Clinical trials: Hypertension Resistant to Conventional Therapy
Hypertension Resistant to Conventional Therapy, Bradycardia
Moderato System: A Double-Blind Randomized Trial Ver 1.1
The purpose of this double blind randomized study is the evaluation of the safety and efficacy of the Moderato System. The Moderato implantable pulse generator is indicated for patients who have hypertension and also require a…
- Conditions
- Hypertension Resistant to Conventional Therapy, Bradycardia, Atrioventricular Block
- Trial name
- NCT02837445
- Testing
- PHC ON, PHC OFF
- Where
- 12 sites in Austria, Belgium and 5 more
- Volunteers
- 70 people
- Sponsor
- BackBeat Medical Inc
Hypertension, Resistant to Conventional Therapy
Continued Safety and Performance of the TIVUS System
The TIVUS II is a prospective, multicenter, non-randomized, open-label clinical study of the safety and performance of the TIVUS™ System consisting of three (3) concurrent cohorts: TIVUS™ Severe Resistant HTN Cohort TIVUS™…
- Trial name
- NCT01835535
- Testing
- TIVUS
- Where
- Australia
- Volunteers
- 80 people
- Sponsor
- Cardiosonic
Hypertension, Resistant to Conventional Therapy
Effect of Renal Sympathetic Denervation on Resistant Hypertension and Cardiovascular Hemodynamic in Comparison to Intensive Medical Therapy Utilizing Impedance Cardiography
The purpose of this study is to demonstrate that Renal Sympathetic Denervation (RDN) improves the control of blood pressure (BP) in patients with treatment-resistant hypertension, as compared to intensive medical therapy (IMT)…
- Trial name
- OsloRDN (NCT01673516)
- Testing
- The SymplicityTM Renal Denervation System, The HOTMAN® System
- Where
- Norway
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Arterial Hypertension, Hypertension, Resistant to Conventional Therapy
The Effect of Spironolactone on Blood Pressure in Type-2 Diabetics With Resistant Hypertension
The purpose of this study is to estimate the effect of spironolactone on blood pressure resistant to therapy in type-2 diabetics.
- Conditions
- Arterial Hypertension, Hypertension, Resistant to Conventional Therapy, Diabetes Mellitus
- Trial name
- SDHDS (NCT01062763)
- Testing
- spironolactone
- Volunteers
- 119 people
- Sponsor
- Ib Abildgaard Jacobsen
Hypertension, Resistant to Conventional Therapy
Renal Denervation in Refractory Hypertension
Open, multicenter, randomized study is enrolling patients in 3 sites in Czech Republic. Patients with refractory hypertension will be randomized in 1:1 manner either to renal denervation plus optimal medical antihypertensive…
- Trial name
- PRAGUE-15 (NCT01560312)
- Testing
- Renal denervation (Symplicity® Catheter System™)
- Where
- 3 sites in Czechia
- Volunteers
- 106 people
- Sponsor
- Charles University, Czech Republic
Hypertension, Resistant to Conventional Therapy
MANP in African Americans With Hypertension
Evaluate the cardiovascular properties of MANP in AA with Hypertension
- Trial name
- MANP-2 (NCT04542681)
- Testing
- MANP - 1st Cycle, MANP - 2nd Cycle
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mayo Clinic
Hypertension, Resistant to Conventional Therapy, Atrioventricular Block
Moderato System in Patients With Hypertension
The purpose of this double blind randomized study is the evaluation of the safety and efficacy of the Moderato System. The Moderato implantable pulse generator is indicated for patients who have hypertension and also require a…
- Trial name
- NCT03757377
- Testing
- BackBeat Moderato System, BackBeat Moderato Sytsem
- Where
- 4 sites in Belgium, Lithuania and 1 more
- Volunteers
- 203 people
- Sponsor
- BackBeat Medical Inc
Hypertensive Disease, Hypertension, Resistant to Conventional Therapy
Medication Adherence and "True" Resistance in Patients With Resistant Hypertension
The purpose of this study is to estimate the proportion of patients with "true" resistance among patients referred to the Medical Outpatient Department of the Charité - Universitätsmedizin Berlin with the diagnosis "resistant…
- Trial name
- NCT02128386
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Charite University, Berlin, Germany
Hypertension Resistant to Conventional Therapy, Bradycardia
Safety and Performance Study of the Moderato System
The purpose of the study is to evaluate the safety and performance of the Moderato System by implanting the Moderato pacemaker in patients who require a dual chamber pacemaker, and who also have hypertension, in order to reduce…
- Conditions
- Hypertension Resistant to Conventional Therapy, Bradycardia, Atrioventricular Block
- Trial name
- NCT02282033
- Testing
- The Moderato System
- Where
- 10 sites in Austria, Chile and 5 more
- Volunteers
- 57 people
- Sponsor
- BackBeat Medical Inc
Hypertension
Safety and Efficacy Study of Renal Artery Ablation in Resistant Hypertension Patients
This is a prospective, multicenter, feasibility study on the safety and efficacy of renal denervation in patients with resistant hypertension.
