Clinical trials: Hyperglycemias
Diabetes Mellitus, Type 2
A Study To Evaluate The Safety And Efficacy Of An Investigational Diabetes Drug In Poorly Controlled Type II Diabetics
The purpose of this research study is to determine if a new investigational diabetes drug is safe and effective in treating people who have Type II diabetes mellitus with very high HbA1c or FPG (fasting plasma glucose) levels.
- Trial name
- NCT00067951
- Testing
- rosiglitazone/metformin
- Where
- 94 sites in United States, Australia and 3 more
- Volunteers
- 190 people
- Sponsor
- GlaxoSmithKline
Glucose Intolerance
Effects of a Dietary Supplement Containing Salacia Extract, Citrus Bioflavonoids, and Trivalent Chromium on Markers of Glucose Control
This study was a double-blind, randomized, placebo-controlled, clinical trial with two parallel groups. Participants reported to a single investigational center in Ohio (i.e., The Center for Applied Health Sciences) during the 12…
- Trial name
- NCT05887050
- Testing
- Active
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- The Center for Applied Health Sciences, LLC
Diabetes Mellitus, Type 2
GLP-1 Receptor Agonist Lixisenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation in Monotherapy
The purpose of this study is to evaluate the benefits and risks of lixisenatide (AVE0010), in comparison to placebo, used in a 2-step dose titration regimen in monotherapy, over a period of 12 weeks of treatment.
- Trial name
- GETGOAL-MONO (NCT00688701)
- Testing
- Lixisenatide (AVE0010), Pen auto-injector
- Where
- 12 sites in United States, Belgium and 10 more
- Volunteers
- 361 people
- Sponsor
- Sanofi
Type 2 Diabetes Mellitus (T2DM)
Study of Efficacy and Safety of Vildagliptin as add-on Insulin Therapy in T2DM Patients
The purpose of this study was to assess the efficacy and safety of vildagliptin 50 mg bid add-on therapy to improve overall glycemic control in patients with T2DM inadequately controlled by insulin, with or without concomitant…
- Trial name
- NCT02002221
- Testing
- Vildagliptin (LAF237), Insulin, Metformin
- Where
- 31 sites in Japan
- Volunteers
- 156 people
- Sponsor
- Novartis Pharmaceuticals
Vascular Diseases, Impaired Glucose Tolerance
Effects of Dietary Ingredients on Vascular Function
The main aim of the study is to investigate the effects of dietary ingredients (polyphenols and carotenoids) on vascular function during acute glucose load.
- Trial name
- NCT02158481
- Testing
- A capsule containing both polyphenols and carotenoids
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Unilever R&D
Weight Loss, Metabolic Syndrome
Use of Continuous Glucose Monitoring in Non-Diabetic Population to Compliment Signos Mobile Health Platform
Metabolic syndrome and resulting downstream health effects remains a growing health concern. In published trials, the use of continuous glucose monitoring (CGM) assists behavioral changes efforts, leading to improved adherence…
- Conditions
- Weight Loss, Metabolic Syndrome, Pre-diabetes, Central Obesity
- Trial name
- NCT05121844
- Testing
- Continuous Glucose Monitor Device
- Where
- United States
- Volunteers
- 31,187 people, healthy volunteers welcome
- Sponsor
- Signos Inc
Glucose Intolerance
Effect of Consuming Oat Bran Mixed in Water Before a Meal on Glycemic Responses in Healthy Humans - a Pilot Study
Viscous dietary fibers including oat β-glucan are one of the most effective classes of functional food ingredients for reducing postprandial blood glucose.
- Trial name
- NCT02801916
- Testing
- 0 grams oat bran, 4.5 grams oat bran, 13.6 grams oat bran
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Glycemic Index Laboratories, Inc
Trauma, Stress Induced Hyperglycemia
Stress Induced Hyperglycemia In Trauma
The clinical relevance of the observed stress induced hyperglycemia in trauma patients remains unclear. The earlier studies suggested the implications of cytokines in stress induced hyperglycemia and the outcomes after trauma.
- Conditions
- Trauma, Stress Induced Hyperglycemia, Diabetes Mellitus
- Trial name
- SIHG (NCT02999386)
- Where
- Qatar
- Volunteers
- 300 people
- Sponsor
- Hamad Medical Corporation
Hyperglycemias, Prediabetes
Efficacy of the pA1c®HI Postbiotic in Metabolic Regulation in Healthy Individuals With Hyperglycemia
This study will evaluate the effects of pA1c®HI, a heat-inactivated postbiotic derived from the bacterium Pediococcus acidilactici, on blood glucose regulation and other aspects of metabolic health in adults with elevated blood…
- Trial name
- CR2027 (NCT07903870)
- Testing
- Postbiotic
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Genbioma Aplicaciones SL
Hypertension, Impaired Glucose Tolerance
Evaluation of Soluble Epoxide Hydrolase (s-EH) Inhibitor in Patients With Mild to Moderate Hypertension and Impaired Glucose Tolerance
The purpose of this study is to determine the safety and efficacy of AR9281, a novel s-EH enzyme inhibitor, in improving glucose metabolism and blood pressure in patients with impaired glucose tolerance and mild to moderate…
- Trial name
- NCT00847899
- Testing
- AR9281
- Where
- 30 sites in United States
- Volunteers
- 150 people
- Sponsor
- Arete Therapeutics
it is a Group of Metabolic Diseases in, Which a Person Has High Blood Sugar, Either
Effect of Taurine on Glycemic Control in Type I and Type II Diabetic Patients
Diabetes mellitus (DM) and its vascular complications are the one of the most prevalent diseases in the state of Qatar. It is a multifactorial disease associated with the development of retinopathy, nephropathy, neuropathy…
- Conditions
- it is a Group of Metabolic Diseases in, Which a Person Has High Blood Sugar, Either, Because the Body Does Not Produce Enough Insulin,, or Because Cells do Not Respond to the Insulin That
- Trial name
- NCT01226537
- Testing
- Taurine
- Volunteers
- 20 people
- Sponsor
- Hamad Medical Corporation
Pre-diabetes, Type II Diabetes
Salivary Transcriptome Biomarkers for Early Diabetes Detection
A PRoBE design study will be used to obtain saliva from patients before undergoing blood study evaluation for screening at risk patients for the presence of undiagnosed pre-diabetes of type II diabetes.
- Conditions
- Pre-diabetes, Type II Diabetes, Insulin Resistance
- Trial name
- NCT02673762
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- PeriRx
Breast Cancer
Survey Among Healthcare Professionals Treating Patients With Metastatic Breast Cancer in Selected European Countries to Evaluate Their Knowledge on Management of Hyperglycemia When Using Alpelisib
This was a multinational, non-interventional, cross-sectional survey conducted among HCPs based in the EU/EEA who prescribe Piqray.
- Trial name
- NCT05073120
- Testing
- Piqray Prescriber's/HCP guide for hyperglycemia
- Where
- Switzerland
- Volunteers
- 103 people
- Sponsor
- Novartis Pharmaceuticals
Type 2 Diabetes, Pre-Diabetes
Sugar Challenge Study
This is a longitudinal study involving use of the January App which collects multiple data streams and employs machine learning techniques to offer personalized lifestyle recommendations and structured food and activity…
- Conditions
- Type 2 Diabetes, Pre-Diabetes, Healthy
- Trial name
- NCT04621656
- Testing
- January Mobile Application (Sugar AI)
- Where
- United States
- Volunteers
- 1,022 people, healthy volunteers welcome
- Sponsor
- January, Inc.
Hyperglycemia
A Clinical Trial Evaluating TQF3250 Capsules in Healthy Adult Subjects
TQF3250 capsule is a biased GLP-1 (glucagon-like peptide-1) receptor agonist developed by Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
- Trial name
- NCT07327281
- Testing
- TQF3250 capsule
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Pre-diabetes
A Study to Evaluate the Effects of Vildagliptin on the Insulin Response to Glucose in Subjects With Pre-diabetes
This is an exploratory study to assess whether vildagliptin, an unapproved drug, can increase insulin secretion in subjects with pre-diabetes who have a defect in the insulin response and elevated levels of fasting glucose.
- Trial name
- NCT00312130
- Testing
- Vildagliptin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Novartis
Postprandial Hyperglycemia
Determination of the PPG and Insulin Responses of Rice Alone and Rice Consumed With Sugardown™
This study was a partly controlled laboratory-based study comparing the short-term postprandial blood glucose and insulin responses produced by 3 test meals containing white rice alone or with SUGARDOWN™ (Galactomannan) in…
- Trial name
- NCT03375398
- Testing
- Rice, Sugardown™
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Boston Therapeutics
Prediabetes, Hyperglycemia
Benefit of IQP-VV-102 in Reducing Postprandial Glucose Level in Overweight Caucasian Subjects
In this trial, the investigational product , the active ingredients which has been proven to reduce postprandial glucose in healthy and diabetic patients, will be tested.
- Trial name
- NCT02541344
- Testing
- Dose 1 of IQP-VV-102, Dose 2 of IQP-VV-102
- Where
- Germany
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- InQpharm Group
Pre Diabetes, Prediabetic State
Study to Assess the Effects of Non Digestible Carbohydrates on Long-Term Glucose Homeostasis in Untreated Prediabetic Subjects
This clinical study aims to prove that the efficacy of non digestible carbohydrates supplementation (daily dose of 20 grams consumed twice a day for 12 weeks) on the regulation of glucose homeostasis is superior than placebo in…
- Conditions
- Pre Diabetes, Prediabetic State, Dysglycemia, PreDiabetes
- Trial name
- FOS_GLUCOSE (NCT04767672)
- Testing
- Non digestible carbohydrates
- Where
- 3 sites in France
- Volunteers
- 66 people
- Sponsor
- Tereos
Low Glycemic Index (GI) Food, Pre Diabetes
Determination of the Glycemic Index Values of 10 Cereal-based Products
To determine the Glycemic index values for 10 cereal-based products
- Conditions
- Low Glycemic Index (GI) Food, Pre Diabetes, Diabetes
- Trial name
- NCT06710743
- Testing
- Glucose solution Day 1, Day 8, and Day 15, Food (cereal). Ten different cereals served once each
- Where
- Australia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D