Clinical trials: Hypertensive Kidney Disease
Hypertension, Acute Myocardial Infarction
PCI and Renal Denervation in Hypertensive Patients With Acute Coronary Syndromes
Research hypothesis: Is the treatment with renal denervation (RDN) early post ACS safe and effective and does it leads to improved cardiac function and attenuation of pathologic left ventricular remodelling? In a following study…
- Trial name
- COMBI-RDN (NCT02272920)
- Testing
- Renal denervation
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Sahlgrenska University Hospital
Diabetic Kidney Disease
Impact of Multidisciplinary Self-care Management of Diabetic Nephropathy on Quality of Life, Self-care Behavior, Glycemic Control, and Renal Function.
Diabetic Kidney Disease (DKD) is becoming a global health concern that affects largely the elderly population. Despite advances in pharmacological and management strategies, DKD remain associated with high morbidity and…
- Trial name
- NCT01967901
- Testing
- Self-care management program
- Where
- Switzerland
- Volunteers
- 36 people
- Sponsor
- University of Applied Sciences of Western Switzerland
Glomerulonephritis, IGA, Hypertension
A Prospective Study of the Kidney Protective Effect of Aliskiren in Hypertensive Patients With IgA Nephropathy
The purpose of this study is to evaluate the effect of aliskiren, a novel direct rennin inhibitor, on renal function and progress of renal disease in hypertensive patients with IgA nephropathy.
- Trial name
- NCT01184599
- Testing
- aliskiren
- Where
- 4 sites in Japan
- Volunteers
- 30 people
- Sponsor
- Kagawa University
Chronic Kidney Disease Stages 3-5, Diabetic Kidney Disease
Role of QRX-3 in Chronic Kidney Disease Patients in Outpatients Clinics
QRX-3, a new drug that stabilized the kidney renal tubular cell and increase the activity of NAD ( nicotinamide adenine dineuclotide )within the kidney cells; leading to decrease oxidative changes intracellularly, repair of renal…
- Conditions
- Chronic Kidney Disease Stages 3-5, Diabetic Kidney Disease, Hypertensive Kidney Disease
- Trial name
- QRX-3 in CKD (NCT06948292)
- Testing
- QRX-3
- Where
- United States
- Volunteers
- 127 people
- Sponsor
- Ebima Clifford Okundaye
Uncontrolled Hypertension
EuroNetrod HTN OFF-Med Study of Renal Denervation With NetrodTM Six-electrode Radiofrequency RDN System
This randomized controlled investigation aims to evaluate the efficacy and safety of the Netrod™ RDN system in patients with uncontrolled primary hypertension in the absence of antihypertensive medication, comparing the outcomes…
- Trial name
- EuroNetrod (NCT06722651)
- Testing
- Netrod™ six-electrode radiofrequency renal denervation system
- Where
- Switzerland
- Sponsor
- Shanghai Golden Leaf MedTec Co. Ltd
Hypertension, Diabetic Nephropathies
A Prospective, Randomised, Double-blind, Double-dummy, Forced-titration, Multicentre, Parallel Group, One Year Treatment Trial to Compare Telmisartan (MICARDIS) 80 mg Versus Losartan (COZAAR) 100 mg, in Hypertensive Type 2 Diabetic Patients With Overt Nephropathy (AMADEO Study)
A number of blood pressure lowering drugs in the class known as angiotensin receptor blockers (ARB) have been shown to slow the decline in kidney function of patients with type 2 diabetes, high blood pressure, and kidney disease.
- Trial name
- NCT00168857
- Testing
- telmisartan, losartan
- Where
- 109 sites in United States, Argentina and 8 more
- Volunteers
- 860 people
- Sponsor
- Boehringer Ingelheim
Hypertension, End Stage Renal Disease
RAAS Inhibitor Drugs in Dialysis Patients
Hypertensive haemodialysis patients are at high risk for cardiovascular events. This study was undertaken to ascertain whether the upstream of aliskirne, a direct renin inhibitor improves mortality and cardiovascular outcomes in…
- Trial name
- NCT01635387
- Testing
- aliskiren
- Volunteers
- 350 people
- Sponsor
- University of Campania Luigi Vanvitelli
Anemia, Diabetes, Kidney Disease, Chronic, Hypertension
Study of Anemia in Chronic Kidney Disease (CKD) Among High-Risk Hypertensive and Diabetic Patients in Pakistan
The purpose of this study is to evaluate the prevalence of CKD-related anemia at an early stage through screening of high-risk patients in Pakistan at the level of physicians, cardiologists, and diabetologists.
- Trial name
- NCT02444845
- Where
- 3 sites in Pakistan
- Volunteers
- 246 people
- Sponsor
- Hoffmann-La Roche
Hypertension (HTN)
Real Life Data From Hypertensive Patients Treated With Renal Denervation in Current Practice in France- French RENal Denervation Registry
Renal denervation (RDN) is a recent procedure that can be used to control BP (blood pressure) in hypertensive patients. Numerous publications from randomised trials have demonstrated the efficacy of RDN in this indication.
- Trial name
- FRIEND (NCT07206030)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Grenoble
Chronic Kidney Disease, Hypertension
Aliskiren and Muscle Sympathetic Nerve Activity
The central hypothesis of this project is that Aliskiren causes a substantial decrease in MSNA in hypertensive patients with CKD.
- Conditions
- Chronic Kidney Disease, Hypertension, Muscle Sympathetic Nerve Activity
- Trial name
- MSNA (NCT00719316)
- Testing
- Aliskiren
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- UMC Utrecht
Chronic Kidney Diseases
Chronic Kidney Disease Among Hypertensive Patients in Ha'il, Saudi Arabia
Chronic kidney disease (CKD) is defined as persistent abnormalities of kidney structure or function for more than 3 months leading to a sustained reduction in glomerular filtration rate (GFR) and/or to the occurrence of kidney…
- Trial name
- CKD (NCT05030480)
- Testing
- renal functions
- Where
- Saudi Arabia
- Volunteers
- 392 people
- Sponsor
- Zagazig University
Infection, Heart Failure
Remote Physician Care for Home Hospital Patients
This study examines the implications of providing remote physician care to home hospitalized patients compared to usual home hospital care with in-person/in-home physician visits.
- Conditions
- Infection, Heart Failure, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT04080570
- Testing
- Remote Visit
- Where
- 2 sites in United States
- Volunteers
- 172 people
- Sponsor
- Brigham and Women's Hospital
Cardiovascular Diseases, Heart Diseases
Genetic Analysis of Human Hypertensive End Stage Renal Disease (H-ESRD)
To identify genes causing hypertensive end-stage renal disease (H-ESRD) in high risk African-American populations
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension, Kidney Failure, Chronic
- Trial name
- NCT00005536
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hypertensive Disease
SMART-IC-Pilot Study
This small-scale, proof-of-concept pilot study aims to obtain preliminary evidence of msRDN procedural safety, feasibility, and short-term efficacy in patients with hypertension without medication therapy, to adequately plan an…
- Trial name
- SMART-IC-Pilot (NCT07336433)
- Testing
- The SymPioneer G2 Mapping/Selective Renal Denervation Device and SyMapCath Catheter II
- Where
- China
- Volunteers
- 15 people
- Sponsor
- SyMap Medical (Suzhou), Ltd.
Hypertension, Diabetes
Tarka® vs. Lotrel® in Hypertensive, Diabetic Subjects With Renal Disease (TANDEM)
The primary objective of this study is to determine if trandolapril/verapamil (Tarka®) is superior to amlodipine/benazepril (Lotrel®) in reduction of albuminuria in hypertensive subjects with Type 2 diabetes mellitus (DM) and…
- Conditions
- Hypertension, Diabetes, Proteinuria
- Trial name
- TANDEM (NCT00234871)
- Testing
- trandolapril/verapamil, Lotrel (amlodipine/benazepril)
- Volunteers
- 357 people
- Sponsor
- Abbott
Hypertension, Renal
Effect of Amlodipine Versus Bisoprolol on Hypertensive Patients With End-stage Renal Disease on Maintenance Hemodialysis.
Hypertension is highly prevalent in hemodialysis (HD) patients and leads to increased morbidity and mortality due to cardiovascular disease(CVD).
- Trial name
- NCT04085562
- Testing
- Bisoprolol Fumarate 5-10 mg, Amlodipine 5-10 mg
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Alexandria University
Chronic Kidney Diseases, Hypertension
Green Propolis Extract and Royal Jelly in Hypertensive Patients and/or With Chronic Kidney Disease
This work aims to evaluate the effects of the association of green propolis extract with royal jelly on inflammation and oxidative stress in participants with chronic kidney diseases (CKD) and Systemic arterial hypertension…
- Conditions
- Chronic Kidney Diseases, Hypertension, Cardiovascular Diseases
- Trial name
- NCT06288204
- Testing
- Propolis associated with Royal Jelly, Royal Jelly
- Where
- 2 sites in Brazil
- Volunteers
- 153 people
- Sponsor
- Universidade Federal Fluminense