Clinical trials: Hyperglycaemia
Diabetes, Pre-diabetes
Northern Manhattan Study of Metabolism and Mind
Pre-diabetes, type 2 diabetes, and their related conditions, adiposity and insulin resistance, are more prevalent in minorities Northern Manhattan compared to the general population of the United States.
- Conditions
- Diabetes, Pre-diabetes, Cognition - Other, Depressive Symptoms
- Trial name
- NOMEM (NCT02470260)
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Columbia University
Fasting, Postprandial Hyperglycemia
Postprandial Metabolome and Metabolic Flexibility
Metabolic flexibility is a process in which the body can switch energy substrates in different physiological states. This flexibility plays an important role in an individual's health because losing it increases the risk of…
- Conditions
- Fasting, Postprandial Hyperglycemia, Lipid Metabolism Disorders, Glucose Metabolism Disorders
- Trial name
- NCT06878781
- Testing
- High carbohydrate challenge, High lipid challenge, High proteinchallenge
- Where
- Mexico
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Medicina Genomica
Impaired Glucose Tolerance
Mechanisms of Exercise Resistance in Metabolic Disease
This project will determine exercise capacity and molecular markers of the response to acute exercise in human subjects with impaired or normal glucose tolerance.
- Trial name
- NCT03945435
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Joslin Diabetes Center
Pre Diabetes, Postpartum Disorder
Treatment to Regress to Normoglycemia in Women with a Recent History of GDM
The purpose of the study is to determine the efficacy of semaglutide 1mg (Ozempic®) to aid recently postpartum women with dysglycemia and a history of GDM to regress to normoglycemia; thereby filling a gap in efficacious…
- Trial name
- SWEET (NCT04873050)
- Testing
- Semaglutide Pen Injector [Ozempic]
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Woman's
Obesity, Pregnancy in Diabetic
Effect of Obesity, Diabetes and Bariatric Surgery on Pregnancy Outcomes
The obesity epidemic is growing worldwide and in the UK this is perpetuated with a third of women classified as overweight/obese in 2020.
- Conditions
- Obesity, Pregnancy in Diabetic, Pregnancy Complications, Pregnancy Related
- Trial name
- NCT05753124
- Testing
- Observational
- Where
- United Kingdom
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
GDM, Insulin Resistance
In Vitro Fertilization Impact on Metabolic Parameters
A quantitative prospective cohort study will be conducted, where blood samples will be collected at different timings during the IVF protocol, to assess the impact of fertility medications on metabolic parameters of patients…
- Conditions
- GDM, Insulin Resistance, Glucose Intolerance, PCOS
- Trial name
- IVF (NCT03426228)
- Testing
- HbA1C
- Where
- United Arab Emirates
- Volunteers
- 344 people, healthy volunteers welcome
- Sponsor
- University of Warwick
Inflammation, Malnutrition
Effects of Camelina Sativa Oil in Free-living Older Adults
The present study aims at evaluating the anti-inflammatory effects of a novel food in older adult volunteers. Briefly, this randomized, double-blind and placebo-controlled study is performed on 91 apparently healthy older adults…
- Conditions
- Inflammation, Malnutrition, Hyperglycemia, Dyslipidemias
- Trial name
- NCT04965948
- Testing
- Novel food snack
- Where
- Italy
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Pavia
Type 2 Diabetes
The Effect of 4 Weeks of L-Citrulline Supplementation on Macro- and Microvascular Function in Type 2 Diabetes
The purpose of this study is to examine the effect of 4 weeks of Citrulline supplementation on macro- and microvascular function during acute hyperglycemia in middle-aged and older adults with type 2 diabetes.
