Clinical trials: Hyperlactatemia
Tissue Hypoxia, Hyperlactatemia
Early Lactate-Directed Therapy in the Intensive Care Unit (ICU)
Blood lactate levels have long been related to tissue hypoxia, a severe condition in critically ill patients associated with the development of organ system failure and subsequent death.
- Trial name
- NCT00270673
- Testing
- Early lactate-directed therapy
- Where
- 5 sites in Netherlands
- Volunteers
- 350 people
- Sponsor
- Erasmus Medical Center
Etiology of Hyperlactathemia, Early Period After Cardiopulmonary Bypass Surgery
NEW MONITORING IN DIFFERENTIAL DIAGNOSIS OF HYPERLACTATHEMIA IN CARDIOPULMONARY BYPASS SURGERY
Objective: The objective of the study was to investigate a reverse correlation between blood lactate levels and rSO2, and distinguish between hypoxic and non-hypoxic hyperlactatemia seen in the early postoperative period.
- Conditions
- Etiology of Hyperlactathemia, Early Period After Cardiopulmonary Bypass Surgery, Washout Phenomenon
- Trial name
- NCT04706884
- Testing
- Near infrared spectroscopy
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Acibadem University
Swimming, Coordination Lack
Swimming Economy in Swimmers and Paraswimmers as a Function of SR(Stroke Rate) and V(Velocity) Manipulations (NePTUNE-3)
The competitive swimming and open water swimming events are scheduled for the 2024 Paris Olympic and Paralympian Games. Generally associated with a non-neglectable number of medals in the last Olympics, swimming performance…
- Conditions
- Swimming, Coordination Lack, Oxygen Consumption, Lactic Acid Blood Increased
- Trial name
- NePTUNE-3 (NCT05011591)
- Testing
- Swimming economy
- Where
- France
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Rouen Normandie
Hyperlactatemia, Actue Circulatory Failure
Treatment of Hyperlactatemia in Acute Circulatory Failure Based on Analysis of CO2: a Prospective Randomized Superiority Study (The LACTEL Study)
The management of a patient with shock is based on improving tissue oxygenation through hemodynamic optimization. Lactate is a marker of tissue hypoperfusion commonly used in the ICU.
- Trial name
- LACTEL (NCT05032521)
- Testing
- collection of biological data, collection of demographic, ventilatory, cardiac echocardiography, arterial and venous gas data, Standard treatment
- Where
- France
- Volunteers
- 180 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Hyperlactacidemia
Sodium Bicarbonate Ringer's Solution for Preventing and Treating Hyperlactacidemia During Hepatectomy
A variety of reasons lead to a sharp increase in lactic acid levels in patients undergoing liver resection, while leading to hyperlactic acidemia, resulting in decreased cardiac output, elevated blood potassium, and response to…
- Trial name
- NCT04547296
- Testing
- Sodium Bicarbonate Ringer's Solution
- Where
- 7 sites in China
- Volunteers
- 484 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Syncope, Lactate Blood Increase
Serum Lactate in Convulsive Syncopes Compared to Non-convulsive Syncopes
The investigators compared the serum lactate, serum prolactin and serum creatine kinase concentrations following convulsive and non-convulsive syncopes.
- Trial name
- NCT03062683
- Testing
- Lactate, prolactin and creatine kinase conc.
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- RWTH Aachen University
HIV Infections
Vitamin B Therapy for Hyperlactatemia
The purpose of this study is to see if vitamin B can treat mild hyperlactatemia (a higher than normal level of lactate in the blood) in patients who take nucleoside reverse transcriptase inhibitors (NRTIs).
- Trial name
- NCT00031057
- Testing
- Thiamine hydrochloride, Riboflavin
- Where
- 3 sites in United States
- Volunteers
- 225 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hyperlactatemia, Healthy
The Role of Lactate in Lipolysis and Catabolism in Humans
Lactate may have anti-lipolytic effects when plasma concentrations of lactate reach levels similar to those seen during high intensity exercise.
- Conditions
- Hyperlactatemia, Healthy, Lactate
- Trial name
- LILACH (NCT04710875)
- Testing
- Na-lactate, Sodium chloride
- Where
- 2 sites in Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Microcirculatory Dysfunction, Tissue Hypoperfusion
Submental Tissue Oxygenation and Arterial Lactate in Major Surgery
During major surgical procedures performed under general anesthesia, changes in blood flow and oxygen delivery to tissues may occur due to blood loss, hemodynamic fluctuations, and anesthesia-related physiological effects.