- Trial name
- EnligHTN-I (NCT01438229)
- Testing
- St. Jude Medical renal artery ablation system: RF ablation generator (IBI 1500T11.5) and Renal artery ablation catheter (DS3D001, DS3D002)
- Where
- 4 sites in Australia, Greece
- Volunteers
- 47 people
- Sponsor
- Abbott Medical Devices
Hypertension, Resistant to Conventional Therapy, Obstructive Sleep Apnea
CPAP Effect on Blood Pressure and Arterial Stiffness in Obstructive Sleep Apnea Patients With Resistant Hypertension
Resistant hypertension is defined as uncontrolled blood pressure (BP ≥ 140/90mmHg) despite the current use of three or more antihypertensive drugs at full doses, including a diuretic.
- Trial name
- POP-ART (NCT02385864)
- Where
- 4 sites in France
- Volunteers
- 166 people
- Sponsor
- University Hospital, Grenoble
Hypertension, Resistant to Conventional Therapy
Optimum Treatment for Drug-Resistant Hypertension
This study was recommended by NICE, as part of its 2006 guidance for the treatment of hypertension, and is urgently required to provide evidence for the treatment recommendations in patients with resistant hypertension.
- Trial name
- PATHWAY2 (NCT02369081)
- Testing
- Spironolactone, Bisoprolol, Doxazosin
- Where
- 16 sites in United Kingdom
- Volunteers
- 348 people
- Sponsor
- University of Cambridge
Hypertension, Uncontrolled Hypertension
Use of Automated Office Blood Pressure Monitoring
Blood pressure measurements by three methods Office Blood Pressure Measurement (OBPM), Automated Office Blood Pressure Measurement (AOBPM), and Home Blood Pressure Measurement (HBPM) were collected retrospectively across three…
- Conditions
- Hypertension, Uncontrolled Hypertension, Hypertension, White Coat, Hypertension, Resistant to Conventional Therapy
- Trial name
- NCT05395403
- Testing
- Blood pressure measurement device
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Alabama at Birmingham
Hypertension Resistant to Conventional Therapy, Kidney Failure, Chronic
Chemical Renal Ethanol Sympatholysis Under CT Guidance Use for the Control of Therapy-Resistant Hypertension
In this study the investigators are going to assess the feasibility of this innovate technique of renal sympathetic denervation by translumbar access under ct-guidance.
- Trial name
- SCRATCH (NCT02653222)
- Testing
- Renal sympathicolysis, Ambulatory Blood Pressure Monitoring, Magnetic Resonance Angiography
- Where
- 2 sites in France
- Volunteers
- 2 people
- Sponsor
- University Hospital, Grenoble
Hypertension, Resistant to Conventional Therapy, Sleep Apnea
Physical Activity Program for Reducing Blood Pressure in Sleep Apnea Patients With Resistant Hypertension
Investigators hypothesize that CPAP treatment for suppressing OSAS in combination with a physical activity program will optimize 24-hour blood pressure control in patients with OSA-related resistant hypertension.
- Trial name
- RAP (NCT02057783)
- Testing
- Physical activity
- Where
- 5 sites in Canada, France and 1 more
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- AGIR à Dom
Hypertension, Resistant to Conventional Therapy, Essential Hypertension
Monotherapy Versus Dual Therapy for Initial Treatment for Hypertension
To test whether the current custom of initiating treatment for hypertension with a single drug is less effective in the short-term than initial combination therapy, and results in the eventual need for comparatively more…
- Trial name
- Pathway 1 (NCT00994617)
- Testing
- Losartan and hydrochlorothiazide, Hydrochlorothiazide switched over with Losartan at 8 weeks
- Where
- 13 sites in United Kingdom
- Volunteers
- 600 people
- Sponsor
- University of Cambridge
Hypertension Resistant To Conventional Therapy, Baroreflex
Effect Baroreflex Activation Therapy on the Carotid Body
Carotid baroreflex activation therapy (BAT) by the Rheos® system produces a sustained fall in blood pressure in patients with resistant hypertension.
- Conditions
- Hypertension Resistant To Conventional Therapy, Baroreflex, Carotid Body
- Trial name
- NCT02210923
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Maastricht University Medical Center
Baroreflex Failure Syndrome, Hypertension, Resistant to Conventional Therapy
UK Registry for Baroreflex Activation Therapy
This study is a post-marketing open label single arm, single centre clinical trial of electrical carotid sinus stimulation with the Barostim Neo device to target sub-optimally controlled arterial hypertension or highly variable…
- Trial name
- UK-BAT (NCT03730519)
- Testing
- Baroreflex Activation Therapy with Barostim Neo
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Queen Mary University of London
Medication Nonadherence, Hypertension, Resistant to Conventional Therapy
The Use of Educational Technology in Improving Adherence Therapy
Few studies show the benefits of educational technologies a support for the control of chronic diseases. The approach known as 'embracement' adopts relational strategies or soft technologies which promote bonding and may impact…
- Trial name
- NCT03324386
- Testing
- Experimental: Individual Orientation, Experimental: VLE for Distance Learning, Experimental: E-blended Lerarning
- Volunteers
- 57 people
- Sponsor
- University of Sao Paulo General Hospital
Hypertension, Resistant to Conventional Therapy
Autonomic Dysfunction in Resistant Hypertension
The contribution of this study is the unedited evaluation of the circadian autonomic profiles of resistant hypertension with and without white-coat response.
- Trial name
- RH (NCT01833429)
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- University of Campinas, Brazil