Clinical trials: Hypertension
Cardiovascular Diseases, Heart Diseases
Treatment of Hypertension
To determine whether the long-term treatment of essential hypertension without significant target organ disease materially influenced mortality and/or cardiovascular renal morbidity.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension, Vascular Diseases
- Trial name
- NCT00000484
- Testing
- chlorothiazide, Rauwolfia alkaloids
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coma
Optic Nerve Sheath Diameter as a Screening Test for Increased Intracranial Pressure
Patients admitted to the ICU may have delayed awakening after their critical illness has resolved. Though most either are due to metabolic causes or delayed elimination of sedative medications, more serious pathologies such as…
- Trial name
- NCT02338284
- Testing
- ultrasound of globe
- Where
- Saudi Arabia
- Volunteers
- 100 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Hypertension
Effectiveness of Inspiratory Muscle Training With Slow Breathing in Elderly With ISH
Study the effects of inspiratory muscle training at Low load of 25 %Maximal inspiratory pressure with slow breathing rate at 6 breaths/min on inspiratory muscle strength, lung function, chest wall expansion, abdominal expansion…
- Trial name
- NCT02752217
- Testing
- Inspiratory Muscle Training, Control
- Where
- Thailand
- Volunteers
- 32 people
- Sponsor
- Khon Kaen University
Cushing Syndrome
A Study of the Efficacy and Safety of Relacorilant in Patients With Endogenous Cushing Syndrome
This is a Phase 3, double-blind, placebo-controlled, randomized-withdrawal study to assess the efficacy, safety and pharmacokinetics (PK) of relacorilant in patients with endogenous Cushing syndrome and concurrent type 2 diabetes…
- Trial name
- GRACE (NCT03697109)
- Testing
- Relacorilant
- Where
- 64 sites in United States, Austria and 9 more
- Volunteers
- 152 people
- Sponsor
- Corcept Therapeutics
Hypertension, Hypercholesterolemia
Vascular Intervention Strategies Trial for Alzheimer's
The proposed pharmacist-led study is a feasibility pilot trial for the management of vascular risk factors of hypertension and hypercholesterolemia in 10 APOE ε4 carriers, 50-75, at-risk for dementia.
- Conditions
- Hypertension, Hypercholesterolemia, Dementia Risk Factors
- Trial name
- VISTA (NCT07447206)
- Testing
- Angiotensin Receptor Blockers (ARBs), Hydrophilic Statins or Non-Statin Alternative
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Southern California
Chronic Kidney Diseases
miRNA in Chronic Kidney Diseases
Oxidative stress and endoplasmic reticulum (ER) stress play a key role in tubular damage in both acute kidney injury and chronic kidney disease (CKD).
- Trial name
- NCT06316284
- Where
- Croatia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Open-angle Glaucoma, Ocular Hypertension
A Study of a Glaucoma Therapy to Treat Open-Angle Glaucoma or Ocular Hypertension
The purpose of this study is to determine whether a glaucoma therapy is safe and effective in treating patients with open-angle glaucoma or ocular hypertension.
- Trial name
- NCT00314158
- Testing
- Brinzolamide 10 mg/ml + Timolol 5 mg/ml eye drops, suspension, Brinzolamide 10 mg/ml (AZOPT) eye drops, suspension, Timolol 5 mg/ml eye drops, solution
- Where
- United States
- Volunteers
- 523 people
- Sponsor
- Alcon Research
Chronic Thromboembolic Pulmonary Hypertension
Registry of Patients With chrOnic thromboemboLic Pulmonary hypErTension
The goal of this observational study is to gather information on background, medical history, symptoms and physical condition, treatment options of people with chronic thromboembolic pulmonary hypertension in real clinical…
- Trial name
- POLET (NCT07254078)
- Testing
- Pulmonary endarterectomy, Balloon pulmonary angioplasty, Pulmonary hypertension-specific therapy
- Where
- Russia
- Volunteers
- 500 people
- Sponsor
- Irina E. Chazova
Portal Hypertension, Chronic Liver Disease
EUS vs TJ for Liver Biopsy and Portal Pressure Gradient Measurement
This study will directly compare the endoscopic ultrasound guided approach to obtain adequate liver biopsies and portal pressure gradient measurements to the current standard of care which uses the transjugular approach.
- Conditions
- Portal Hypertension, Chronic Liver Disease, Cirrhosis
- Trial name
- NCT05118308
- Testing
- Transjugular hepatic venous pressure gradient measurement with liver biopsy, Endoscopic ultrasound portal pressure gradient measurement with liver biopsy
- Where
- Canada
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Nutrition, Healthy, Type 2 Diabetes
Medically Tailored Groceries and Food Resource Coaching
Eating healthy foods can help people manage health problems, like Type 2 diabetes and heart disease. Many people want to eat healthier, but changing eating behaviors is hard.
- Conditions
- Nutrition, Healthy, Type 2 Diabetes, Hypertension, Dyslipidemias
- Trial name
- NCT06242808
- Testing
- Food resource coaching, Free community food support, Medically tailored groceries
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- University of Texas Southwestern Medical Center
Hypertension, Aldosteronemia
Decode the Environment Variation of Targeted Aldosterone Inducer and siLencer
Clinical outcome to identify and analyze the epigenetic, phenotypic, protein variation, metabolites of CYP450 Family 11 Subfamily B, both 1 and 2, human-associated aldosterone protein release, and signaling inhibitory pathways…
- Conditions
- Hypertension, Aldosteronemia, CYP11B1, CYP11B2
- Trial name
- DETAIL (NCT07748975)
- Testing
- Aldosterone circulation, Medication, Operation
- Where
- Thailand
- Volunteers
- 100 people
- Sponsor
- DejthidaNathaphong
Open Angle Glaucoma
Comparative Effectiveness of Treatment Strategies for Primary Open-Angle Glaucoma
The primary objectives of the study are: 1. To compare the proportion of patients who achieve a successful response to treatment (reduction in Intraocular Pressure (IOP) of >15%) between patients treated with laser surgery…
- Trial name
- RiGOR (NCT01645319)
- Where
- United States
- Volunteers
- 2,597 people
- Sponsor
- Agency for Healthcare Research and Quality (AHRQ)
Polycystic Kidney, Autosomal Dominant
Effect of Statin Therapy on Disease Progression in Autosomal Dominant Polycystic Kidney Disease (ADPKD)
The purpose of this study is to determine whether the medication pravastatin will ameliorate renal and cardiovascular disease over a 3-year period in children and young adults with autosomal dominant polycystic kidney disease…
- Trial name
- NCT00456365
- Testing
- pravastatin
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of Colorado, Denver
Hypertension
Evaluation of Splenic Metabolic Activity With 18FDG-PET in Hypertension
The purpose of this study is to evaluate the splenic activation in hypertensive patients, as compared to normotensives, using FDG-PET/CT imaging.
- Trial name
- NCT02572765
- Testing
- PET/CT scan
- Where
- Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Hypertension
Study to Evaluate Symptoms in Patients Treated With Nebivolol or Metoprolol Extended-release (ER) for Hypertension
The purpose of this study was to compare the tolerability of nebivolol to metoprolol ER in a general population of patients with mild to moderate hypertension receiving hydrochlorothiazide (HCTZ)
- Trial name
- NCT00547300
- Testing
- Metoprolol ER, Nebivolol
- Where
- 24 sites in United States
- Volunteers
- 49 people
- Sponsor
- Forest Laboratories
Pregnancy Related, Pre-Eclampsia
Natural Versus Programmed Frozen Embryo Transfer (NatPro)
NatPro is a two-arm, parallel-group, multi-center, randomized trial in which women undergoing frozen embryo transfer (FET) will be randomized to receive either a modified natural cycle (corpus luteum present) or a programmed…
- Trial name
- NatPro (NCT04551807)
- Testing
- Modified natural cycle, Programmed cycle
- Where
- 15 sites in United States
- Volunteers
- 788 people, healthy volunteers welcome
- Sponsor
- JHSPH Center for Clinical Trials
Hypertension
LAAS (Losartan Anti-Atherosclerosis Study)(0954-330)(COMPLETED)
The primary objective of this study is to evaluate efficacy, arterial stiffness measured by Pulse Wave Velocity (PWV) of Losartan potassium group compared to Carvedilol group after 24 weeks of treatment in patients with the…
- Trial name
- NCT00496834
- Testing
- losartan potassium, Comparator: carvedilol, Comparator: losartan (+) hydrochlorothiazide (HCTZ)
- Volunteers
- 201 people
- Sponsor
- Organon and Co
Diabetes Mellitus, Hypertension
Oxidative Stress Lowering Effect of Simvastatin and Atorvastatin.
Background: HMG-CoA reductase inhibitors (statins) are effective lipid-lowering agents and are known to reduce cardiovascular events.
- Trial name
- SOS (NCT00404599)
- Testing
- atrorvastatin 10mg, simvastatin 40mg
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Amsterdam UMC, location VUmc
Primary Arterial Hypertension
Effects of Nebivolol on Subclinical Left Ventricular dySfunction: A Comparative Study Against Metoprolol
Summary: Study title: Effects of Nebivolol on subclinical left ventricular dysfunction. A comparative study against Metoprolol. (ENESYS study) Study phase: 3 Study design (parallel, cross-over, etc.), randomisation and blinding…
- Trial name
- ENESYS (NCT00942487)
- Testing
- Nebilet, Corvitol
- Where
- Romania
- Volunteers
- 60 people
- Sponsor
- Berlin-Chemie Menarini
Chronic Obstructive Pulmonary Disease, Hypertension, Pulmonary
Study of Dehydroepiandrosterone (DHEA) in Respiratory Pulmonary Hypertension in Adults
DHEA prevents and reverses chronic hypoxic pulmonary hypertension in a chronic hypoxic-pulmonary hypertension model in the rat. However, no study has been performed in human.
- Trial name
- DHEA-HTAP (NCT00581087)
- Testing
- DHEA treatment
- Where
- 5 sites in France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Bordeaux