- Conditions
- Microcirculatory Dysfunction, Tissue Hypoperfusion, Microcirculatory Status, Microvascular Circulation
- Trial name
- NCT07399275
- Testing
- No intervention. This is a prospective observational study. Near-infrared spectroscopy measurements are performed for monitoring purposes only and do not influence clinical management.
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Bursa Sevket Yilmaz Training and Research Hospital
Severe Sepsis With Septic Shock, Lactate Blood Increase
Saving Lives by Early Detection and Treatment of Sepsis and Septic Shock by Point of Care Lactate Test in Adults
Burden: The global burden of sepsis is difficult to ascertain, although a recent scientific publication estimated that in 2017 there were 48.9 million cases and 11 million sepsis-related deaths worldwide, which accounted for…
- Trial name
- POCLactate (NCT05108467)
- Testing
- Point of care Lactate
- Where
- Bangladesh
- Volunteers
- 80 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Surgical Procedure, Unspecified, Postoperative Complications
Hyperlactacidemia in Major Abdominal Surgery and Monocarboxylate Receptors
The goal of this clinical trial is to identify those situations in which the increase of lactate levels is not clinically relevant since it is associated with altered genetic polymorphism of the genes involved in the membrane…
- Conditions
- Surgical Procedure, Unspecified, Postoperative Complications, Hyperlactatemia, Abdomen Disease
- Trial name
- NETTUNO (NCT06222021)
- Testing
- Genetic analysis of polymorphism of membrane receptors involved in lactate transport
- Where
- Italy
- Volunteers
- 109 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Sepsis, Lactate Blood Increase
Blood Lactate Level for Pre-hospital Orientation of Septic Shock
In the pre-hospital setting, the severity assessment of septic shock is essential to decide the optimal initial in-hospital level of care.
- Trial name
- LAPHSUS (NCT03831685)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Hôpital Necker-Enfants Malades
Post-cardiac Surgery, Hyperlactatemia
Lactate Acidosis in Postoperative Hearts
This is a single-center, observational study. Investigators aim to characterize the metabolism of lactate in children over the first forty-eight hours following cardiac surgery. Blood samples will be obtained up to 12 timepoints.
- Trial name
- NCT03025659
- Testing
- Pyruvate levels
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Florida
Trauma, Multiple, Lactate Blood Increase
Feasibility of Lactate Level Evaluation in Prehospital Care in Trauma
Capillary or venous lactate level evaluation in prehospital care could be simple and beneficial tool for optimising prehospital care in patients with severe trauma.
- Trial name
- NCT03115970
- Testing
- capillary and venous lactate level measurement
- Volunteers
- 30 people
- Sponsor
- Masaryk Hospital Usti nad Labem
Sepsis, Diabetes Mellitus
The Prognostic Value of Lactate is Different Among Septic Patients
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Early diagnosis of sepsis and identification of more severe sepsis is important to improve the outcomes .Therefore…
- Trial name
- NCT04155060
- Where
- China
- Volunteers
- 256 people
- Sponsor
- Shanghai Zhongshan Hospital
Hyperlactatemia
Does Intravenous Lactated Ringer Solution Raise Measured Serum Lactate?
Lactated Ringer's (LR) solution bolus is commonly administered in the emergency department setting to seriously ill patients. It is also common to obtain blood samples to determine serum lactate levels to aid in the assessment of…
- Trial name
- NCT02950753
- Testing
- Lactated Ringer Solution, Normal Saline
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Medical Center of Southern Nevada
Sepsis, Hypoperfusion
Use of Dobutamine in Patients With Sepsis and Maintained Hypoperfusion After Initial Volemic Resuscitation.
This phase 2 study aim to investigate the effect of dobutamine in patients with sepsis/ septic shock after fluid resuscitation and with hypoperfusion (lactate and central venous oxygen saturation or prolonged capillary refill…
- Conditions
- Sepsis, Hypoperfusion, Hyperlactatemia
- Trial name
- DEEP (NCT05953142)
- Testing
- Dobutamine
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Federal University of São Paulo