Clinical trials: Hyperpigmentation
Picoseconds Laser, Melasma
A Comparative Study for Efficacy and Safety Between 4% Hydroquinone Cream With or Without Fractional Picosecond 1,064 nm Laser for the Treatment of Dermal or Mixed Type Melasma
A Comparative study for Efficacy and Safety Between 4% hydroquinone cream with or without Fractional Picosecond 1,064 nm Laser for the Treatment of Dermal or Mixed Type Melasma
- Trial name
- NCT03049059
- Testing
- Fractional Picosecond 1,064 nm laser, 4% hydroquinone cream
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mae Fah Luang University Hospital
Freckles
Efficacy and Safety of Fractional Carbon Dioxide Laser for Treatment of Facial Freckles.
Freckles are clusters of melanin in the superficial epidermis. They affect mostly face and sun exposed areas, and appear as flat brown or red macules that fade in winter, usually in a fair complexion patient, but may be present…
- Trial name
- NCT01545869
- Testing
- Fractional carbon dioxide laser
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University
Familial Pancreatic Cancer, BRCA1 Mutation
Registry of Subjects at Risk of Pancreatic Cancer
IRFARPC is a multicenter national registry designed to study the diagnosis and predisposing factors of subjects with an inherited increased risk for pancreatic cancer.
- Conditions
- Familial Pancreatic Cancer, BRCA1 Mutation, BRCA2 Mutation, Lynch Syndrome
- Trial name
- IRFARPC (NCT04095195)
- Testing
- MRCP, Endoultrasonography
- Where
- 4 sites in Italy
- Volunteers
- 1,000 people
- Sponsor
- Associazione Italiana per lo Studio del Pancreas
Nevus, Hyperpigmentation
Effect of Cold Air Cooling on the Incidence of Post Inflammatory Hyperpigmentation Following Laser Treatment
To investigate the benefit of epidermal cooling on the incidence of post inflammatory hyperpigmentation after laser irradiation
- Trial name
- NCT00287001
- Testing
- Cold air cooling
- Where
- Thailand
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Skin Pigmentation, Skin Irritation
Efficacy and Safety of Biocellulose Sheet Containing Anti-hyperpigmentation Agent ("Biocellulose Mask", "Farhorm®") in Patients Receiving Laser Treatment
The laser areas treated with biocellulose sheet from coconut juice containing anti-hyperpigmentation agent ("biocellulose mask", "Farhorm®") heal faster than vaseline ointment which is a standard treatment.
- Trial name
- NCT01806831
- Testing
- "Biocellulose Mask", Farhorm®"
- Where
- Thailand
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Photoaging, Hyperpigmentation
Randomized, Double-Blind Evaluation of Maple Leaf Extract (Maplifa) for Photoaging
Recent research has reported that the maple leaf extract exhibits anti-aging effects by inhibiting elastase activity, thereby preventing the breakdown of elastin and interfering with the formation of wrinkles.
- Conditions
- Photoaging, Hyperpigmentation, Rhytides
- Trial name
- NCT04586816
- Testing
- 1% red maple leaf extract in cream base, 5% red maple leaf extract, vehicle
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Integrative Skin Science and Research
Facial Hyperpigmentation
Efficacy and Tolerability of an Isobutylamido-thiazolyl-resorcinol Cream 0.2% for Facial Hyperpigmentation
Facial hyperpigmentation is a common skin issue that can cause embarrassment and affect the quality of life in majority of people.
- Trial name
- NCT03926845
- Testing
- Isobutylamido-thiazolyl-resorcinol Cream 0.2%, Vehicle
- Where
- Thailand
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Institute of Dermatology, Thailand
Chloasma
Efficacy and Safety Trial of Using Ultra-Pulsed Shockwaves to Deliver Tranexamic Acid for the Treatment of Melasma
Melasma is a prevalent chronic facial pigmentation condition affecting Asian women of childbearing age, attributed to genetic predisposition, sunlight exposure, and hormonal changes.
- Trial name
- NCT06418568
- Testing
- Ultra-pulsed Shockwave Therapy Device by Shenzhen Lifotronic Technology Co., Ltd.
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hyperpigmentation
The Effectiveness of a Novel Lip Product Containing Caulerpa Lentillifera Extract for Reducing Lip Hyperpigmentation
The goal of this clinical trial is to evaluate the efficacy of the novel lip product containing Caulerpa lentillifera extract on the appearance and perception of dark lips in Thai adults aged 18 to 60 who report concerns about…
- Trial name
- NCT07067879
- Testing
- Lip product
- Where
- Thailand
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Periorbital Hypermelanosis
Evaluation of the Therapeutic Effect of Platelet Rich Plasma (PRP) in Periorbital Hyperpigmentation(POH)
To evaluate the saftey and efficicacy of autologous PRP in treatment of POH.
