Clinical trials: Hyperinsulinism
Postmenopausal Metabolic Health
Physical Activity and Basal Metabolic Rate in Postmenopausal Women
The primary purpose of this study is to expand research on the effects of physical activity on basal metabolic rate (BMR) in healthy postmenopausal women, and to further compare the effects of long-term habitual exercise to the…
- Trial name
- NCT01550536
- Testing
- Resistance and aerobic exercise
- Where
- 3 sites in United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Metabolic Syndrome
Metformin and Dietary Restriction to Prevent Age-related Morbid Events in People With Metabolic Syndrome
Phase III randomized controlled trial on men and women with Metabolic syndrome (MetS) to test the hypothesis that comprehensive life-style changes and/or metformin treatment prevent age-related chronic non-communicable diseases…
- Trial name
- MeMeMe (NCT02960711)
- Testing
- Metformin Hydrochloride 850 MG Oral Tablet [Glucophage], Ludipress, mg stereate, micronized hydrated silica, talcum
- Where
- Italy
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Diet Modification, Insulin Resistance
Saliva Insulin Responses to a Standardized Meal Tolerance Test in Humans
Recent evidence suggests that hyperinsulinemia (i.e., elevated insulin levels) is the primary causative factor in obesity. Insulin promotes fat storage and prevents fat breakdown, suggesting that weight loss would be optimized if…
- Conditions
- Diet Modification, Insulin Resistance, Hyperinsulinemia
- Trial name
- NCT04309071
- Testing
- Dietary intervention
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Obesity
Reduction of Abdominal Obesity and Insulin Resistance in Women
The purpose of the study was to assess the effects of equivalent diet- or exercise-induced weight loss and related insulin resistance in abdominally obese women.
- Trial name
- NCT00664495
- Testing
- Diet Weight Loss, Exercise Weight Loss, Exercise Without Weight Loss
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Queen's University
Obesity, Insulin Resistance
Guided Imagery Intervention for Obese Latino Adolescents
Guided imagery, a mind-body complementary/alternative treatment modality, offers promise to reduce stress and promote lifestyle behavior change to reduce diabetes and heart disease risk in obese Latino adolescents.
- Conditions
- Obesity, Insulin Resistance, Metabolic Syndrome
- Trial name
- NCT01895595
- Testing
- Guided Imagery, Digital Storytelling
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Idiopathic Ketotic Hypoglycemia
A Glucometabolic Evaluation of Patients With Idiopathic Ketotic Hypoglycemia
The project will evaluate 1) the postprandial metabolism and 2) continuous glucose levels in subjects diagnosed with Idiopathic Ketotic Hypoglycemia (IKH)) and healthy control subjects.
- Trial name
- IKH_MetEx (NCT05310292)
- Testing
- Oral glucose tolerance test, Mixed meal test
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Diabetes, Hypertension
Effects of Intralipid Versus Olive Oil Infusions on Endothelial Function, Immune Function, Inflammatory Markers
Recent evidence suggests that increased levels of a circulation fat (free fatty acids or FFAs) can cause high blood pressure and cardiac complications. Intralipid is the only type of fat approved by the FDA for clinical use.
- Conditions
- Diabetes, Hypertension, Obesity
- Trial name
- NCT00989339
- Testing
- Twenty-four Hour TPN and Saline Infusion
- Volunteers
- healthy volunteers welcome
- Sponsor
- Emory University
Insulin, Glucose
Evaluation of Kisspeptin Glucose-Stimulated Insulin Secretion With Physiologic Mixed Meal Tolerance
This study utilizes infusions of kisspeptin in healthy women to isolate the impact of kisspeptin on beta-cell responsivity assessed by the mixed meal tolerance test.
- Conditions
- Insulin, Glucose, Healthy Volunteers, Women
- Trial name
- NCT04532801
- Testing
- Kisspeptin-10, mixed meal tolerance test
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Stephanie B. Seminara, MD
Cardiovascular Heart Disease, Metabolic Syndrome
The Effect of n-3 LCPUFA on Immune Function and Cardiovascular Risk Factors
The purpose of this study is to investigate the effects of long-chain n-3 polyunsaturated fatty acids (n-3 LCPUFA) on immune function and cardiovascular disease risk
- Trial name
- NCT00266292
- Testing
- Fish oil (Bio-Marine, Pharma Nord), n-6 PUFA intake (Margarine+sunflower oil vs. butter product+rapeseed oil)
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Healthy
Metabolic Syndrome and Leptin Level Associated With Fructose Consumption in Spain
A Food Frequency Questionnaire (FFQ), will be provided to 800 adults to assess overall fructose intake and this will be related to a number of features related to the metabolic syndrome, including serum leptin, characteristic…
- Trial name
- NCT00651001
- Where
- Spain
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Hospital Mateo Orfila
Smoking Cessation
Neuro Biomarkers of Smoking Behavior
The purpose of this study is to evaluate cognition in smokers and nonsmokers. It involves administration of intranasal insulin (Novolin R), an investigational medication followed by a brief non-invasive cognitive test.