- Trial name
- NCT06016478
- Testing
- L-citrulline
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Pre Diabetic
PASO A PASO: Tailored Diabetes Prevention Program for Spanish-Speaking Communities Feasibility Study
The interdisciplinary and interprofessional community-academic partnership (CAP) has been working with Spanish-speaking H/L Salt Lake City residents and organization leaders to adapt the National Diabetes Prevention Program to…
- Trial name
- NCT07392008
- Testing
- Paso a Paso
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Utah
Hyperglycemia
Efficacy and Safety Between Different Dilution of Insulin
Hyperglycemia associated with insulin resistance is common in critically ill patients, even in those nondiabetic patients. Hyperglycaemia or relative insulin deficiency (or both) during critical illness may directly or indirectly…
- Trial name
- NCT06180824
- Testing
- Gelafundin
- Where
- Malaysia
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Postprandial Hyperglycemia, Metabolic Disorder, Glucose
Westlake N-of-1 Trials for Macronutrient Intake 2 ( WE-MACNUTR 2)
Diet and nutrition are key to maintain human health. Westlake N-of-1 Trials for Macronutrient Intake (WE-MACNUTR) trial investigates individualized postprandial glycemic responses to different proportions of dietary fat and…
- Trial name
- NCT05161182
- Testing
- High fat, low carbohydrate diet, Low fat, high carbohydrate diet
- Where
- China
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Westlake University
Prediabetic State
RCT of a Polyherbal Dietary Supplement for Prediabetes
The primary purpose of this study is to evaluate the impact of a polyherbal dietary supplement (Designs for Health - GlucoSupreme™ Herbal) on markers of glycemic control and other structure/function outcomes among a sample of…
- Trial name
- NCT03388762
- Testing
- GlucoSupreme™ Herbal
- Where
- 4 sites in United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Impaired Glucose Tolerance
Cognitive Effects of Aerobic Exercise for IGT Adults
The specific aims for the study will be to determine if aerobic exercise enhances cognition for older adults who are at risk for developing type II diabetes mellitus (T2DM), and to evaluate whether change in insulin sensitivity…
- Trial name
- NCT00220441
- Testing
- Aerobic exercise
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Cardiovascular Diseases, Inflammation
Diet Intervention and GEnetic STudy (DIGEST-Pilot)
Genetic factors contribute to risk factors for cardiovascular disease, such as blood lipids, blood pressure, obesity, diabetes, and may also influence dietary choices, physical activity, and responses to stress.
- Conditions
- Cardiovascular Diseases, Inflammation, Dyslipidemias, Blood Pressure
- Trial name
- DIGEST (NCT01658137)
- Testing
- Prudent Diet, Typical Western Diet
- Where
- Canada
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- McMaster University
Obesity, Glucose Intolerance
Age, Lifestyle, Muscle Mechanisms in Insulin Resistance
The purpose of this study is to investigate the mechanisms by which physical inactivity and obesity alter skeletal muscle insulin signaling to cause insulin resistance and increase the development of impaired glucose tolerance…
- Conditions
- Obesity, Glucose Intolerance, Exercise Capacity
- Trial name
- NCT00971594
- Testing
- Dietary counseling, AEX
- Where
- 2 sites in United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Impaired Glucose Tolerance
Postprandial Fatty Acid Metabolism in the Natural History of Type 2 Diabetes (T2D)
Lipotoxicity-causing fatty acid overexposure and accretion in lean tissues leads to insulin resistance and impaired pancreatic β-cell function - the hallmarks of T2D - contributing to associated complications such as heart…
- Trial name
- AGL11 (NCT02808182)
- Testing
- Nicotinic acid, [7,7,8,8-2H]-palmitate, [U-13C]-palmitate
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Type 1 Diabetes
Closed-loop Glucose Control for Automated Management of Type 1 Diabetes
We hypothesize that our integrated closed-loop glucose-control system can provide effective, tight, and safe blood glucose (BG) control in type 1 diabetes, thereby establishing the feasibility of closed-loop BG control.
- Trial name
- NCT00811317
- Testing
- Closed-loop
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Glucose Intolerance, Aortic Stiffness
Healthy Aging Through Functional Food
The purpose of this study is to determine whether dietary inducers of glyoxalase 1 are effective in improving metabolic and vascular health.
- Conditions
- Glucose Intolerance, Aortic Stiffness, Vasodilation
- Trial name
- HATFF (NCT02095873)
- Testing
- Glyoxalase 1 (Glo1) inducer
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Warwick
Healthy, Type 2 Diabetes
Glucagon Suppression by Hyperglycemia in the Presence and Absence of Amino Acid Infusion
This study is being done to better understand how amino acids alter the release of glucagon and insulin compared to glucose alone in health and disease.
- Conditions
- Healthy, Type 2 Diabetes, Obesity
- Trial name
- NCT05264727
- Testing
- Dextrose, Clinisol 15%
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Adipose Tissue, Brown, Glucose Intolerance
L-arginine and Brown Adipose Tissue
The South Asian population is facing an epidemic of type 2 diabetes, of which the underlying cause is still unknown. It is currently hypothesized that an ethnic susceptibility towards a disturbed energy metabolism may underlie…
- Conditions
- Adipose Tissue, Brown, Glucose Intolerance, Nitric Oxide
- Trial name
- ArgMB (NCT02291458)
- Testing
- L-arginine
- Where
- Netherlands
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center