Clinical trials: Hypertensive Patients
End-stage Renal Disease
Effects of Strict Volume Control in Hypertensive Hemodialysis Patients on Cardiac Structure and Chronic Inflammation
This study aims mainly to investigate the effects of two approaches to control blood pressure in hypertensive hemodialysis patients; using antihypertensive drugs versus strict volume control (by strict dietary salt restriction…
- Trial name
- NCT00307463
- Testing
- strict volume control policy, antihypertensive drugs administration
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 258 people
- Sponsor
- Ege University
Hypertension
Variability of Sulfotransferase Activity in Humans: an Approach to Improve Predictive Drug Response Part II: Analysis of Interindividual Variation in Hypertensive Patients
An open-label, single center, nonrandomized clinical study in hypertensive patients, with intervention, over a 5-week period. After written informed consent, subjects will undergo screening evaluations, including blood and urine…
- Trial name
- NCT06782204
- Testing
- Paracetamol
- Where
- Portugal
- Volunteers
- 7 people
- Sponsor
- Hospital da Luz, Portugal
Hypertension
Study of Co-administration of Olmesartan Medoxomil Plus Amlodipine in Patients With Mild to Severe Hypertension
This study assesses the efficacy and safety of co-administration of olmesartan medoxomil plus amlodipine in mild to severe hypertensive patients older than 18 years of age
- Trial name
- NCT00185133
- Testing
- Olmesartan medoxomil, Amlodipine
- Where
- 139 sites in United States
- Volunteers
- 1,900 people
- Sponsor
- Daiichi Sankyo
Hypertension, Cardiovascular Risk Factors
Rosuvastatin Effect on Serial Echocardiographic Measurement of Coronary Flow Velocity Reserve
In ASCOT study, lipid lowering with a statin provided additional beneficial effects in hypertensive patients with average levels of serum total cholesterol.
- Trial name
- RESERVE (NCT01490398)
- Testing
- Rosuvastatin
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- Asan Medical Center
Peripheral Artery Disease, Hypertension
Comparison of 2 Beta Blocker Drugs on Peripheral Arterial Disease in Patients With High Blood Pressure
This is a 26-week, prospective double-blind, randomized pilot trial of nebivolol versus an active control, metoprolol succinate, in patients with established lower-extremity peripheral artery disease, hypertension, and at least…
- Trial name
- ENCOMPASS (NCT01499134)
- Testing
- nebivolol, Metoprolol succinate
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Thomas Jefferson University
Essential Hypertension
Efficacy and Safety of LCZ696 200 mg + Amlodipine 5 mg in Comparison With Amlodipine 5 mg in Hypertensive Patients Not Responding to Amlodipine
This study will assess whether LCZ696 when used in combination with amlodipine will provide greater BP lowering benefit compared to amlodipine alone in Asian hypertensive patients not adequately responsive to amlodipine therapy.
- Trial name
- NCT01663233
- Testing
- LCZ696, Amlodipine
- Where
- 28 sites in China, Japan and 4 more
- Volunteers
- 266 people
- Sponsor
- Novartis Pharmaceuticals
Resistant Hypertensive Patients
Effect of Renal deNervation on Arterial Stiffness and Haemodynamics in Patients With UncontRolled hypErtension (ENSURE)
The ENSURE study is a multi-center, prospective, single-blind, randomized, controlled study of the effect of renal denervation on arterial stiffness and haemodynamics in subjects with uncontrolled hypertension.
- Trial name
- ENSURE (NCT02102126)
- Testing
- Renal denervation
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai 10th People's Hospital
Diabetes Mellitus, Type 2
Study to Assess the Optimal Renoprotective Dose of Aliskiren in Hypertensive Patients With Type 2 Diabetes and Incipient or Overt Nephropathy
This study will assess the optimal renoprotective dose of Aliskiren in hypertensive type 2 diabetes patients with incipient or overt nephropathy
- Trial name
- NCT00464776
- Testing
- Aliskiren
- Where
- Denmark
- Volunteers
- 26 people
- Sponsor
- Novartis
Hypertension
Irbesartan in Chinese Hypertensive Diabetics With Microalbuminuria
Primary objective: To determine if irbesartan 300mg is better than 150mg in protecting the kidneys in hypertensive patients with diabetes and microalbuminuria.
- Trial name
- NCT00334581
- Testing
- Irbesartan
- Where
- China
- Volunteers
- 192 people
- Sponsor
- Sanofi
Hypertension
COREG MR Versus TOPROL-XL On The Lipid Profile Of Normolipidemic Or Mildly Dyslipidemic Patients With Hypertension
This study was designed to determine whether treatment with COREG MR is more effective at maintaining a better lipid profile than treatment with TOPROL-XL for hypertension.
