Clinical trials: Hyperpigmentation
- Condition Hyperpigmentation
- Funder type Industry (pharma, biotech, devices)
- Accepts healthy volunteers yes
Skin Pigmentation, Healthy Volunteers
Efficacy of Cosmetic Products in Preventing Pigmentation Induced by High Energy Visible Light (HEVL) [400-450nm]
The goal of this double-blind, randomized clinical trial is to evaluate the efficacy of anti-pigmentation cosmetic products in preventing skin pigmentation induced by High Energy Visible Light (HEVL) [400-450nm] in healthy…
- Conditions
- Skin Pigmentation, Healthy Volunteers, Hyperpigmentation
- Trial name
- NCT07537595
- Testing
- Treated and exposed zones (cosmetic topical products applied), Untreated and exposed zone (no product applied)
- Where
- Romania
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Periorbital Hyperpigmentation, Periorbital Edema
A 12 Week Study to Evaluate the Efficacy of an Eye Cream
This single center, open-label clinical study was conducted to assess the efficacy and tolerance of a topical eye cream when used over the course of 12 weeks by healthy women with moderate to severe under-eye dark circles…
- Conditions
- Periorbital Hyperpigmentation, Periorbital Edema, Fine Lines, Wrinkle
- Trial name
- NCT05807620
- Testing
- Gentle Cleansing Lotion, Facial Moisturizer, Sunscreen SPF 30
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Revision Skincare
Hyperpigmentation, Skin Ageing
Evaluation of the Safety and Tolerability of a Brightening Treatment Paired With a Skincare Regimen
A12-week single-center, open-label, clinical study is being conducted to assess the efficacy and tolerability of the Brightening Treatment paired with a skincare regimen on healthy female subjects aged 20-65 years with…
- Conditions
- Hyperpigmentation, Skin Ageing, Post Inflammatory Hyperpigmentation, Skin Roughness
- Trial name
- NCT07501000
- Testing
- Brightening Treatment
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Revision Skincare
Photoaging, Hyperpigmentation
Randomized, Double-Blind Evaluation of Maple Leaf Extract (Maplifa) for Photoaging
Recent research has reported that the maple leaf extract exhibits anti-aging effects by inhibiting elastase activity, thereby preventing the breakdown of elastin and interfering with the formation of wrinkles.
- Conditions
- Photoaging, Hyperpigmentation, Rhytides
- Trial name
- NCT04586816
- Testing
- 1% red maple leaf extract in cream base, 5% red maple leaf extract, vehicle
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Integrative Skin Science and Research
Acne, Postinflammatory Hyperpigmentation
Efficacy of La Roche Posay Routine in the Management of Facial Post Inflammatory Hyperpigmentation (PIHP)
The goal of this clinical trial is to test and compare La Roche Posay routine --the studied product-- with a comparator product in participants with acne.
- Trial name
- PIHP (NCT06770127)
- Where
- Mauritius
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Melasma
Sylfirm X Radiofrequency Microneedling for the Treatment of Melasma
Microneedling radiofrequency technology has been shown in clinical studies to improve skin quality, tone, pigment, and to treat various skin conditions related to aging.
- Trial name
- NCT06415435
- Testing
- Radiofrequency Microneedling
- Where
- 3 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Benev Company, Inc.
Hyperpigmentation, Photodamaged Skin
A Multi-Center, Open-label Study Evaluate the Efficacy and Tolerability of a Dual Skincare Regimen Treatment for Facial Hyperpigmentation and Photodamaged Skin in Patients Exposed to Extrinsic Factors of Aging
This open-label, multi-center clinical trial was conducted to evaluate the dual skincare regimen of vitamin C serum and moisturizing sunscreen SPF 45 to improve facial hyperpigmentation and photodamage after 12 weeks of twice…
- Conditions
- Hyperpigmentation, Photodamaged Skin, Wrinkle, Fine Lines
- Trial name
- NCT05423873
- Testing
- Gentle Cleansing Lotion, Revision Skincare
- Where
- 3 sites in United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Revision Skincare
Hyperpigmentation, Dark Spots
A 16-week Clinical Study Investigating a Dark Spot Corrector Serum in Women With Moderate Discrete Hyperpigmentation
This was a single-center, double-blinded, randomized, controlled cosmetic clinical trial to investigate the efficacy and tolerance of dark spot corrector serum and regimen skincare products when used over the course of 16 weeks…
- Trial name
- NCT07468175
- Testing
- Cosmetic dark spot corrector serum
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Revision Skincare
Skin Barrier to Water Loss, Skin Health
Apple Peptide Complex for Post-Surgical and Aesthetic Skin Recovery
This clinical study evaluates a topical botanical formulation for supporting skin recovery following invasive and non-invasive aesthetic procedures.
