Clinical trials: Hypermobility Type Ehlers-Danlos Syndrome
Hypermobile EDS (hEDS), Hypermobility Syndrome
Dyspnea in Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorder
Individuals with hypermobile Ehlers-Danlos Syndrome (hEDS) and Hypermobility Spectrum Disorders (HSD) often experience dyspnea. Inspiratory Muscle Training (IMT) has been shown to improve dyspnea and respiratory muscle function…
- Trial name
- NCT04972565
- Testing
- Usual Care plus Inspiratory Muscle Training (IMT)
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- University Health Network, Toronto
Low Back Pain, Mechanical, Spinal Stenosis
Investigation of Hypermobility, Biomarkers, and Pain Generators in Chronic Pain Patients
Observational study of axial spine pain and hyperflexibility. Patients will receive physical exam maneuvers (traditional straight leg raise, FABER, facet loading as well as Beighton's hypermobility score) and blood / urine /…
- Conditions
- Low Back Pain, Mechanical, Spinal Stenosis, Nerve Root Disorder, Radiculopathy, Cervical
- Trial name
- Hypermoble (NCT02761928)
- Testing
- Beighton score for hypermobility
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- The University of Texas Health Science Center, Houston
Hypermobile Ehlers-Danlos Syndrome, Hypermobile Spectrum Disorder
Hypermobile Ehlers-Danlos Syndrome - Transcutaneous Auricular Neuromodulation
Investigate whether at-home transcutaneous auricular VNS (tAN: transcutaneous auricular neurostimulation) improves a battery of nine key physical and psychological symptoms of a group of hEDS (Hypermobile Ehlers-Danlos Syndrome…
- Conditions
- Hypermobile Ehlers-Danlos Syndrome, Hypermobile Spectrum Disorder, Ehlers-Danlos Syndrome
- Trial name
- hEDS-tAN (NCT06105541)
- Testing
- Transcutaneous Auricular Neurostimulation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Medical University of South Carolina
Hypermobile EDS (hEDS), Hypermobile Ehlers-Danlos Syndrome
Hamstring Strengthening in Hypermobile Conditions
The goal of this clinical trial is to determine how strengthening the hamstring muscles affects the knee joint in people living with hypermobility spectrum disorders (HSD) and hypermobile Ehlers-Danlos syndrome (hEDS).
- Conditions
- Hypermobile EDS (hEDS), Hypermobile Ehlers-Danlos Syndrome, Hypermobile Spectrum Disorder, Hypermobility Type Ehlers-Danlos Syndrome
- Trial name
- NCT07626957
- Testing
- Progressive resistance exercise with an emphasis on eccentric hamstring loading.
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Hypermobile Ehlers-Danlos Syndrome, Heavy Menstrual Bleeding
Identifying the Determinants of Bleeding and Hypermobility in Patients With Heavy Menstrual Bleeding
In this study, researchers want to learn about the connection between heavy bleeding issues and joint hypermobility (loose joints).
- Conditions
- Hypermobile Ehlers-Danlos Syndrome, Heavy Menstrual Bleeding, Hypermobility Syndrome (Disorder)
- Trial name
- NCT05685199
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- St. Jude Children's Research Hospital
Hypermobile Ehlers-Danlos Syndrome
TMD-specific Physiotherapy in hEDS Patients Individuals With Hypermobile Ehlers-Danlos Syndrome
The aim of this study is to analyze the effects of strictly defined physiotherapy in patients temporomandibular dysfunction (TMD) and hypermobile Ehlers-Danlos Syndrome (hEDS).
- Trial name
- NCT05757960
- Testing
- Physiotherapy
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- University Hospital Muenster
Ehlers-Danlos Syndrome Hypermobility Type (hEDS)
3D Printed Orthosis for Wrist Instability for Ehlers-Danlos Syndrome Patient
This study will determine if using 3D scanning and 3D printing technology to create an orthosis to improve the quality of life for people with Ehlers Danlos Syndrome (EDS) compared to existing prefabricated orthoses.
- Trial name
- NCT07565636
- Testing
- 3D scanned and 3D printed wrist hand orthosis
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- ELewis
Ehlers-Danlos Syndrome (EDS), Hypermobile EDS (hEDS)
STABLE Pilates for Hypermobility
This study is looking at whether Pilates-based exercise can help with hypermobility-related symptoms, like pain.
- Conditions
- Ehlers-Danlos Syndrome (EDS), Hypermobile EDS (hEDS), Hypermobile Spectrum Disorder
- Trial name
- STABLE (NCT07464093)
- Testing
- Pilates, Education
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Brigham and Women's Hospital
Hypermobility Syndrome, Hypermobile Ehlers-Danlos Syndrome
Dynamic Stability Exercises in Patients With Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorder
Background: Symptomatic hypermobility may lead to a number of restrictions in daily life. So far, there is a lack of effective treatments.
- Trial name
- NCT05800262
- Testing
- Dynamic stability exercises
- Where
- 2 sites in Sweden
- Volunteers
- 15 people
- Sponsor
- University Hospital, Linkoeping
Ehlers-Danlos Syndrome Hypermobility Type
Wearing a Compression Garment for Patients With Hypermobility Type of Ehlers-Danlos Syndrome
The Ehlers-Danlos syndrome (EDS) is a rare genetic disease caused by an anomaly of the connective tissue. This syndrome has different forms. Hypermobility type is the most common.
