Clinical trials: Hyperalgesia
Inflammation, Pruritus
L-menthol as a Topical Counter-irritant to TRPA1-induced Neurogenic Inflammation and Pain
The aim of this study is to quantitatively characterize the effects of L-menthol as a topical counter-irritant on cutaneous pain and hyperalgesia provoked by topical application of the TRPA1-agonist trans-cinnamaldehyde (CA) in…
- Conditions
- Inflammation, Pruritus, Hyperalgesia
- Trial name
- NCT02653703
- Testing
- Topical L-menthol 40%, Vehicle, topical ethanol 96%
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Hyperalgesia
The Effect of High-dose Remifentanil on Established Sunburn-induced Hyperalgesia in Human Volunteers (HighDose RemiSun)
Treatment of chronic pain is a major clinical challenge since chronic pain is frequent and leads to deterioration of quality of life.
- Trial name
- NCT01015482
- Testing
- Remifentanil, Midazolam
- Where
- Austria
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Healhty
Acute Analgesic Effects of MDMA on Experimentally Induced Acute Pain, Hyperalgesia and Allodynia in Healthy Participants
This study investigates whether MDMA may have a pain-reducing effect. The effect of MDMA is compared with a placebo (a substance with no active effect).
- Trial name
- MDPS (NCT07494214)
- Testing
- MDMA 25 mg, MDMA 75 mg, MDMA 125 mg
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Hyperalgesia
Hyperalgesia and Pain
Evaluation of the effects of 35%/15%/50% N2O/N2/O2 mixtures on the area of hyperalgesia induced by remifentanil in the CCES (Continuous Cutaneous Electrical Stimulation) model in 20 healthy volunteers.
- Trial name
- NCT01581450
- Testing
- Nitrous Oxide
- Where
- 2 sites in Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Air Liquide Santé International
Postoperative Pain
Factors Predicting Postoperative Cesarean Section Pain
In spite of identical analgesic protocols, parturients suffer different levels of pain postoperative lay. In this study we hope to identify factors which influence the perception of pain including preoperative anxiety, sleep…
- Trial name
- NCT02033304
- Where
- 2 sites in Israel
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
Hyperalgesia, Chronic Pain Syndrome
Pain-related Fear as a Facilitator of Nocebo Hyperalgesia
Nocebo hyperalgesia is characterized by adverse pain outcomes, induced by patients' expectations. In the lab, nocebo effects are commonly studied via classical conditioning, a method that employs pairings of neutral…
- Conditions
- Hyperalgesia, Chronic Pain Syndrome, Chronic Pain, Psychogenic, Fear of Pain
- Trial name
- LFS (NCT04197154)
- Testing
- Threat manipulation (control, no threat), Threat manipulation, Conditioning of moderate pain
- Where
- Netherlands
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Pain, Hyperalgesia
Reducing Nocebo Effects on Pressure Pain
Nocebo effects are known to adversely affect the experience of various physical symptoms, such as pain and itch. Nocebo effects can be induced by associative learning mechanisms of classical conditioning.
- Trial name
- NCT05284383
- Testing
- Closed-label nocebo conditioning, Closed-label counterconditioning, Open-label counterconditioning
- Where
- Netherlands
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Leiden University
Central Sensitisation
Differences in Pain Processing Between Men and Women
Many chronic pain conditions show clear differences between between men and women, such as reported pain intensities or treatment effects, with chronic pain conditions being generally more frequent in women.
- Trial name
- NCT05031286
- Testing
- Cutaneous thermal stimuli
- Where
- Switzerland
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Balgrist University Hospital
Hyperalgesia
The Effect of Remifentanil on Established Capsaicin-Induced Hyperalgesia in Human Volunteers
Treatment of chronic pain is a major clinical challenge since chronic pain is frequent and leads to deterioration of quality of life.
- Trial name
- RemiCaps2 (NCT00789386)
- Testing
- Remifentanil, Midazolam
- Where
- Austria
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Healthy, Hyperalgesia
Influence of Genetics in Pain Sensitivity
The purpose of this study is to learn more about the role of genetics in pain sensitivity. Pain perception varies widely among individuals, and information gained from this trial may lead to better methods of preventing and…
- Conditions
- Healthy, Hyperalgesia, Pain
- Trial name
- NCT00001956
- Testing
- Blood draw, Oral surgery, Tissue biopsy
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Healthy, Hyperalgesia
Positron Emission Tomography to Measure Pain and Pain Control
This study will examine how the brain processes pain signals and how the different parts of the brain work with each other in response to painful stimuli.
- Conditions
- Healthy, Hyperalgesia, Pain, Peripheral Nervous System Disease
- Trial name
- NCT00001307
- Testing
- Oxygen-15 Water, Capsaicin
- Where
- United States
- Volunteers
- 273 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Secondary Hyperalgesia, Inflammation
The Effect of Hyperbaric Oxygen Therapy on Inflammatory Parameters Induced by a Heat Injury Model
Hyperbaric oxygen may reduce neurophatic pain and promote wound healing. Established anti inflammatory effects of HBO may contribute to this effect.
- Trial name
- HBO-SHA (NCT02397343)
- Testing
- Hyperbaric oxygen
- Where
- Denmark
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Pro-inflammatory Activity, Immunologic Activity Alteration
Pain, Opioids and Pro-Inflammatory Immune Responses
Providing pain management to the patient who abuses prescription opioids presents a clinical challenge, not only due to concerns about "drug-seeking", but because they have increased sensitivity to pain, a phenomenon identified…
- Trial name
- NCT01210066
- Testing
- Fentanyl, Cold pressor test, Fentanyl plus cold pressor test
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Pain Sensation, Hyperalgesia
Pain Response to Cannabidiol in Induced Acute Nociceptive Pain, Allodynia and Hyperalgesia By Using a Model Mimicking Acute Pain in Healthy Adults
This study is to investigate the effect of CBD on acute pain in healthy volunteers in a well-established acute pain model.
- Conditions
- Pain Sensation, Hyperalgesia, Allodynia
- Trial name
- CANAB I (NCT03985995)
- Testing
- CBD 800 mg p.o
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Pain
The Effect of Intravenous Lidocaine on Normal Sensation and Pain in Healthy Volunteers
The purpose of this study is to study if lidocaine, given intravenously, reduces pain.
- Trial name
- NCT00657358
- Testing
- Lidocaine
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Chronic Pain
The Effects of Water Temperature on the Cold Pressor Test
This current study is intended to be completed under the umbrella of the current GHUCCTS IRB- approved study "Opioid-Induced Hyperalgesia In Prescription Opioid Abusers: Effects of Pregabalin" (Lyrica study) (PRO00000669).
- Trial name
- NCT03083626
- Testing
- Cold pressor test
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Georgetown University