Clinical trials: Hypertension, Ocular
Glaucoma
Patient Preference Comparison of AZARGA Versus COSOPT in Patients With Glaucoma
The purpose of this study is to assess patient preference of AZARGA® compared to COSOPT® after a single drop of each medication is administered to both eyes, in patients with open-angled glaucoma or ocular hypertension.
- Trial name
- NCT01471158
- Testing
- Brinzolamide/Timolol Maleate Fixed Combination (AZARGA), Dorzolamide/timolol Maleate Fixed Combination (COSOPT)
- Where
- Argentina
- Volunteers
- 120 people
- Sponsor
- Alcon Research
Primary Open-angle Glaucoma, Low Tension Glaucoma
Metabolomics in Surgical Ophthalmological Patients
Metabolomics consists in the study of metabolites in body fluids or tissues. It investigates the consequences of the activity of genes and proteins.
- Trial name
- MISO (NCT03098316)
- Testing
- Metabolomics analysis of patient samples
- Where
- Belgium
- Volunteers
- 90 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Glaucoma
Metformin as a Neuroprotective Therapy for Glaucoma
Glaucoma, a chronic degenerative disease of the optic nerve, is the leading cause of irreversible blindness worldwide. Although lowering the intraocular pressure (IOP) has been shown to be effective to slow optic nerve…
- Trial name
- NCT05426044
- Testing
- Metformin
- Where
- Hong Kong
- Volunteers
- 125 people
- Sponsor
- Christopher Kai Shun Leung
Glaucoma, Ocular Hypertension
Intraocular Pressure Measured by a Novel Sensing Contact Lens Versus Tonometry
While elevated intraocular pressure (IOP) is no longer part of the definition of glaucoma it remains the sole proven modifiable risk factor for the onset and progression of glaucoma.
- Trial name
- NCT04024293
- Testing
- Goldfish (GF)
- Where
- Switzerland
- Volunteers
- 12 people
- Sponsor
- Sensimed AG
Acute Primary Angle-closure Glaucoma
Corneal Densitometry in Acute Primary Angle Closure Glaucoma
Purpose: Our purpose was to investigate the laser peripheral iridotomy (LPI) induced changes in corneal densitometry in acute primary angle closure glaucoma (PACG) cases during the post-laser 1 month period.
- Trial name
- NCT04254458
- Testing
- Corneal densitometry
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people
- Sponsor
- Ulucanlar Eye Training and Research Hospital
Glaucoma
Effectiveness of a Procedure for Previously Failed Glaucoma Surgery
Transconjunctival mitomycin-C in needle bleb revision may be an effective procedure to treat cases with a previously failed trabeculectomy. We will investigate approximately 100 consecutive cases with follow up of up to 9 years.
- Trial name
- NCT00347789
- Testing
- Glaucoma surgery- Bleb revision
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Glaucoma Research & Education Group
Open Angle Glaucoma, Normal Tension Glaucoma
Reproducibility of Blood Flowmetry in Human Retina Using the Nidek Laser Speckle Flowgraphy LSFG-NAVI System
In addition to intraocular pressure blood perfusion pressure in the optic nerve is an important factor determing the cause of glaucoma. Increasing evidence suggests that in glaucoma patients retinal blood may be decreased.
- Conditions
- Open Angle Glaucoma, Normal Tension Glaucoma, Healthy
- Trial name
- LSFG Repro (NCT04014933)
- Testing
- LASER SPECKLE FLOWGRAPHY
- Where
- Switzerland
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Intracranial Pressure Increase, Seizures
Study on Optic Nerve Sheath Diameter Measurements in Prolonged Pediatric Seizures
A total of 88 postictal children with generalized or focal seizures were included in the study. The ONSD and ONSD/ETD ratio was measured independently by a pediatric neurologist and pediatric emergency expert, three times in both…
- Conditions
- Intracranial Pressure Increase, Seizures, Children, Only
- Trial name
- ONSD (NCT06451289)
- Testing
- Head computered tomography
- Where
- Turkey (Türkiye)
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- Balikesir University
Medication Adherence, Glaucoma
A Universal Eye Drop Adherence Monitor to Measure and Improve Adherence to Ocular Medications
Glaucoma is the second leading cause of visual impairment worldwide. Eye drop medications reduce vision loss from glaucoma by at least 60%, but eye drops must be taken every day to be effective.
