Clinical trials: Hyperbaric
Pyoderma Gangrenosum
Hyperbaric Oxygen Therapy for Pyoderma Gangrenosum
Rationale: Pyoderma gangrenosum (PG) is a rare auto-inflammatory neutrophilic dermatosis characterized by a spectrum of clinical presentations with variable courses. Diagnosis and management are challenging in PG.
- Trial name
- HOTPANTS (NCT05343754)
- Testing
- Hyperbaric oxygen, Control group
- Where
- Netherlands
- Volunteers
- 3 people
- Sponsor
- Erasmus Medical Center
PTSD - Post Traumatic Stress Disorder
Hyperbaric Oxygen Therapy for Post Traumatic Stress Disorder - a Pragmatic, Double Blinded Randomized Trial
Post-traumatic stress disorder (PTSD), affecting approximately 6% of the general population and up to one-third of individuals exposed to combat zones and disasters, is a significant contributor to morbidity and mortality among…
- Trial name
- NCT07473362
- Testing
- Hyperbaric Oxygen Therapy
- Where
- Israel
- Volunteers
- 72 people
- Sponsor
- Medical Corps, Israel Defense Force
Elite Male Sailing Athletes
Study on the Effect of Hyperbaric Oxygen Intervention on Relieving Sports Fatigue of Sailors
1. Research Purpose Intensive training often causes autonomic nerve imbalance, poor microcirculation and slow fatigue recovery in elite sailing athletes.
- Trial name
- NCT07625696
- Testing
- Mild Hyperbaric Oxygen Therapy
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Shanghai Research Institute of Sports Science
Analgesia
Efficacy of Coadministration of Calcitonin and Hyperbaric Bupivacaine in Spinal Anesthesia in Tramadol-abuse Patients
Increasing duration of local anesthetic action is desired for prolongation of postoperative patient comfort, as well as decreasing perioperative opioid consumption and subsequent side effects.
- Trial name
- NCT04445857
- Testing
- Calcitonin presented as Miacalcic® ampoules 100 IU/ml (1ml) intrathecally, Calcitonin presented as Miacalcic® ampoules 100 IU/ml (1ml) intravenously, Normal Saline (NS)
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Traumatic Brain Injury
Hyperbaric Oxygen Brain Injury Treatment Trial
The purpose of this innovative adaptive phase II trial design is to determine the optimal combination of hyperbaric oxygen treatment parameters that is most likely to demonstrate improvement in the outcome of severe TBI patients…
- Trial name
- HOBIT (NCT02407028)
- Testing
- Hyperbaric oxygen (1.5 ATA, no NBH), Hyperbaric oxygen (2.0 ATA, no NBH), Hyperbaric oxygen (2.5 ATA, no NBH)
- Where
- 11 sites in United States, Canada
- Volunteers
- 200 people
- Sponsor
- Gaylan Rockswold
Tibial Fracture, Soft Tissue Injury
Hyperbaric Oxygen in Lower Leg Trauma
Study hypothesis :Hyperbaric Oxygen may prevent complications and improve outcomes in severe lower limb trauma. We propose to investigate this hypothesis by conducting an International multi centre randomised control trial of…
- Trial name
- NCT00264511
- Testing
- Hyperbaric Oxygen Treatment
- Where
- 10 sites in United States, Australia and 7 more
- Volunteers
- 120 people
- Sponsor
- Bayside Health
Cystoscopy
Comparison of Hemodynamic Stability With 0.75percent and 0.5percent Hyperbaric Bupivacaine During Spinal Anesthesia in Cystoscopic Procedures
Purpose:The aim of this study is to determine the intrathecal Bupivacaine concentration(0.5% vs 0.75%) with better anesthesia and little hemodynamic disturbance during cystoscopic procedures.In comparing these bupivacaine…
- Trial name
- NCT07590544
- Testing
- 0.5% Hyperbaric Bupivicaine, 0.75% hyperbaric bupivacaine
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- PAEC General Hospital, Islamabad
Interstitial Cystitis/Bladder Pain Syndrome, Underactive Bladder
SNM vs. HBOT for Refractory IC/BPS
This study is for people with long-term bladder pain and urinary problems (known as Interstitial Cystitis/Bladder Pain Syndrome or IC/BPS) that have not improved with other treatments.
- Trial name
- NCT07091266
- Testing
- Sacral Neuromodulation (SNM), Hyperbaric Oxygen Therapy (HBOT)
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Shiyan City Renmin Hospital
Breast Cancer, CIPN - Chemotherapy-Induced Peripheral Neuropathy
Efficacy and Safety of Hyperbaric Oxygen Therapy in Improving Nab-paclitaxel-Induced Peripheral Neuropathy
The goal of this research is to assess whether hyperbaric oxygen therapy can alleviate the symptoms of Nab-paclitaxel-induced peripheral neuropathy and improve patient-reported quality of life.
- Conditions
- Breast Cancer, CIPN - Chemotherapy-Induced Peripheral Neuropathy, Paclitaxel-induced Peripheral Neuropathy
- Trial name
- NCT07410169
- Testing
- Hyperbaric oxygen treatment, Standard Care (in control arm)
- Where
- 2 sites in China
- Volunteers
- 160 people
- Sponsor
- Guangdong Provincial People's Hospital
Arthroplasty, Knee
Effect of Body-mass Index (BMI) on Median Effective Dose of Intrathecal Hyperbaric Bupivacaine
The effect of Body-mass index (BMI) on requirements of local anesthetics used in spinal anesthesia has not been well established.