- Conditions
- Skin Barrier to Water Loss, Skin Health, Skin Discoloration, Skin Irritation
- Trial name
- APC-SKIN (NCT07807085)
- Testing
- Apple Peptide Complex Post-Aesthetic Care Protocol
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Grow Out Oils Clinical Aromatherapy Company
Melasma
LaseMD System for the Treatment of Melasma
This study will evaluate the clinical outcomes associated with use of the LaseMD Laser System for the treatment of melasma.
- Trial name
- NCT03456674
- Testing
- LaseMD System
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- CynosureLutronic
Hyperpigmentation, Skin Aging
Identification of Gene Biomarkers in Aging Skin
This study is a blinded, prospective, single-center, clinical study conducted in Japanese female subjects between the ages of 20-75 years.
- Trial name
- NCT00884936
- Where
- Japan
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Interleukin Genetics, Inc.
Hyperpigmentation
Efficacy and Tolerability of the Tested Formula After 3 Months in Treatment of Facial Hyperpigmentation of 3 Origins
The objective of this study is to evaluate the efficacy, cosmetic acceptability and improvement of the stigmatization of the tested product (2039125 03) used bis in die (BID) for 3 months in adult patients suffering from mild to…
- Trial name
- NCT06253455
- Testing
- tested product
- Where
- China
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Melasma
Efficacy and Safety of PiQo4 Device for Treatment of Melasma
Single center, Prospective, Open Label with Split-face Study Design. Face sides will be randomized to receive either 1064nm alone or 1064nm \& 585nm combination treatment.
- Trial name
- NCT03565341
- Testing
- PiQo4
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Focus Medical, LLC
Hyperpigmentation, Melasma
Evaluation of Efficacy and Tolerabilty of MelaB3 Serum in Combination of 35% Glycolic Acid Peeling Compared to 35% Glycolic Acid Peeling Alone in Various Hyperpigmentation Conditions
Randomized clinical trial to assess the effectiveness and tolerability of Mela B3 serum in combination with 35% glycolic acid peel vs.
- Conditions
- Hyperpigmentation, Melasma, Solar Lentigo, Peeling
- Trial name
- NCT07429786
- Testing
- Glycolic acid peel alone, MelaB3 serum
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Healthy
Safety and Efficacy of Topical Cream for Post-inflammatory Hyperpigmentation Skin Among Malaysians
This study was conducted to determine safety and efficacy of topically applied cream containing combination of niacinamide, arbutin, Scutellaria Baicalensis Root Extract, Centella Asiatica Extract and Camellia Sinensis Leaf…
- Trial name
- NCT05986123
- Testing
- Topical cream Z for PIH
- Where
- Malaysia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- USMARI Research & Innovation Centre
Melasma
Efficacy and Tolerability of Test Product Versus Cysteamine 5% in Treatment of Facial Epidermal Melasma
This interventional, randomized, investigator blinded, controlled study conducted in one centre consists in a 4-month evaluation period within the same season avoiding sunny season on 140 subjects with facial epidermal melasma.
- Trial name
- NCT06278948
- Testing
- Group TP, Group CYS
- Where
- India
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Melasma
EFFICACY and TOLERABILITY of TESTED FORMULA VS. HYDROQUINONE 4% in the TREATMENT of FACIAL MELASMA
This study aims at assessing the non-inferiority of tested formula facial serum (2039125 03) versus hydroquinone 4% over 3 months for treatment and then 3 months for maintenance ofwomen subjects presenting facial melasma.
- Trial name
- NCT06787846
- Testing
- Experimental: Group TP, Active Comparator: Group HQ: Hydroquinone 4%
- Where
- Brazil
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Hyperpigmentation
Efficacy and Tolerability of Tested Formula After 3 Months in Treatment of Facial Hyperpigmentation of 3 Origins
The objective of this study is to evaluate the efficacy, cosmetic acceptability and improvement of the stigmatization of the tested product (2039125 03) used bis in die (BID) for 3 months in adult patients suffering from mild to…
- Trial name
- NCT06320314
- Testing
- tested product (2039125 03)
- Where
- Portugal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Hyperpigmentation
Efficacy and Tolerability of Tested Formula After 3 Months of Treatment of Facial Hyperpigmentation of 3 Origins
The objective of this study is to evaluate the efficacy, cosmetic acceptability and improvement of the stigmatization of the tested product (2039125 03) used bis in die (BID) for 3 months in adult patients suffering from mild to…
- Trial name
- NCT06253468
- Testing
- tested product
- Where
- Singapore
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Lentigines
A Single-Center 2-Arm Study for Lentigines on the Hands
The purpose of this study is to evaluate the effectiveness and safety of two laser systems for improvement of lentigines on the hands.
- Trial name
- NCT02763072
- Testing
- Enlighten Laser, Excel V Laser
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cutera Inc.