Clinical trials: Hypersecretion; Cortisol
Cushing's Syndrome I, Cushing Disease Due to Increased ACTH Secretion
SPI-62 as a Treatment for Adrenocorticotropic Hormone-dependent Cushing's Syndrome
This is a randomized, placebo-controlled, study of SPI-62 in subjects with ACTH-dependent Cushing's syndrome caused by a non-adrenal tumor.
- Conditions
- Cushing's Syndrome I, Cushing Disease Due to Increased ACTH Secretion, Cortisol Excess, Cortisol; Hypersecretion
- Trial name
- RESCUE (NCT05307328)
- Testing
- SPI-62
- Where
- 12 sites in United States, Bulgaria and 1 more
- Volunteers
- 26 people
- Sponsor
- Sparrow Pharmaceuticals
Diabetes Mellitus, Type 2, Obesity
Type 2 Diabetes, Obesity and Cortisol Excess
The present observational cross-sectional study is aimed to assess: the hidden hypercortisolism (HidHyCo) prevalence in a sample of Type 2 diabetes (T2D) patients and the clinical characteristics more frequently associated with…
- Conditions
- Diabetes Mellitus, Type 2, Obesity, Cortisol; Hypersecretion
- Trial name
- DOCOR (NCT05759637)
- Testing
- 1mg DST
- Where
- 5 sites in Italy
- Volunteers
- 3,200 people
- Sponsor
- Istituto Auxologico Italiano
Crp, Insulin Resistance
The Effect of Oral Whey Consumption on Insulin Resistance, Cortisol, Crp, Albumin Level and Healing Quality Before Total Hip Arthroplasty
Purpose: It was planned to determine the effect of oral whey given before total hip arthroplasty (THA) on postoperative insulin resistance, cortisol, CRP((C reactive protein), albumin level and healing quality.
- Conditions
- Crp, Insulin Resistance, Cortisol; Hypersecretion, Albus; Lichen
- Trial name
- WHEY THA (NCT06307782)
- Testing
- whey protein intake before surgery, Water before surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Acute Coronary Syndrome, Stress Hyperglycemia
Cellular Immunity, Neuroendocrine, and Inflammatory Factors for Clinical Prognosis in Acute Coronary Syndrome
In acute coronary syndrome (ACS), there is an increase in cortisol levels, as an expression of the stress response, and C-reactive protein, as an expression of the inflammatory response, which are in turn associated with changes…
- Conditions
- Acute Coronary Syndrome, Stress Hyperglycemia, Cortisol; Hypersecretion, Inflammatory Response
- Trial name
- NCT06513611
- Testing
- Serum cortisol.
- Where
- Argentina
- Volunteers
- 150 people
- Sponsor
- Hospital de Clinicas José de San Martín
Sleep Disturbance, Craving
The Efficacy of Suvorexant in Treatment of Patients With Substance Use Disorder and Insomnia: A Pilot Open Trial
Insomnia is an extremely common and poorly treated problem in patients with substance use disorders (SUD)s undergoing rehabilitation treatment in a residential facility.
- Conditions
- Sleep Disturbance, Craving, Cortisol; Hypersecretion
- Trial name
- Suvsubuse (NCT03412591)
- Testing
- Suvorexant 20 mg
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Milton S. Hershey Medical Center
Stress, Cortisol; Hypersecretion
Effect of Maternal Cortisol Levels on Fetal Heart Rate Patterns
Objective: This study was designed to determine whether maternal cortisol levels affect fetal heart rate (FHR) patterns at third trimester. Design: Cross-sectional descriptive study.
- Conditions
- Stress, Cortisol; Hypersecretion, Fetal Heart Rate Disorder
- Trial name
- NCT05503433
- Volunteers
- 392 people, healthy volunteers welcome
- Sponsor
- Halic University
Stress, Emotional, Dental Anxiety
Salivary Immune/Stress Biomarkers Among Children
Background: The use of easily accessible biomarkers for assessing young patients' health is important. This study's aim is a measuring stress/immune biomarkers in saliva of healthy school-age children and compare subgroups…
- Conditions
- Stress, Emotional, Dental Anxiety, Dental Pain and Sensation Disorder, Cortisol; Hypersecretion
- Trial name
- OPI2 (NCT05021380)
- Testing
- GROUP
- Where
- Poland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Poznan University of Medical Sciences
Femoral Fracture, Cognition Disorders
Influence of Intrathecal Dexamethasone Administration for Proximal Femoral Fractures
Spinal anesthesia blocks acute pain in older patients with femur fracture. Delirium is a common complication seen after femur fracture, affecting approximately 10-16% of patients.
- Conditions
- Femoral Fracture, Cognition Disorders, Cortisol; Hypersecretion
- Trial name
- NCT03856502
- Testing
- 8 mg of dexamethasone, 12,5 mg of 0,5 % of levobupivacaine
- Where
- Croatia
- Volunteers
- 60 people
- Sponsor
- General Hospital Sveti Duh
Ischemic Stroke, Cortisol; Hypersecretion
Neuroactive Steroids in Acute Ischemic Stroke
Acute ischemic stroke (AIS) represents an economical challenge for health systems all over the globe. Despite increasing knowledge of the pathophysiology of AIS, there is no satisfactory treatment to revert the resulting brain…
- Trial name
- Cortisol (NCT03242304)
- Testing
- Behavioral tests
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hospital Militar Central, Argentina
Disorder of Endocrine Ovary, Hypersecretion; Cortisol
Pathogenesis of Functional Hypothalamic Amenorrhea
This is a randomized pilot study of the use of cognitive behavior therapy versus observation to treat functional hypothalamic amenorrhea, often termed stress-induced anovulation.
- Conditions
- Disorder of Endocrine Ovary, Hypersecretion; Cortisol, Metabolic Disturbance, Stress, Psychological
- Trial name
- NCT01674426
- Testing
- Cognitive behavior therapy
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Pittsburgh
Metabolic Syndrome, Hypersecretion; Cortisol
Effects of IL-1 Beta on the HPA-axis in Obese Persons
In obese individuals cortisol production and secretion is increased but the underlying mechanism is not known. Obesity leads to a pathological activation of the innate immune system partly driven by tissue production of IL-1β.
- Trial name
- CortIL (NCT02227420)
- Testing
- Anakinra
- Where
- Switzerland
- Volunteers
- 76 people
- Sponsor
- University Hospital, Basel, Switzerland