Clinical trials: Hyperinflammatory Syndrome
Sepsis, Acute Respiratory Distress Syndrome
Corticosteroids in Hyperinflammatory Phenotype of Critical Illness
The goal of this clinical trial is to learn whether methylprednisolone improves outcomes in critically ill patients with a hyperinflammatory phenotype. It will also evaluate the safety of methylprednisolone at different doses.
- Trial name
- CHIP (NCT07511582)
- Testing
- Methylprednisolone (MP)
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Bin Du
Intensive Care Units, ARDS, Human
Therapeutic Plasma Exchange to Alleviate Hyperinflammatory Condition During Severe Covid-19 Infections
Severe Covid-19 (Coronavirus Disease 2019) infections generate major but inappropriate production of cytokines and, in some cases, generate anti-IFN (Interferon) auto-antibodies, inducing acute respiratory distress syndrom…
- Conditions
- Intensive Care Units, ARDS, Human, Covid19
- Trial name
- CovidEP (NCT04751643)
- Testing
- Therapeutic plasma exchange : 3 sessions in 3 consecutive days (day 1 to day 3), Usual treatments in intensive care unit according to the current state of knowledge
- Where
- 8 sites in France
- Volunteers
- 21 people
- Sponsor
- Hospices Civils de Lyon
Coronavirus Infection, Diabetes Mellitus, Type 2
Canakinumab in Patients With COVID-19 and Type 2 Diabetes
The purpose of this study is to evaluate whether Canakinumab has beneficial effects on patients with Type 2 diabetes mellitus and coronavirus disease 19 (COVID19).
- Trial name
- CanCovDia (NCT04510493)
- Testing
- Canakinumab
- Where
- 9 sites in Switzerland
- Volunteers
- 116 people
- Sponsor
- University Hospital, Basel, Switzerland
Lymphohistiocytosis, Hemophagocytic, Secondary Hemophagocytic Lymphohistiocytosis
Hemophagocytic Lymphohistiocytosis (HLH) Evaluation and Research of Clinical, ImmUnoLogic and TranscriptomE Study
Background: Hemophagocytic lymphohistiocytosis (HLH) is a disease caused by disrupted immune function. People with HLH are prone to fevers and illnesses, which can be fatal.
- Conditions
- Lymphohistiocytosis, Hemophagocytic, Secondary Hemophagocytic Lymphohistiocytosis, Macrophage Activation Syndrome, Hyperinflammatory Syndromes
- Trial name
- NCT06339177
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
COV-HI, COVID-19
COVID-19 Hyperinflammation Syndrome (COV-HI): Protocol for a Rapidly Executed Cohort Study
Based on emerging experience and trials from countries affected early by the COVID-19 (COV19) pandemic, there is evidence that a subgroup of severely affected people develop a hyperinflammatory (HI) syndrome (COV-HI).
- Conditions
- COV-HI, COVID-19, COVID-19 (COV) Hyperinflammatory (HI) Syndrome
- Trial name
- COV-HI (NCT04385069)
- Where
- 5 sites in United Kingdom
- Volunteers
- 500 people
- Sponsor
- University College, London
Acute Respiratory Distress Syndrome (ARDS), Acute Respiratory Failure (ARF)
The Association Between IL17, Acute Respiratory Distress Syndrome and Acute Respiratory Failure
This study will look at a protein called Interleukin (IL)-17A and how it relates to health markers in patients with a serious lung condition known as Acute Respiratory Distress Syndrome (ARDS).
- Trial name
- FROG-ARDS (NCT06779942)
- Where
- 2 sites in France
- Volunteers
- 414 people
- Sponsor
- Bayer
Heart Surgery, Vascular Surgery
Anticoagulation and Inflammation Monitoring in Patients After Heart and Vascular Interventions
The goal of this prospective observational study is to evaluate the most appropriate anticoagulation monitoring tool for unfractionated heparin (UFH), by comparison of different monitoring modalities in relation to adverse events…
- Conditions
- Heart Surgery, Vascular Surgery, Delirium, Hyperinflammatory Syndrome
- Trial name
- PAC-AIM (NCT06222866)
- Testing
- Anticoagulation monitoring
- Where
- Austria
- Volunteers
- 400 people
- Sponsor
- Medical University Innsbruck
Critical Illness, Sepsis
Hyperinflammation and Hyperferritinemia in Critically Ill Patients
Analysing trajectory of critically ill patients with signs of hyperinflammation
- Conditions
- Critical Illness, Sepsis, Hyperferritinemia, Hyperinflammatory Syndrome
- Trial name
- HYFER (NCT06820905)
- Where
- Czechia
- Volunteers
- 1,962 people
- Sponsor
- Charles University, Czech Republic
Monoclonal Gammopathy of Undetermined Significance, Multiple Myeloma
Establishment of Genomic, Transcriptomic and Functional Characteristics of Tumor Cells in Hyperinflammatory Hemopathies
Patients with monoclonal gammopathies either benign or malignant may develop inflammatory symptoms such as Schnitzler syndrome. We proposed to name those cases as monoclonal gammopathy of inflammatory significance, or MGIS.
- Conditions
- Monoclonal Gammopathy of Undetermined Significance, Multiple Myeloma, Waldenstrom Macroglobulinemia
- Trial name
- GEN-HEMO-INF (NCT04702932)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sepsis, Neuroinflammatory Response
Immunomodulatory Effects of Dexamethasone, Tocilizumab and Anakinra During Experimental Human Endotoxemia
The goal of this clinical trial is to investigate the immunomodulatory effects of the drugs dexamethasone, tocilizumab and anakinra in healthy male subjects aged 18 to 35 undergoing experimental endotoxemia.
- Conditions
- Sepsis, Neuroinflammatory Response, Immunosuppresion, Endotoxemia
- Trial name
- DEDICATE-LPS (NCT06624436)
- Testing
- Dexamethasone, Tocilizumab, Anakinra
- Where
- Netherlands
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Dengue, Dengue With Warning Signs
Anakinra in Dengue With Hyperinflammation ( AnaDen )
This study aims to evaluate the effect of anakinra in dengue patients with hyperinflammation as compared to placebo Primary Objective: To evaluate the efficacy of Anakinra in moderate-severe dengue patients with…
- Conditions
- Dengue, Dengue With Warning Signs, Severe Dengue, Anakinra
- Trial name
- NCT05611710
- Testing
- Anakinra
- Where
- Vietnam
- Volunteers
- 160 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam