Monash University
Hyperlipidemia, Hypercholesterolemia
Cholesterol and Pharmacogenetic Study
The overall objective of the CAP study was to determine genetic influences on efficacy of simvastatin treatment with regard to LDL cholesterol reduction and changes in other markers of cardiovascular disease risk.
- Conditions
- Hyperlipidemia, Hypercholesterolemia, Coronary Heart Disease, Cardiovascular Disease
- Trial name
- CAP (NCT00451828)
- Testing
- Simvastatin
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Coronary Artery Disease, Hypercholesterolemia
The Role of Atorvastatin on Monocyte Function in Patients With Coronary Artery Disease and Hypercholesterolemia
The aim of this study is to determine, whether an intensified atorvastatin therapy can improve monocyte function in patients with coronary artery disease and hypercholesterolemia.
- Conditions
- Coronary Artery Disease, Hypercholesterolemia, Monocyte Function
- Trial name
- NCT00329069
- Testing
- atorvastatin (drug)
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Healthy
Observational Usage Study of Statins in Primary Care in France
To describe the way statins are used in France in primary care, that is to determine patients profile (particularly CV risk factors), to determine the way statins are initiated by general practitioners, to evaluate aftercare and…
- Trial name
- NCT00680082
- Where
- 25 sites in China
- Volunteers
- 2,100 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Hypercholesterolemia
Validating the "Foods for Health" Portfolio of Functional Food Products
The objective of this research project is to investigate the ability to affect cardiovascular disease (CVD) risk factors through a novel, easily implemented functional food-based approach.
- Trial name
- NCT02341924
- Testing
- Portfolio of functional foods, Control foods
- Where
- 2 sites in United States, Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Cardiovascular Diseases
Combined Bioactive Therapy Effects Over Cardiovascular Markers in Statin Treated Patients
Atherosclerosis, one major cause of morbidity and mortality worldwide, is a complex and multifactorial disease triggered especially due to high level of plasma lipids and that involves three mainly conditions: chronic…
- Trial name
- NCT02732223
- Testing
- Functional treatment, Control treatment
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
Dyslipidemia
Study of Trilipix Effects on Lipids and Arteries
Fibrates reduce atherosclerosis and cardiovascular disease events. A major mechanism of this benefit appears to be their ability to raise plasma high density lipoprotein cholesterol (HDL-C), especially in patients with high…
- Trial name
- NCT01025492
- Testing
- Trilipix
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Utah
Metabolite
Study on the Effect of Atorvastatin Co-administered With Omeprazole on Statin Lactone
This is a 2-arm, prospective, randomized, parallel-group, open-label, longitudinal study that lasts 30 days for each study participant.
- Trial name
- SEACOL (NCT06690164)
- Testing
- Atorvastatin 40mg Tablet, Omeprazole 20mg Capsule
- Where
- Singapore
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Myopathy; Primary
Annatto-derived GG for Statin-associated Myopathy
To evaluate the effects of 3-months annatto-derived geranylgeraniol (GG) supplementation on statin-associated skeletal muscle health.
- Trial name
- GG-statin (NCT05312424)
- Testing
- Low GG, High GG
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Drug Intolerance
Statin Immune Study
Statins are widely used drugs to treat hypercholesterolaemia. In general, they are very safe drugs. However, up to one third of statin users can experience muscle symptoms, which are most commonly mild without any conventional…
- Trial name
- ImmunoStat (NCT02984293)
- Testing
- Atorvastatin
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Dundee
Cardiovascular Risk Factor, Cardiovascular Diseases
The DEtermining Statin Intolerance FOr Rosuvastatin (DESIFOR) Trial
This study will enroll patients who previously were not able to tolerate being on a statin medication due to muscle-related side effects.
- Conditions
- Cardiovascular Risk Factor, Cardiovascular Diseases, Adverse Effect
- Trial name
- DESIFOR (NCT03889314)
- Testing
- Rosuvastatin 20mg
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Minneapolis Heart Institute Foundation
HMG-CoA Reductase Inhibitor Toxicity
Pharmacogenomic Modulators of Impaired Exercise Adaptation in Statin Users
3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) have beneficial effects (prevent stroke, heart attack) but also some bad ones (block some good effects of exercise).
- Trial name
- NCT04636138
- Testing
- Exercise
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Endothelial Function
Pleiotropism of Statin Therapy in High Dose Versus Low Dose Combined With Ezetimibe
To test the hypothesis that therapy with high dose statin provides endothelial superior benefit to the same cholesterol lowering with low-dose statin combined with ezetimibe.
- Trial name
- NCT01241097
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Federal University of Bahia
Healthy Subjects
Effect of Statin Use on Aldosterone Secretion
The purpose of this research protocol is to determine if the same effects are observed in vivo in humans through a randomized controlled study.
- Trial name
- NCT02871687
- Testing
- Simvastatin, Pravastatin
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Healthy Volunteers
Effects of Statins on the Pharmacokinetics for Midazolam in Healthy Volunteers
The purpose of this study is to investigate whether statins have any influence on cytochrome P450 (CYP) 3A4 enzyme activity using a probe drug midazolam.
- Trial name
- H-17-21 (NCT00716846)
- Testing
- simvastatin, atorvastatin, pitavastatin
- Where
- Japan
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Hamamatsu University
Hydroxymethylglutaryl-CoA Reductase Inhibitors, Muscular Diseases
The Effect of Statin Medications on Muscle Performance (The STOMP Study)
Statins are a group of medications that are used to lower cholesterol levels. Although serious side effects are rare, some people taking statins experience muscle pain or weakness.
- Trial name
- STOMP (NCT00609063)
- Testing
- Atorvastatin
- Where
- 3 sites in United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Pharmacodynamics
KF2023#1-Trial: Influence of Statin Intake on Cellular Readouts
A majority of high-risk patients does not achieve their cholesterol target levels and most of these patients do not receive more effective combination therapy, which goes beyond statin monotherapy.
- Trial name
- NCT06469450
- Testing
- Atorvastatin
- Where
- Finland
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Mikko Niemi
Hyperlipidemia
A Study to Determine the Bioequivalence of SCH 900068 Compared to Marketed Products (Protocol No. P07551)
The intent of this study is to demonstrate that single doses of the Final Market Image (FMI) ezetimibe/atorvastatin 10mg/10mg and 10mg/80mg fixed dose combination (FDC) tablets are bioequivalent to the same doses of ezetimibe…
- Trial name
- NCT01236430
- Testing
- Ezetimibe, Ezetimibe/atorvastatin 10mg/10mg FDC, Atorvastatin 10mg
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Organon and Co
ST Elevation Myocardial Infarction
Effect of Upstream Treatment With High Intensity Statin on the Outcomes of STMI Patients Treated With PPCI
Effect of upstream treatment with high intensity statin on the outcome of ST segment elevation myocardial infarction patients treated with primary percutaneous coronary intervention
- Trial name
- NCT04754789
- Testing
- Atorvastatin, Aspirin
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Assiut University
Medication Adherence
Investigation of a Patient Support Intervention for Statin Medication Adherence
Statins have been demonstrated to significantly reduce the risk of cardiovascular disease, but adherence to these medications is suboptimal.
- Trial name
- NCT06972979
- Testing
- Text Message Gamification and Remote Support
- Where
- United States
- Volunteers
- 2,200 people, healthy volunteers welcome
- Sponsor
- Ascension Health