Clinical trials: Hyperinflation
Bronchiectasis
Investigation of Dynamic Hyperinflation and Its Relationship With Functional Exercise Capacity in Children With Bronchiectasis
Prevalence of dynamic hyperinflation and its relationship with functional exercise capacity will be evaluated in children with bronchiectasis.
- Trial name
- NCT04885790
- Testing
- Respiratory assessment using "Spiropalm 6MWT" portable spirometry, Evaluation of functional exercise capacity, Evaluation of peripheral muscle strength
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Izmir Bakircay University
Emphysema, Pulmonary, Emphysema or COPD
An Evaluation of the AeriSeal System for CONVERTing Collateral Ventilation Status in Patients With Severe Emphysema
This is a prospective, open-label, multi-center, single-arm study planned to enroll 200 subjects with heterogeneous emphysema and collateral ventilation (CV) in the target lobe.
- Trial name
- CONVERT_II (NCT06035120)
- Testing
- AeriSeal System
- Where
- 38 sites in United States, Australia and 8 more
- Volunteers
- 200 people
- Sponsor
- Pulmonx Corporation
COPD, Obesity
Effects of Obesity on COPD
The purpose of this study is to investigate whether obese COPD patients experience more or less discomfort in daily life. Furthermore the investigators will evaluate if body composition or body fat distribution has effects on…
- Conditions
- COPD, Obesity, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT06474858
- Where
- Netherlands
- Volunteers
- 166 people
- Sponsor
- Rijnstate Hospital
Pulmonary Disease, Chronic Obstructive
Effects of SIMEOX on Static Hyperinflation in Patients With COPD
This study will investigate the effects on the SIMEOX technology on static hyperinflation in patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT04157972
- Testing
- SIMEOX, PEP
- Where
- Belgium
- Volunteers
- 25 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Chronic Obstructive Pulmonary Disease
Effects of Pursed-lip Breathing on Exercise Tolerance and Dynamic Hyperinflation in COPD
Pursed-lip breathing (PLB) has been advocated to reduce respiratory rate and improve oxygen saturation in patients with chronic obstructive pulmonary disease (COPD) at rest.
- Trial name
- NCT01173328
- Testing
- Pursed-lip breathing, Normal Breathing
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Pulmonary Complications
Hemodynamic Responses to Ventilator Hyperinflation Technique
The purpose of this study is to explore acute hemodynamic responses to VHI technique in critical traumatic patients with pulmonary complications in the intensive care unit.
- Trial name
- NCT02739841
- Testing
- Ventilator hyperinflation, Chest physical therapy
- Where
- Thailand
- Volunteers
- 15 people
- Sponsor
- Khon Kaen University
Pulmonary Disease, Chronic Obstructive
Measurements of Diaphragmatic Mobility on COPD Patients
To determine whether the COPD impairs the diaphragmatic mobility (DM), and verify improvements after an inpatient pulmonary rehabilitation (PR).
- Trial name
- NCT02838953
- Testing
- Pulmonary Rehabilitation
- Where
- Italy
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Casa Di Cura Villa Serena SpA
Sepsis
Biomarkers of Lung Injury in Hyperinflation in the Mechanical Ventilator Versus Manual Hyperinflation
Due to the failure of the respiratory system, many patients admitted to the Intensive Care Units (ICUs) require the institution of invasive mechanical ventilation (MV), aiming at maintaining gas exchange, reversing respiratory…
- Trial name
- NCT03464071
- Testing
- Hyperinflation with mechanical ventilator, Manual hyperinflation
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Emphysema or COPD
Study to Assess Safety, Feasibility, and Preliminary Efficacy of the Apreo Implant for Severe Emphysema
The goal of this clinical trial is to test the feasibility of an implant for severe emphysema in up to 30 participants at up to 5 study centers located in Europe and the United Kingdom.
- Trial name
- BREATHE-2 (NCT05949645)
- Testing
- Apreo Implant Group
- Where
- 3 sites in Austria, Netherlands and 1 more
- Volunteers
- 30 people
- Sponsor
- Apreo Health, Inc.
Pulmonary Disease, Chronic Obstructive
Effect of Aclidinium/Formoterol on Lung Hyperinflation, Exercise Capacity and Physical Activity in Moderate to Severe COPD Patients
The present study is planned to evaluate the effect of the aclidinium bromide/formoterol fumarate 400/12 μg FDC BID on the hyperinflation, exercise endurance and physical activity in patients with moderate to severe COPD.
- Trial name
- ACTIVATE (NCT02424344)
- Testing
- Aclidinium/Formoterol
- Where
- 26 sites in Canada, Germany and 2 more
- Volunteers
- 267 people
- Sponsor
- AstraZeneca
Pulmonary Disease, Chronic Obstructive
A Study of Exercise Endurance and Lung Hyperinflation in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
This study evaluated the effect of inhaled aclidinium bromide on exercise endurance and in reducing resting and dynamic lung hyperinflation in patients with moderate to severe COPD.
