Clinical trials: Hypertension, Resistant
Essential Hypertension
Imidapril and Candesartan on Fibrinolysis and Insulin-Sensitivity in Patients With Mild to Moderate Hypertension
BACKGROUND The effects of ACE-inhibitors on fibrinolysis are well documented. Experimental and clinical studies have shown that ACE inhibitors induce a reduction in plasma PAI-1 levels in many cardiovascular diseases, like…
- Trial name
- NCT00644475
- Testing
- Imidapril, Candesartan
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Pavia
Essential Hypertension
Effectiveness of Eplerenone to Improve Target Organ Damage in Patients With Resistant Arterial Hypertension
Resistant hypertension is defined as hypertension not controlled (i.e. blood pressure not below 140/90 mmHg) with the use of adequate doses of at least three different anti-hypertensives including a diuretic.
- Trial name
- NCT00138944
- Testing
- eplerenone
- Where
- Germany
- Volunteers
- 85 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Hypertension, Hypercholesterolemia
Effects of Purple Vegetables on Cardiovascular Disease (CVD) Risk Factors
The hypothesis is that richly coloured purple vegetables, rich in polyphenolic compounds including anthocyanins will have higher antioxidant and other biological activities, than more lightly coloured versions of these foods.
- Conditions
- Hypertension, Hypercholesterolemia, Type II Diabetes, Obesity
- Trial name
- NCT01564498
- Testing
- vegetable
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Guelph
Metabolic Syndrome
Pomegranate Consumption by Poly-medicated Metabolic Syndrome Patients
The objective is to evaluate whether the medication in polymedicated metabolic syndrome patients could determine the effects of a pomegranate extract on i) metabolic markers, ii) inflammatory markers, and iii) the modulation of…
- Trial name
- NCT04075032
- Testing
- Pomegranate extract
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- National Research Council, Spain
Hypertension
Efficacy and Safety of Lorundrostat in Subjects With Uncontrolled and Resistant Hypertension
This is a Phase 3 trial to evaluate the BP-lowering effect of lorundrostat (an aldosterone synthase inhibitor) in subjects with uncontrolled and resistant hypertension taking between 2 and 5 anti-hypertensive (AHT) medications.
- Trial name
- NCT06153693
- Testing
- lorundrostat Dose 1, lorundrostat Dose 2
- Where
- 184 sites in United States, Australia and 11 more
- Volunteers
- 1,083 people
- Sponsor
- Mineralys Therapeutics Inc.
Hypertension, Oxidative Stress
Effect of Antioxidant Supplementation on the Autonomic Balance
Recent evidence suggests that there is a directly proportional relationship between diets with a high concentration of antioxidants and the reduction of blood pressure and the risk of cardiovascular events.
- Conditions
- Hypertension, Oxidative Stress, Autonomic Imbalance, Insulin Resistance
- Trial name
- NCT03510221
- Testing
- Antioxidants capsules
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Metabolic Syndrome, Obesity
Low-intensity Exercise in Metabolic Syndrome
People with metabolic syndrome (MetS) are characterized by a lower quality of life in terms of reduced vital activity, emotional state, and social functioning.
- Conditions
- Metabolic Syndrome, Obesity, Hypertension, Hyperlipidemias
- Trial name
- NCT04346836
- Testing
- Low-intensity, general-fitness exercises, Psychoeducation
- Where
- Poland
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Wroclaw University of Health and Sport Sciences
Obesity (Disorder)
Repeated Far Infrared Sauna Bathing in Adults With Obesity
This is a clinical trial to determine if 30 sessions of far infrared sauna bathing can improve cardiovascular and metabolic function in adults with obesity.
- Trial name
- NCT07158047
- Testing
- Heat therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Oregon
Pulmonary Hypertension
Early Intervention With Inhaled Treprostinil Among Patients With Exercise-Induced Pulmonary Hypertension (EPIH)
This prospective open-label matched-control pilot study evaluates whether inhaled treprostinil improves exercise pulmonary vascular resistance and functional outcomes in adults with interstitial lung disease or connective tissue…
- Trial name
- EPIH IIT (NCT07837830)
- Testing
- Treprostinil, Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Valley Health System
Metabolic Syndrome, Hypertension
Effect of Two Doses of Olmesartan Medoxomil and Amlodipine on Vascular Markers in Hypertensive Patients With Metabolic Syndrome
The purpose of this study is to study the effect of two doses of olmesartan medoxomil and amlodipine on vascular markers in hypertensive patients with metabolic syndrome.
