Clinical trials: Hypertension, Pregnancy Induced
Low Birth Weight, Small for Gestational Age (SGA)
Improving Aspirin Prescription Rates in Outpatient Clinic
Ρrееςlаmpѕia is a syndrome characterised by the new onset of hуреrtеnѕion plus proteinuria, end-organ dysfunction, or both after 20 weeks of gestation. It complicates 3-5% of pregnancies.
- Conditions
- Low Birth Weight, Small for Gestational Age (SGA), Preeclampsia (PE), Prevention &Amp; Control
- Trial name
- NCT06694233
- Testing
- Aspirin prescription on outpatient basis
- Where
- Kuwait
- Volunteers
- 300 people
- Sponsor
- Cairo University
Pre-Eclampsia, Cathepsin B Level
The Role of Pentraxin 3 and Cathepsin B Levels in Preeclamptic Pregnancy
In this study, the investigator aim was to compare Cathepsin B and Pentraxin 3 levels measured from maternal serum of pregnant women diagnosed with preeclampsia in the second trimester, the effects of these levels on maternal/…
- Conditions
- Pre-Eclampsia, Cathepsin B Level, Pentraxin 3 Level
- Trial name
- NCT05924061
- Testing
- Cathepsin B and pentraxin 3 levels in preeclampsia with pregnant women
- Where
- Turkey (Türkiye)
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Sanliurfa Mehmet Akif Inan Education and Research Hospital
Pre-Eclampsia, Intrauterine Growth Restriction
Inter- and Multidisciplinary, Cross-sectoral Feto-neonatal Pathway
Due to the fetoneonatal pathway it is possible to identify pregnant women with an increased risk of fetal growth restriction or pre-eclampsia in early stages (from 10th week of pregnancy).
- Conditions
- Pre-Eclampsia, Intrauterine Growth Restriction, Maternal Care for Known or Suspected Poor Fetal Growth
- Trial name
- NCT04514276
- Testing
- consecutive fetoneonatal healthcare pathway
- Where
- 2 sites in Germany
- Volunteers
- 828 people
- Sponsor
- Technische Universität Dresden
Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose…
- Conditions
- Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension, Urinary Tract Infections in Children, Hypertension
- Trial name
- POPS or POP02 (NCT04278404)
- Testing
- The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Preeclampsia
Antenatal Platelet Response on Aspirin: a Pharmacokinetic Study Through Pregnancy
Longitudinal pharmacokinetic and pharmacodynamic study in first and third trimester of pregnancy
- Trial name
- APROACH-PK (NCT04645004)
- Testing
- Aspirin 81Mg Non-enteric coated Tab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Thomas Jefferson University
Maternal-Fetal Exchange
Maternal High Blood Pressure and Newborn's Blood Profile
Maternal high blood pressure remodels the intrauterine environment of the fetus by altering hormonal and cellular signaling patterns and, as a result increases the risk of fetal and neonatal mortality and morbidity.
- Trial name
- MPIHHPN (NCT03265704)
- Testing
- AGA - Control group, SGA - Control group, AGA-PIH Study group
- Where
- Romania
- Volunteers
- 6,108 people
- Sponsor
- Romanian Society of Anesthesia and Intensive Care
Sickle Cell Disease, Chronic Kidney Disease
Hydroxyurea and Erythropoietin to Treat Sickle Cell Anemia
This study will examine the use of hydroxyurea and erythropoietin for treating sickle cell disease in patients who also have kidney disease or pulmonary hypertension (high blood pressure in the lungs).
- Conditions
- Sickle Cell Disease, Chronic Kidney Disease, Pulmonary Hypertension
- Trial name
- NCT00270478
- Testing
- Erythropoietin and Hydroxyurea
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Pre-Eclampsia, Pregnacy
Acute Beetroot Juice Supplementation in Pre-eclampsia Pregnancies
Pre-eclampsia is a serious condition that typically affects pregnant women after the 20th week of pregnancy, characterized by high blood pressure and damage to organs such as the kidneys and liver.
- Trial name
- BEET_PE (NCT06387784)
- Testing
- Beetroot juice
- Where
- 2 sites in Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
Pre-Eclampsia
Study of the Physiology of Pre-eclampsia and Vascular IUGR With Constitution of a Biological Collection
Preeclampsia and intrauterine growth retardation (IUGR) are serious and frequent pathologies, specific to pregnancy. They represent 70 000 new cases a year, or 9% of pregnancies and cause 50,000 premature births per year in…
- Trial name
- CPVP (NCT03626233)
- Testing
- collect of placenta, blood and urinary samples at delivery
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Hypertension in Pregnancy
Chronic Hypertension and Pregnancy 2 (CHAP2) Pilot Project
The CHAP2 study is designed to provide preliminary data for a larger multicenter study to assess whether treatment of stage 1 hypertension (HTN) in pregnancy improves maternal and or neonatal outcomes.
- Trial name
- CHAP2 (NCT05989581)
- Testing
- Labetalol or Nifedipine
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Pulmonary Edema, Acute Lung Injury
Fluid Management in the Post-Anesthetic Care Unit (PACU) at Sourasky Medical Center
Peri-operative fluid therapy is a controversial area with few randomized trials to guide practice. Fluid management has a significant influence on outcome following surgery.
