Clinical trials: Hypertensive Patients
Hypertension, Diabetes Mellitus Type 2
Irbesartan Effects on Endothelial Dysfunction in Hypertensive Type II Diabetic Patients Comparing Atenolol
To show that Irbesartan improves endothelial dysfunction and the procoagulant state which are thought to be the possible mechanisms, inducing a generalized vasculopathy associated with microalbuminuria and vascular events in type…
- Trial name
- IREDIS (NCT00549133)
- Testing
- Irbesartan
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Sanofi
Hypertension, Oxidative Stress
Effect of Antioxidant Supplementation on the Autonomic Balance
Recent evidence suggests that there is a directly proportional relationship between diets with a high concentration of antioxidants and the reduction of blood pressure and the risk of cardiovascular events.
- Conditions
- Hypertension, Oxidative Stress, Autonomic Imbalance, Insulin Resistance
- Trial name
- NCT03510221
- Testing
- Antioxidants capsules
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Hypertension
Impact of Pacing Site and AV Delay on Blood Pressure in Hypertensive Patients
The purpose of this study is to test whether the A-V sequential pacing strategy shown to effectively reduce blood pressure in a dog model of hypertension also reduces blood pressure acutely in patients with hypertension (systolic…
- Trial name
- NCT02382484
- Testing
- A dual chamber pacing system (BackBeat Medical)
- Where
- China
- Volunteers
- 19 people
- Sponsor
- BackBeat Medical Inc
Hypertension
VALIDATE Valsartan and Supportive Measures - Impact on Drug Adherence of Treated Hypertensive Patients
The purpose of this study is to assess the impact of supportive measures on the drug adherence of patients with essential hypertension
- Trial name
- NCT00394823
- Testing
- Set of supportive tools/measures vs. standard care
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 206 people
- Sponsor
- Novartis
Hypertensive Left Ventricular Hypertrophy
Eplerenone and Aliskiren Research Targeting Hypertensive Patients With Left Ventricular Hypertrophy
The primary objective of this study is to determine which treatment will be more effective to reduce left ventricular mass in hypertensive patients with left ventricular hypertrophy comparing aliskiren and eplerenone.
- Trial name
- EARTH (NCT01893788)
- Testing
- Aliskiren, Eplerenone
- Where
- Japan
- Volunteers
- 100 people
- Sponsor
- Nagoya University
Hypertension
Telmisartan With or Without Hydrochlorothiazide (HCTZ) Compared With Losartan With or Without HCTZ in Mild to Moderate Hypertensive Patients
Study to assess the efficacy of telmisartan 40-80 mg once daily compared with losartan 50-100 mg once daily in hypertensive patients evaluated by change from baseline in diastolic blood pressure (DBP) during the last 6 hours of…
- Trial name
- NCT02172586
- Testing
- Telmisartan, Losartan, Hydrochlorothiazide
- Volunteers
- 363 people
- Sponsor
- Boehringer Ingelheim
Hypertension, Hypertensive Patients
DCP3 Based Multi-component Intervention for Hypertension Management and Control
This study aims to enable delivery of a multi-component intervention comprising of strategies based on Disease Control Priorities 3rd edition for management of hypertension among hypertensive patients.
- Trial name
- NCT04336631
- Testing
- Intervention on DCP3 based strategies for Hypertension Management and Control
- Where
- Pakistan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Health Services Academy, Islamabad, Pakistan
Hypertension, Metabolic Syndrome
Regulation of Inflammatory Parameters by Telmisartan in Hypertensive Patients
A number of studies have shown that certain blood-pressure medications such as ACE-inhibitors and angiotensin-II-receptor blockers (ARB) can reduce the incidence of diabetes mellitus type 2.
