Clinical trials: Hypertension in Pregnancy
Chronic Kidney Disease, Diet Interventions
Dine and DASH Into Wellness Pilot Study
The purpose of this study is to determine the feasibility and acceptability of a16-week diet coaching program enhanced with cooking classes to improve adherence to the Dietary Approaches to Stop Hypertension (DASH) diet among…
- Conditions
- Chronic Kidney Disease, Diet Interventions, Disease Prevention
- Trial name
- NCT07175896
- Testing
- Immediate delivery of low-sodium DASH (Dietary Approaches to Stop Hypertension) diet group coaching plus hand-on cooking program, Delayed delivery of low-sodium DASH (Dietary Approaches to Stop Hypertension) diet group coaching plus hand-on cooking program
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Duke University
Preeclampsia
Cardiovascular and Autonomic Reactivity in Women With a History of Pre-eclampsia
A history of preeclampsia is associated with a low plasma volume and higher sympathetic activity. Methyldopa will suppress sympathetic activity to normal values.
- Trial name
- NCT00117546
- Testing
- alpha methyldopa
- Where
- Netherlands
- Volunteers
- 35 people
- Sponsor
- Radboud University Medical Center
Hypertension, Preeclampsia
A Randomized Feasibility Trial Comparing Drospirenone and Norethindrone for Postpartum Hypertension Management in Preeclampsia
This is an open-label, randomized feasibility trial in which patients admitted to Oregon Health \& Science University (OHSU) after a pregnancy complicated by preeclampsia who are considering a progestin-only pill contraception…
- Trial name
- NCT07293728
- Testing
- Norethindrone 0.35 MG, Drospirenone
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Oregon Health and Science University
Hypertension in Pregnancy, Diabetes Mellitus in Pregnancy
Insulin Resistance and Hypertensive Disorders in Pregnancy
The purpose of this study is to determine whether insulin resistance might affect the pathogenesis of hypertensive disorders in pregnancy since midtrimester.
- Trial name
- NCT00412230
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Messina
Preeclampsia/Eclampsia
Pre-eclampsia/Eclampsia in Italy Over the Years 2010-2016
Pre-eclampsia is a heterogeneous multisystem disorder that complicates 2-8% of pregnancies and remains a leading cause of maternal and perinatal mortality and morbidity.
- Trial name
- NCT02982265
- Where
- Italy
- Volunteers
- 1,527 people
- Sponsor
- Papa Giovanni XXIII Hospital
Cardiovascular Diseases, Heart Diseases
Angiotensinogen Variants and Adverse Pregnancy Outcomes
To examine angiotensinogen genetic variants and adverse pregnancy outcomes.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Pre-Eclampsia
- Trial name
- NCT00005400
- Sponsor
- University of Utah
Preeclampsia
Preeclampsia Ratio (sFlt-1/PlGF)
The aim of the PRECOG study is to determine in a prospective interventional randomized study whether the implementation of a predictive test based on the sFLT-1/PlGF ratio improves perinatal care and reduces costs, in patients…
- Trial name
- PRECOG (NCT03289611)
- Testing
- sFlt-1 / PlGF ratio
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Amniotic Fluid Embolism, Pulmonary Hypertension
Effect of Tourniquet Binding of Cervical on the Blood Volume of Amniotic Fluid in Cesarean Section
This study was conducted to investigate whether the use of tourniquet after delivery of the fetus could reduce the amount of amniotic fluid entering the bloodstream and thus reduce the incidence of intraoperative adverse events.
- Trial name
- NCT06254092
- Testing
- tourniquet binding of cervical
- Where
- China
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- First People's Hospital of Chenzhou
Hypertension, Diabetes
Tarka® vs. Lotrel® in Hypertensive, Diabetic Subjects With Renal Disease (TANDEM)
The primary objective of this study is to determine if trandolapril/verapamil (Tarka®) is superior to amlodipine/benazepril (Lotrel®) in reduction of albuminuria in hypertensive subjects with Type 2 diabetes mellitus (DM) and…
- Conditions
- Hypertension, Diabetes, Proteinuria
- Trial name
- TANDEM (NCT00234871)
- Testing
- trandolapril/verapamil, Lotrel (amlodipine/benazepril)
- Volunteers
- 357 people
- Sponsor
- Abbott
Gestational Diabetes Mellitus, Hypertensive Disorder of Pregnancy
Effects of Dietary and Weight Management on Pregnancy Outcomes in Mobile Medical Platform
With the opening up of the two-child policy , the composition of pregnant women in China has changed significantly . The proportion of high-risk pregnant women in the elderly has increased significantly , and the risk of adverse…
- Trial name
- NCT04989634
- Testing
- Intensive dietary and weight management, Standard care
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Capital Medical University
Hypertension in Pregnancy, Obstetrical Complications
Gestational Hypertension and Preeclampsia Blood Pressure (BP) Treatment Goals Less Than 140/90 vs. Less Than 160/110 mmHg: The GOALPOST Trial
This is a phase-III multi-center open-label randomized clinical trial of 4,120 individuals between 23 weeks, 0 days and 35 weeks, 6 days gestation with gestational hypertension or preeclampsia without severe features randomized…
- Trial name
- GOALPOST (NCT07746271)
- Testing
- Anti-hypertensive medication titrated to a BP goal of <140/90 mmHg, Usual Care: Anti-hypertensive medication for BP ≥160/110 mmHg titrated to a goal of < 160/110 mmHg
- Where
- 14 sites in United States
- Volunteers
- 4,120 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
Chronic Kidney Disease
Study on the Safety of the Drug Runcaciguat and How Well it Works When Given at the Highest Dose as Tolerated by Individual Patient Whose Kidneys Are Not Working Properly and Suffering at the Same Time From High Blood Sugar and/or High Blood Pressure and a Disease of the Heart and the Blood Vessels.