- Trial name
- NCT03862118
- Testing
- PRP
- Volunteers
- 30 people
- Sponsor
- Assiut University
Pancreas Cancer, Peutz-Jeghers Syndrome (PJS)
The Cancer of the Pancreas Screening-5 CAPS5)Study
Johns Hopkins clinical research office quality assurance group will monitor and audit this study at Johns Hopkins. The Sub Investigator at each site will be responsible for internal monitoring at their site.
- Conditions
- Pancreas Cancer, Peutz-Jeghers Syndrome (PJS), Gene Mutation, Germline Mutation Carrier
- Trial name
- CAPS5 (NCT02000089)
- Testing
- Secretin, MRI, Tumor marker gene test with CA19-9
- Where
- 9 sites in United States
- Volunteers
- 9,000 people
- Sponsor
- Johns Hopkins University
Melasma
Comparison Of Efficacy Of Combination Of TAM Formula Vs Kligman Formula For Melasma.
This study would offer the participants about the knowledge of these formula in the treatment of melasma and help the investigators in incorporating and updating the management protocols in medical practice.
- Trial name
- NCT06013540
- Testing
- TAM formula (hydroquinone 2%, tretinoin 0.05% and 5% vitamin C), Kligman formula (hydroquinone 4%, fluocinolone acetonide 0.01% and tretinoin 0.05%)
- Where
- Pakistan
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Jinnah Postgraduate Medical Centre
Skin Quality
Laser Treatment to Improve Skin Quality
To assess the efficacy of a 1064nm picosecond laser (PicoWay; Candela; Marlborough, MA) with diffractive lens array and a picosecond 755nm laser (PicoSure®; Cynosure®; Westford, MA) with diffractive lens array in subjects for the…
- Trial name
- NCT05595525
- Testing
- 1064NM pico Laser, 755NM pico Laser
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Goldman, Butterwick, Fitzpatrick and Groff
Gingival Hyperpigmentation
Clinical Effectiveness Of Polishing Brush Compared To Ceramic Soft Tissue Trimming Bur In Gingival Depigmentation
Gingival hyperpigmentation, particularly of melanin origin, can pose significant aesthetic concerns, especially among patients with a high smile line.
- Trial name
- NCT07402720
- Testing
- Gingival Depigmentation using polishing brush, Depigmentation using ceramic soft tissue trimming bur
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University
Melasma
USE THE SYSTEMIC METFORMIN IN MELASMA
Melasma is a chronic and relapsing acquired dyschromia due to an increased epidermal-melanin unit activity that affects sun-exposed areas mainly in women throughout the reproductive years.
- Trial name
- NCT03475524
- Testing
- MetFORMIN 1000 Mg Oral Tablet, Trichloroacetic Acid Peeling, MetFORMIN 500 Mg Oral Tablet
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Scars, Delayed Wound Healing
Nanofat on Wound Healing and Scar Formation
This study will evaluate the effectiveness and safety of intradermal injection of Nanofat on wound healing and scar formation.
- Conditions
- Scars, Delayed Wound Healing, Hypertrophic Scar, Post Inflammatory Hyperpigmentation
- Trial name
- NFWHSF (NCT03850119)
- Testing
- Nanofat injection
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Melasma
Efficacy and Safety of Therapy With Tri-Luma® Cream in Sequence With Glycolic Acid Peels for Melasma
To determine the effectiveness and safety of sequential therapy with of Tri-Luma® Cream and a series of Glycolic Acid peels in treatment of moderate to severe melasma.
- Trial name
- NCT00472966
- Testing
- Fluocinolone acetonide 0.1%/hydroquinone 4%/tretinoin 0.05% Cream in sequence with glycolic acid peels
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Galderma R&D
Acne, Postinflammatory Hyperpigmentation
Efficacy of La Roche Posay Routine in the Management of Facial Post Inflammatory Hyperpigmentation (PIHP)
The goal of this clinical trial is to test and compare La Roche Posay routine --the studied product-- with a comparator product in participants with acne.
- Trial name
- PIHP (NCT06770127)
- Where
- Mauritius
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Melasma
Stem Cell Derived Exosomes in the Treatment of Melasma and Its Percutaneous Penetration
Melasma is a refractory skin disease due to its complex pathogenesis and difficult treatment. Studies have found that human umbilical cord mesenchymal stem cell-derived exosomes (hUCMSC-Exos) could serve as a novel cell-free…
- Trial name
- NCT06221787
- Testing
- 1565 nm non-ablative fractional laser combined with normal saline, microneedles combined with hUCMSC-Exos, 1565 nm non-ablative fractional laser combined with hUCMSC-Exos
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University Union Hospital
Acanthosis Nigricans
Study of the Effect of Fractional co2 Laser Versus Q Switched:NdYAG Laser in the Treatment of Acanthosis Nigricans
This prospective randomized comparative split study will be conducted at the outpatient clinic, Dermatology department, Faculty of Medicine, Cairo University and will include 20 patients with acanthosis nigricans in otherwise…
- Trial name
- NCT04893304
- Testing
- co2 laser
- Volunteers
- 20 people
- Sponsor
- Cairo University