Clinical trials: Hyperoxia
Hyperoxia
Proteomics for Identification of Hyperoxia-induced Changes in Protein Expression
Aim of the present study is to investigate the influence of hyperoxia on the protein expression using the differential analysis of protein expression in tissues (proteomics).
- Trial name
- NCT02553668
- Testing
- Oxygen (FiO2 1,0), Facemask
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital of Cologne
Sleep Apnea, Elderly Adults
Sleep Apnea in Elderly
Sleep-disordered breathing (SDB or sleep apnea) is very common among elderly Veterans and leads to increased morbidity and mortality in this population.
- Trial name
- NCT02703220
- Testing
- Hyperoxia/oxygen, Acetazolamide, Finasteride
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Ocular Physiology, Regional Blood Flow
Effects of Vitamin C on Hyperoxia-Induced Reduction of Retinal Blood Flow
High arterial blood oxygen tension leads to vasoconstriction of retinal vessels, possibly related to an interaction between reactive oxygen species and endothelium-derived vasoactive factors.
- Trial name
- NCT00712907
- Testing
- vitamin C (Mayrhofer) 24mg/min i.v. for 64 min, 100% O2 (AGA) two times for 12 min
- Where
- Austria
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Healthy, Normoxia
Measurement of Retinal Blood Flow, Retinal Oxygenation and Retinal Oxygen Extraction in Healthy Subjects During Normoxia and Systemic Hyperoxia
The inner retina is crucially dependent on an adequate retinal blood supply. When the retina becomes ischemic and hypoxic this results in severe vision loss due to retinal neovascularization.
- Conditions
- Healthy, Normoxia, Systemic Hypoxia
- Trial name
- NCT00914407
- Testing
- Oxygen
- Where
- Austria
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Hyperoxia, Hypoxia
The Association Between Sensory Block Level, Oxygen Therapy, and ORi in Varicose Vein Patients Undergoing Spinal Anesthesia (ORi: Oxygen Reserve Index)
The assessment of peripheral capillary oxygen saturation (SpO2) by pulse oximetry has become standard in perioperative care for the detection of hypoxaemia.
- Trial name
- ORi (NCT06566690)
- Testing
- Addition of ORi monitoring to SpO2 monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Healthy
The Validity of Retinal Blood Flow Measurements During Hyperoxia in Humans Using Fourier Domain Color Doppler Optical Coherence Tomography (CDOCT)
Noninvasive monitoring of blood flow in retinal circulation may elucidate the progression and treatment of ocular disorders, including diabetic retinopathy, age-related macular degeneration and glaucoma.
- Trial name
- NCT00431600
- Testing
- 100% Oxygen
- Where
- Austria
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Chronic Obstructive Pulmonary Disease
Effect of Supplemental Oxygen on Maximal Oxygen Consumption in Patients With Chronic Obstructive Pulmonary Disease
Maximal consumption of oxygen (VO2max) during exercise is used in patients with chronic obstructive pulmonary disease (COPD) to stratify perioperative risk.
- Trial name
- NCT01294033
- Testing
- Fractional inspired oxygen (FiO2) 0.21, Fractional inspired oxygen 0.28
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Hypovolemia, Hyperoxia
Supplemental Oxygen in Hypovolemia
Supplemental oxygen is frequently administered in acutely and critically ill patients, specifically, it is often administered in trauma patients to avoid arterial hypoxemia and tissue hypoxia.
- Trial name
- NCT05150418
- Testing
- Oxygen gas, Air
- Where
- Norway
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Cognition
Acute Effects of Supplemental Oxygen on Memory Testing in Healthy Adult Volunteers
Forty healthy adults (i.e., not recruited with respect to any particular diagnosis) are each alternately provided with supplemental oxygen and air via nasal cannula at about 6 Liters per Minute (LPM), while completing memory…
- Trial name
- NCT06555484
- Testing
- Cross Over Assignment Supplemental Oxygen and Supplemental Air
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Inogen Inc.
Oxygen Toxicity, Oxidative Stress
Effect of Hydrogen Gas on Hyperbaric Oxygen Toxicity
The goal of this trial is to investigate whether adding a small fraction of hydrogen gas to an oxygen-enriched breathing mixture can reduce pulmonary oxygen toxicity (POT) in healthy and active divers from the Swedish Armed…
- Conditions
- Oxygen Toxicity, Oxidative Stress, Hyperoxia, Hyperbaric Oxygen
- Trial name
- NCT07263399
- Testing
- Inhaled Hydrogen-Enriched Oxygen Gas, Inhaled Nitrogen-Enriched Oxygen Gas
- Where
- 2 sites in Sweden
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Blekinge Institute of Technology
Intraocular Pressure
The Response of Intraocular Pressure to Systemic Hypercapnia and Hyperoxia
The purpose of this study is to determine how intraocular pressure responds to changes in the levels of carbon dioxide or oxygen that a healthy individual inspires.