Researchers in this study want to learn more about the safety of the drug runcaciguat and how well it works when given at the highest dose as tolerated by the individual patient whose kidneys are not working properly and…
- Trial name
- CONCORD (NCT04507061)
- Testing
- runcaciguat
- Where
- 71 sites in Austria, Belgium and 11 more
- Volunteers
- 243 people
- Sponsor
- Bayer
Preeclampsia
Aspirin for Prevention of Preeclampsia
Prophylaxis with low-dose aspirin has been recommended to prevent preeclampsia, the rationale being that hypertension and abnormalities of coagulation in this disease are caused in part by an imbalance between vasodilating and…
- Trial name
- NCT03726177
- Testing
- aspirin 162 mg, aspirin 81 mg
- Where
- Egypt
- Volunteers
- 600 people
- Sponsor
- Aswan University Hospital
Hypertension Disorders in Pregnancy, Blood Pressure Measurement in Pregnancy
Breathing for Two: Inspiratory Muscle Strength Training for Supporting Healthy Blood Pressure in Pregnancy
This is an interventional study that will test whether a breathing exercise called Inspiratory Muscle Strength Training (IMST) can safely and effectively lower blood pressure during late pregnancy.
- Conditions
- Hypertension Disorders in Pregnancy, Blood Pressure Measurement in Pregnancy, Inspiratory Strength Training (IST), Pregnancy
- Trial name
- NCT07687745
- Testing
- Exercise at 15% PI max, Exercise at 50% PI max
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Arterial Hypertension, Albuminuria
Effects of Linagliptin on Endothelial- , Renal-, and Retinal Function in Patients With Hypertension and Albuminuria
A recent study with the DPP-IV inhibitor Linagliptin showed an improvement in the urinary albumin creatinine ratio in patients with diabetic nephropathy. Gutzwiller et. Al.
- Trial name
- NCT02376075
- Testing
- Linagliptin
- Where
- Germany
- Volunteers
- 43 people
- Sponsor
- ikfe-CRO GmbH
Pregnancy, Vitamin D Deficiency
Trial of Vitamin D Supplements to Raise Calcidiol Levels of Pregnant Women in Mongolia
A double-blind randomized, placebo-controlled trial comparing the impact of 600 IU, 2000 IU, or 4000 IU of Vitamin D3 on third trimester 25(OH)D levels and change from baseline.
- Trial name
- NCT02395081
- Testing
- 600 IU Vitamin D3 in prenatal vitamin, 2000 IU Vitamin D3 in prenatal vitamin, 4000 IU Vitamin D3 in prenatal vitamin
- Where
- Mongolia
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Hypertension, Pregnancy-Induced
Kidney Injury Biomarkers in Preeclampsia
we found different pattern of podocyte glycoproteins and kidney injury biomarkers in urine specimens between preeclampsia and pregnancy complicated with chronic hypertention compared with normotensive pregnant controls.abnormally…
- Trial name
- NCT03217916
- Testing
- Elisa assay of podocyte glycoprotein in urine
- Volunteers
- 40 people
- Sponsor
- Woman's Health University Hospital, Egypt
Arterial Stiffness, Fetal Growth Retardation
Bioimpedence and Arterial Function Monitoring at Birth and in Infants
Babies may be born appropriately grown for gestational age (AGA, >10th centile) or small for gestational age (SGA, <10th centile).
- Conditions
- Arterial Stiffness, Fetal Growth Retardation, Small for Gestational Age at Delivery, Pre-Eclampsia
- Trial name
- BAMBI (NCT04720690)
- Testing
- Vicorder: pulse wave velocity, pulse wave analysis, stroke volume, cardiac output, NICaS, Echocardiography and ultrasound of arteries
- Where
- 2 sites in United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Imperial College Healthcare NHS Trust
Preeclampsia, Severe Preeclampsia
First-trimester Prediction of Preeclampsia
Preeclampsia is a complication of pregnancy related to adverse maternal and neonatal outcomes, including fetal growth restriction and perinatal death.
- Conditions
- Preeclampsia, Severe Preeclampsia, Fetal Growth Restriction, Preterm Birth
- Trial name
- PREDICTION (NCT02189148)
- Where
- 4 sites in Canada
- Volunteers
- 7,554 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Kidney Disease, Chronic, Transplant Complication
Plant-based Diet for Kidney Transplant Recipients
The goal of this clinical trial is to evaluate cardiometabolic and inflammatory parameters in kidney transplant recipients after transitioning to a plant-based diet (PBD).
- Conditions
- Kidney Disease, Chronic, Transplant Complication, Hypertension, Diabetes Mellitus
- Trial name
- NCT06186843
- Testing
- Plant-based diet
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- George Washington University
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