Clinical trials: Hypertension, Pregnancy Induced
Fetal Growth Retardation, Preeclampsia
Management of Early-onset Fetal Growth Restriction: Angiogenic Factors Versus Feto-placental Doppler
This is a multicentre, open-label, randomized controlled trial. A total of 340 singleton pregnancies with an EFW ≤10th percentile between 26+0 and 31+6 weeks will be recruited and randomly allocated to either the control or the…
- Conditions
- Fetal Growth Retardation, Preeclampsia, Placenta Diseases
- Trial name
- earlyGRAFD (NCT05284474)
- Testing
- soluble fms-like tyrosine kinase to placental growth factor ratio (sFlt-1/PlGF)
- Where
- 27 sites in Spain
- Volunteers
- 340 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Preeclampsia
Prevalence of Antiphospholipid Antibodies Among Women With Preeclampsia
The purpose of this study is to determine the prevalence of positive antiphospholipid antibodies among women with preeclampsia and to determine the effect of antiphospholipid antibodies on the severity of preeclampsia and the…
- Trial name
- NCT02699437
- Testing
- Testing for antiphospholipid antibodies
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Mohamed Sayed Abdelhafez
Pre-Eclampsia
Peri-operative Dexmedetomidine Infusion in Pre-eclamptic Patients
The purpose of this study is to investigate the effects of dexmedetomidine infusion on the stress response to intubation, postoperative analgesia, and renal functions (urinary output [UOP], creatinine and glomerular filtration…
- Trial name
- NCT03391609
- Testing
- Dexmedetomidine infusion
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assiut University
Pre-eclampsia, Pregnancy
Gestational Changes in Hemodynamics and Respiratory Mechanics in Association With Pre-Eclampsia
This study focuses on elucidating the changes of hemodynamics assessed by USCOM and respiratory mechanics assessed by impedance oscillometry (IOS) over the course of pregnancy and the postpartum period.
- Conditions
- Pre-eclampsia, Pregnancy, Post Partum
- Trial name
- TREMOFLO (NCT07695909)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Prenatal Disorder, Premature Birth
Develop a Multi-disciplinary Approach for a Personalized Prenatal Diagnostics and Care for Twin Pregnancies
Different screening modalities evaluation to develop algorithms to predict pregnancy complications in twin pregnancies, and evaluation of serologic response to BNT162b2 Pfeizer/BioNTech vaccination.
- Conditions
- Prenatal Disorder, Premature Birth, Twin Pregnancy With Antenatal Problem, Twin; Pregnancy, Affecting Fetus or Newborn
- Trial name
- PRETWINSCREN (NCT04595214)
- Testing
- TTTS cases are treated by intra-uterine laser for separation.
- Where
- 7 sites in Belgium, Canada and 4 more
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Pregnancy Complications
Oral Prophylactic Measures on the Occurrence of Pre-eclampsia (OP-PE)
Pre-eclampsia (PE) remains a major source of maternal and perinatal morbidity and mortality especially in low- and middle-income settings.
- Trial name
- OP-PE (NCT04989075)
- Testing
- Oral prophylactic intervention
- Where
- Senegal
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Claude Bernard University
Pre-Eclampsia, Fetal Growth Retardation
Doppler and Biological Second Trimester Placental Insufficiency Screening
To assess the role of uterine artery and maternal serum leptin and lipids and their combination in screening for pre-eclampsia and small-for-gestational-age (SGA) fetuses at 20-24 weeks of gestation
- Conditions
- Pre-Eclampsia, Fetal Growth Retardation, Placental Insufficiency
- Trial name
- ARTULEP (NCT00465634)
- Where
- France
- Volunteers
- 235 people
- Sponsor
- University Hospital, Tours
Preeclampsia
Predicitve Use of Spot Urine Protein/Creatinine Ratios in Preeclampsia
The investigators intend to perform a large prospective study looking at the predictability of the random urine protein-to-creatinine ratio compared to the gold standard 24-hour urine protein collection.
- Trial name
- NCT00870428
- Where
- United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- MemorialCare
Preeclampsia
Hypertonic Saline Use in Preeclampsia
To compare hypertonic saline to Lactated Ringer's solution and assess whether one speeds up the process of getting rid of extra body water faster in women with preeclampsia.
- Trial name
- NCT00181077
- Testing
- 2% buffered hypertonic saline administration
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Pre-Eclampsia, Eclampsia
An mHealth Strategy to Reduce Pre-Eclampsia and Infant Death in Tanzania
The core of this study is a cluster randomized controlled trial (RCT) of antenatal clinics which are located in four districts in Tanzania.