- Conditions
- Pulmonary Edema, Acute Lung Injury, Hypertension, Renal Failure
- Trial name
- NCT00995228
- Where
- Israel
- Volunteers
- 1,000 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Severe Preeclampsia
Algorithm-Based Timing of Delivery Using the sFlt-1/PlGF Ratio in Early-Onset Severe Preeclampsia. (MAP 2 Study : Management Based on Angiogenic Markers in Preeclampsia 2 Study )
Preeclampsia is a serious pregnancy complication caused by abnormal placental development and function. It can lead to high blood pressure and damage to organs such as the liver, kidneys, brain, or cardiovascular system.
- Trial name
- MAP 2 (NCT07665112)
- Testing
- sFlt-1/PlGF ratio-guided management algorithm, Usual Care
- Where
- Spain
- Volunteers
- 386 people
- Sponsor
- Hospital Clinic of Barcelona
Breast Cancer, Cardiovascular Complications
Potential Biomarkers for Bevacizumab-Induced High Blood Pressure in Patients With Solid Tumor
RATIONALE: Studying samples of blood and urine in the laboratory from patients with cancer receiving bevacizumab may help doctors learn more about changes that occur in DNA and identify biomarkers related to high blood pressure.
- Conditions
- Breast Cancer, Cardiovascular Complications, Colorectal Cancer, Fallopian Tube Cancer
- Trial name
- NCT01096381
- Testing
- laboratory biomarker analysis, questionnaire administration
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Hypertension in Pregnancy
Invasive Versus Non-invasive Assessment of Blood Pressure in Hypertensive Disorders of Pregnancy
Hypertensive disorders of pregnancy are important causes of maternal morbidity and mortality worldwide. Hypertension is one of the most commonly reported health conditions among pregnant women and complicates 5-10% of all…
- Trial name
- NCT04303871
- Testing
- Invasive blood pressure assessment by radial artery canulation
- Where
- Egypt
- Volunteers
- 117 people
- Sponsor
- Assiut University
Pre-Eclampsia, Neurocognitive Dysfunction
Changes in fMRI and Neurocognitive Function in Women With Pre-eclampsia
This is a pilot study assessing fMRI changes and neurocognitive function in women with pre-eclampsia and healthy controls. Neurocognitive testing will be done during pregnancy and after delivery up to 2-6 weeks postpartum.
- Trial name
- NCT03863639
- Testing
- Neuroimaging Procedures, Neuropsychological Assessment Procedures
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Duke University
Sickle Cell Disease, Pregnancy Related
LEARNER- Low dosE AspiRiN prEterm tRial (Angola)
This study is being conducted to evaluate the safety and effect of starting daily use of low dose (100 mg) aspirin in pregnant women with sickle cell disease, who are being followed in two county hospitals in Angola, in the first…
- Conditions
- Sickle Cell Disease, Pregnancy Related, Pregnancy Complications, Pre-Eclampsia
- Trial name
- LEARNER (NCT06417411)
- Testing
- Aspirin 100mg
- Where
- Angola
- Volunteers
- 450 people
- Sponsor
- Instituto Nacional de Investigacao em Saude, Angola
Pre-Eclampsia, Morbid Obesity
Non-invasive Versus Invasive Blood Pressure Measurement in the Morbidly Obese Parturient With Severe Preeclampsia
The study will compare agreement of invasive blood pressure measurements with non-invasive blood pressure measurements measured with a conical blood pressure and large standard upper arm rectangular cuff in morbidly obese…
- Conditions
- Pre-Eclampsia, Morbid Obesity, Parturient, Blood Pressure
- Trial name
- NCT03222414
- Testing
- Non-invasive BP recording with conical Ultracheck Curve BP cuff, Non-invasive BP recording with traditional cylindrical BP cuff, Direct invasive arterial pressure
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Vanderbilt University Medical Center
Preeclampsia
Serum LncRNAs as Early Potential Biomarkers for the Prediction of Preeclampsia
To identify lncRNAs differentially expressed at early stages of gestation in the serum of pregnant women, who later developed severe preeclampsia (sPE) in the third trimester of pregnancy compared to women with normal pregnancy .
- Trial name
- NCT03903393
- Where
- China
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Pregnancy-Induced Hypertension in Postpartum, Postpartum Pre-Eclampsia
Management of Hypertension in the Early Postpartum: a Randomized Controlled Trial
In hypertensive mothers, it is common in clinical practice to substitute methyldopa for another medication, such as captopril, immediately after delivery, which may, as a consequence, cause a rebound effect or an initial lack of…
- Conditions
- Pregnancy-Induced Hypertension in Postpartum, Postpartum Pre-Eclampsia, Hypertension
- Trial name
- NCT04835233
- Testing
- Methyldopa 250 MG
- Where
- Brazil
- Volunteers
- 180 people
- Sponsor
- Federal University of Paraíba
Hypertension in Pregnancy
Effect of Hydroxytyrosol on NLR, MLR, and SOD in Hypertensive Pregnant Women
The goal of this clinical trial is to evaluate whether hydroxytyrosol supplementation (10 mg/day for 4 weeks) is effective in improving inflammatory and oxidative stress markers in pregnant women diagnosed with hypertensive…
- Trial name
- HyPreg (NCT07074548)
- Testing
- Hydroxytyrosol
- Where
- Indonesia
- Volunteers
- 42 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
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