Clinical trials: Hypercoagulability
Sepsis, Disseminated Intravascular Coagulation (DIC)
Safflower (Carthamus Tinctorius L.) Granules for Sepsis-associated Coagulopathy
Sepsis is a life-threatening condition in which infection triggers widespread inflammation and blood clotting abnormalities. Many patients with sepsis develop coagulopathy (impaired blood clotting), which contributes to organ…
- Trial name
- HH-SAC (NCT07897006)
- Testing
- High-dose safflower granules, Medium-dose safflower granules
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Thrombotic Thrombocytopenic Purpura (TTP)
A Study of TAK-755 (rADAMTS13) With Little to No Plasma Exchange (PEX) Treatment in Adults With Immune-mediated Thrombotic Thrombocytopenic Purpura (iTTP)
This is a study of TAK-755 in adults with immune-mediated thrombotic thrombocytopenic purpura (iTTP). The main aim of this study is to determine the percentage of participants with a clinical (Part 1) or platelet (Part 2)…
- Trial name
- NCT05714969
- Testing
- TAK-755
- Where
- 22 sites in United States, Austria and 4 more
- Volunteers
- 29 people
- Sponsor
- Takeda
Thrombophilia
Fertility, Hypercoagulability, and Inflammation (FREYA) Registry
A PubMed search of "thrombophilia" and "infertility" yields only 98 articles, the majority found in foreign medical journals and subspecialty journals with narrow readerships.
- Trial name
- FREYA (NCT04537416)
- Testing
- No intervention
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Brigham and Women's Hospital
Thrombotic Thrombocytopenic Purpura
Aspirin for Prophylaxis of TTP
Thrombotic thrombocytopenic purpura (TTP) is a rare and life-threatening thrombotic microangiopathy characterized by thrombocytopenia, microangiopathic hemolytic anemia, and microvascular thrombosis causing neurological and renal…
- Trial name
- NCT05568147
- Testing
- Aspirin tablet
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Thrombotic Microangiopathy, Thrombotic Thrombocytopenic Purpura
Clinical Outcome Study of ARC1779 Injection in Patients With Thrombotic Microangiopathy
The purpose of this ascending-dose research study is to determine whether the administration of ARC1779 Injection improves subject's health profile by protecting the brain, heart, and kidney from damage due to formation of small…
- Trial name
- NCT00726544
- Testing
- ARC1779 Injection
- Where
- 17 sites in United States, Austria and 3 more
- Volunteers
- 100 people
- Sponsor
- Archemix Corp.
Neutrophil Extracellular Trap Formation, Portal Vein Thrombosis
Analysis of Neutrophil Extracellular Traps in Hypercoagulability and Portal Vein Thrombosis in Liver Cirrhosis Patients
The aim of this study was to investigate whether NETs markers can enhance procoagulant activity and predict portal vein thrombosis in patients with live cirrhosis, so as to establish a novel predictor to guide clinical…
- Conditions
- Neutrophil Extracellular Trap Formation, Portal Vein Thrombosis, Liver Cirrhosis
- Trial name
- NCT05012501
- Testing
- test NETs markers
- Where
- China
- Volunteers
- 79 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Cirrhosis
Rôle of the Soluble Endothelial Protein C Receptor in Cirrhosis-associated Hypercoagulability State (EXERCISE)
Cirrhosis is a condition in which the liver does not function properly due to long-term damage. This damage is characterized by the replacement of normal liver tissue by scar tissue.
- Trial name
- EXERCISE (NCT03625726)
- Testing
- Thrombin generation assay (in vitro)
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Liver Disease, Pulmonary Embolism
Pulmonary Embolism After Liver Resection
Major surgery is associated with a postoperative hypercoagulable state related to the surgical trauma that may lead to thromboembolic complications.
- Conditions
- Liver Disease, Pulmonary Embolism, Thrombophilia, Death
- Trial name
- NCT01486511
- Testing
- Liver resection, Computed Tomography
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Beaujon Hospital
Acute Coronary Syndrome, Venous Thromboembolism
The Effect of Reduced Dose of Enoxaparin on the Outcomes of Treatment With Enoxaparin
We hypothesize that reduced dose of enoxaparin in elderly patients will result in reduced proportion of patients with therapeutic anti Xa activity and reduced clinical efficacy.
- Conditions
- Acute Coronary Syndrome, Venous Thromboembolism, Atrial Fibrillation, Hypercoagulability
- Trial name
- NCT00354796
- Where
- Israel
- Volunteers
- 500 people
- Sponsor
- Hadassah Medical Organization
COVID-19, SARS-CoV-2 Infection
Novel Experimental COVID-19 Therapies Affecting Host Response
The overarching goal of the Master Protocol is to find effective strategies for inpatient management of patients with COVID-19. Therapeutic goals for patients hospitalized for COVID-19 include hastening recovery and preventing…
- Conditions
- COVID-19, SARS-CoV-2 Infection, Coronavirus Infection
- Trial name
- NECTAR (NCT04924660)
- Testing
- TXA127, TRV027, Fostamatinib
- Where
- 51 sites in United States
- Volunteers
- 1,060 people
- Sponsor
- Sean Collins
Thrombophilia, Thyroid Autoimmunity
Thrombophilia and Thyroid Autoimmunity in Implantation Failure and Recurrent Miscarriage
This study was designed to evaluate the incidence of both, inherited and adquired thrombophilia, and thyroid autoinmunity in unknown infertility (UI), implantation failure (IF) and recurrent miscarriage (RM).
- Trial name
- NCT00485446
- Testing
- blood analysis
- Where
- Spain
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
COVID-19
Therapeutic Plasma Exchange for COVID-19-associated Hyperviscosity
Many patients with Coronavirus Disease 2019 (COVID-19) have atypical blood clots. These blood clots can occur in either veins or arteries and be large, like in stroke or heart attack, or very tiny, called microthrombi.
- Trial name
- NCT04441996
- Testing
- Therapeutic plasma exchange (TPE), Standard of care
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Emory University
IUGR, Thrombophilia
Thrombophilia Screening After Severe IUGR
This retrospective study aims to assess the input of thrombophilia screening in pregnant women with severe intra-uterine growth restricted babies.
- Conditions
- IUGR, Thrombophilia, Pregnancy Complications
- Trial name
- NCT05551078
- Testing
- thrombophilia screening
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Central Hospital, Nancy, France