- Trial name
- NCT00500318
- Testing
- Aclidinium Bromide
- Where
- 52 sites in United States, Canada
- Volunteers
- 181 people
- Sponsor
- AstraZeneca
Mechanically Ventilated Patients, Lung Compliance
Effects of Ventilator Hyperinflation Versus Vibrocompression in Mechanically Ventilated Patients
The aim of the current study is to compare the effects of ventilator hyperinflation and vibrocompression on lung compliance in mechanically ventilated patients.
- Conditions
- Mechanically Ventilated Patients, Lung Compliance, Airway Clearance Impairment
- Trial name
- NCT06791798
- Testing
- Ventilator Hyperinflation, Vibrocompression, Traditional Chest Physical Therapy Program
- Where
- Egypt
- Volunteers
- 81 people
- Sponsor
- Cairo University
Obstructive Sleep Apnea
The Effect of CPAP on Lung Hyperinflation in Patients With OSA
Assessment of the lung hyperinflation by bodypletysmography in patients with obstructive sleep apnoea treated with continuous positive airway pressure therapy.
- Trial name
- NCT04084899
- Testing
- Continuous Positive Airway Pressure therapy
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- University Hospital Olomouc
Acute Hypoxemic Respiratory Failure, Ventilation, Mechanical
Association Between EIT and CT During PEEP Titration in Patients With Acute Respiratory Failure
This observational study will analyze data already collected by the investigators as part of their routine clinical practice from patients with acute respiratory failure (ARF) treated with mechanical ventilation.
- Trial name
- TAC-EIT-20-5 (NCT07175194)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Istituto Clinico Humanitas
COPD
Diagnostic and Therapeutic Approaches to Hyperinflation and Small Airway Disease in COPD
Current guideline-based criteria defining COPD do not meet the challenges set by the complex pathophysiology of the disease. Hyperinflation and affection of the small airways are two components that are not represented in current…
- Trial name
- NCT03287921
- Testing
- mono bronchodilatation, dual bronchodilatation
- Where
- Germany
- Volunteers
- 26 people
- Sponsor
- Universitätsmedizin Mannheim
Moderate COPD
Endobronchial Valves in Moderate COPD
Despite the best medical therapy many people with emphysema remain breathless and limited in their daily activities. In emphysema the lungs do not empty properly when the person breathes out.
- Trial name
- REMODEL (NCT01969734)
- Testing
- Zephyr endobronchial valve placement
- Where
- United Kingdom
- Volunteers
- 7 people
- Sponsor
- Sherwood Forest Hospitals NHS Foundation Trust
Idiopathic Pulmonary Arterial Hypertension.
Albuterol and Dynamic Hyperinflation in Idiopathic Pulmonary Arterial Hypertension
The purpose of this study is to determine if dynamic hyperinflation seen in patients with idiopathic pulmonary artery hypertension (iPAH) improves with albuterol therapy.
- Trial name
- NCT02108743
- Testing
- Albuterol.
- Where
- United States
- Sponsor
- American Medical Association Foundation
COPD, Hyperinflation
Acute Effect of Pulmonary Desufflation on Cardiac Performance in COPD Patients
Chronic Obstructive Pulmonary disease (COPD) is one of the major clinical entities that causes thousands of deaths every year all over the world and weights a lot on the health care system of every country in terms of direct and…
- Conditions
- COPD, Hyperinflation, Right Cardiac Failure
- Trial name
- NCT01996124
- Testing
- Indacaterol Fumarate
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Milan
Respiratory Failure, Respiration Disorders
Selecting the Best Ventilator Hyperinflation Settings
Ventilator hyperinflation (VHI) has been shown to be effective in improving respiratory mechanics, secretion removal, and gas exchange in mechanically ventilated patients; however, there are no recommendations on the best…
- Trial name
- VHI1 (NCT03327610)
- Testing
- VC-CMV20, VC-CMV50, PC-CMV1
- Volunteers
- 30 people
- Sponsor
- Centro Universitário Augusto Motta
Pulmonary Disease, Chronic Obstructive
Effects of Tiotropium on Breathing Capacity and Exercise Limitation in Early Stages of Chronic Obstructive Pulmonary Disease
Optimal clinical management in early stages of COPD is not established. Tiotropium has been shown to improve exercise tolerance during (CWR) cycle ergometry with GOLD stage II to IV COPD, improvements in constant speed treadmill…
- Trial name
- NCT01072396
- Testing
- Tiotropium
- Where
- 15 sites in United States, Canada
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim