Clinical trials: Hypertensive Heart Disease
Hypertension, Hypertensive Heart Disease
Renal Sympathetic Denervation Prevents Atrial Fibrillation in Patients With Hypertensive Heart Disease: a Pilot Study
The autonomic nervous system plays an important role in the precipitation of AF in structurally-abnormal hearts. Restoration of autonomic imbalance may therefore prevent new-onset AF.
- Conditions
- Hypertension, Hypertensive Heart Disease, Atrial Fibrillation, Autonomic Imbalance
- Trial name
- RDPAF (NCT01990911)
- Testing
- Renal denervation, Medical therapy
- Where
- South Africa
- Volunteers
- 80 people
- Sponsor
- Pace Clinic
Cardiovascular Disease, Diabetes
To Understand the Self-care Ability of Farmers and Fishermen With CMDs (Hypertension, Heart Disease, Hyperlipidemia, Type 2 Diabetes), Whether They Are Aware of CMDs, Their Treatment Status, Treatment Effectiveness, and Their Ability to Describe Known and Practice the Self-care Content of CMDs.
This project will be based on nursing scholar Dorothea Orem's self-care theory, integrating the concept of the [life essential 8, LE8] proposed by the American Heart Association, as well as our team's recent research findings.
- Conditions
- Cardiovascular Disease, Diabetes, Hyperlipidemia, Stroke
- Trial name
- CMDs (NCT06703151)
- Testing
- CMDs (Cardiometabolic Diseases) Self-Care Manual
- Where
- Taiwan
- Volunteers
- 338 people
- Sponsor
- Chang Gung Memorial Hospital
Hypertension, Cardiovascular Risk
Effect of Pitavastatin on Coronary Flow Reserve in Hypertensive Patients
Although statins reduce cardiac events in hypertensive patients with cardiovascular risk factors, the effect of statins on coronary flow reserve (CFR) has not been examined in such patients.
- Trial name
- EPOCH (NCT02144922)
- Testing
- Pitavastatin, Control
- Where
- South Korea
- Volunteers
- 85 people
- Sponsor
- Asan Medical Center
Obesity, Heart Disease
Weight Loss in Pre-Hypertensive Patients With Diastolic Dysfunction
The focus of this study is to observe the impact of weight loss in overweight individuals who have pre-hypertension (have a blood pressure reading of 121-139/81-89 mm Hg).
- Conditions
- Obesity, Heart Disease, Weight Loss, Diastolic Dysfunction
- Trial name
- NCT00911209
- Testing
- Dietitian counselling
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Ragavendra Baliga
COVID-19 Pandemic, Diabetes
Study on the Effect of Incentive Spirometer-based Respiratory Training on the Long COVID-19
The COVID-19 pandemic has emerged as the most significant public health crisis of the 21st century. As of the end of January 2023, global confirmed cases have exceeded 670 million, with a domestic cumulative total of 10.24…
- Conditions
- COVID-19 Pandemic, Diabetes, Hypertension, Cardiac Disease
- Trial name
- NCT06231225
- Testing
- Incentive Spirometer respiratory training
- Volunteers
- 100 people
- Sponsor
- National Taipei University of Nursing and Health Sciences
Stroke, Myocardial Infarction
Predictors of Blood Pressure Control and Associations With Cardiovascular Diseases in Individuals With High Blood Pressure: a CALIBER Study
Current guidelines for the clinical management of hypertension in adults recommend to achieve and maintain blood pressure levels of <140/90 mmHg.
- Conditions
- Stroke, Myocardial Infarction, Stable Angina Pectoris, Heart Failure
- Trial name
- NCT02285322
- Where
- United Kingdom
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- University College, London
Hypertension, Coronary Artery Disease
The Effect of Nebivolol in Hypertensive Patients With Coronary Artery Disease
This study is being done to see if the blood pressure lowering effect of an approved drug nebivolol is comparable to that of another approved drug carvedilol for the treatment of hypertension in patients who have coronary artery…
- Trial name
- NCT00673075
- Testing
- Nebivolol, Carvedilol
- Where
- 34 sites in United States
- Volunteers
- 39 people
- Sponsor
- Forest Laboratories
Hypertension, Left Ventricular Diastolic Dysfunction
Effect of Nebivolol on the Blood Flow in Hearts of Adults With High Blood Pressure and Abnormal Filling of Heart
To investigate whether treatment with Nebivolol in subjects with high blood pressure and abnormal filling of left ventricle (LVDD) improves exercise time by improving Left Ventricular deformation and filling.
- Trial name
- NCT01961323
- Testing
- Nebivolol
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Congestive Heart Failure, Hypertension
Sacubitril-valsartan Versus Usual Anti-hypertensives in LVAD
This pilot, feasibility study evaluates the efficacy of sacubitril-valsartan (Entresto) versus usual anti-hypertensive medications in patients with left ventricular assist devices (LVAD).