- Conditions
- Pre-Eclampsia, Eclampsia, Hypertension, Pregnancy-Induced
- Trial name
- NCT03978429
- Testing
- Community-based Pre-eclampsia/Eclampsia Detection and Management, Strengthened Referral Network from Community to Referral hospital levels
- Where
- Tanzania
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Dr. Karen Yeates
Preeclampsia
Vitamin D Therapy to Prevent Recurrent Preeclampsia in High-Risk Pregnancies
The goal of this clinical trial is to determine whether vitamin D supplementation can reduce the recurrence of preeclampsia in pregnant women with a previous history of preeclampsia.
- Trial name
- NCT07717931
- Testing
- Vitamin D (Cholecalciferol )
- Where
- Pakistan
- Volunteers
- 146 people
- Sponsor
- CMH Multan Institute of Medical Sciences
HELLP Syndrome
Dexamethasone Efficacy in HELLP I Syndrome
The purpose of this study is to determine the efficacy of dexamethasone for treatment of HELLP I (hemolysis, elevated liver enzymes and low platelet count) syndrome.
- Trial name
- NCT01138839
- Testing
- Dexamethasone, sterile water
- Where
- Colombia
- Volunteers
- 160 people
- Sponsor
- Universidad del Valle, Colombia
Preeclampsia (PE), Hypertensive Disorder of Pregnancy
Endothelial Dysfunction for Prognosis In Patients With preeClampSia
Preeclampsia is a pregnancy-specific hypertensive disorder and can progress rapidly to severe adverse outcomes affecting both the mother and the fetus.
- Trial name
- EPICS (NCT06912477)
- Testing
- Hyperspectral imaging, Further markers of endothelial dysfunction
- Where
- Germany
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Preeclampsia
Hypertensive Disorders of Pregnancy in Adolescence and Primipaternity
Hypertensive disorders of pregnancy are one of the most frequent complications of pregnancy, being a serious health problem around the world.
- Trial name
- NCT01374477
- Where
- Panama
- Volunteers
- 110 people
- Sponsor
- Saint Thomas Hospital, Panama
Hypertension
Validation of Pulsewave Blood Pressure Monitor in Hypertensive and Normotensive Pregnant and Postpartum Women
The purpose of this study is to test the accuracy of the Pulsewave wrist blood pressure cuff in pregnant and postpartum women who have either normal blood pressure or high blood pressure.
- Trial name
- NCT02823873
- Testing
- Pulsewave oscillometric wrist cuff blood pressure monitor
- Where
- United States
- Sponsor
- University of Arkansas
Childhood Obesity, Anemia
The Jiaxing Birth Cohort in China
The Jiaxing Birth Cohort (JBC) is the largest prospective cohort study to explore prenatal risk factors, early life feeding practice and growth pattern/ adiposity in Chinese children.Between 1999 and 2013, 338 413 mother-child…
- Conditions
- Childhood Obesity, Anemia, Pregnancy Complications, Pregnancy; Hypertension
- Trial name
- JBC (NCT03217656)
- Testing
- No intervention
- Where
- China
- Volunteers
- 500,000 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Preeclampsia
Aggressive Versus Expectant Management of Severe Preeclampsia Remote From Term
How best to manage preeclampsia remote from term is controversial because of conflicting maternal and neonatal risks. Gestational age is the most important determinant of neonatal outcome.
- Trial name
- MEXPRE-Latin (NCT01164852)
- Testing
- Delivery
- Where
- 8 sites in Ecuador, Guatemala and 4 more
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- Complejo Hospitalario Dr. Arnulfo Arias Madrid
Elevated Blood Pressure, Pregnancy Induced Hypertension
Treatment of Elevated Blood Pressures in Early Pregnancy
This is a randomized controlled trial comparing the outcomes of treatment and non-treatment of elevated blood pressures in early pregnancy.
- Trial name
- NCT05955040
- Testing
- Nifedipine, Labetalol
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Marshall University
Preeclampsia
PP13 and Doppler Study to Predict Preeclampsia
Assessment of biochemical and sonographic marker to predict the risk for developing preeclampsia Among biochemical markers are serum level of Placental Protein 13 (PP13) and Placenta Growth factor (PIGF).
- Trial name
- NCT00928213
- Testing
- Progesterone, Low molecular weight Heparin, No Drug
- Where
- Israel
- Volunteers
- 1,000 people
- Sponsor
- Ben-Gurion University of the Negev
Pre-Eclampsia, Hypertension, Pregnancy-Induced
Self-management of Postnatal Anti-hypertensive Treatment: a Trial Development Pilot Study
New-onset raised blood pressure (BP) affects about one in ten pregnancies. For some women, raised BP is an indication of pre-eclampsia: newly arising high blood pressure in pregnancy combined with protein leaking into the urine.
- Trial name
- SNAP-HT (NCT02333240)
- Testing
- Self-management of postnatal anti-hypertensive treatment
- Where
- 5 sites in United Kingdom
- Volunteers
- 101 people
- Sponsor
- University of Oxford
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