- Trial name
- VAMOS (NCT00891267)
- Testing
- Olmesartan medoxomil tablets low dose, Olmesartan medoxomil tablets high dose, Amlodipine
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company
Resistant Hypertension
Neuroinflammation in Hypertension Study
To demonstrate that in patients with resistant hypertension oral treatment with minocycline via inhibition of central immune cell activation and inflammation results in reduced central sympathetic outflow and concomitant lowering…
- Trial name
- MINIHT (NCT04478500)
- Testing
- Minocycline
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- Royal Perth Hospital
Chronic Kidney Insufficiency, Hypertension
Renal and Systemic Vascular Resistance in Chronic Kidney Disease (CKD)
Patients with reduced kidney function have a higher risk of heart disease and death. Studies have shown that blood vessels in patients with hypertension change with a decrease of lumen size and growth of the vessel wall.
- Conditions
- Chronic Kidney Insufficiency, Hypertension, Vasodilation
- Trial name
- RenVas (NCT01380717)
- Testing
- Beta-blocker, ACE-inhibitor, Calcium Channel Blockers, ACE-Inhibitor
- Where
- Denmark
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Pulmonary Artery Hypertension
Skeletal Muscle Mitochondrial Abnormalities and the Metabolic Syndrome in PAH
Pulmonary arterial hypertension (PAH) is characterized by the progressive increase in pulmonary vascular resistance ultimately leading to right ventricular (RV) failure.
- Trial name
- NCT03979482
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Laval University
Hypertension, Healthy
Effect of Exercise on Endothelial Injury in Hypertensive Patients
Introduction: Endothelial dysfunction precedes atherosclerosis being evidenced in patients with hypertension. Increasing physical activity levels and/or physical exercise are part of the recommendations of antihypertensive…
- Trial name
- NCT02937922
- Testing
- AEROBIC, RESISTANCE, COMBINED
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Hypertension
Spironolactone Versus Amiloride as an Add on Agent in Resistant Hypertension
Joint National Committee 7 (JNC-7) defines resistant hypertension as a persistent elevation of blood pressure (BP) above goal - ≥ 140/90 mm Hg for the general hypertensive population or ≥ 130/80 mm Hg for persons with diabetes…
- Trial name
- NCT00709137
- Testing
- spironolactone, amiloride
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- VA Salt Lake City Health Care System
Metabolic Syndrome, Diabetes
Cardiovascular-Kidney-Metabolic Syndrome in Shanghai Zicitizens
The main purpose of this study is to conduct follow-up assessments and update the cardiorenal outcomes among the STONE cohort that was established during 2016-2017.
- Conditions
- Metabolic Syndrome, Diabetes, Obesity and Overweight, Hypertension
- Trial name
- NCT07043166
- Where
- China
- Volunteers
- 4,094 people, healthy volunteers welcome
- Sponsor
- Shanghai Changzheng Hospital
Hypertension, Hyperlipidemias
Clinical Trials of Two Helichrysum Infusions in Adults
The study evaluates the effects of Helichrysum italicum and Helichrysum Arenarium on different components of the metabolic syndrome.
- Conditions
- Hypertension, Hyperlipidemias, Inflammation, Hyperglycemia
- Trial name
- SMILJ (NCT04866628)
- Testing
- Helichrysum italicum infusion, Helichrysum arenarium
- Where
- Slovenia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Primorska
Coronary Artery Disease, Non-significant Coronary Artery Disease
TweeSteden Mild Stenosis Study
Psychosocial factors have been found to be associated with an increased risk for coronary artery disease incidence, progression and worse clinical outcomes.
- Conditions
- Coronary Artery Disease, Non-significant Coronary Artery Disease, Mild Stenosis, Vascular Irregularities
- Trial name
- TWIST (NCT01788241)
- Where
- Netherlands
- Volunteers
- 547 people
- Sponsor
- Tilburg University
Fasting, Intermittent, Diet
Intermittent Fasting Versus Diet to Stop Hypertension on Metabolic Risk Profile in Nonalcoholic Fatty Liver Patients
This study was conducted to compare between the effect of intermittent fasting and diatery approach to stop hypertension on metabolic risk profile in nonalcoholic fatty liver patients.
- Conditions
- Fasting, Intermittent, Diet, Hypertension, Metabolic Syndrome
- Trial name
- NCT06666894
- Testing
- Intermittent fasting, Dietary approach to stop hypertension (DASH)
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Atherosclerosis Cardiovascular Disease
Isometric Resistance Exercise on Accelerated Atherosclerosis in Hypertension
Background: Hypertension (HT) is the most common condition worldwide, predisposing to atherosclerotic disease. However, most HT patients have suboptimal BP control despite anti-HT medications.
- Trial name
- IRE-HT (NCT07665034)
- Testing
- Squatting Exercise, Stretching (Yoga) Exercise
- Where
- Hong Kong
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong