Clinical trials: Hyperoxemia, active
Hyperoxia, Hyperoxemia
Hyperoxemia and Oxygen Reserve Index During Neurointerventional Anesthesia
The goal of this observational study is to learn how often high blood oxygen levels (hyperoxemia) occur in adults receiving general anesthesia for planned (elective) neurointerventional procedures, such as brain aneurysm coiling…
- Conditions
- Hyperoxia, Hyperoxemia, Cerebrovascular Disorders, Intracranial Aneurysms
- Trial name
- NCT07859982
- Testing
- Oxygen Reserve Index Monitoring (Observational)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Hyperoxemia, Cerebrovascular Circulation
HYPER MIND - Hyperoxia Effects on Cerebral Hemodynamics
This study aims to better understand how short periods of exposure to high oxygen levels affect blood flow in the brain of patients who are intubated and mechanically ventilated in the Intensive Care Unit (ICU).
- Conditions
- Hyperoxemia, Cerebrovascular Circulation, Cerebral Autoregulation, Critical Illness
- Trial name
- HYPER-MIND (NCT07377162)
- Testing
- Normobaric Hyperoxic Stimulus (NBHO)
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Erasme University Hospital
Critical Illness, Wounds and Injury
Strategy to Avoid Excessive Oxygen in Major Burn Patients
The objective is to determine the effectiveness of a multimodal educational intervention to reduce supplemental oxygen use in major burn patients.
- Conditions
- Critical Illness, Wounds and Injury, Disease Attributes, Pathologic Processes
- Trial name
- SAVE-O2 (NCT04534972)
- Testing
- Targeting Normoxemia (SpO2 90-96%; PaO2 60-100 mmHg)
- Where
- 6 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- University of Colorado, Denver
Respiratory Failure, Hypoxemia
Comparison of Pulse Oximetry (SpO2) With Different Oximeters and Arterial Saturation (SaO2): Oxygap2 Study
The oximeter is used to monitor intensive care patients undergoing oxygen therapy. It indicates pulsed oxygen saturation (SpO2), a reflection of arterial oxygen saturation (SaO2) which enables detection of hypoxemia and…
- Conditions
- Respiratory Failure, Hypoxemia, Hyperoxemia
- Trial name
- Oxygap 2 (NCT06102499)
- Testing
- SpO2 and SaO2 comparison
- Where
- 5 sites in Canada, Guadeloupe and 1 more
- Volunteers
- 250 people
- Sponsor
- Laval University
Hyperoxemia, Intraoperative Oxygen Therapy
Oxygen Reserve Index-Guided Oxygen Titration During Surgery in the Beach Chair Position
This study aims to evaluate whether guidance by the Oxygen Reserve Index (ORi) improves inspiratory oxygen fraction (FiO₂) titration compared with conventional pulse oximetry (SpO₂)-guided oxygen administration in adult patients…
- Conditions
- Hyperoxemia, Intraoperative Oxygen Therapy, Beach Chair Position, Cerebral Oxygenation
- Trial name
- ORI-BCP (NCT07404267)
- Testing
- ORi-Guided FiO₂ Titration, SpO₂-Guided FiO₂ Titration
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Critical Illness, Wounds and Injury
Strategy to Avoid Excessive Oxygen for Critically Ill Trauma Patients
The objective is to determine the effectiveness of a multimodal educational intervention to reduce supplemental oxygen use in critically injured patients.
- Conditions
- Critical Illness, Wounds and Injury, Disease Attributes, Pathologic Processes
- Trial name
- SAVE-O2 (NCT04534959)
- Testing
- Targeting Normoxemia (SpO2 90-96%; PaO2 60-100 mmHg)
- Where
- 8 sites in United States
- Volunteers
- 6,000 people
- Sponsor
- University of Colorado, Denver
Thoracic Surgery With One-lung Ventilation
ORI-Guided Oxygen Therapy During One-Lung Ventilation
High inspired oxygen concentrations (FiO₂) are commonly administered during general anesthesia to prevent hypoxemia. However, excessive oxygen administration may result in hyperoxemia, which has been associated with impaired…
- Trial name
- ORI-OLV (NCT07720778)
- Testing
- ORI-Guided FiO2 Titration, Conventional SpO₂-Guided FiO₂ Titration
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Konkuk University Medical Center