Clinical trials: Hyperfibrinolysis
Hyperfibrinolysis, Haemorrhage
Effects of an Early Prehospital Administration of Tranexamic Acid on Hyperfibrinolysis in Multiple Trauma
Severe external and internal bleedings are common in multiple trauma patients. Uncontrollable blood loss is the cause for about one third of all trauma deaths.
- Conditions
- Hyperfibrinolysis, Haemorrhage, Mortality
- Trial name
- NCT01938768
- Where
- Germany
- Volunteers
- 110 people
- Sponsor
- University of Göttingen
Coagulopathy, Endstage Liver Disease
Evaluation of the Safety of Octaplas™ Versus Plasma in Patients Undergoing Orthotopic Liver Transplantation
Post-Marketing Requirement study to evaluate the safety of octaplas™ versus plasma in patients undergoing orthotopic liver transplantation (OLT).
- Trial name
- NCT02037373
- Testing
- Octaplas™, Plasma
- Where
- 4 sites in United States
- Volunteers
- 43 people
- Sponsor
- Octapharma
Cirrhosis
Correlation of Hepatitis C, Alcoholic Liver Disease, and Renal Failure With Hyperfibrinolysis in Liver Failure
1. Further characterize the incidence of hyperfibrinolysis in cirrhotics 2. Correlate hyperfibrinolysis with 1. hepatitis C 2. alcoholic liver disease 3. the subset of a\&b with renal failure with and without dialysis 3.
- Trial name
- NCT02737345
- Testing
- Rotem
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Scott Allen
Early Allograft Dysfunction, Ischemic Reperfusion Injury
Evaluation of Preimplantation Portal Vein and Hepatic Artery Flushing With Tacrolimus
The purpose of this study is to determine whether the Tacrolimus added to histidine-tryptophan-ketoglutarate (HTK) solution given through intraportal and intraarterial infusion during back-table procedure is capable of reducing…
- Conditions
- Early Allograft Dysfunction, Ischemic Reperfusion Injury, Liver Transplantation, Hyperfibrinolysis
- Trial name
- PATAC (NCT01887171)
- Testing
- Tacrolimus
- Where
- Belarus
- Volunteers
- 86 people
- Sponsor
- Republican Scientific and Practical Center for Organ and Tissue Transplantation
Hyperfibrinolysis
Evaluation of the Minimum Concentration of Tranexamic Acid Required to Inhibit Fibrinolysis in a Population of Pregnant Women at Term.
Pregnancy induces a physiological change of hemostasis to a prothrombotic state : protein S decrease and increase of virtually all the clotting factors, in particular fibrinogen, von Willebrand factor and factor VIII.
- Trial name
- NCT02579941
- Testing
- Blood sampling (pregnant), Blood sampling (non pregnant)
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Brugmann University Hospital
Hyperfibrinolysis, Cesarean Section Complications
The Incidence of Hyperfibrinolysis During Vaginal Delivery and Cesarean Section
This study aims to find out if there are common major changes in coagulation immediately after delivery of the newborn during Cesarean (C) -section and vaginal birth.
- Conditions
- Hyperfibrinolysis, Cesarean Section Complications, Coagulation Defect; Bleeding, Peripartum Haemorrhage
- Trial name
- NCT05975112
- Testing
- Coagulation tests (TEG, Levels of F1, F2, hs-D-dimer, Plasminogen, PAI 1+2), SpHb before discharge
- Where
- Austria
- Volunteers
- 780 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Liver Transplantation
Rapid Diagnostic of Hyperfibrinolysis in Liver Transplantation
During liver transplantation (LT), hyperfibrinolysis is one of the most important modification of haemostasis. It is associated with t-PA and protein C increased activity.
- Trial name
- FILYTHO (NCT03012633)
- Testing
- Lysis timer
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Bordeaux
Early Trauma Induced Coagulopathy, Tic
The Incidence of Early Trauma Induced Coagulopathy and Hyperfibrinolysis in Severely Injured Trauma Patients in the Emergency Room: a Retrospective Cohort Study
The aim of this study is to quantify the incidence of eTIC (defined as an elevated appt) and hyperfibrinolysis (defined as Ly30>7) in early trauma patients.
- Trial name
- eTIC (NCT07186712)
- Where
- Austria
- Volunteers
- 263 people
- Sponsor
- Medical University of Graz
Hyperfibrinolysis
A Novel Viscoelastic Test Based on Ultrasonic Guided Wave for Identifying Hyperfibrinolysis Rapidly
This study compares the results of the existing fibrinolysis monitoring technology to the Ultrasound-based viscoelastic hemostasis analysis, a new method, using small amount of extra blood obtained during routine blood draws in…
- Trial name
- NCT06374953
- Testing
- Ultrasound-based viscoelastic hemostasis analysis
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Postpartum Hemorrhage, Hyperfibrinolysis
Haemostasis and Tranexamic Acid in Caesarean Delivery
The aim of the study is to evaluate haemostasis and fibrinolysis in peripartum of caesarean delivery and the effect of tranexamic acid (TXA) given in prevention of post-partum haemorrhage (PPH).
- Trial name
- BIO-TRAAP (NCT03742947)
- Testing
- peripartum haemostasis
- Where
- France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Bordeaux