- Trial name
- NCT01291186
- Testing
- BPV6NO, BPV7NO, BPV8NO
- Where
- South Korea
- Volunteers
- 108 people
- Sponsor
- Seoul Medical Center
Ulcerative Colitis
Hyperbaric Oxygen Therapy for Ulcerative Colitis (HBOT-UC)
Chronic intestinal hypoxia and accompanying mucosal inflammation is a hallmark of ulcerative colitis (UC). Hyperbaric oxygen therapy (HBOT) involves breathing 100% oxygen under increased atmospheric pressure to increase tissue…
- Trial name
- HBOT-UC (NCT05987852)
- Testing
- Hyperbaric Oxygen Therapy
- Where
- 13 sites in United States
- Volunteers
- 126 people
- Sponsor
- Northwestern University
Periodontal Disease
Periodontal Treatment Associated With Hyperbaric Oxygen Therapy
Evaluation of the clinical effect of hyperbaric oxygen therapy (HBOT) adjunctively to scaling and root planing (SRP) in the treatment of severe case of chronic periodontitis.
- Trial name
- NCT00955643
- Testing
- oxygen, other
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Escola Bahiana de Medicina e Saude Publica
Chemical Peeling
Hyperbaric Therapy and Deep Chemical Peeling
To evaluate whether treatment with Hyperbaric oxygen can accelerate skin recovery after deep peeling, and decrease frequency and severity of local side effects and complications.
- Trial name
- NCT00425789
- Testing
- Treatment with Hyperbaric oxygen
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Knee Surgery, Pelvic Surgery
ED50 of Dexmedetomidine as an Adjuvant to 0.5% Hyperbaric Bupivacaine 12.5 mg for Spinal Anesthesia in Hip and Knee Surgery: An Up-and-Down Method Approach
Determine ED50 dexmedetomidine adjuvant that can provide spinal anesthetic sensory blockade duration of 200 minutes on knee and pelvis surgery with up-and-down method.
- Conditions
- Knee Surgery, Pelvic Surgery, Spinal Aneshtesia
- Trial name
- NCT07144215
- Testing
- Dexmedetomidine 3 mcg, Dexmedetomidine 4 mcg, Dexmedetomidine 5 mcg
- Where
- Indonesia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
COVID, Coronavirus
Hyperbaric Oxygen Therapy in Non-ventilated COVID-19 Patients
This study is a prospective randomized controlled, double blind clinical trial performed on laboratory confirmed COVID-19 infection admitted patients in the Shamir Medical Center.
- Trial name
- HBOT (NCT04409886)
- Testing
- Hyperbaric Oxygen Therapy
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Maimonides Medical Center
Prodromal Alzheimer's Disease, Cerebral Vascular Disorder
Hyperbaric Oxygen Therapy for Prodromal Alzheimer´s Disease With Cerebrovascular Disease
Alzheimer´s disease is a devastating illness that effects the patients as well as their family members. Its prevalence increases exponentially and the burden on the healthcare system is enormous.
- Conditions
- Prodromal Alzheimer's Disease, Cerebral Vascular Disorder, Mild Cognitive Impairment, Vascular Cognitive Impairment
- Trial name
- NCT05349318
- Testing
- Hyperbaric oxygen therapy
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Assaf-Harofeh Medical Center
Mild Traumatic Brain Injury, Post-Concussive Syndrome
Hyperbaric Oxygen Therapy (HBO2T) for Post-Concussive Symptoms (PSC) After Mild Traumatic Brain Injury (mTBI)
The goal of this research is to serve as a demonstration project to determine the tolerability of individuals with persistent post-concussive symptoms from combat-related mild TBI (traumatic brain injury), identify dose-finding…
- Trial name
- HBOT (NCT01220713)
- Testing
- Hyperbaric Oxygen Therapy
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Virginia Commonwealth University
Hemondynamic Changes in Spinal Anesthesia
Comparison of Hemodynamic Effects of Bupivacaine in Spinal Anesthesia
To assess hemodynamic changes with hyperbaric bupivacaine with spinal anesthesia
- Trial name
- Nill (NCT07616882)
- Testing
- Spinal Anesthesia (bupivacaine)
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Liaquat National Hospital & Medical College
Pain
Selective Unilateral Spinal Anesthesia Versus Selective Sensory Spinal Anesthesia for Knee Arthroscopy Surgery
Background: Selective unilateral spinal anesthesia is the gold standard spinal anesthesia technique for knee arthroscopy. Selective sensory spinal anesthesia has recently been validated for this surgery.
- Trial name
- NCT01356797
- Testing
- hypobaric levobupivacaine with fentanyl, hyperbaric bupivacaine 0,5%
- Where
- Spain
- Volunteers
- 54 people
- Sponsor
- USP Hospital La Colina
Combined Spinal Epidural Anesthesia, Prilocaine
Spinal Prilocaine for Caesarian Sections
Prilocaine theoretically could provide faster onset because of its lower pKa (7,7) compared to bupivacaine (8,1). The primary objective of this prospective double blind randomized trial is to determine block onset of spinal…
- Conditions
- Combined Spinal Epidural Anesthesia, Prilocaine, Bupivacaine, Pain
- Trial name
- NCT03219086
- Testing
- combined spinal epidural anaesthesia, Prilocaine, Bupivacaine
- Where
- 3 sites in Belgium
- Volunteers
- 182 people
- Sponsor
- University Hospital, Antwerp