Clinical trials: Hypercapnia
Hypercapnia, Ventilatory Depression
Effect of Selective Serotonin Reuptake Inhibitors (SSRIs) and an Opioid on Ventilation
This study is designed to evaluate the effects of the coadministration of paroxetine or escitalopram with an opioid on ventilation. Ventilation will be assessed using a rebreathing methodology.
- Trial name
- NCT05470465
- Testing
- Paroxetine and Oxycodone, Escitalopram and Oxycodone
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Food and Drug Administration (FDA)
Respiratory Failure With Hypercapnia
Listen to a Audio Book
This study investigates how listening to audiobooks affects agitation scores and respiratory parameters (like breathing rate, depth, and oxygen saturation) in patients receiving non-invasive mechanical ventilation (NIMV) for…
- Trial name
- NCT06944093
- Testing
- audio book
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Hypoxia, Brain, Hyperoxia
The Effect of Respiratory Challenge on the BOLD Signal
The purpose of this research study is to better understand how blood flow and metabolism are different between normal controls and patients with disease.
- Conditions
- Hypoxia, Brain, Hyperoxia, Hypercapnia, Hypocapnia
- Trial name
- NCT04258774
- Testing
- Carbon Dioxide
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Acute Severe Respiratory Failure, Acute Respiratory Distress Syndrome
Impact of Arterial CO2 Tension on Management and Outcome in Patients With Acute Hypoxemic Respirator Failure and ARDS
There appears to be considerable variability in the approach physicians use to manage arterial carbon dioxide tensions, in patients in the early phases [first 48 hours] of ARDS (Acute hypoxemic respiratory failure and).
- Trial name
- CO2 LUNG SAFE (NCT03415529)
- Where
- Belgium
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- European Society of Intensive Care Medicine
Hypoxia, Hypercapnia
Pulse Oximeter and Respiratory Rate Test
Assessment of Spry Health's Loop oximetry accuracy in profound hypoxia Assessment of Spry Health's Respiratory rate accuracy in normal conditions and profound hypoxia
- Conditions
- Hypoxia, Hypercapnia, Hypocapnia
- Trial name
- NCT03797300
- Testing
- Spry Loop Band
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Spry Health
Orthostatic Hypotension, Neurogenic Orthostatic Hypotension
Hypercapnia in Orthostatic Hypotension
The Autonomic (or "automatic") Nervous System (ANS) regulates internal processes, including control of heart rate and blood pressure (BP).
- Trial name
- NCT05295810
- Testing
- Sequential Gas Delivery
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Thoracic Surgery
The Effect of Permissive Hypercapnia on Oxygenation and Post-operative Pulmonary Complication During One-lung Ventilation
Permissive hypercapnia increased the survival rate in patients with acute respiratory distress syndrome (ARDS) who required mechanical ventilation in critical care medicine.
- Trial name
- NCT04175379
- Testing
- group 40, group 50, group 60
- Where
- South Korea
- Volunteers
- 279 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Accident Caused by Snow Avalanche
Evaluation of Gas Propagation in Snow During Breathing of Subjects Under Simulated Avalanche Snow
The study is aimed at investigation of respiratory gases propagation in snow. The study involves volunteers breathing into the snow whereas concentrations of gases are measured at various positions in the snow.
- Trial name
- GasProp (NCT05262894)
- Testing
- extreme hypercapnia induced by ventilation insufficiency
- Where
- Czechia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Czech Technical University in Prague
Cerebrovascular Regulation
Brain Blood Flow Responses at Rest and During Exercise
Tight regulation of brain blood flow is integral for delivery of oxygen and energy for survival. During childhood, the brain has a twofold higher metabolic requirement, thus requires greater blood flow to match this.
- Trial name
- NCT06142045
- Testing
- RespirACT RA-MR System
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Amyotrophic Lateral Sclerosis (ALS)
Developing New Ways to Detect Respiratory Impairment Early in ALS
The goal of this observational study is to develop new ways to detect early changes associated with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease.
- Trial name
- NCT07844590
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Hypoxia, Hypercapnia
To Determine the Efficacy of the TwinGuard in Oxygen Delivery During and Post Endoscopic Procedure
A comparative study which compares the end-tidal carbon dioxide and oxygen saturation levels of patients during endoscopy which have used either the new oral-nasal oxygenating device (TwinGuard), or a standard bite block plus…
- Trial name
- NCT00619606
- Testing
- TwinGuard, Standard endoscopic bite block, Standard nasal cannula
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Trawax Pty Limited
Coronary Artery Disease
CO2 as a Stress Agent for Perfusion Imaging
Myocardial perfusion imaging (MPI) is a nuclear scan using a radioisotope to see blood flow to the muscles of the heart when the heart is at rest and when it is under stress.