- Trial name
- NCT01325285
- Testing
- RespirAct
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Oxygen, Hyperoxemia
Cerebral Hemodynamic Effects of Oxygen and Antioxidants (CHEOXANT)
This study is called CHE-OX-ANT (Cerebral Hemodynamic Effects of Oxygen and Antioxidants). It is a single-center, academic research project led by the Department of Intensive Care at Erasme Hospital (Université Libre de…
- Conditions
- Oxygen, Hyperoxemia, Antioxidant, Cerebral Autoregulation
- Trial name
- CHEOXANT (NCT07369232)
- Testing
- Oxygen, Vitamin C (Ascorbic Acid)
- Where
- Belgium
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Cerebrovascular Disorders
HYPEROXIA Responses and ROS
30 participants (15 males and 15 females) who are ≥18 - ≤ 40 years old and considered healthy will be enrolled into this study to test the role of reactive oxygen species (ROS) in regulating cerebral blood flow (CBF).
- Trial name
- NCT05958303
- Testing
- Antioxidant Cocktail
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Atelectasis
Effect of Hyperoxia and Hypergravity on Lung Ventilation and Perfusion
The primary aim of this project is to get further knowledge on the effects of + Gz accelerations and hyperoxia on lung ventilation in humans.
- Trial name
- NCT01993394
- Testing
- hypergravity, gas mixture
- Where
- 2 sites in France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Hyperoxia
Assessment of Oxygenation With Oxygen Reserve Index for General Anesthesia
To assess oxygenation with the oxygen reserve index in desflurane anesthesia administration using low and high fresh gas flows for tympanomastoidectomy surgeries.
- Trial name
- NCT04698863
- Testing
- Oxygen reserve index
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Zonguldak Bulent Ecevit University
Athletic Performance, Hyperbaric Oxygenation
Acute Effects of Post-Exercise Hyperoxia on Recovery in Cycling
This study examines whether exposition to hyperbaric oxygen after a road-race simulation can help competitive cyclists recover and perform better the following day.
- Conditions
- Athletic Performance, Hyperbaric Oxygenation, Physical Endurance, Muscle Fatigue
- Trial name
- NCT07659301
- Testing
- Post-exercise Recovery
- Where
- Belgium
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) (ICD-10 G93.3)
Investigating the Effects of Intermittent Hypoxia-Hyperoxia Treatment (IHHT) in People With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) to Improve Fatigue, Pain, and Quality of Life by Targeting Mitochondrial Dysfunction and Autonomic Nervous System Impairment
This study is testing a new treatment for people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and long-term symptoms after COVID-19.
- Trial name
- REenergizeME (NCT07317401)
- Testing
- Intermittent hypoxia-hyperoxia treatment (IHHT)
- Where
- Denmark
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Aging
A Dosing Study of Hyperbaric Oxygen Therapy (HBOT) on Epigenetic Aging
This study aims to assess the impact of hyperbaric oxygen therapy on a number of outcomes, including epigenetic aging, inflammation, and cellular health.
- Trial name
- HBOT (NCT05297019)
- Testing
- Hyperbaric Oxygen Therapy
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- TruDiagnostic
Retinopathy of Prematurity
Time Outside Target Oxygen Saturation Range in Preterm Infants and Long Term Outcomes and Preterm Infants
The purpose of this study is to determine if there is a relationship between time spent out the targeted oxygen saturation range in preterm infants is associated with long-term outcomes such as Retinopathy of Prematurity.
- Trial name
- SAT01ROP (NCT00845624)
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Hyperoxia, Hypoxia, Brain
Neuroimaging During Pure Oxygen Breathing
The investigators will conduct a non-randomized clinical trial to examine the effect of pure oxygen breathing on the brain. The study will compare cerebral blood flow, cortical electrical activity, and cognitive performance in 32…
- Conditions
- Hyperoxia, Hypoxia, Brain, Neurobehavioral Manifestations
- Trial name
- NCT03268590
- Testing
- Oxygen
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University