- Conditions
- Hypertension, Metabolic Syndrome, Hypertriglyceridemia
- Trial name
- METATEL (NCT00560430)
- Testing
- telmisartan
- Where
- 2 sites in Germany
- Volunteers
- 56 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Obesity, Hypertension
A Study of the Effects of Eplerenone and Amlodipine on Blood Pressure and Basal Metabolic Rate in Obese Hypertensives
Obesity and hypertension are independent risks for congestive heart failure (CHF) and chronic kidney disease. In obesity induced hypertension, the most common cause of human essential hypertension, the potential importance of…
- Trial name
- NCT00825188
- Testing
- eplerenone, amlodipine, eplerenone, amlodipine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Mississippi Medical Center
Hypertension
Effects of Silybin in Hypertensive Patients
Background: Hypertensive patients with normal glucose tolerance (NGT) but 1-h post load plasma glucose >155 mg/dl (1-h high), during the oral glucose tolerance test (OGTT), show an unfavorable metabolic profile characterized by…
- Trial name
- NCT03538327
- Testing
- Silybin
- Volunteers
- 50 people
- Sponsor
- University Magna Graecia
Hypertension
Irbesartan in Hypertension
Study objectives: To demonstrate the effect of irbesartan on the regulation of diastolic blood pressure, in case of missing one dose after a period of administration for 6 to 8 weeks To evaluate the safety of irbesartan
- Trial name
- NCT00265967
- Testing
- Irbesartan
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Sanofi
Hypertension
Effect of Rosuvastatin on Coronary Flow Reserve in Hypertensive Patients With Cardiovascular Risk
Investigators recently demonstrated that coronary flow reserve (CFR) significantly improved after rosuvastatin therapy in hypertensive patients with average levels of serum cholesterol by measuring the change in CFR after 1 year…
- Trial name
- RESERVE II (NCT02482207)
- Testing
- Rosuvastatin, Life style modification
- Where
- South Korea
- Volunteers
- 96 people
- Sponsor
- Asan Medical Center
Hypertension (HTN), Hyperhomocysteinemia
Homocysteine and Early Diastolic Dysfunction in Newly Diagnosed Hypertension
This prospective single-center observational study aims to evaluate the relationship between elevated plasma homocysteine levels and early echocardiographic abnormalities in patients with newly diagnosed essential hypertension.
- Conditions
- Hypertension (HTN), Hyperhomocysteinemia, Diastolic Dysfunction
- Trial name
- HHT-EDD (NCT07480265)
- Testing
- Homocysteine Measurement and Echocardiography
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people
- Sponsor
- Necmettin Erbakan University
Hypertension
Dietary Counseling or Potassium Supplement to Increase Potassium Intake in Patients With High Blood Pressure
High blood pressure is the leading cause of cardiovascular disease worldwide. Many medicines are available to lower blood pressures successfully, as well as many non-medical options, such as dietary changes.
- Trial name
- NCT03809884
- Testing
- Dietary Counselling, Potassium Citrate
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- Ottawa Hospital Research Institute
Hypertension, Abdominal Obesity
Effects of Aliskiren and Amlodipine on the Renin-Angiotensin System (RAS) and Lipid/Carbohydrate Metabolism in Obese Patients With Hypertension
Part 1 determined: aliskiren, amlodipine and angiotensin II concentrations in interstitial fluid of fat and skeletal muscle; aliskiren and angiotensin II concentrations, and renin activity and concentration in fat and skeletal…
- Trial name
- NCT00498433
- Testing
- Aliskiren, Amlodipine
- Where
- 2 sites in Germany
- Volunteers
- 46 people
- Sponsor
- Novartis
Hypertension
Effects of Jacobson's Progressive Muscular Relaxation Technique in Hypertensive Patients
Effects of Jacobson's progressive muscular relaxation technique on blood pressure regulation and activity of daily living in hypertensive patient
- Trial name
- NCT05650138
- Testing
- Jacobson's progressive muscular relaxation technique, 30 min walk
- Where
- Pakistan
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Blood Pressure, Adhesion
Evaluation of the Effect of an APP in Improving Treatment Adherence in Hypertensive Patients in Hypertension Ambulatory
Brief Summary: Through the App, the user will have the opportunity to connect directly with the health professional, clarify doubts and manage the treatment of their hypertension.
- Trial name
- NCT04475367
- Testing
- App hypercross group, without App hypercross group
- Volunteers
- 44 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Primary Hypertension
Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients
The Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients (STEP) is a 2-arm, multi-center, prospective, randomized, open-labeled, blinded-endpoint trial.
- Trial name
- STEP (NCT03015311)
- Testing
- Intensive BP control, Standard BP control
- Where
- 42 sites in China
- Volunteers
- 8,000 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Hypertension, Obesity
Antihypertensive Pharmacological Therapy With Mineralocorticoid Receptor Antagonists in Obese Hypertensive Patients
Obesity is a complex metabolic state at which many pathophysiological pathways seem to interfere, like imbalance of autonomic nervous system, as well as renin-angiotensin-aldosterone system (RAAS) activation.
- Trial name
- HEBRO (NCT03476616)
- Testing
- Eplerenone (-based therapy) arm, Valsartan (-based therapy) arm
- Where
- Greece
- Volunteers
- 198 people
- Sponsor
- Hippocration General Hospital
Resistant Hypertensive Patients
Effect of Renal deNervation on Arterial Stiffness and Haemodynamics in Patients With UncontRolled hypErtension (ENSURE)
The ENSURE study is a multi-center, prospective, single-blind, randomized, controlled study of the effect of renal denervation on arterial stiffness and haemodynamics in subjects with uncontrolled hypertension.
- Trial name
- ENSURE (NCT02102126)
- Testing
- Renal denervation
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai 10th People's Hospital