Clinical trials: Hypertension, Pregnancy Induced
Preeclampsia
Clonidine Versus Captopril for Treatment of Postpartum Very High Blood Pressure
The postpartum period represents a stage of the pregnancy-puerperal still rarely addressed scientifically. There are no reports in the literature and concrete enough to elucidate important issues, especially in the field of…
- Trial name
- CLONCAP (NCT01761916)
- Testing
- CLONIDINE, CAPTOPRIL
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Preeclampsia, Pregnancy Loss
Placental Organoids Development: Application in the Study of the Human Reproduction Pathophysiology.
Placental organoids represent an in vitro 3D reconstruction model of the human placenta and of its complex cellular organization to evaluate the pharmacological effect in terms of placentation, gene expression, protein synthesis…
- Conditions
- Preeclampsia, Pregnancy Loss, Preterm Birth, Healthy
- Trial name
- PLORG (NCT06893978)
- Testing
- Placenta organoids treatment
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Preeclampsia, Dyslipidemia
Prolongation of Pregnancy in Preeclampsia by Therapeutic Lipid Apheresis
Preeclampsia is a disease which occurs in about 6-8% of all pregnancies and is the main cause of maternal and fetal morbidity and mortality.
- Conditions
- Preeclampsia, Dyslipidemia, Proteinuria, Hypertension
- Trial name
- NCT01967355
- Testing
- lipid apheresis
- Where
- Germany
- Volunteers
- 6 people
- Sponsor
- Karl Winkler
Gestational Hypertension
Effect of Pilates Exercise Versus Circuit Exercise Training on Gestational Hypertension
The purpose of the study is to investigate the effect of Pilates exercises versus circuit exercise training on blood pressure and lipids in gestational hypertensive women.
- Trial name
- NCT06618521
- Testing
- Anti-hypertensive drug (Methyldopa 250 mg), Pilates exercise, Circuit exercise training
- Where
- Egypt
- Volunteers
- 69 people
- Sponsor
- Cairo University
Hypertensive Disorders of Pregnancy, Chronic Hypertension in Pregnancy
MH-Rx Study (Baby on Board: Check-in on You, Your Medication, & Your Blood Pressure)
This randomized controlled trial will evaluate whether adding Community Health Worker (CHW)/Social Worker (SW)-led support for non-medical health related needs (NMHRN) and clinician-led Medication Therapy Management (MTM) to…
- Conditions
- Hypertensive Disorders of Pregnancy, Chronic Hypertension in Pregnancy, Gestational Hypertension
- Trial name
- NCT07842341
- Testing
- Community Health Worker (CHW)/Social Worker (SW)-led non-medical health related needs (NMHRN) intervention + Clinician-Led Medication Therapy Management (MTM) with remote blood pressure monitoring, Active Comparator (Control group)
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- Texas Southern University
Preeclampsia, Eclampsia
uChek Pilot Study for Urinalysis in the Antenatal Care Setting
A prospective observational study to test the feasibility of smartphone enabled uChek urinalysis device to detect biomarkers (protein, microalbumin and protein:creatine ratio) in urine, indicative of preeclampsia/eclampsia at…
- Conditions
- Preeclampsia, Eclampsia, Pregnancy, Proteinuria
- Trial name
- uChekBangla (NCT02256995)
- Testing
- uChek
- Where
- Bangladesh
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Maternova Research
Fetal Growth Retardation, Pre-Eclampsia
Cardiac Output Monitoring to Predict Pre-Eclampsia and Restricted Growth (COMPaRE)
Pre-eclampsia (PET) and fetal growth restriction (FGR) are common complications of pregnancy that affect up to 15% of pregnancies in the UK.
- Trial name
- COMPaRE (NCT05123677)
- Testing
- Non-invasive haemodynamic assessment, Maternal ophthalmic artery doppler
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sandwell & West Birmingham Hospitals NHS Trust
Pre-Eclampsia
CA-125 and Severity of Pre-Eclampsia
The Aim of this study is to determine the relationship between serum concentrations of cancer antigen-125 (CA-125) and pre-eclampsia severity.
- Trial name
- NCT02704676
- Testing
- marker(CA-125)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Preeclampsia
First Trimester Fetal Thymus Volume May Predict Preeclampsia
The exact etiology of preeclampsia remains unclear but is known to involve immunological factors. The thymus is one of the main organs involved in the development of the fetal immune system.
- Trial name
- NCT04264247
- Testing
- routine fetal ultrasonography at 11-14 weeks
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Karadeniz Technical University
Young Adult, Hypertension in Pregnancy
Cardiovascular Longitudinal ALSPAC Research Investigations Following Hypertensive Pregnancy in Young Adulthood
The purpose of this study is to understand more about why young people who were born to a hypertensive pregnancy may have increased risk of high blood pressure and are often at increased risk of heart and blood vessel disease…
- Conditions
- Young Adult, Hypertension in Pregnancy, Hypertension, Cardiovascular Diseases
- Trial name
- CLARITY (NCT05683093)
- Testing
- History of being born to hypertensive or normal pregnancy
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- University of Oxford
Obesity; Endocrine, Pregnancy in Diabetic
Female Obesity Cohort and Intervention Study Group (MOCART Study Group)
This prospective observational trial includes women with high risk pregnancies complicated with hyperglycemia in pregnancy and excessive body weight.