- Trial name
- NCT03506568
- Testing
- Devers Drop Device (D3) app
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universal Adherence LLC
Glaucoma
Paul Glaucoma Implant Versus Ahmed Glaucoma Valve in Childhood Glaucoma
A randomized controlled trial comparing the efficacy and safety of Paul glaucoma implant and Ahmed glaucoma valve in refractory childhood glaucoma patients
- Trial name
- NCT05797350
- Testing
- Glaucoma Drainage Device
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Al Watany Eye Hospital
Glaucoma
Bimatoprost/Timolol Versus Travoprost/Timolol
The purpose of this study is to compare 2 fixed combination medications in intraocular pressure lowering.
- Trial name
- NCT01542710
- Testing
- Ganfort, Duotrav
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Kasr El Aini Hospital
Angle-closure Glaucoma, Minimally Invasive Glaucoma Surgery
Biometric Changes After Intervention of Anterior Chamber Angle : an Observational Study
The drainage angle in the anterior chamber of the eye mediates the outflow of aqueous humor, and pathological changes here can lead to high intraocular pressure and glaucoma.
- Conditions
- Angle-closure Glaucoma, Minimally Invasive Glaucoma Surgery, Goniosynechialysis, Goniotomy
- Trial name
- NCT06492538
- Testing
- various types of angle interventions
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Glaucoma
Advanced Glaucoma Intervention Study (AGIS)
To assess the long-range outcomes of sequences of interventions involving trabeculectomy and argon laser trabeculoplasty in eyes that have failed initial medical treatment for glaucoma.
- Trial name
- NCT00000148
- Testing
- Argon Laser Trabeculoplasty, Trabeculectomy
- Where
- 13 sites in United States
- Sponsor
- National Eye Institute (NEI)
Open-angle Glaucoma, Papilledema
aICP in Glaucoma and Papilledema
Glaucoma remains a disease with an unclear and complex underlying pathophysiology. Recently, researchers have emphasized not only intraocular pressure (IOP) or vascular dysregulation, but also translaminar pressure's (TPG) role…
- Trial name
- aICP Ophtha (NCT02410148)
- Testing
- Non-invasive ICP measurement (Vittamed 305)
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Kantonsspital Aarau
Glaucoma
Intraocular Pressure (IOP) Lowering Efficacy of Transdermal Brimonidine Therapy
The purpose of this study is to evaluate the safety and effectiveness in lowering intraocular pressure (IOP) utilizing an experimental lotion containing 0.1% Brimonidine that is applied to the outside of one eyelid.
- Trial name
- NCT01345448
- Testing
- Brimonidine
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Nanduri, Padma, M.D., FACS
Glaucoma
Satisfaction With XEN Gel Stent Versus Trabeculectomy for the Treatment of Glaucoma
This is a prospective, observational, non-interventional study of patients scheduled to receive surgical intervention either via XEN or trabeculectomy for open-angle glaucoma.
- Trial name
- XENPRO (NCT03852810)
- Where
- 10 sites in Canada, Germany and 1 more
- Volunteers
- 28 people
- Sponsor
- Allergan
Glaucoma, Ocular Hypertension
An Efficacy and Safety Study of Bimatoprost 0.01% Alone Compared With Travoprost 0.004% and Timolol 0.5% in Subjects With Glaucoma or Ocular Hypertension
This efficacy and safety study will evaluate LUMIGAN® RC/ LUMIGAN® .01 (bimatoprost 0.01%) alone compared to TRAVATAN Z® (travoprost 0.004%) and TIMOLOL MALEATE-EX, 0.5%/TIMOLOL GFS 0.5% (timolol 0.5% ophthalmic gel forming…
- Trial name
- NCT01881126
- Testing
- bimatoprost 0.01%, travatan 0.004%, timolol 0.5%
- Where
- 2 sites in Canada
- Volunteers
- 93 people
- Sponsor
- Allergan
Glaucoma, Diagnostic Self-evaluation
Development and Evaluation of a Self-administered/Assisted Visual Field Screening Tool for Glaucoma
This project aims to evaluate a self-administered screening test for glaucoma, the second largest cause of blindness in the western world.
- Trial name
- NCT02162043
- Where
- United Kingdom
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Glaucoma, Trabeculectomy
Multidrug Resistance After Trabeculectomy With Mitomycin C
We investigate whether mitomycin C treatment during previous filtration surgery induces P-glycoprotein expression.
- Trial name
- NCT00449631
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University of Cologne
Primary Open Angle Glaucoma
Pharmacokinetics, Efficacy and Safety Assessment of T2345 Compared With Active Comparator in Newly Diagnosed Patients With Open-angle Glaucoma or Ocular Hypertension
The purpose of this study is to assess the pharmacokinetics, efficacy and safety of T2345 versus an active comparator.
- Trial name
- NCT01494753
- Testing
- T2345, Prostaglandin
- Volunteers
- 30 people
- Sponsor
- Laboratoires Thea