Clinical trials: Hyperandrogenemia
Puberty, Hyperandrogenism
Acute Progesterone Suppression of Wake vs. Sleep Luteinizing Hormone Pulse Frequency in Pubertal Girls With and Without Hyperandrogenism
The purpose of this study is two-fold. (1) We will determine if in mid- to late pubertal girls without hyperandrogenism (HA), progesterone (P4) acutely reduces waking luteinizing hormone (LH) frequency to a greater extent than…
- Trial name
- CRM003 (NCT00929006)
- Testing
- Micronized progesterone suspension
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Polycystic Ovary Syndrome, Insulin Resistance
Endocrine and Menstrual Disturbances in Women With Polycystic Ovary Syndrome (PCOS)
Polycystic ovary syndrome (PCOS) is a common endocrine disorder in reproductive age women, which causes disordered follicle growth and ovulation resulting in infertility.
- Conditions
- Polycystic Ovary Syndrome, Insulin Resistance, Vitamin D Deficiency, Obesity
- Trial name
- EMDPCOS (NCT03652987)
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- St George's, University of London
Polycystic Ovary Syndrome, Hyperandrogenism
Effect of Metformin on Sensitivity of the GnRH Pulse Generator to Suppression by Estradiol and Progesterone
Many, but not all, girls with high levels of the male hormone testosterone go on to develop polycystic ovary syndrome (PCOS) as adults.
- Trial name
- NCT01427595
- Testing
- Metformin, Progesterone, estrace
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Virginia
Polycystic Ovary Syndrome
Effects of GLP-1 Analogue Combined With Metformin and Metformin on Gonadal and Metabolic Profiles in Chinese Overweight/Obese PCOS Patients With Hyperandrogenemia.
To study the effects of GLP-1 analogues combined with metformin and metformin on gonadal and metabolic profiles in PCOS patients with BMI ≥ 24 in China. 60 cases of overweight PCOS patients were collected from Shengjing hospital.
- Trial name
- NCT04969627
- Testing
- Metformin, Exenatide
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Bing He
Hyperandrogenism
Sleep-wake Changes of Luteinizing Hormone Frequency in Pubertal Girls With and Without High Testosterone
The purpose of this study is to determine whether sleep-wake changes of luteinizing hormone pulse frequency are different in early pubertal girls with high testosterone levels compared to early pubertal girls with normal…
- Trial name
- CRM005 (NCT00930007)
- Testing
- Blood sampling
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Polycystic Ovary Syndrome
Effect of High Testosterone on Sleep-associated Slowing of Follicular Luteinizing Hormone (LH) Frequency in Polycystic Ovary Syndrome
The purpose of this study is to determine whether a testosterone receptor blocker (flutamide) will normalize sleep-wake luteinizing hormone pulse frequency relationships in women with polycystic ovary syndrome.
- Trial name
- CRM004 (NCT00930228)
- Testing
- Flutamide
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Hyperandrogenemia, Polycystic Ovary Syndrome
Evaluation of Adrenal Androgens in Normal and Obese Girls After Suppression and Stimulation
Women with polycystic ovary syndrome (PCOS) often have irregular menstrual periods, too much facial and body hair, and weight gain. Women with PCOS also have a hard time becoming pregnant.
- Conditions
- Hyperandrogenemia, Polycystic Ovary Syndrome, Obesity
- Trial name
- NCT01421797
- Testing
- Dexamethasone, Cortrosyn
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Hyperandrogenemia, Polycystic Ovary Syndrome
Assessment of Sensitivity of the Hypothalamic GnRH Pulse Generator to Estradiol and Progesterone Inhibition
Gonadotropin-releasing hormone (GnRH) is a hormone that regulates the ability of the pituitary to secrete two hormones, luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
- Trial name
- JCM026 (NCT01428245)
- Testing
- Progesterone, Estrace (estrogen)
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Polycystic Ovary Syndrome
Effects of Interleukin-1 Receptor Antagonism on Hyperandrogenemia in Women With Polycystic Ovary Syndrome
A prospective, interventional, open-label, single-arm, proof-of-concept study: 18 women with Polycystic Ovary Syndrome (PCOS) will be treated with 100 mg of Anakinra/Kineret® for 4 weeks.
- Trial name
- FertIL (NCT03578497)
- Testing
- IL-1 receptor antagonist Anakinra
- Where
- Switzerland
- Volunteers
- 18 people
- Sponsor
- University Hospital, Basel, Switzerland
PCOS
Theca Cell Function in Adolescents With Polycystic Ovary Syndrome (PCOS)
In women with polycystic ovary syndrome (PCOS), the cardinal physiological abnormality is excessive ovarian androgen production marked by increased serum testosterone (T) and androstenedione (A) levels.
