Clinical trials: Hyperparathyroidism, Primary
Hyperparathyroidism
Swalqol in Primary Hyperparathyroidism
Swallow related quality of life before and after parathyroidectomy will be evaluated in patients with primary hyperparathyridism.
- Trial name
- NCT03968510
- Testing
- parathyroidectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Uşak University
Primary Hyperparathyroidism
OPG/Soluble RANKL (sRANKL) and Bone Mineral Density in Primary Hyperparathyroidism
The purpose of this study is to determine whether osteoprotegerin and RANKL (receptor activator of nuclear factor-κB ligand) are involved in bone remodeling in patients with primary hyperparathyroidism (PHPT), and whether…
- Trial name
- NCT01889134
- Testing
- Sedron (alendronate), Parathyroidectomy
- Where
- Poland
- Volunteers
- 112 people
- Sponsor
- Wroclaw Medical University
Primary Hyperparathyroidism, Osteoporosis
Osteoporosis in Primary Hyperparathyroidism
Investigators will prospectively include 40 postmenopausal women with secondary osteoporosis due to primary hyperparathyroidism who have refused surgery.
- Trial name
- NCT04085419
- Testing
- Denosumab 60 MG/ML Prefilled Syringe [Prolia], Zoledronic Acid
- Where
- Slovenia
- Volunteers
- 40 people
- Sponsor
- University Medical Centre Ljubljana
Multiple Endocrine Neoplasia, Pancreatic Neuroendocrine Tumors
Variables That Are Correlated to Developing Multiple Endocrine Neoplasia (MEN) and Pancreatic Neuroendocrine Tumors (PNET)
The study aims to identify predictors of disease in patients with hyperparathyroidism (HPTH) who undergo surgery.
- Conditions
- Multiple Endocrine Neoplasia, Pancreatic Neuroendocrine Tumors, Hyperparathyroidism
- Trial name
- NCT03053999
- Testing
- Genome Sequencing, Data Review
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- M.D. Anderson Cancer Center
Primary Hyperparathyroidism
NIRAF-camera Versus Conventional Surgery in Preoperative Imaging Negative Primary Hyperparathyroidism
Primary hyperparathyroidism (PHPT) is a prevalent endocrine disorder, with an estimated prevalence of 0.86% in the United States. The only definitive treatment for PHPT is parathyroidectomy.
- Trial name
- NCT07812649
- Testing
- NIRAF-camera
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- The Cleveland Clinic
Primary Hyperparathyroidism
11C Methionine PET for the Detection of Hyperfunctional Parathyroid Tissues
The overall sensitivity and specificity of 11C-MET PET/CT is superior to 18F-FDG PET/CT and conventional SPECT-CT for the detection of abnormal parathyroid glands.
- Trial name
- NCT01783002
- Testing
- 11C-Methionine PET/CT scanning, 18F-FDG PET/CT scanning, SPECT-CT scanning
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of British Columbia
Primary Hyperparathyroidism, Vitamin D Deficiency
Vitamin D Repletion in Primary Hyperparathyroidism
This study will look at the effect of 2 treatment regimens that contain vitamin D in a six-month treatment trial of patients with PHPT who are vitamin D deficient.
- Trial name
- NCT01306656
- Testing
- 10,000 IU Vitamin D3, Vitamin D
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Columbia University
Hyperparathyroidism, Secondary, Hyperparathyroidism, Primary
Study on the Use of Cinacalcet in Phosphocalcic Context.
Currently, the indications used for MA (Marketing Authorization) Cinacalcet in France are hyperparathyroidism (hyperPTH) in adults, whether primary (for patients in whom parathyroidectomy is theoretically indicated but in whom it…
- Trial name
- CALCI-CINA (NCT04126954)
- Testing
- Serum PTH concentrations results
- Where
- 10 sites in France
- Volunteers
- 25 people
- Sponsor
- Hospices Civils de Lyon
Primary Hyperparathyroidism
Near Infrared Fluorescent Imaging in Thyroid and Parathyroid Surgery With the Fluobeam(TM) System of Fluoptics
Hypothesis: Intraoperative use of near infrared fluorescent imaging technology and detection of Methylene Blue fluorescence will improve outcomes following thyroid and parathyroid surgery.
- Trial name
- NCT01598727
- Testing
- Fluobeam(TM) Imaging System (Fluoptics)
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Cure Rate, Complication Rate
Thermal Ablation Versus Parathyroidectomy for Primary Hyperparathyroidism
This study is a prospective, multicenter study designed to compare the efficacy and safety of surgical treatment versus ablation therapy (including radiofrequency ablation and microwave ablation) for patients with primary…
- Conditions
- Cure Rate, Complication Rate, Efficacy and Safety
- Trial name
- NCT06708871
- Testing
- Thermal ablation, Parathyroidectomy
- Volunteers
- 520 people
- Sponsor
- Chinese PLA General Hospital
Primary Hyperparathyroidism
Primary Hyperparathyroidism: Short-term Calcimimetics Treatment - Relevance for Parathyroid Surgery Decisions?
Patients with primary hyperparathyroidism (pHPT) often present with fatigue, psychological and cognitive symptoms. Improvement in these symptoms after parathyroid adenomectomy (PTX) has been reported.
- Trial name
- NCT02227264
- Testing
- Cinacalcet, parathyroid adenomectomy
- Where
- Sweden
- Volunteers
- 110 people
- Sponsor
- Karolinska University Hospital
Primary Hyperparathyroidism
Impact of Parathyroidectomy on Renal Function
Primary hyperparathyroidism (PHPT) is a disorder of one or more of the parathyroid glands. The parathyroid gland(s) becomes overactive and secretes excess amounts of parathyroid hormone (PTH).
- Trial name
- PARA-REIN (NCT04798092)
- Testing
- parathyroidectomy
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Central Hospital, Nancy, France
Primary Hyperparathyroidism
Evaluating Alternative Medical Therapies in Primary Hyperparathyroidism
This study will evaluate whether blocking the mineralocorticoid receptor, alone, or in combination with the calcimimetic cinacalcet, can lower parathyroid hormone and calcium levels in primary hyperparathyroidism.
- Trial name
- NCT02525796
- Testing
- eplerenone, amiloride, Cinacalcet
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Brigham and Women's Hospital
Primary Hyperparathyroidism
Effect of Parathyroidectomy on Cardiovascular Health
The aim of this study is to establish whether patients with mild primary hyperparathyroidism (PHPT) have an increased risk of cardiovascular diseases.
- Trial name
- NCT02989428
- Testing
- Early parathyroidectomy group (EPTX-group)
- Where
- Denmark
- Volunteers
- 69 people
- Sponsor
- University of Aarhus
Primary Hyperparathyroidism
Surgery for Primary Hyperparathyroidism (pHPT) in Patients Older Than 65 Years Compared With Follow-up
General consensus and contemporary guidelines, recommend surgery for primary hyperparathyroidism (pHPT)for all patients below the age of 50, for patients with pronounced hypercalcemia and for patients with organ complications to…
- Trial name
- NCT01087619
- Testing
- Parathyroid surgery
- Where
- Sweden
- Volunteers
- 102 people
- Sponsor
- Region Skane
Primary Hyperparathyroidism, Bone Metabolism
Primary Hyperparathyroidism: Does a Systematic Treatment Improve the Calcium and Bone Metabolism After Surgery?
Primary Hyperparathyroidism (pHPT) increases bone turnover and resorption and thus calcium efflux out of bone. After successful surgical treatment of pHPT, bone takes up calcium again which may result in secondary…
- Trial name
- NCT00973336
- Testing
- Calcium and vitamin D
- Where
- Austria
- Volunteers
- 80 people
- Sponsor
- Medical University of Vienna
Primary Hyperparathyroidism
Preliminary Study Concerning the Validity of Parathyroid Exploration on a CZT Camera
The goal of this study is to assess the performance of parathyroid imaging on a cardiac-dedicated CZT camera, compared to planar pinhole imaging, in patients referred for primary hyperparathyroidism.
- Trial name
- PARAT-CZT (NCT02854345)
- Testing
- Tomoscintigraphic parathyroid imaging on a CZT camera
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Hyperparathyroidism
Comparison of Two Methods of Parathyroidectomy for Primary Hyperparathyroidism
Parathyroid glands are small endocrine glands that secrete a hormone which controls blood calcium levels. Primary hyperparathyroidism (PH) is a common disorder whereby one or more of these glands may enlarge and overproduce their…
- Trial name
- NCT00006329
- Testing
- Minimally invasive radioguided parathyroidectomy
- Where
- United States
- Sponsor
- National Center for Research Resources (NCRR)
Parathyroid Carcinoma
European Multicentric Study on Parathyroid Carcinoma
The main aim of the study is to evaluate the incidence of post-operative diagnosis of PC and atypical parathyroid neoplasm in patients who underwent surgery for pHPT in different European centers using the EUROCRINE® database.
- Trial name
- EMS-PC (NCT05789680)
- Testing
- Surgical treatment of parathyroid carcinoma
- Where
- Italy
- Volunteers
- 17 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Primary Hyperparathyroidism, Type 2 Diabetes
Glycemic Control, Type II Diabetes, Parathyroidectomy
The purpose of this study is to assess glycemic control after parathyroidectomy in patients with primary hyperparathyroidism and concomitant type 2 diabetes mellitus.
- Trial name
- NCT05761743
- Testing
- Urine and Blood Test
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- The Cleveland Clinic