Clinical trials: Hyperlipemia
Hyperlipidaemia, Liver Biomarkers
Therapeutic Effects of Cinnamon-Enriched Cookies on Hypercholesterolemia and Liver Function
Cinnamon-enriched cookies were developed and evaluated for their sensory acceptability and potential as a functional food for adults with hyperlipidemia.
- Conditions
- Hyperlipidaemia, Liver Biomarkers, Weight Change
- Trial name
- NCT07740473
- Testing
- Treatment group T1
- Where
- Pakistan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Lahore
Hypercholesterolemia
Influence of Simvastatin on Apolipoprotein B-100 (apoB-100) Secretion
3-Hydroxy-3-methylglutaryl coenzyme A-reductase inhibitors (statins) decrease apolipoprotein B-100-containing lipoproteins by increasing their fractional catabolic rates through low-density lipoproteins (LDL) receptor-mediated…
- Trial name
- SVS (NCT00905541)
- Testing
- simvastatin
- Where
- Germany
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Diabetes, Hypercholesterolaemia
The Effect of Providing Genetic Risk Information on Lifestyle Behaviors in African Americans
Cardiovascular disease (CVD) is a major and persistent health disparity for African Americans. Linking GAINS is a randomized pilot and feasibility study designed to evaluate whether receiving genetic risk information early in a…
- Conditions
- Diabetes, Hypercholesterolaemia, Hypertension, Obesity Type 2 Diabetes Mellitus
- Trial name
- LINKING GAINS (NCT07833384)
- Testing
- Color Genomics Genetic Testing Panels
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Hypertriglyceridemia, Glucose Intolerance
Impact of Plasma Lipids on β Cell Function and Insulin Sensitivity
The investigators aim to evaluate whether and to what extent glucose tolerance, beta cell function, insulin clearance, and glucose metabolic fluxes change in response to an acute increase in plasma triglycerides during lipid…
- Trial name
- NCT05181514
- Testing
- 20% Intralipid, Normal Saline
- Where
- Italy
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Hypercholesterolemia
Middle Term Effect of Red Yeast Rice on Plasma Lipids and Proteoma in Individuals With Suboptimal Cholesterolemia
The primary purpose of our research will be to evaluate if, in healthy subjects with a low- moderate cardiovascular risk (CV risk>1% but < 5%) evidenced by sub-optimal cholesterol levels as per ESC/EAS guidelines (LDL cholesterol…
- Trial name
- NCT06368258
- Testing
- Red yeast rice
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Bologna
Hypercholesterolemia, Physical Performance
CoQ10 in Statin-associated Asthenia
This was a double-blind, randomized, placebo-controlled clinical study aiming to assess the effects of supplementation with CoQ10 phytosome on physical performance in older adults with self-reported statin-associated asthenia.
- Trial name
- NCT06391606
- Testing
- Coenzyme Q10
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Bologna
Hyperlipidemia, Cardiovascular Diseases
The Influence of Soy Isoflavnoids on the Hypocholesterolemic Effects of Soy
Isoflavonoids, through their estrogen-like activity, are in part responsible for the cholesterol lowering properties of soy foods.
- Trial name
- NCT00877825
- Testing
- dairy food control diet and high- and low- isoflavone soyfood diets
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Toronto
Hypercholesterolemia, Cardiovascular Disease
Barley Protein and CVD
The Question posed is: Does an barley protein concentrate have health benefits similar to those demonstrated for soy protein foods which would justify the use of the non-fiber components of barley as functional food ingredients?…
- Conditions
- Hypercholesterolemia, Cardiovascular Disease, Diet Therapy
- Trial name
- NCT00334308
- Testing
- Barley protein bread or control (casein) bread
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Hypercholesterolemia, Healthy Volunteers
A Study on Evaluating the Safety of HST101 in Healthy Chinese Participants
This is a single-center, randomized, double-blind, placebo-controlled, single HST101 SC dose cohort study to evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Healthy Chinese Participants with Elevated…
- Conditions
- Hypercholesterolemia, Healthy Volunteers, LDL-Cholesterol
- Trial name
- NCT06504043
- Testing
- HST101
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hasten Biopharmaceutical Co., Ltd.
Hypertriglyceridemia
Interaction of Epanova on Warfarin Pharmacokinetic and Anticoagulant Activity and Comparison of the Effects of Epanova and Lovaza on Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) After Low-fat Meals
The primary objective of this study is to determine the effect of Epanova® on the pharmacokinetic and anticoagulant activity of warfarin.