- Trial name
- NCT03279861
- Testing
- Entresto, Valsartan
- Sponsor
- University of Maryland, Baltimore
Infection, Heart Failure
Prediction of Expected Length of Hospital Stay Using Machine Learning
This is a retrospective observational study drawing on data from the Brigham and Women's Home Hospital database. Sociodemographic and clinic data from a training cohort were used to train a machine learning algorithm to predict…
- Conditions
- Infection, Heart Failure, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT04784351
- Where
- 2 sites in United States
- Sponsor
- Brigham and Women's Hospital
Physical Exercise, Hypertension
Cardiac Response to Strength Training in Hypertensive Individuals
This study aims to determine the acute effects of high and low-intensity strength training on cardiac autonomic control in hypertensive subjects
- Trial name
- NCT06370546
- Testing
- Low intensity, high intensity
- Where
- Chile
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Universidad Católica del Maule
Hypertension
An Observational Study to Describe the Effectiveness of Angiotensin Converting Enzyme Inhibitor and Calcium Channel Blocker Combination in the Management of Hypertensive Patients With Elevated Heart Rate and Type 2 Diabetes
To describe the effectiveness of angiotensin-converting enzyme inhibitor and non-dihydropyridine calcium channel blocker single pill combination on systolic blood pressure (SBP) lowering in hypertensive patients with elevated…
- Trial name
- HARVEST-TR (NCT02298556)
- Where
- 23 sites in Turkey (Türkiye)
- Volunteers
- 270 people
- Sponsor
- Abbott
Hypertension in Pregnancy, Pre-Eclampsia
Mobile Health Interventions to Prevent Heart Disease After Hypertensive Disorders of Pregnancy
The purpose of this research is to study digital health interventions to prevent cardiovascular disease in individuals who have had a hypertensive disorder of pregnancy (HDP).
- Conditions
- Hypertension in Pregnancy, Pre-Eclampsia, Eclampsia, Gestational Hypertension
- Trial name
- mHEART (NCT06523569)
- Testing
- Digital Blood Pressure Monitoring System, Mobile health application
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Northwestern University
Catecholamine; Overproduction, Catecholamine; Secretion
Sympathetic Activity and Cardiometabolic Complications
Recent studies on catecholamine physiology have shown a direct correlation with arterial hypertension, overcoming the exclusive role in the diagnosis and follow-up of chromaffin tumors.
- Conditions
- Catecholamine; Overproduction, Catecholamine; Secretion, Metabolic Syndrome, Hypertensive Heart Disease
- Trial name
- SYMPACT (NCT04495231)
- Where
- Italy
- Volunteers
- 1,380 people
- Sponsor
- University of Turin, Italy
Atrial Fibrillation, Hypertension
Renal Denervation Therapy in Hypertensive Patients Undergoing A-Fib Ablation
We propose a pilot study to assess safety and benefit of renal artery ablation at the time of planned atrial fibrillation ablation.
- Trial name
- NCT01952743
- Testing
- AF ablation with Renal Denervation, AF ablation alone
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Siva Mulpuru
Hypertension, Coronary Artery Disease
Effects of Different Exercise Training Programs on Short-term Blood Pressure Variability and Atrial Function in Hypertension
The study aim is to compare the effects produced by two different exercise training modalities on short-term blood pressure variability and atrial function evaluated by speckle-tracking echocardiography in hypertensive patients…
- Trial name
- TACITO (NCT04763629)
- Testing
- Physical exercise
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS San Raffaele Roma
Hypertension Complicated, Hypertrophy, Left Ventricular
Efficacy and Safety of Valsartan and Nebivolol/Valsartan in Hypertensive Patients With LVH
To assess the efficacy of Left Ventricular Hypertrophy (LVH) reduction and 24-hour blood pressure control of Valsartan 80mg or Nebivolol/Valsartan 5/80mg once daily as replacement therapy for currently treated or untreated…
- Conditions
- Hypertension Complicated, Hypertrophy, Left Ventricular, Blood Pressure
- Trial name
- BVreduce (NCT03180593)
- Testing
- Valsartan 80 mg
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Trinity Hypertension & Metabolic Research Institute
Prehypertension
Potassium Supplementation to Reduce Blood Pressure
The aim of this study is to conduct a definitive trial to assess the efficacy of consuming 1L/day of water rich in potassium to reduce blood pressure in mild to moderately hypertensive adults.
- Trial name
- NCT05412654
- Testing
- High potassium water, Control low potassium water
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Oxford Brookes University
Heart Failure
Anti-Hypertensive Agent (ACEi) and Heart Function Improvement in Association With Rho Kinase Activity Changes in Human
Hypothesis: Rho, one of the small GTPase proteins, and its downstream target molecule, Rho-kinase (ROCK), play important roles in mediating various cellular functions, including contractility, actin cytoskeleton organization…
- Trial name
- NCT01069042
- Testing
- Enalapril
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Cheng-Kung University Hospital
Diastolic Heart Failure, Hypertensive Heart Disease
Dietary Approaches to Stop Hypertension in 'Diastolic' Heart Failure 2 (DASH-DHF 2)
The purpose of this study is to examine how dietary changes affect the heart and blood vessels in patients with hypertension (high blod pressure) who have a condition called 'heart failure with preserved ejection fraction"…
- Trial name
- NCT01942395
- Testing
- DASH/sodium-restricted diet (DASH/SRD), Control Diet
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Michigan