- Trial name
- NCT01154192
- Testing
- Dexamethasone, recombinant human chorionic gonadotropin (r-hCG)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Obesity, Hyperandrogenemia
Effect of Spironolactone on Adrenal or Ovarian Androgen Production in Overweight Pubertal Girls With Androgen Excess
Whether 12 weeks of spironolactone can reduce androgen production from ovaries and adrenal glands of girls with obesity and androgen excess
- Conditions
- Obesity, Hyperandrogenemia, Polycystic Ovary Syndrome
- Trial name
- NCT01422759
- Testing
- Spironolactone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Virginia
Hyperandrogenemia, Obesity
Effect of Short Term Ovarian Suppression on Androgen Overproduction in Overweight Girls With Androgen Excess
This study will test whether short-term suppression of ovarian function can ameliorate androgen (male hormone) overproduction in overweight girls with androgen excess.
- Conditions
- Hyperandrogenemia, Obesity, Polycystic Ovary Syndrome
- Trial name
- NCT01422096
- Testing
- Leuprolide
- Where
- United States
- Sponsor
- University of Virginia
Polycystic Ovary Syndrome, Puberty Disorders
Does Treatment of Androgen Excess Using Spironolactone Improve Ovulatory Rates in Girls With Androgen Excess?
Adolescent girls with androgen excess have a higher rate of irregular periods and decreased ovulation rates compared to normal girls, and are considered at-risk for developing polycystic ovary syndrome (PCOS).
- Conditions
- Polycystic Ovary Syndrome, Puberty Disorders, Ovulation Disorder
- Trial name
- CBS009 (NCT04075149)
- Testing
- Spironolactone
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Virginia
Polycystic Ovary Syndrome, Hyperandrogenism
Suppression of Daytime and Nighttime Luteinizing Hormone Frequency by Progesterone
During childhood, the levels of certain hormones: gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), estrogen, and progesterone are very low.
- Conditions
- Polycystic Ovary Syndrome, Hyperandrogenism, Normal Puberty
- Trial name
- NCT01428089
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Puberty, Hyperandrogenism
Assessment of Day-night Secretion of Progesterone and LH Across Puberty
Hormones are substances that are made by the body and are sent directly out into the bloodstream to increase or decrease the function of certain organs, glands, or other hormones.
- Trial name
- LH (NCT02155933)
- Testing
- Blood sampling
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Development
The Adrenal Contribution to Androgen Production in Girls During Puberty
In girls with elevated androgens the precise source of androgen excess throughout puberty and early adolescence has not been carefully examined.
- Trial name
- NCT01062568
- Testing
- Adrenocorticotropin, Dexamethasone
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Overweight and Obesity, Hyperandrogenemia
Evaluating the Influence of Diet-induced Weight Loss on Fat (Adipose) Tissue's Insulin Sensitivity and Testosterone Synthesis in Women With Overweight or Obesity, Insulin Resistance, and Hyperandrogenemia
The investigators will measure plasma concentrations of the hormones insulin and testosterone as well as measures of insulin sensitivity in women with overweight or obesity who have insulin resistance (IR).
- Conditions
- Overweight and Obesity, Hyperandrogenemia, Insulin Resistance
- Trial name
- WAIST (NCT06998238)
- Testing
- Mediterranean-based, carbohydrate restricted, calorie reduced diet
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Missouri-Columbia
Hyperandrogenemia, Polycystic Ovary Syndrome (PCOS)
Assessment of the Sensitivity of the Hypothalamic GnRH Pulse Generator to Estradiol and Progesterone Inhibition
Girls with high levels of the male hormone testosterone often develop polycystic ovary syndrome (PCOS) as adults. Women with PCOS often have irregular menstrual periods, excess facial and body hair, and weight gain.
- Trial name
- NCT01425541
- Testing
- estrace, Progesterone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Virginia
Polycystic Ovary Syndrome
Weight Cycling on Hyperandrogenemia and Insulin Resistance in Polycystic Ovary Syndrome
This study prospectively includes PCOS patients with normal weight and overweight/obesity, closely follows up and intensively manages them, and observes the level and distribution of weight reduction achieved by patients after…
- Trial name
- WHIP (NCT06545721)
- Testing
- Adjusting dietary structure + exercise + behavioral intervention, Precision dietary prescription, Standard guideline-based low-energy diet
- Where
- China
- Volunteers
- 425 people
- Sponsor
- Peking Union Medical College Hospital
Polycystic Ovary Syndrome
Effects of Pioglitazone Combined With Metformin on Gonadal and Metabolic Profiles in Chinese Nonobese PCOS Patients.
To study the effects of pioglitazone combined with metformin and metformin on gonadal and metabolic profiles in PCOS patients with BMI < 24 in China. 60 cases of nonobese PCOS patients were collected from Shengjing hospital.
- Trial name
- NCT05519813
- Testing
- Metformin, Pioglitazone Hydrochloride And Metformin Hydrochloride Tablets
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Bing He