- Trial name
- NCT01431690
- Testing
- warfarin, omefas, omega-3-acid ethyl esters
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy Subjects
A Multiple Oral Doses Study Of PF-06427878 In Healthy Adult Subjects
PF-06427878 is a new compound proposed for the treatment of hyperlipidemia. The primary purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics of multiple oral doses of PF-06427878 in healthy adult…
- Trial name
- NCT02391623
- Testing
- PF-06427878
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Pfizer
Familial Hypercholesterolemia
Coronary and Heart Effects of Early Treatment in Familial Hypercholesterolemia
This study evaluates plaque burden and characteristics in early-treated FH patients compared to late-treated FH patients and healthy individuals.
- Trial name
- CHEETAH (NCT05352386)
- Testing
- Coronary computed tomography angiography (CCTA)
- Where
- Netherlands
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Hyperlipidemia, HIV
Pharmacokinetic Study of Pitavastatin and Ritonavir-Boosted Darunavir or Efavirenz
The main goal of this study is to determine how taking efavirenz affects the levels of pitavastatin in the bloodstream when both drugs are taken together and to see how darunavir with ritonavir affects the levels of pitavastatin…
- Trial name
- NCT01695954
- Testing
- Pitavastatin, Darunavir, Ritonavir
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Hypercholesterolaemia
A Study of PCSK9 Inhibitor AK102 in Healthy Subjects
This is a first-in-human,randomized, double-blind, placebo-controlled, single dose escalation, phase 1 study to evaluate the safety, tolerability, PK/PD and immunogenicity of AK102 administered subcutaneously in healthy subjects.
- Trial name
- NCT04169386
- Testing
- AK102
- Where
- China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Akeso
Hypercholesterolemia
Effect of a Treatment With a Nutraceutical Combination on Sub-optimal LDL Cholesterol Levels
High cholesterol is one of the major controllable risk factor for coronary heart disease. It is well demonstrated that drugs that reduce the intestinal absorption of cholesterol or block the synthesis of cholesterol or the…
- Trial name
- NATCOL (NCT03739242)
- Testing
- Nutraceutical combination
- Where
- Italy
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- A. Menarini Industrie Farmaceutiche Riunite S.r.l.
Obesity, Diabetes
Differential Metabolism of Dietary Fatty Acids
Differences in how diet fats are converted to energy could explain some of the reported differences in health effects among different classes of dietary fat (e.g. monounsaturated vs. saturated).
- Conditions
- Obesity, Diabetes, Hyperlipidemia
- Trial name
- NCT00059254
- Testing
- Oleic acid (OA), Palmitic Acid (PA)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Hypercholesterolemia, Hyperlipidemia
Assessment of Interaction Between Vytorin and Niaspan in Healthy Subjects (P04955AM2)
This is a single-center, randomized, open-label, 3-period, 3-treatment multiple-dose crossover study designed to assess the interaction between VYTORIN® (Ezetimibe and Simvastatin) and NIASPAN® (Niacin Extended-Release Tablets)…
- Trial name
- NCT00652431
- Testing
- Vytorin + Niaspan, Vytorin, Niaspan
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Organon and Co
Hypercholesterolemia
Cholesterol Lowering Effect of Cardio-Complement, an Ayurveda Formulation
The aim of this feasibility study was to assess the lipid-lowering effects and safety of a Ayurveda formulation containing Terminalia Arjuna, Withania Sominifera, Garcinia Cambogia and piperine (as bioenhancer)
- Trial name
- NCT04974853
- Testing
- Cardio-complement
- Where
- India
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- NMP Medical Research Institute
Hypercholesterolemia, Hyperlipidemias
Independent Effects of High-cholesterol (High-egg) and High-saturated Fat Diets on LDL-cholesterol
This study will comprise a randomized controlled, counter-balanced, cross-over trial to evaluate the independent effects of a high cholesterol (high egg), low saturated fat diet and a high saturated fat, low cholesterol diet on…
- Conditions
- Hypercholesterolemia, Hyperlipidemias, Physical Inactivity, Diet, Healthy
- Trial name
- NCT05267522
- Testing
- Egg diet, Egg-free Diet, Control Diet
- Where
- Australia
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of South Australia
Hypercholesterolemia
Validating the "Foods for Health" Portfolio of Functional Food Products
The objective of this research project is to investigate the ability to affect cardiovascular disease (CVD) risk factors through a novel, easily implemented functional food-based approach.
- Trial name
- NCT02341924
- Testing
- Portfolio of functional foods, Control foods
- Where
- 2 sites in United States, Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Manitoba