Clinical trials: Hyperinsulinemia
Muscle Atrophy, Insulin Sensitivity
Metabolic and Muscular Adaptations During Inactivity in 3 Days of Bed-rest
Space flight is associated with detrimental changes to the human body, including bone and muscle loss, fluid changes and deconditioning of muscles in the heart and blood vessels.
- Trial name
- NCT03495128
- Testing
- Bed Rest, Reconditioning
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Insulin Resistance, Obesity
Pilot Study of GLY-LOW Supplementation in Postmenopausal Women With Obesity
A combination of generally regarded as safe (GRAS) compounds named GLY-LOW, which included: alpha lipoic acid, pyridoxamine, nicotinamide, piperine and thiamine, were examined in pre-clinical experiments.
- Conditions
- Insulin Resistance, Obesity, Cardiovascular Diseases, Cognitive Impairment
- Trial name
- NCT06242535
- Testing
- GLY-LOW
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Hoskinson Health and Wellness Clinic
Metabolic Syndrome
Early Vascular Wall Changes by Magnetic Resonance Imaging (MRI) in Metabolic Syndrome Versus Metabolically Normal Pre-Menopausal Women: A Pilot Study
The purpose of this study is to compare the vascular permeability of blood vessel walls (of the carotid artery) in pre-menopausal women who have metabolic syndrome (syndrome of having at least 3/5 following features- increased…
- Trial name
- NCT01068535
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Washington
Chronic Kidney Diseases, Metabolic Syndrome
Theory-based Health Behaviour Change Intervention in Patients of Metabolic Syndrome With Chronic Kidney Disease
The pilot study will adopt a 2-arm, pretest-posttest, and assessor-blind randomized controlled trial design to examine the feasibility and acceptability of a theory-based health behaviour change intervention and examine its…
- Trial name
- NCT06527768
- Testing
- Theory-based health behaviour change interventio
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Obesity, NAFLD
Low-Calorie Diet in People With Prediabetes/Metabolic Syndrome
Significant weight reduction, achieved by low-calorie diet (LCD), will mobilise ectopic fat (visceral and particularly liver fat), improving insulin sensitivity and other metabolic syndrome components, with secondary beneficial…
- Conditions
- Obesity, NAFLD, Fatty Liver, Pre Diabetes
- Trial name
- CALIBRATE (NCT04786418)
- Testing
- Standard of care, Low-calorie diet
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Liverpool
Metabolic Syndrome, Hypertriglyceridemia
Nutritional Transitions to More Plant Proteins and Less Animal Proteins: Understanding the Induced Metabolic Reorientations and Searching for Their Biomarkers (ProVegOmics)
The dietary shift from animal to plant protein sources is one of the key aspects of the nutritional transition towards more sustainable food system and diets.
- Conditions
- Metabolic Syndrome, Hypertriglyceridemia, Fasting Blood Sugar Above Normal, Lower Than Standard HDL-cholesterol Level
- Trial name
- ProVegOmics (NCT04236518)
- Testing
- Diets with either predominantly animal protein sources., Diets with predominantly plant protein sources
- Where
- France
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Diabetes Mellitus, Type 2, Insulin Resistance
Day-Night Rhythm in Human Skeletal Muscle
This study evaluates the existence of a day-night rhythm in skeletal muscle energy metabolism in healthy lean subjects. Subjects will stay at the research facility for 44 hours with a standardized living protocol during which…
- Trial name
- NCT02261168
- Testing
- Standardized living protocol
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Metabolic Syndrome
New Insights Into the Metabolic Syndrome: the Role of Alpha Defensin
The purpose of this study is to find out if there is a connection between a higher level of peptide alpha defensin in blood serum with the metabolic profile of adolescents aged 13-17.
- Trial name
- NCT03469115
- Testing
- Serum blood
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Insulin Resistance, Impaired Glucose Tolerance
The Effects of an Obesogenic Lifestyle in Recreationally Active, Young Adults
This clinical trial aims to learn about the alterations in insulin resistance and metabolic flexibility following a transition to an obesogenic lifestyle in fit young men and women. The main questions it aims to answer are: 1.
- Conditions
- Insulin Resistance, Impaired Glucose Tolerance, Obesity, Metabolic Disturbance
- Trial name
- NCT05912348
- Testing
- Low Physical Activity and Added Carbohydrate Group, Low physical Activity Control, High Physical Activity and Added Carbohydrate Group
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of New Hampshire
Obesity, Intra-Abdominal Fat
Effect of a Probiotic on Visceral Fat Accumulation
The study's main objective is to investigate if an extract containing the probiotic Bifidobacterium animalis subsp. lactis BPL1 (CECT 8145) has a positive effect on the accumulation of abdominal visceral fat in people with…
- Conditions
- Obesity, Intra-Abdominal Fat, Subcutaneous Fat, Abdominal
- Trial name
- BIFFAT (NCT02921217)
- Testing
- Active Probiotic, Inactivated probiotic, Control
- Where
- Spain
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Biopolis S.L.
