Clinical trials: Hyperactive Delirium
Hyperactive Delirium, Mixed Delirium
Valproic Acid for Treatment of Hyperactive or Mixed Delirium in ICU
Delirium is the most often encountered psychiatric diagnosis in the general hospital, with incidence up to 85% in the intensive care unit (ICU) setting and with significant consequences on patients' morbidity and mortality.
- Trial name
- NCT02343575
- Testing
- Valproic Acid, Haloperidol
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Stanford University
Covid19, Hyperactive Delirium
Valproate Alone or in Combination With Quetiapine for Severe COVID-19 Pneumonia With Agitated Delirium
The primary purpose of this research is to determine whether Valproate alone, and in combination with Quetiapine, lowers confusion and agitation in persons with severe Corona Virus Disease (COVID)19 pneumonia during weaning from…
- Conditions
- Covid19, Hyperactive Delirium, Pneumonia, Viral
- Trial name
- NCT04513314
- Testing
- Valproate, Quetiapine, Standard of Care
- Sponsor
- University of Miami
Dexmedetomidine, Ketamine
Safety and Efficacy of Esketamine - Dexmedetomidine Combination Versus Dexmedetomidine Monotherapy for Hyperactive Delirium in ICU Patients on Non-Invasive Respiratory Support (SEED-NIRS Trial): Study Protocol of a Randomized Controlled Trial
This investigator-initiated, randomized, controlled, single-blind, superiority trial aims to assess the efficacy and safety of esketamine combined with dexmedetomidine for the management of agitation or delirium in intensive care…
- Conditions
- Dexmedetomidine, Ketamine, Analgesia, Respiratory Therapy
- Trial name
- SEED-NIRS (NCT07377981)
- Testing
- Esketamine combined with dexmedetomidine, Dexmedetomidine
- Where
- China
- Volunteers
- 356 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Haloperidol, Advanced Cancer
HALO Trial: Haloperidol vs Olanzapine in Hyperactive Delirium in Palliative Care Patients; A Multi-Centre, Randomised-Controlled Trial
1. Background and Clinical Need: Delirium is common at the end of life and is challenging to control. There is a clinical need to study the benefits of commonly used drugs like Haloperidol and Olanzapine in the management of…
- Conditions
- Haloperidol, Advanced Cancer, Hyperactive Delirium, Olanzapine
- Trial name
- NCT04833023
- Testing
- Haldol 2mg/ml oral solution, Olanzapine Actavis 5mg orodispersible tablet
- Where
- 3 sites in Singapore
- Volunteers
- 22 people
- Sponsor
- Tan Tock Seng Hospital
Agitated Delirium, Delirium Confusional State
Phenobarbital for Agitated Delirium
The goal of this clinical trial is to test whether the medication phenobarbital is as effective for treating agitated delirium among adult patients admitted to the intensive care unit.
- Conditions
- Agitated Delirium, Delirium Confusional State, Delirium in the Intensive Care Unit, Hyperactive Delirium
- Trial name
- NCT07548489
- Testing
- Phenobarbital, Conventional therapy group
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Duke University
Delirium, Confusion
Intelligent Intensive Care Unit
Delirium, as a common complication of hospitalization, poses significant health problems in hospitalized patients. Though about a third of delirium cases can benefit from intervention, detecting and predicting delirium is still…
- Trial name
- ICU_Delirium (NCT02465307)
- Testing
- Confusion Assessment Method, Accelerometer, Commercially available camera
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Florida
Hyperactive Delirium, Hypoactive Delirium
A Pilot Study of "Stanford Proxy Test for Delirium" (S-PTD)
Although there are several tools available for the screening of delirium among the medically ill, they all have some limitations.
- Conditions
- Hyperactive Delirium, Hypoactive Delirium, Mixed Type Delirium
- Trial name
- NCT03954769
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Stanford University
Delirium
Influence of Dexmedetomidine or Propofol on ICU Delirium
In this randomized study, the investigators aim to test the hypothesis that the reinstitution of a normal circadian rhythm by continuous infusions of dexmedetomidine compared to propofol between 8pm and 6am after diagnosis of…
- Trial name
- NCT02807467
- Testing
- Dexmedetomidine, Propofol
- Where
- Switzerland
- Volunteers
- 37 people
- Sponsor
- University Hospital, Basel, Switzerland
Hyperactive Delirium, Delirium of Mixed Origin
Effects of Dexmedetomidine in Patients With Agitated Delirium in Palliative Care
The goal of this multi-centre phase I/II open-label, single-arm study is to determine the feasibility, optimal dose, and preliminary efficacy of dexmedetomidine to manage agitated delirium among patients near the end of life…
- Trial name
- NCT04824144
- Testing
- Dexmedetomidine Hydrochloride
- Where
- 3 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Bruyère Health Research Institute.
Hyperactive Delirium
Quetiapine Versus Haloperidol in the Management of Hyperactive Delirium
In population of intensive care unit (ICU), most studies compared atypical antipsychotics such as quetiapine with the traditional haloperidol in delirious patients of various forms and etiologies.
- Trial name
- NCT05690698
- Testing
- Quatiapine, Haloperidol
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Alexandria University
Hyperactive Delirium
MindfulGarden in Treatment of Hyperactive Delirium in a Hospital Setting
This pilot study is designed to address feasibility for a larger randomized control clinical study that will determine the efficacy of exposure to the MindfulGarden - an interactive digital technology - in reducing hyperactive…
- Trial name
- NCT03621228
- Testing
- MindfulGarden
- Volunteers
- 24 people
- Sponsor
- Simon Fraser University
Alcohol Withdrawal Delirium, Alcohol Withdrawal Associated Autonomic Hyperactivity
Dexmedetomidine (Precedex®) for Severe Alcohol Withdrawal Syndrome (AWS) and Alcohol Withdrawal Delirium (AWD)
This is a prospective, randomized, double-blind, placebo-controlled, parallel-group study of dexmedetomidine versus placebo, with lorazepam rescue, for the management of severe alcohol withdrawal syndrome (AWS) and alcohol…
- Conditions
- Alcohol Withdrawal Delirium, Alcohol Withdrawal Associated Autonomic Hyperactivity, Alcohol Withdrawal Hallucinosis, Alcohol Withdrawal-Induced Delirium Tremens
- Trial name
- NCT01362205
- Testing
- Dexmedetomidine
- Where
- 7 sites in United States
- Volunteers
- 49 people
- Sponsor
- Denver Health and Hospital Authority
Hypoactive Delirium, Hyperactive Delirium
Delirium Prevention in Patients From the Intensive Care Unit (DELA)
"To determine the efficacy of program of prevention of delirium in critically ill patients from the intensive care units of Bucaramanga and Floridablanca.
- Conditions
- Hypoactive Delirium, Hyperactive Delirium, Delirium of Mixed Origin
- Trial name
- DELA (NCT03215745)
- Testing
- Delirium prevention program
- Where
- Colombia
- Volunteers
- 200 people
- Sponsor
- Universidad de Santander
Advanced Cancer
Subcutaneous Olanzapine for Hyperactive or Mixed Delirium
The objective of this study is to determine the tolerability and safety of olanzapine administered as a subcutaneous injection to hospitalized patients with hyperactive or mixed delirium.
- Trial name
- NCT00512291
- Testing
- Olanzapine
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- M.D. Anderson Cancer Center