- Trial name
- NCT00273052
- Testing
- Carvedilol Phosphate modified release formulation, metoprolol succinate
- Where
- 120 sites in United States, Canada and 1 more
- Volunteers
- 514 people
- Sponsor
- GlaxoSmithKline
Hypertension
The Blood Pressure and Metabolic Effects of Nebivolol in Hypertensive Patients With Impaired Glucose Tolerance or Impaired Fasting Glucose
This study is being done to see if the blood pressure and metabolic effects of an approved drug nebivolol is comparable to that of another approved drug hydrochlorothiazide (HCTZ) and placebo in hypertensive patients.
- Trial name
- NCT00673790
- Testing
- Nebivolol with concomitant losartan or lisinopril, HCTZ with concomitant losartan or lisinopril
- Where
- 88 sites in United States
- Volunteers
- 537 people
- Sponsor
- Forest Laboratories
Arterial Hypertension
Acute Effect of Isometric Exercise on Blood Pressure in Hypertensive Patients
International recommendations advocate dynamic or isometric strength training as an adjunct to aerobic exercise. Due to a lack of consensus, this research addresses the acute effects of isometric exercises by handgrip or lower…
- Trial name
- NCT03982758
- Testing
- isometric handgrip exercise, isometric of the lower limbs
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Primary Hypertension
A National Multicentre Study to Assess the Efficacy of the Fixed Combination of Valsartan and Amlodipine in Hypertensive Patients Not Controlled by Monotherapy
This study is to assess the efficacy of the fixed combination of Valsartan and Amlodipine in hypertensive patients uncontrolled by monotherapy.
- Trial name
- NCT01241487
- Testing
- valsartan/amlodipine
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Novartis
Coronary Microvascular Dysfunction, Resistant Hypertension
Impact of Renal Denervation in Patients With Coronary Microvascular Dysfunction: Study Design and Rationale
Long-standing hypertension may cause an impairment in microvascular coronary circulation which is involved in many different cardiac conditions.
- Conditions
- Coronary Microvascular Dysfunction, Resistant Hypertension, Hypertensive Heart Disease
- Trial name
- IMPRESSION (NCT05994729)
- Testing
- Invasive Physiological Assessment of Coronary Circulation
- Volunteers
- 87 people
- Sponsor
- Aurelia Hospital
Preeclampsia, Preeclampsia (PE)
Evaluation of Patients With Hypertensive Disorders of Pregnancy: An Ambispective Observational Study
The overall objective of this study is to evaluate the prognostic role of ultrasound and laboratory parameters, specifically their potential ability to predict severe forms of preeclampsia and adverse maternal-fetal outcomes.
- Conditions
- Preeclampsia, Preeclampsia (PE), Hypertensive Disorder of Pregnancy
- Trial name
- PREP (NCT07299773)
- Testing
- Doppler evaluation
- Volunteers
- 120 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Hypertension
Effects of Doxazosin Gastrointestinal Therapeutic System on Ambulatory Blood Pressure and Cardiovascular Risk Factors in Uncontrolled Hypertensive Patients
The primary objective was to determine the effects of the Gastrointestinal Therapeutic System (GITS) formulation of Doxazosin when used in combination therapy with the 5 major classes of antihypertensive agents as measure by…
- Trial name
- NCT00646841
- Testing
- Doxazosin gastrointestinal therapeutic system (GITS)
- Where
- 7 sites in Italy, Spain and 1 more
- Volunteers
- 89 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Diabetes Mellitus
Effects of Valsartan and Aliskiren on Hemostatic Indices in Hypertensive Diabetics
People with both hypertension and diabetes have a higher chance of developing heart and arterial problems that could be reduced with anti-coagulant therapy.
- Trial name
- NCT01095822
- Testing
- Aliskiren + Valsartan
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- HeartDrug Research LLC
Hypertension, Vascular Function
Anti-hypertensive Therapy and Exercise Treatment to Improve Vascular Health in Patients With Hypertension.
This is a prospective, monocentric, randomized controlled trial to investigate the effect of anti-hypertensive treatment and/or individualized exercise training intervention on blood pressure and vascular health.
- Conditions
- Hypertension, Vascular Function, Fitness Testing, Metabolism Changes
- Trial name
- Antitension (NCT06823570)
- Testing
- Individualized exercise therapy, Lifestyle recommendations
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Hypertension
Effect of a Pharmacist-led Multifaceted Intervention on Treatment Outcomes in Hypertensive Patients
The objective of this cluster randomized controlled trial is to evaluate the effectiveness of a pharmacist-led multifaceted intensive blood pressure intervention on poorly controlled hypertensive patients in phase 1 (1 month, 3…
- Trial name
- NCT06558877
- Testing
- pharmacist-led multifaceted intervention, conventional health education
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Xijing Hospital
Hypertension
A Study to Evaluate the Combination of Valsartan + Amlodipine in Hypertensive Patients
The purpose of this study is to evaluate the efficacy of valsartan plus amlodipine in hypertensive patients not responding to treatment with amlodipine or felodipine alone.
- Trial name
- NCT00392262
- Testing
- valsartan + amlodipine
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 224 people
- Sponsor
- Novartis