- Trial name
- VETCOSED (NCT02144532)
- Testing
- short-sleeved vest CICATREX SED®)
- Where
- France
- Volunteers
- 48 people
- Sponsor
- Hospices Civils de Lyon
Ehlers-Danlos Syndrome Hypermobility Type (hEDS), Ehlers-Danlos Syndrome (EDS)
Regenerative Medicine for Joint Hypermobility and Instability
This clinical trial is designed to evaluate whether a stepwise injection-based treatment approach can reduce pain and improve function in adults with joint hypermobility, connective tissue laxity, and joint instability.
- Conditions
- Ehlers-Danlos Syndrome Hypermobility Type (hEDS), Ehlers-Danlos Syndrome (EDS), Joint Hypermobility, Joint Instability
- Trial name
- NCT07688096
- Testing
- Dextrose 20% Prolotherapy, Autologous Platelet-Rich Plasma, Doxycycline Hyclate Injectable (Investigational)
- Volunteers
- 100 people
- Sponsor
- Manhattan Pain Medicine, PLLC
Benign Hypermobility Syndrome, Functional Constipation
The Comorbidity of Benign Hypermobility Joint Syndrome and Functional Constipation in Children
Benign Hypermobility Joint Syndrome is a group of inherited abnormalities in the structure of connective tissues, manifested by disturbances in the proportion of collagen.
- Trial name
- MobCon (NCT02854098)
- Where
- Poland
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Hypermobility Type Ehlers-Danlos Syndrome
Compression Garments on Hypermobility Type of Ehlers-Danlos Syndrome (CGhEDS)
This study evaluates the effects of wearing a compression garment on the postural balance of patients with hypermobility type of Ehlers-Danlos syndrome, in randomised controlled study.
- Trial name
- VECO (NCT03359135)
- Testing
- Rehabilitation, Compression Garment
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Hôpital Raymond Poincaré
Hypermobile Ehlers-Danlos Syndrome, Irritable Bowel Syndrome
Comprehensive Assessment of Nutrition and Dietary Intervention in Hypermobile Ehlers Danlos Syndrome
This study involves a comprehensive nutritional assessment of hEDS participants who have functional gastrointestinal disorders and dietary intervention to broaden their food choices and nutritional intake.
- Conditions
- Hypermobile Ehlers-Danlos Syndrome, Irritable Bowel Syndrome, Functional Gastrointestinal Disorders
- Trial name
- CANDI-hEDS2 (NCT05148039)
- Testing
- Dietician advice
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Queen Mary University of London
Joint Hypermobility Syndrome, Hypermobile Ehlers-Danlos Syndrome
Central Sensitization and Physical Activity in Adolescents With HSD/hEDS
Hypermobility Spectrum Disorder and hypermobile Ehlers-Danlos Syndrome (HSD/hEDS) is under-recognized and poorly understood and its management is therefore not clear.
- Trial name
- NCT05633225
- Testing
- Submax exercise test on a bicycle ergometer
- Where
- 2 sites in Sweden
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vastra Gotaland Region
Hypermobile EDS (hEDS)
Out of State - tAN hEDS
Hypermobile EDS and hypermobile spectrum disorder (collectively referred to as hEDS) are estimated to affect 1 in 500 individuals worldwide.
- Trial name
- NCT06548594
- Testing
- Transcutaneous Auricular Neurostimulation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Medical University of South Carolina
Hypermobile Ehlers-Danlos Syndrome, Hypermobile Spectrum Disorder
Online Pilates Exercise for People With Hypermobility
People with hypermobile Ehlers-Danlos Syndrome/Hypermobility Spectrum Disorder (hEDS/HSD) often have pain, coordination problems, and low tolerance to activity and exercise.
- Trial name
- NCT07118865
- Testing
- Online Pilates exercise
- Where
- United States
- Volunteers
- 440 people
- Sponsor
- Clarkson University
Ehlers-Danlos Syndrome, EDS
Characterization of Bleeding Disorders in EDS
Ehlers-Danlos Syndrome (EDS) is a disease that weakens the connective tissues (i.e. tendons and ligaments) in the human body. EDS can make the joints loose and alter skin and wound healing.
- Conditions
- Ehlers-Danlos Syndrome, EDS, Classical Ehlers-Danlos Syndrome, Classical EDS (cEDS)
- Trial name
- NCT05434728
- Testing
- 20 ml venous blood collection
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- University Health Network, Toronto
Hypermobile Ehlers-Danlos Syndrome, Hypermobility Syndrome
Patient-based Care Versus Standard Care for Patients With hEDS/HSD and Multidirectional Shoulder Instability
For hEDS or HSD patients with MDI, a multidisciplinary treatment approach is suggested. As follows, physiotherapy plays a key role in this integrative management.
- Conditions
- Hypermobile Ehlers-Danlos Syndrome, Hypermobility Syndrome, Multidirectional Subluxation of Shoulder
- Trial name
- NCT04666896
- Testing
- Tailored home-based exercise therapy, Standard home-based exercise therapy
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- University Ghent
Hypermobile Ehlers-Danlos Syndrome
Lung Volume Perception and Impact of a Cognitive Task on Ventilation in Hypermobile Ehlers-Danlos Syndrome.
Patients with hypermobile Ehlers-Danlos syndrome have respiratory and proprioceptive disorders. The aim of this study is to explore whether there is an alteration in lung volume perception in patients with hEDS compared to…
- Trial name
- ProprioRespi (NCT05000151)
- Where
- France
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Hakimi Adrien