- Conditions
- Obesity; Endocrine, Pregnancy in Diabetic, Child Obesity, Hypertension in Pregnancy
- Trial name
- MOCART (NCT04924738)
- Testing
- Monitoring and lifestyle
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Poznan University of Medical Sciences
Preeclampsia, Anxiety
Psychosocial Effects of Coloring in Preeclamptic Pregnant Women
Preeclampsia is one of the major causes of maternal and neonatal mortality and morbidity, affecting approximately 3-5% of pregnancies.
- Conditions
- Preeclampsia, Anxiety, Pregnancy, Stress
- Trial name
- NCT06925841
- Testing
- Experimental, routine care
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Necmettin Erbakan University
Preeclampsia
Comparison of High- Versus Low-Dose Aspirin for Pregnancy Outcomes in Women at High Risk of Preeclampsia
The goal of this randomized clinical trial is to compare the effects of two doses of aspirin, 75 mg and 150 mg, in pregnant women who are at high risk of developing preeclampsia. The main question the study aims to answer is: 1.
- Trial name
- NCT07779057
- Testing
- Aspirin
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Medicare Hospital (Pvt) Limited
Gestational Diabetes, Pre-Eclampsia
Glucose and Blood Pressure During Pregnancy
The purpose of this research is to examine the beneficial effects of regular, non-invasive, glucose (sugar) assessment on glucose (sugar) and blood pressure regulation during pregnancy to help in predicting gestational diabetes…
- Conditions
- Gestational Diabetes, Pre-Eclampsia, Blood Pressure
- Trial name
- NCT04979312
- Testing
- LabClasp
- Where
- United States
- Sponsor
- Mayo Clinic
Pre-Eclampsia
Precision Medicine for Prediction & Prevention of Early Pre-eclampsia
This study aims to evaluate the feasibility of implementing a clinical model for precision screening of early pre-eclampsia into the current prenatal screening service at Sunnybrook Health Sciences Center (SHSC).
- Trial name
- NCT04412681
- Testing
- Enhanced PE Screening
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Hypertensive Disorder of Pregnancy, Preeclampsia
Blood Pressure Goal in Preterm Preeclampsia
The purpose of this study is to compare latency (prolongation of pregnancy from diagnosis till delivery) in patients with hypertensive disorders of pregnancy (HDP) with severe features < 34 weeks gestational age (GA), undergoing…
- Trial name
- NCT07894705
- Testing
- Treating BP acutely with intravenous or rapid acting oral medications
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Ohio State University
Hypertensive Disorder of Pregnancy, Pregnancy Complications
Breastfeeding and Postpartum Cardiovascular Health
Hypertensive disorders of pregnancy (HDP) are increasingly recognized sex-specific risk factors for premature cardiovascular disease (CVD) in women.
- Conditions
- Hypertensive Disorder of Pregnancy, Pregnancy Complications, Pre-Eclampsia, Hypertension, Pregnancy-Induced
- Trial name
- sheMATTERS (NCT04580927)
- Testing
- Breastfeeding self-efficacy (BSE)
- Where
- 4 sites in Canada
- Volunteers
- 221 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Preterm Birth, Preeclampsia
The ROOT Study: Scaling the 'Standard of Care Plus' Obstetric Nutrition Model to Optimize Maternal and Infant Health
The 'Standard of Care Plus' ('PLUS') model in the ROOT Study consists of analyzing select micronutrient and gene variants of pregnant females to construct trimester-specific and personalized nutrition and lifestyle…
- Conditions
- Preterm Birth, Preeclampsia, Gestational Diabetes Mellitus (GDM), Small for Gestational Age (SGA)
- Trial name
- ROOT (NCT07559773)
- Testing
- 'Standard of Care PLUS'
- Volunteers
- 500 people
- Sponsor
- GrowBaby Life Project
Preeclampsia/Toxemia
The Prediction of Preeclampsia/Toxemia in Twin Pregnancy
The purpose of this study is to finout whetere uterinae artery flow , PP13 and endogolin levels in the serum and kongo red in the urine can predict preeclamsia toxemia in twin pregnancies.
- Trial name
- NCT01255202
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Preeclampsia
Improving Patient Understanding of Preeclampsia
Participants counseled with the preeclampsia educational tool will have a better understanding of preeclampsia than those not counseled using the tool.
- Trial name
- NCT01119183
- Testing
- ACOG education pamphlet on preeclampsia, Preeclampsia education tool
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Northwestern University
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