- Trial name
- NCT03811951
- Testing
- Novolin R
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Hypertension, Hyperlipidemias
Clinical Trials of Two Helichrysum Infusions in Adults
The study evaluates the effects of Helichrysum italicum and Helichrysum Arenarium on different components of the metabolic syndrome.
- Conditions
- Hypertension, Hyperlipidemias, Inflammation, Hyperglycemia
- Trial name
- SMILJ (NCT04866628)
- Testing
- Helichrysum italicum infusion, Helichrysum arenarium
- Where
- Slovenia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Primorska
Obstructive Sleep Apnea, Metabolic Syndrome X
Obstructive Sleep Apnea (OSA) and Metabolic Syndrome: Role of Oxidative Stress
The purpose of this study is to define the mechanism(s) through which Obstructive Sleep Apnea/Hypopnea (OSAH) promotes abnormal metabolic processes which characterize the metabolic syndrome.
- Trial name
- NCT00177892
- Testing
- sleep disruption, sleep with and without positive pressure
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Type 2 Diabetes, Prediabetes
Seum Bile Acid Profile in Type 2 Diabetes and Association Between Bile Cid Profile and Adipokine or Oxidative Stress
"The goal of this work is to critically test the hypothesis that there exists a different profile of bile acids (BAs) in patient with type 2 diabetes mellitus (T2DM) compared with normal controls.
- Conditions
- Type 2 Diabetes, Prediabetes, Non-alcoholic Fatty Liver Disease, Metabolic Syndrome
- Trial name
- NCT02650830
- Where
- South Korea
- Volunteers
- 362 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Insulin Sensitivity, Glucose Metabolism Disorders
Bisphenol A and Muscle Insulin Sensitivity
This study examine oral bisphenol A consumption on muscle insulin sensitivity and hepatic glucose suppression. Half of the participants will receive a diet plus BPA and the other half will receive a diet plus no bisphenol A.
- Conditions
- Insulin Sensitivity, Glucose Metabolism Disorders, Microtia
- Trial name
- NCT03771066
- Testing
- bisphenol A
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- California Polytechnic State University-San Luis Obispo
Metabolic Syndrome
Effect of Brown Rice on the Risk Factors for Metabolic Syndrome
The purpose of the study is to determine the effect of consumption of brown rice on the risk factors of metabolic syndrome (MetS) as compared to consumption of white rice.
- Trial name
- NCT02321553
- Testing
- Brown rice, White rice
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Tufts University
Metabolic Syndrome
Exercise and Carotid Artery Function in Metabolic Syndrome
The purpose of this study is to determine 1) if young adults with metabolic syndrome display endothelial dysfunction of the internal carotid artery in a sex-specific fashion and 2) if this endothelial dysfunction can be acutely…
- Trial name
- NCT07430839
- Testing
- exercise, Diagnostics, Inhaled CO2-mixed air
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Insulin Sensitivity
Insulin Resistance and Substrate Metabolism After Acute Erythropoietin (EPO) Administration
Recently EPO receptors have been found in human muscle tissue, but what is still not known is the physiological role of these receptors.
- Trial name
- NCT00793767
- Testing
- erythropoietin
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Preoperative Care, Anxiety
Use of Maltodextrins in the ERAS Preoperative Fasting Protocol in Pediatric Surgery
This monocentric prospective randomized controlled pilot study aims to evaluate the effectiveness of preoperative maltodextrin administration within an Enhanced Recovery After Surgery (ERAS) protocol in pediatric surgical…
- Conditions
- Preoperative Care, Anxiety, Pediatric Surgery
- Trial name
- ERAS-MALTO (NCT07686029)
- Testing
- Maltodextrin Clear Liquid, Non-Sugared Clear Liquid
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Sarcopenia, Insulin Resistance
Insulin Resistance, Sarcopenia and Plasma BAIBA Levels
Insulin resistance (IR) is an early metabolic alteration in chronic kidney disease (CKD) patients, becoming almost universal in those who reach the end stage of kidney failure.
- Trial name
- NCT04309201
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tungs' Taichung Metroharbour Hospital
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