- Trial name
- CO2 STRESS (NCT02043535)
- Testing
- Delivery of precise levels of carbon dioxide with the RA-MR™ Virtual Sequential Gas Delivery System., Delivery of rubidium radioisotope (Rb-82) using the automated pump/elution system
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
Panic Disorder
A Trial of the Effect of CVL-865 on Panic Symptoms Induced by Carbon Dioxide Inhalation in Healthy Subjects
The purpose of this study is to determine anxiolytic effect of multiple doses of CVL-865 using an experimental medicine model of carbon dioxide (CO2) inhalation in healthy volunteers.
- Trial name
- NCT04592536
- Testing
- CVL-865 High dose, Alprazolam 1mg XR, CVL-865 low dose
- Where
- Netherlands
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Cerevel Therapeutics, LLC
Hypercapnia, Exercise
Hypercapnia: Cognitive Effects and Monitoring
The investigators will simulate the conditions of a working, helmeted diver by using exercising, "head out" immersed subjects to test the following hypotheses: 1.
- Conditions
- Hypercapnia, Exercise, Nitrogen Narcosis, Diving
- Trial name
- NCT01782625
- Testing
- NO exercise at depth, exercise at depth
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Duke University
Acute Respiratory Failure With Hypercapnia
High Flow Nasal Oxygen Therapy in Perioperative Period of the Adult With Hypercapnic and Hypoxemic Respiratory Faliure
The purpose of this study is to determine the impact of hign-flow nasal therapy on the adult with hypercapnia and hpoxemia respiratory faliure in comparison with standard oxygen therapy ang noninvasive ventilation.
- Trial name
- NCT03229460
- Testing
- standard low flow therapy, high flow nasal oxygen therapy, association of high flow nasal oxygen therapy and non invasive positive pressure ventilation
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Accident Caused by Snow Avalanche
Snow Properties and Its Modeling for Studying Gas Exchange Under the Simulated Avalanche Snow
The aim of the study is to investigate respiratory parameters of a person in the simulated avalanche snow and consequent use of the measured data for development of a mathematical-physical model of breathing during increasing…
- Trial name
- SPAM (NCT03413878)
- Testing
- Breathing in the simulated avalanche snow
- Where
- 2 sites in Czechia
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Czech Technical University in Prague
Pulmonary Vascular Sensibility in Hypoxia, Hypercapnia
Effects of O2 and/or CO2 Inhalation on Rest and Exercise Pulmonary Hemodynamic
The aim of this study is to describe the pulmonary hemodynamic evolution at rest and during a short constant load exercise in 4 conditions : normoxia hypoxia hypercapnia association hypoxia and hypercapnia
- Conditions
- Pulmonary Vascular Sensibility in Hypoxia, Hypercapnia, Hypoxia and Hypercapnia
- Trial name
- H2PAP (NCT01898858)
- Testing
- Hypercapnia inhalation (Altitrainer NP 190), Hypoxia and hypercapnia (Altitrainer NP 190), Hypoxia inhalation (Altitrainer NP 190)
- Where
- France
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Hypercapnia, Ventilatory Depression
Clinical Study to Investigate the Effect of the Combination of Psychotropic Drugs and an Opioid on Ventilation
Opioids can decrease breathing and co-administration of benzodiazepines with opioids can further decrease breathing. It is unknown whether certain other drugs also decrease breathing when co-administered with opioids.
- Trial name
- NCT04310579
- Testing
- Oxycodone and Midazolam, Oxycodone, Paroxetine, and Quetiapine
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Food and Drug Administration (FDA)
Dyspnea
Effect of Non-invasive Magnetic Stimulation of the Brain on Breathlessness in Healthy Individuals.
The purpose of this study is to see if the front part of the brain called the "Dorsolateral Prefrontal Cortex" (DLPFC) has a role in our ability to feel breathlessness.
- Trial name
- AHrTMS (NCT05623696)
- Testing
- rTMS-L-DLPFC, rTMS-R-DLPFC
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Oxford Brookes University
TBI
Non-invasive Measurement of Cerebrovascular Reactivity After Traumatic Brain Injury
The investigators will longitudinally measure cerebrovascular reactivity (CVR) by functional near-infrared spectroscopy (fNIRS) in acute (≤3 days from injury), subacute, and chronic phases after TBI as a biomarker of TCVI as…
- Trial name
- NCT02990078
- Testing
- Sildenafil citrate, Functional Near Infared Spectroscopy, Hypercapnia Challenge
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania