Clinical trials: Hyperglycemic Therapy
AMI
Effect of Lantus and Apidra in Patients With Acute ST Elevation Myocardial Infarction
Primary objective: To demonstrate that in hyperglycemic subjects with anterior STEMI (ST Elevation Myocardial Infarction) undergoing Percutaneous Coronary Intervention (PCI), tight glycemic control using insulin glulisine and…
- Trial name
- INTENSIVE (NCT00670228)
- Testing
- Insulin Glargine (LANTUS), Insulin Glulisine (Apidra), Standard Therapy
- Where
- 5 sites in United States, Argentina and 3 more
- Volunteers
- 34 people
- Sponsor
- Sanofi
Sleep Apnea, Diabetes
Hyperglycemic Profiles in Obstructive Sleep Apnea: Effects of PAP Therapy
This is a randomized control trial in people with diabetes and obstructive sleep apnea who will be randomly assigned for 3 months to PAP therapy along with healthy lifestyle and sleep education or healthy lifestyle and sleep…
- Trial name
- HYPNOS (NCT02454153)
- Testing
- REMStar Positive Airway Pressure, LifeStyle Counseling
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- Johns Hopkins University
Hypoglycemic Events, Hyperglycemic Therapy
Developing a Model to Predict Inpatient Hypoglycemic Episodes
This study will create a new model to predict hypoglycemic events in diabetic inpatients on anti-hyperglycemic therapy using retrospective data with the goal of developing a model that will accurately predict hypoglycemic…
- Trial name
- NCT05989256
- Testing
- EndoTool, glucose management team, standard of care glucose management
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences
Dyslipidemia, Hyperlipidemia
Colesevelam Treatment for Impaired Fasting Glucose During Niacin Therapy
The present study will assess the low-density lipoprotein cholesterol (LDL-C) lowering effect of colesevelam as an adjunct to niacin for the improvement of lipids and glycemic control in dyslipidemic subjects with impaired…
- Conditions
- Dyslipidemia, Hyperlipidemia, Hyperglycemia
- Trial name
- CERTAIN (NCT01239004)
- Testing
- Colesevelam
- Where
- 4 sites in United States
- Volunteers
- 140 people
- Sponsor
- Radiant Research
Diabete Type 2, Hyperglycemic Therapy
Medical Education to Improve Diabetes Care and Outcomes in Hospitalized Patients
This clinical trial aims to evaluate whether a structured medical education strategy can improve the quality of care provided to hospitalized patients with diabetes or hyperglycemia.
- Conditions
- Diabete Type 2, Hyperglycemic Therapy, Medical Education, Telemedecine
- Trial name
- LELOHG (NCT07108426)
- Testing
- Educational Intervention via Telemedicine
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Catholic University of Pelotas
HIV Infections
HIV Antiretroviral Drugs and Metabolism
Hypothesis 1: Ritonavir-based regimens increase triglycerides and VLDL by both increasing VLDL production and decreasing VLDL clearance.
- Trial name
- NCT00525239
- Testing
- ritonavir, lopinavir/ritonavir, atazanavir/ritonavir, efavirenz
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetes Mellitus Type 2
A Study of Aleglitazar in Monotherapy in Patients With Type 2 Diabetes Mellitus Who Are Drug-Naïve to Anti-Hyperglycemic Therapy
This multicenter, randomized, double-blind, placebo-controlled study will evaluate the efficacy, safety and tolerability of aleglitazar monotherapy in patients with Type 2 diabetes mellitus who are drug-naïve to…
- Trial name
- NCT01871428
- Testing
- aleglitazar
- Where
- 7 sites in China, Hong Kong and 1 more
- Volunteers
- 13 people
- Sponsor
- Hoffmann-La Roche
Diabetes Mellitus Type 2
A Study of Aleglitazar in Patients With Type 2 Diabetes Mellitus Who Have Not Previously Received Anti-Hyperglycemic Therapy
This multicenter, randomized, double-blind, placebo-controlled study will assess the efficacy, safety and tolerability of aleglitazar monotherapy compared with placebo in patients with type 2 diabetes mellitus who have not…
- Trial name
- NCT01691755
- Testing
- aleglitazar
- Where
- 34 sites in United States, Mexico
- Volunteers
- 196 people
- Sponsor
- Hoffmann-La Roche
Type 2 Diabetes Mellitus
Evaluation of the Effects of Different Interventions on Glycemic Control in Newly-Diagnosed Type 2 Diabetic Patients
The purpose of this study is to investigate and evaluate the effects of different interventions (1.continuous subcutaneous insulin infusion,2.multiple daily injections, 3.anti-hyperglycemic agents) on glycemic control, B-cell…
- Trial name
- NCT00147836
- Testing
- Human Insulin (Novolin-R, Novo Nordisk), H-Tron Plus V100; Disetronic Medical System, Burgdorf, Switzerland, Pre-meal
- Where
- China
- Volunteers
- 436 people
- Sponsor
- Sun Yat-sen University
Diabetes Mellitus, Type 2, Hypertension
Evaluation of Blood Pressure Reduction, Safety, and Tolerability of Canagliflozin in Patients With Hypertension and Type 2 Diabetes Mellitus on Stable Doses of Anti-hyperglycemic and Anti-hypertensive Agents
The purpose of this study is to evaluate the effect of canagliflozin (JNJ-28431754) on blood pressure reduction, compared to placebo, in patients with hypertension and type 2 diabetes mellitus and who are on stable doses of…
- Trial name
- NCT01939496
- Testing
- Canagliflozin
- Where
- 57 sites in United States, Puerto Rico
- Volunteers
- 171 people
- Sponsor
- Janssen Scientific Affairs, LLC
Hyperglycemia, Acute Coronary Syndromes
Intravenous Exenatide in Coronary Intensive Care Unit (ICU) Patients
The purpose of this study is to determine the efficacy of intravenous Exenatide therapy in hyperglycemic patients admitted to the coronary intensive care unit.
- Conditions
- Hyperglycemia, Acute Coronary Syndromes, Myocardial Infarction
- Trial name
- NCT00736229
- Testing
- Exenatide
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Saint Luke's Health System
Diabetes Mellitus Self Management Education, Hyperglycemic Control
Disease Management and Educational Intervention Outcomes in High-Risk Diabetics
Social, medical and economic burdens of diabetes care result from microvascular, macrovascular and neurological complications. Sustained reduction in hyperglycemia can reduce the incidence of these complications by as much as 50…
- Conditions
- Diabetes Mellitus Self Management Education, Hyperglycemic Control, High Risk Diabetes
- Trial name
- NCT00012662
- Testing
- Diabetes Self Management Education
- Where
- United States
- Volunteers
- 1,800 people
- Sponsor
- US Department of Veterans Affairs
Type 2 Diabetes Mellitus
A Study to Evaluate the Food Effect on Drug Availability, Pharmacokinetic (PK) Properties, Safety and Tolerability of Two Different Dose Combination Therapy of Saxagliptin/Dapagliflozin/Metformin Extended-release (XR) Against Individual Component Co-administration.
A Study to Assess the Fed-state Bioequivalence of a Triple Fixed-Combination Drug Product (FCDP) of 2.5 mg Saxagliptin / 5 mg Dapagliflozin / 1000 mg Metformin XR and 5 mg Saxagliptin /10 mg Dapagliflozin /1000 mg Metformin XR…
- Trial name
- NCT03169959
- Testing
- 2.5 mg Saxagliptin tablet, 5 mg dapagliflozin / 1000 mg metformin XR tablet, Triple FCDP - 2.5 mg saxagliptin / 5 mg dapagliflozin / 1000 mg metformin XR
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Stroke, Acute, Hyperglycemia
Pioglitazone Treatment for Hyperglycemic Acute Ischemic Stroke
Study objective is to determine whether Pioglitazone (PGZ) can improve clinical outcomes in hyperglycemic acute ischemic stroke (IS).
- Conditions
- Stroke, Acute, Hyperglycemia, Diabetes
- Trial name
- NCT04123067
- Testing
- Pioglitazone 45 mg
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Milton S. Hershey Medical Center
Type-2-diabetes Mellitus, New Onset
Efficacy and Safety of DLBS3233 in Subjects With New Onset of Type 2 Diabetes Mellitus
This is a 2-arm, double-blind, parallel, randomized, placebo-controlled clinical study, with 12 weeks of therapy to evaluate the efficacy and safety of DLBS3233 in improving metabolic control in newly diagnosed type-2-diabetic…
- Trial name
- NCT01645332
- Testing
- DLBS3233, Lifestyle modification
- Where
- Indonesia
- Volunteers
- 104 people
- Sponsor
- Dexa Medica Group
Diabetes Mellitus, Type 2
Glycemic Control and Treatment Satisfaction Using Finesse Versus Pen for Initiating Bolus Insulin Dosing in Type 2 Diabetes Patients
To compare glycemic control and treatment satisfaction using a novel bolus insulin patch (Finesse) versus a pen for initiating and managing bolus insulin dosing in patients with T2DM not achieving glycemic targets on basal…
- Trial name
- NCT02542631
- Testing
- Bolus Insulin Patch (Calibra Finesse), Insulin Pen (Novo-Nordisk FlexPen®)
- Where
- 52 sites in United States, France and 2 more
- Volunteers
- 278 people
- Sponsor
- Calibra Medical, Inc.
Diabetes Mellitus
Evaluating the Effects of Kombucha as a Hyperglycemic Therapeutic Agent Within Diabetic Human Subjects
This study's primary objective is to determine the ability of Kombucha to impact blood sugar levels in patients with diabetes mellitus type II.
- Trial name
- NCT04107207
- Testing
- Ginger Kombucha, Ginger Water
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Georgetown University