Diabetes Mellitus, Type 2, Metabolic Syndrome
Randomized Control Trial for Overweight Employees in Worksites
Impact of lifestyle intervention in at-risk Asian Indians at worksite remains largely unexplored. The aim of this study was to assess impact of the multi-component interventions on body weight, body fat patterning and…
- Conditions
- Diabetes Mellitus, Type 2, Metabolic Syndrome, Lifestyle Risk Reduction
- Trial name
- NCT03249610
- Testing
- Lifestyle intervention
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Diabetes Foundation, India
Hypertension, Hyperlipidemias
Clinical Trials of Two Helichrysum Infusions in Adults
The study evaluates the effects of Helichrysum italicum and Helichrysum Arenarium on different components of the metabolic syndrome.
- Conditions
- Hypertension, Hyperlipidemias, Inflammation, Hyperglycemia
- Trial name
- SMILJ (NCT04866628)
- Testing
- Helichrysum italicum infusion, Helichrysum arenarium
- Where
- Slovenia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Primorska
Obesity
Fatty Acid Metabolism and Insulin Sensitivity After Exercise in Obesity
Alterations in fatty acid mobilization and oxidation may be primary adaptations responsible for the improvements in metabolic health after a single session of endurance exercise.
- Trial name
- NCT01451957
- Testing
- Exercise - caloric balance, No Exercise - hyper-caloric diet, No exercise - caloric balance
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Obesity (BMI>30), Insulin Resistance
Interplay of Central and Peripheral Vascular Effects of Insulin in Obesity
Determine the impact of obesity with insulin resistance on the neurovascular response to brain insulin stimulation.
- Trial name
- NCT07653464
- Testing
- human insulin
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Sleep, Sleep Deprivation
Sleep Loss and Energy Metabolism in People With Family History of Type 2 Diabetes.
The use of energy from food changes when people sleep. However, it is still not known if differences in the amount of nighttime sleep have an effect on the amount of energy that people who have a relative with type 2 diabetes…
- Conditions
- Sleep, Sleep Deprivation, Insulin Resistance, Type 2 Diabetes
- Trial name
- NCT00724087
- Testing
- 5.5-hour bedtime, 8.5-hour bedtime
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Obesity, Metabolic Syndrome
Milk Types and Fish Oil in 9- to 12-Month-Old Infants
The objective of this intervention study is to examine the effect of whole cow's milk versus infant formula as primary milk sources with or without supplements of n-3 LCPUFA for growth, nutritional status, development, risk…
- Conditions
- Obesity, Metabolic Syndrome, Growth, Blood Pressure
- Trial name
- NCT00379171
- Testing
- Cow's milk with fish oil, Cow's milk without fish oil, Formula with fish oil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Obesity
Medium-term Effects of Molecular Hydrogen on Metabolic Fitness in Obesity
Molecular hydrogen (H2) effectively tackles obesity-related disorders in animal models yet no studies so far investigated the effectiveness of H2 for improving biomarkers of obesity in humans.
- Trial name
- NCT02832219
- Testing
- Molecular hydrogen
- Where
- Serbia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Center for Health Sciences, Serbia
Obesity, Metabolic Syndrome
Effects of Exercise on Abdominal Obesity and Risk Factors for Cardiovascular Disease
The investigators will randomize abdominally obese men and women at increased health risk to one of the following 4 conditions: 1) No-exercise, wait list controls (C), 2) Low volume, low intensity exercise (LVLI), 3) High volume…
- Conditions
- Obesity, Metabolic Syndrome, Cardiovascular Disease
- Trial name
- NCT00955071
- Testing
- Exercise: LVLI, Exercise: HVLI, Exercise: LVHI
- Where
- Canada
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Queen's University
Obesity, Insulin Resistance
Protection Against Insulin Resistance in Obesity
The overall goal of this project is to identify factors that "protect" some obese adults from becoming insulin resistant. Identifying mechanisms that help protect some obese adults from developing insulin resistance could lead to…
- Trial name
- PAIR (NCT02717832)
- Testing
- hyperinsulinemic-euglycemic clamp
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Michigan
NAFLD, Insulin Resistance
Determination of Insulin-stimulated Hepatic Glucose Uptake by PET-CT Measurements
In the absence of excessive alcohol consumption, increased levels of fat in the liver (>5%) are diagnosed as non-alcoholic fatty liver (NAFL).
- Conditions
- NAFLD, Insulin Resistance, Overweight and Obesity
- Trial name
- ISGU (NCT04938544)
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
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